AR051965A1 - Sales de la n-[2-( { (3r)-1-[trans-4-hidroxi-4-(6- metoxipiridin-3-il)-ciclohexil] pirrolidin-3- il} amino)-2- oxoetil]-3-(trifluormetil) benzamida - Google Patents
Sales de la n-[2-( { (3r)-1-[trans-4-hidroxi-4-(6- metoxipiridin-3-il)-ciclohexil] pirrolidin-3- il} amino)-2- oxoetil]-3-(trifluormetil) benzamidaInfo
- Publication number
- AR051965A1 AR051965A1 ARP050104879A ARP050104879A AR051965A1 AR 051965 A1 AR051965 A1 AR 051965A1 AR P050104879 A ARP050104879 A AR P050104879A AR P050104879 A ARP050104879 A AR P050104879A AR 051965 A1 AR051965 A1 AR 051965A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxoetil
- metoxipiridin
- trifluormetil
- ciclohexil
- benzamida
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Abstract
Reivindicacion 1: Una sal farmacéutica aceptable de un compuesto de la formula (1), caracterizada en que dicha sal es una sal del ácido metanosulfonico, del ácido bis etanosulfonico o del ácido canforico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63014604P | 2004-11-22 | 2004-11-22 | |
US69963705P | 2005-07-15 | 2005-07-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051965A1 true AR051965A1 (es) | 2007-02-21 |
Family
ID=36647947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104879A AR051965A1 (es) | 2004-11-22 | 2005-11-21 | Sales de la n-[2-( { (3r)-1-[trans-4-hidroxi-4-(6- metoxipiridin-3-il)-ciclohexil] pirrolidin-3- il} amino)-2- oxoetil]-3-(trifluormetil) benzamida |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060111404A1 (es) |
EP (1) | EP1819694A2 (es) |
JP (1) | JP2008520722A (es) |
AR (1) | AR051965A1 (es) |
CA (1) | CA2587919A1 (es) |
PA (1) | PA8653301A1 (es) |
PE (1) | PE20061082A1 (es) |
TW (1) | TW200633703A (es) |
UY (1) | UY29219A1 (es) |
WO (1) | WO2006073592A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG173922A1 (en) * | 2002-11-27 | 2011-09-29 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
JP4740151B2 (ja) * | 2003-12-18 | 2011-08-03 | インサイト コーポレイション | ケモカイン受容体のモジュレーターとしての3‐シクロアルキルアミノピロリジン誘導体 |
BRPI0512352A (pt) * | 2004-06-28 | 2008-03-04 | Incyte Corp | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimiocinas |
WO2007143600A2 (en) | 2006-06-05 | 2007-12-13 | Incyte Corporation | Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
WO2008145681A2 (en) * | 2007-05-31 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
WO2009130915A1 (ja) | 2008-04-25 | 2009-10-29 | 株式会社日本触媒 | ポリアクリル酸(塩)系吸水性樹脂およびその製造方法 |
ES2555004T3 (es) * | 2008-12-10 | 2015-12-28 | Janssen Pharmaceutica N.V. | Antagonistas 4-azetidinil-1-heteroaril ciclohexanol de CCR2 |
CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
WO2010090322A1 (ja) | 2009-02-06 | 2010-08-12 | 株式会社日本触媒 | ポリアクリル酸(塩)系親水性樹脂およびその製造方法 |
CN102459225B (zh) * | 2009-04-16 | 2014-08-20 | 詹森药业有限公司 | Ccr2的4-氮杂环丁烷基-1-杂芳基-环己烷拮抗剂 |
EP2419418B1 (en) * | 2009-04-17 | 2015-04-15 | Janssen Pharmaceutica NV | 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2 |
MX2011010964A (es) | 2009-04-17 | 2011-11-02 | Janssen Pharmaceutica Nv | Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano. |
KR101151415B1 (ko) * | 2009-07-10 | 2012-06-01 | 양지화학 주식회사 | Ccr2 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체 |
