PE20120517A1 - Inhibidores del virus de la hepatitis c - Google Patents

Inhibidores del virus de la hepatitis c

Info

Publication number
PE20120517A1
PE20120517A1 PE2011001733A PE2011001733A PE20120517A1 PE 20120517 A1 PE20120517 A1 PE 20120517A1 PE 2011001733 A PE2011001733 A PE 2011001733A PE 2011001733 A PE2011001733 A PE 2011001733A PE 20120517 A1 PE20120517 A1 PE 20120517A1
Authority
PE
Peru
Prior art keywords
imidazol
pyrrolidinyl
cyclohexen
hepatitis
alkyl
Prior art date
Application number
PE2011001733A
Other languages
English (en)
Inventor
Omar D Lopez
Qi Chen
Makonen Belema
Lawrence G Hamann
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42313493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120517(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20120517A1 publication Critical patent/PE20120517A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE s ES 0 O 1; L ES -L1-L2-; L1 Y L2 SON CICLOHEXILO, FENILO, CICLOHEXENO, ENTRE OTROS; Y E Y' SON O O NH; R1 ES H O C(O)Rx; R2 ES H O C(O)Ry; Rx Y Ry SON CICLOALQUILO C3-C8; ALQUILO C1-C10; ALCOXI C1-C10, ENTRE OTROS; R100 Y R110 SON H, ALQUILO C1-C10, CIANOALQUILO C1-C10 Y HALO. SON COMPUESTOS PREFERIDOS: ((1S)-1-(((2S)-2-(4-(4'-(2-((2S)-1-((2S)-2-((METOXICARBONIL)AMINO)-3-METILBUTANOIL-2-PIRROLIDINIL)-1H-IMIDAZOL-4-IL)-1,1'-BI(3-CICLOHEXEN-1-IL)-4-IL)-1H-IMIDAZOL-2-IL)-1-PIRROLIDINIL)CARBONIL)-2-METILPROPIL)CARBAMATO DE METILO, ((1S)-2-((2S)-2-(4-(4'-(2-((2S)-1-(N-(METOXICARBONIL)-L-ALANIL)-2-PIRROLIDINIL)-1H-IMIDAZOL-4-IL)-1,1'-BI(3-CICLOHEXEN-1-IL)-4-IL)-1H-IMIDAZOL-2-IL)-1-PIRROLIDINIL)-1-METIL-2-OXOETIL)CARBAMATO DE METILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA PROTEINA NS5A CODIFICADA POR EL VIRUS DE LA HEPATITIS C
PE2011001733A 2009-03-30 2010-03-29 Inhibidores del virus de la hepatitis c PE20120517A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16457909P 2009-03-30 2009-03-30

Publications (1)

Publication Number Publication Date
PE20120517A1 true PE20120517A1 (es) 2012-05-09

Family

ID=42313493

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001733A PE20120517A1 (es) 2009-03-30 2010-03-29 Inhibidores del virus de la hepatitis c

Country Status (20)

Country Link
US (2) US20100249190A1 (es)
EP (1) EP2414352B1 (es)
JP (1) JP5612661B2 (es)
KR (1) KR20110134497A (es)
CN (1) CN102378762B (es)
AR (1) AR076170A1 (es)
AU (1) AU2010234861A1 (es)
BR (1) BRPI1014084A2 (es)
CA (1) CA2758047C (es)
CL (1) CL2011002453A1 (es)
CO (1) CO6361922A2 (es)
EA (1) EA021260B1 (es)
ES (1) ES2524542T3 (es)
IL (1) IL214939A0 (es)
MX (1) MX2011009644A (es)
NZ (1) NZ594981A (es)
PE (1) PE20120517A1 (es)
TW (1) TWI476190B (es)
WO (1) WO2010117704A1 (es)
ZA (1) ZA201106669B (es)

