CL2016002888A1 - Compuestos derivados de pirazolopiridinas y pirazolopirimidinas; composicion farmacéutica y su uso como inhibidores selectivos de janus quinasas (jak) en el tratamiento de enfermedades como congestion nasal, asma, epoc, rinitis alergica, diabetes entre otras. - Google Patents
Compuestos derivados de pirazolopiridinas y pirazolopirimidinas; composicion farmacéutica y su uso como inhibidores selectivos de janus quinasas (jak) en el tratamiento de enfermedades como congestion nasal, asma, epoc, rinitis alergica, diabetes entre otras.Info
- Publication number
- CL2016002888A1 CL2016002888A1 CL2016002888A CL2016002888A CL2016002888A1 CL 2016002888 A1 CL2016002888 A1 CL 2016002888A1 CL 2016002888 A CL2016002888 A CL 2016002888A CL 2016002888 A CL2016002888 A CL 2016002888A CL 2016002888 A1 CL2016002888 A1 CL 2016002888A1
- Authority
- CL
- Chile
- Prior art keywords
- pyrazolopyridines
- epoc
- pyrazolopyrimidines
- asthma
- diabetes
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Compuestos derivados de pirazolopiridinas y pirazolopirimidinas; composición farmacéutica y su uso como inhibidores selectivos de Janus quinasas para el tratamiento de enfermedades tales como congestión nasal, asma, epoc, rinitis alérgica, artritis, enfermedad cardiovascular, aterosclerosis, infarto de miocardio, trombosis, insuficiencia cardíaca congestiva, diabetes tipo 1 y 2, cáncer, fibrosis, obesidad, distrofia muscular, polimiositis, enfermedad de Alzheimer, enrojecimiento de la piel, eczema, psoriasis, dermatitis atópica y quemadura de sol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461993138P | 2014-05-14 | 2014-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016002888A1 true CL2016002888A1 (es) | 2017-05-12 |
Family
ID=53264695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2016002888A CL2016002888A1 (es) | 2014-05-14 | 2016-11-14 | Compuestos derivados de pirazolopiridinas y pirazolopirimidinas; composicion farmacéutica y su uso como inhibidores selectivos de janus quinasas (jak) en el tratamiento de enfermedades como congestion nasal, asma, epoc, rinitis alergica, diabetes entre otras. |
Country Status (29)
Country | Link |
---|---|
US (2) | US9518052B2 (es) |
EP (1) | EP3143021B1 (es) |
JP (1) | JP6663857B2 (es) |
KR (1) | KR20170002623A (es) |
CN (1) | CN106459048A (es) |
AP (1) | AP2016009562A0 (es) |
AR (1) | AR100438A1 (es) |
AU (1) | AU2015260905A1 (es) |
CA (1) | CA2948587C (es) |
CL (1) | CL2016002888A1 (es) |
CR (1) | CR20160525A (es) |
CU (1) | CU20160167A7 (es) |
DO (1) | DOP2016000298A (es) |
EA (1) | EA201650029A1 (es) |
EC (1) | ECSP16087271A (es) |
ES (1) | ES2737696T3 (es) |
GE (1) | GEP20186921B (es) |
IL (1) | IL248970A0 (es) |
MD (1) | MD20160121A2 (es) |
MX (1) | MX2016014878A (es) |
NI (1) | NI201600170A (es) |
PE (1) | PE20161475A1 (es) |
PH (1) | PH12016502228A1 (es) |
SG (1) | SG11201609139WA (es) |
SV (1) | SV2016005318A (es) |
TN (1) | TN2016000503A1 (es) |
TW (1) | TWI591067B (es) |
UY (1) | UY36121A (es) |
WO (1) | WO2015173683A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015173683A1 (en) | 2014-05-14 | 2015-11-19 | Pfizer Inc. | Pyrazolopyridines and pyrazolopyrimidines |
TWI714528B (zh) | 2014-05-14 | 2021-01-01 | 瑞士商諾華公司 | 甲醯胺衍生物 |
EP3865481A1 (en) | 2015-11-03 | 2021-08-18 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
US10100049B2 (en) | 2015-11-03 | 2018-10-16 | Theravance Biopharma R&D Ip, Llc | JAK kinase inhibitor compounds for treatment of respiratory disease |
EP3371185B1 (en) | 2015-11-03 | 2020-09-30 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
ES2882186T3 (es) | 2017-03-09 | 2021-12-01 | Theravance Biopharma R&D Ip Llc | Inhibidores de JAK que contienen una amida heterocíclica de 4 miembros |
AU2018261591B2 (en) | 2017-05-01 | 2021-09-02 | Theravance Biopharma R&D Ip, Llc | Crystalline forms of a JAK inhibitor compound |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
AU2018261588A1 (en) | 2017-05-01 | 2019-10-31 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a JAK inhibitor compound |
BR112020002265A2 (pt) | 2017-08-01 | 2020-07-28 | Theravance Biopharma R&D Ip, Llc | compostos pirazólicos e triazólicos bicíclicos como inibidores de jak quiinase |
CN111566095B (zh) | 2017-11-03 | 2024-09-27 | 阿克拉瑞斯治疗股份有限公司 | 被取代的吡咯并吡啶jak抑制剂及其制造方法和使用方法 |
AU2019317625A1 (en) | 2018-08-10 | 2021-02-18 | Aclaris Therapeutics, Inc. | Pyrrolopyrimidine ITK inhibitors |
CN110833555B (zh) * | 2018-08-15 | 2023-03-24 | 广西梧州制药(集团)股份有限公司 | 吡唑并嘧啶衍生物在治疗溃疡性结肠炎的用途 |
SG11202101785UA (en) | 2018-09-04 | 2021-03-30 | Theravance Biopharma R&D Ip Llc | Process for preparing jak inhibitors and intermediates thereof |
BR112021004063A2 (pt) | 2018-09-04 | 2021-05-25 | Theravance Biopharma R&D Ip, Llc | amidas heterocíclicas com 5 a 7 membros como inibidores de jak |
PL3837258T3 (pl) | 2018-09-04 | 2024-09-16 | Theravance Biopharma R&D Ip, Llc | Amidy dimetyloaminoazetydyny jako inhibitory jak |
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