DK1912979T3 - Phenyl-{3-{3-(1H-pyrrol-2-YL)-[1,2,4]oxadiazol-5-YL]piperidin-1-YL}-methanon-derivater og beslægtede forbindelser som positive allosteriske modulatorer af metabotrope glutamat-receptorer - Google Patents

Phenyl-{3-{3-(1H-pyrrol-2-YL)-[1,2,4]oxadiazol-5-YL]piperidin-1-YL}-methanon-derivater og beslægtede forbindelser som positive allosteriske modulatorer af metabotrope glutamat-receptorer

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Publication number
DK1912979T3
DK1912979T3 DK06779899.1T DK06779899T DK1912979T3 DK 1912979 T3 DK1912979 T3 DK 1912979T3 DK 06779899 T DK06779899 T DK 06779899T DK 1912979 T3 DK1912979 T3 DK 1912979T3
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Prior art keywords
metabotrope
oxadiazol
pyrrol
piperidin
phenyl
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DK06779899.1T
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English (en)
Inventor
Stefania Gagliardi
Lain Lingard
Giovanni Palombi
Poul Emmanuel Le
Sonia Maria Poli
Jean-Philippe Rocher
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Addex Pharmaceuticals Sa
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/36—Opioid-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
DK06779899.1T 2005-05-18 2006-05-17 Phenyl-{3-{3-(1H-pyrrol-2-YL)-[1,2,4]oxadiazol-5-YL]piperidin-1-YL}-methanon-derivater og beslægtede forbindelser som positive allosteriske modulatorer af metabotrope glutamat-receptorer DK1912979T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0510141.5A GB0510141D0 (en) 2005-05-18 2005-05-18 Novel compounds B3
PCT/IB2006/002047 WO2006123257A2 (en) 2005-05-18 2006-05-17 Phenyl-3-{(3-(1h-pyrrol-2-yl)-[1, 2 , 4]0xadiaz0l-5-yl]piperidin-1-yl}-methanone derivatives and related compounds as positive allosteric modulators of metabotropic glutamate receptors

Publications (1)

Publication Number Publication Date
DK1912979T3 true DK1912979T3 (da) 2011-08-22

Family

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DK06779899.1T DK1912979T3 (da) 2005-05-18 2006-05-17 Phenyl-{3-{3-(1H-pyrrol-2-YL)-[1,2,4]oxadiazol-5-YL]piperidin-1-YL}-methanon-derivater og beslægtede forbindelser som positive allosteriske modulatorer af metabotrope glutamat-receptorer

Country Status (24)

Country Link
US (1) US20090203737A1 (da)
EP (1) EP1912979B1 (da)
JP (2) JP2008540637A (da)
KR (1) KR20080014046A (da)
CN (1) CN101218234B (da)
AT (1) ATE513828T1 (da)
AU (1) AU2006248657B2 (da)
BR (1) BRPI0610059A2 (da)
CA (1) CA2608324A1 (da)
CY (1) CY1111859T1 (da)
DK (1) DK1912979T3 (da)
EA (1) EA014081B1 (da)
ES (1) ES2367663T3 (da)
GB (1) GB0510141D0 (da)
HK (1) HK1112909A1 (da)
IL (1) IL187187A0 (da)
MX (1) MX2007014403A (da)
NO (1) NO20076480L (da)
NZ (1) NZ564202A (da)
PL (1) PL1912979T3 (da)
PT (1) PT1912979E (da)
UA (1) UA92494C2 (da)
WO (1) WO2006123257A2 (da)
ZA (1) ZA200710279B (da)

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GB0510141D0 (en) 2005-06-22
UA92494C2 (ru) 2010-11-10
CN101218234A (zh) 2008-07-09
JP2012184254A (ja) 2012-09-27
CY1111859T1 (el) 2015-11-04
WO2006123257A2 (en) 2006-11-23
WO2006123257A8 (en) 2007-03-15
CA2608324A1 (en) 2006-11-23
ES2367663T3 (es) 2011-11-07
US20090203737A1 (en) 2009-08-13
NZ564202A (en) 2011-04-29
JP2008540637A (ja) 2008-11-20
EP1912979B1 (en) 2011-06-22
WO2006123257A3 (en) 2007-05-03
AU2006248657A1 (en) 2006-11-23
ATE513828T1 (de) 2011-07-15
EP1912979A2 (en) 2008-04-23
MX2007014403A (es) 2008-04-21
PT1912979E (pt) 2011-08-22
ZA200710279B (en) 2009-03-25
PL1912979T3 (pl) 2011-11-30
EA014081B1 (ru) 2010-08-30
CN101218234B (zh) 2011-12-14
KR20080014046A (ko) 2008-02-13
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