JP5629688B2 (ja) | 2009-08-27 | 2014-11-26 | 株式会社日本触媒 | ポリアクリル酸(塩)系吸水性樹脂およびその製造方法 |
CN102548654A (zh) | 2009-09-29 | 2012-07-04 | 株式会社日本触媒 | 颗粒状吸水剂及其制造方法 |
PT3091012T (pt) | 2009-12-17 | 2018-06-27 | Centrexion Therapeutics Corp | Antagonistas do receptor ccr2 e suas utilizações |
WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
BR112012031873A2 (pt) * | 2010-06-17 | 2016-11-08 | Janssen Pharmaceutica Nv | antagonistas de ciclo-hexil-azetidinila do ccr2 |
EP3520978B1 (en) | 2013-08-28 | 2020-11-04 | Nippon Shokubai Co., Ltd. | Polyacrylic acid (salt)-based water absorbent resin powder |
EP3401070B1 (en) | 2013-08-28 | 2021-04-21 | Nippon Shokubai Co., Ltd. | Water absorbent resin powder comprising polyacrylic acid (salt)-based water absorbent resin |
AU2016263579B2 (en) | 2015-05-21 | 2020-12-03 | Chemocentryx, Inc. | CCR2 modulators |
MX2017017177A (es) | 2015-07-02 | 2018-11-09 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona. |
AU2018335486A1 (en) | 2017-09-25 | 2020-03-26 | Chemocentryx, Inc. | Combination therapy using a Chemokine Receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
EP3737367A4 (en) | 2018-01-08 | 2022-11-09 | ChemoCentryx, Inc. | METHODS OF TREATING SOLID TUMORS USING CCR2 ANTAGONISTS |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU175454B (hu) * | 1977-07-25 | 1980-08-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh predel'nykh i chastichno predel'nykh n-acil-pirrol-2,5-dionov |
US5770573A (en) * | 1993-12-06 | 1998-06-23 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
KR100622613B1 (ko) * | 1997-11-18 | 2006-09-11 | 데이진 화-마 가부시키가이샤 | 시클릭 아민 유도체 및 그 약제로서의 용도 |
GB2355263A (en) * | 1999-09-30 | 2001-04-18 | Merck & Co Inc | Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists |
US6362177B1 (en) * | 2000-05-16 | 2002-03-26 | Teijin Limited | Cyclic amine derivatives and their use as drugs |
SG173922A1 (en) * | 2002-11-27 | 2011-09-29 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
-
2005
- 2005-11-18 UY UY29219A patent/UY29219A1/es not_active Application Discontinuation
- 2005-11-18 PA PA20058653301A patent/PA8653301A1/es unknown
- 2005-11-21 CA CA002587919A patent/CA2587919A1/en not_active Abandoned
- 2005-11-21 WO PCT/US2005/042115 patent/WO2006073592A2/en active Application Filing
- 2005-11-21 JP JP2007543339A patent/JP2008520722A/ja not_active Abandoned
- 2005-11-21 US US11/284,220 patent/US20060111404A1/en not_active Abandoned
- 2005-11-21 AR ARP050104879A patent/AR051965A1/es unknown
- 2005-11-21 EP EP05856986A patent/EP1819694A2/en not_active Withdrawn
- 2005-11-22 PE PE2005001365A patent/PE20061082A1/es not_active Application Discontinuation
- 2005-11-22 TW TW094141007A patent/TW200633703A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1819694A2 (en) | 2007-08-22 |
UY29219A1 (es) | 2006-04-28 |
PA8653301A1 (es) | 2006-11-09 |
WO2006073592A3 (en) | 2006-09-28 |
US20060111404A1 (en) | 2006-05-25 |
JP2008520722A (ja) | 2008-06-19 |
CA2587919A1 (en) | 2006-07-13 |
WO2006073592A2 (en) | 2006-07-13 |
PE20061082A1 (es) | 2006-12-08 |
TW200633703A (en) | 2006-10-01 |
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