PE20040837A1 - Compuestos de amina - Google Patents

Compuestos de amina

Info

Publication number
PE20040837A1
PE20040837A1 PE2003001164A PE2003001164A PE20040837A1 PE 20040837 A1 PE20040837 A1 PE 20040837A1 PE 2003001164 A PE2003001164 A PE 2003001164A PE 2003001164 A PE2003001164 A PE 2003001164A PE 20040837 A1 PE20040837 A1 PE 20040837A1
Authority
PE
Peru
Prior art keywords
carbonyl
group
dimethylamine
hydrocarbon
piperidinocarboxamide
Prior art date
Application number
PE2003001164A
Other languages
English (en)
Inventor
Hidenori Abe
Masanori Watanabe
Shiro Takekaw
Shinichiro Matsunaga
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of PE20040837A1 publication Critical patent/PE20040837A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

SE REFIERE A DERIVADOS DE AMINA DE FORMULA I DONDE A ES UN ANILLO AROMATICO; B, Y E Ya SON UN ENLACE ESPACIADOR QUE TIENE UNA CADENA PRINCIPAL DE 1 A 6 ATOMOS; R1 Y R2 SON H, UN HIDROCARBURO QUE TIENE UN GRUPO HETEROCICLO GRUPO; R1 Y R2 JUNTO AL ATOMO DE N ADYACENTE FORMA UN ANILLO HETEROCICLICO; R3 ES H, GRUPO HIDROCARBURO , GRUPO HETEROCICLICO; R4 Y R5 SON H, HIDROCARBURO O JUNTO AL ATOMO DE CARBONO ADYACENTE FORMAN UN ANILLO; R6 ES UN GRUPO INDOLILO; Z Y Za SON H, HALO, GRUPO CICLICO. SON COMPUESTOS PREFERIDOS N-((1R,2S)-1-(((5-((DIMETILAMINO)METIL)-2-((METILAMINO)CARBONIL)FENIL)AMINO)CARBONIL)-2-(1H-INDOL-3-IL)PROPIL)-4-(2-METILFENIL)-1-PIPERIDINOCARBOXAMIDA; N-((1R,2S)-1-(((2-((DIMETILAMINO)CARBONIL)-5-((DIMETILAMINO)METIL)FENIL)AMINO)CARBONIL)-2-(1H-INDOL-3- IL)PROPIL)-4-(4-FLUOROFENIL)-1- PIPERIDINOCARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS TIENEN ACTIVIDAD INHIBIDORA DEL ENLACE DEL RECEPTOR DE SOMATOSTATINA
PE2003001164A 2002-11-19 2003-11-18 Compuestos de amina PE20040837A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002335661 2002-11-19
JP2003076435 2003-03-19

Publications (1)

Publication Number Publication Date
PE20040837A1 true PE20040837A1 (es) 2004-12-24

Family

ID=32328326

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001164A PE20040837A1 (es) 2002-11-19 2003-11-18 Compuestos de amina

Country Status (8)

Country Link
US (1) US20060223826A1 (es)
EP (1) EP1562898A1 (es)
AR (1) AR042064A1 (es)
AU (1) AU2003280838A1 (es)
CA (1) CA2506735A1 (es)
PE (1) PE20040837A1 (es)
TW (1) TW200420559A (es)
WO (1) WO2004046107A1 (es)

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PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
CN100391938C (zh) * 2005-09-02 2008-06-04 上海奥博生物医药技术有限公司 (s)-n-乙基-n-甲基-3-[1-(二甲氨基)乙基]-氨基甲酸苯酯(ⅰ)及其酒石酸盐(ⅱ)的制备方法
GB0601031D0 (en) * 2006-01-18 2006-03-01 Novartis Ag Organic compounds
KR100795462B1 (ko) * 2006-09-27 2008-01-16 한국생명공학연구원 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물
KR20110021958A (ko) * 2008-06-04 2011-03-04 아스트라제네카 아베 소분자 렙틴 수용체 조절제
UY33726A (es) 2010-11-15 2012-06-29 Abbott Lab Inhibidores de nampt y rock
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
TN2016000503A1 (en) 2014-05-14 2018-04-04 Pfizer Pyrazolopyridines and pyrazolopyrimidines
WO2016196895A1 (en) * 2015-06-05 2016-12-08 Joslin Diabetes Center, Inc. Methods amd compositions for promoting thermogenic potential
US20200000816A1 (en) 2017-02-08 2020-01-02 Ono Pharmaceutical Co., Ltd. Compound having somatostatin receptor agonistic activity and pharmaceutical use thereof
US11028068B2 (en) 2017-07-25 2021-06-08 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
JP2023530267A (ja) 2020-06-10 2023-07-14 アリゴス セラピューティクス インコーポレイテッド コロナウイルス、ピコルナウイルス及びノロウイルス感染を治療するための抗ウイルス化合物
KR20240035513A (ko) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 항바이러스 화합물

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JPS5826745B2 (ja) * 1976-06-01 1983-06-04 三共株式会社 Ｎα−アシル−α−Ｌ−アミノ酸アニリド化合物
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CA2203428A1 (en) * 1995-08-21 1997-02-27 Philip Arthur Hipskind 2-acylaminopropanamides as growth hormone secretagogues
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Also Published As

Publication number Publication date
EP1562898A1 (en) 2005-08-17
AR042064A1 (es) 2005-06-08
CA2506735A1 (en) 2004-06-03
WO2004046107A8 (en) 2005-06-16
TW200420559A (en) 2004-10-16
US20060223826A1 (en) 2006-10-05
AU2003280838A1 (en) 2004-06-15
AU2003280838A8 (en) 2004-06-15
WO2004046107A1 (en) 2004-06-03

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