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EP2367823A1 (en) 2008-12-23 2011-09-28 Abbott Laboratories Anti-viral compounds
US8314135B2 (en) 2009-02-09 2012-11-20 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole antivirals
US8242156B2 (en) 2009-02-17 2012-08-14 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8394968B2 (en) 2009-02-17 2013-03-12 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI438200B (zh) * 2009-02-17 2014-05-21 必治妥美雅史谷比公司 Ｃ型肝炎病毒抑制劑
US8188132B2 (en) 2009-02-17 2012-05-29 Enanta Pharmaceuticals, Inc. Linked dibenzimidazole derivatives
US8673954B2 (en) 2009-02-27 2014-03-18 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US9765087B2 (en) 2009-02-27 2017-09-19 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8101643B2 (en) 2009-02-27 2012-01-24 Enanta Pharmaceuticals, Inc. Benzimidazole derivatives
US8796466B2 (en) 2009-03-30 2014-08-05 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201038559A (en) 2009-04-09 2010-11-01 Bristol Myers Squibb Co Hepatitis C virus inhibitors
US8143414B2 (en) 2009-04-13 2012-03-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN102459165B (zh) * 2009-04-15 2015-09-02 Abbvie公司 抗病毒化合物
TWI629981B (zh) 2009-05-13 2018-07-21 基利法瑪席特有限責任公司 抗病毒化合物
US8211928B2 (en) 2009-05-29 2012-07-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8138215B2 (en) 2009-05-29 2012-03-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
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US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
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US8609648B2 (en) 2009-07-02 2013-12-17 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
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US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110269956A1 (en) 2009-11-11 2011-11-03 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110281910A1 (en) 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
US20110137633A1 (en) * 2009-12-03 2011-06-09 Abbott Laboratories Anti-viral compounds and methods of identifying the same
EP2512480A4 (en) 2009-12-14 2013-05-15 Enanta Pharm Inc HEPATITIS C-VIRUS HEMMER
US8377980B2 (en) 2009-12-16 2013-02-19 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN104530079B (zh) * 2009-12-18 2017-10-20 北京凯因科技股份有限公司 C型肝炎病毒复制的新型抑制剂
US8362020B2 (en) 2009-12-30 2013-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8933110B2 (en) 2010-01-25 2015-01-13 Enanta Pharmaceuticals, Inc. Hepatitis C virus inhibitors
SG188957A1 (en) 2010-01-25 2013-05-31 Enanta Pharm Inc Hepatitis c virus inhibitors
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
US8178531B2 (en) 2010-02-23 2012-05-15 Enanta Pharmaceuticals, Inc. Antiviral agents
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LT2950786T (lt) 2013-01-31 2020-03-10 Gilead Pharmasset Llc Dviejų antivirusinių junginių preparatų kompozicija
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US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
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SG10201702522UA (en) * 2009-06-11 2017-05-30 Abbvie Bahamas Ltd Anti-viral compounds to treat hcv infection

Also Published As

Publication number Publication date
TW201038555A (en) 2010-11-01
US8822444B2 (en) 2014-09-02
AR076170A1 (es) 2011-05-26
TWI476190B (zh) 2015-03-11
CA2758047C (en) 2016-05-17
ZA201106669B (en) 2013-02-27
EA021260B1 (ru) 2015-05-29
CL2011002453A1 (es) 2012-03-02
MX2011009644A (es) 2011-09-28
CO6361922A2 (es) 2012-01-20
BRPI1014084A2 (pt) 2016-04-19
US20100249190A1 (en) 2010-09-30
ES2524542T3 (es) 2014-12-10
JP5612661B2 (ja) 2014-10-22
JP2012522056A (ja) 2012-09-20
KR20110134497A (ko) 2011-12-14
WO2010117704A1 (en) 2010-10-14
AU2010234861A1 (en) 2011-09-22
US20120277266A1 (en) 2012-11-01
EP2414352B1 (en) 2014-10-01
CN102378762B (zh) 2014-10-29
EA201101240A1 (ru) 2012-05-30
NZ594981A (en) 2013-05-31
CA2758047A1 (en) 2010-10-14
CN102378762A (zh) 2012-03-14
EP2414352A1 (en) 2012-02-08
IL214939A0 (en) 2011-11-30

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