MX2022010520A - Macrociclos peptidicos contra acinetobacter baumannii. - Google Patents

Macrociclos peptidicos contra acinetobacter baumannii.

Info

Publication number
MX2022010520A
MX2022010520A MX2022010520A MX2022010520A MX2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A
Authority
MX
Mexico
Prior art keywords
sup
acinetobacter baumannii
against acinetobacter
peptide macrocycles
macrocycles against
Prior art date
Application number
MX2022010520A
Other languages
English (en)
Inventor
Hans Hilpert
Hong Shen
taishan Hu
Sabine Kolczewski
Theodor Stoll
Konrad Bleicher
Bernhard Fasching
Alexander Alanine
Julien Beignet
Dwight Macdonald
Stephen Jackson
Carsten Kroll
Adrian Schaeublin
Helmut Thomas
Amal Wahhab
Claudia Zampaloni
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2022010520A publication Critical patent/MX2022010520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención proporciona compuestos de fórmula (I) (ver Fórmula) (I) en donde de X1 a X8 y de R1 a R8 son tal como se definen en el presente documento, así como sales farmacéuticamente aceptables de los mismos. Además, la presente invención se refiere a la fabricación de compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y su uso como medicamentos para el tratamiento de enfermedades e infecciones causadas por Acinetobacter baumannii.
MX2022010520A 2015-10-27 2018-04-26 Macrociclos peptidicos contra acinetobacter baumannii. MX2022010520A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15191743 2015-10-27
CN2016100125 2016-09-26

Publications (1)

Publication Number Publication Date
MX2022010520A true MX2022010520A (es) 2022-09-19

Family

ID=57200005

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005236A MX2018005236A (es) 2015-10-27 2016-10-24 Macrociclos peptidicos contra acinetobacter baumannii.
MX2022010520A MX2022010520A (es) 2015-10-27 2018-04-26 Macrociclos peptidicos contra acinetobacter baumannii.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018005236A MX2018005236A (es) 2015-10-27 2016-10-24 Macrociclos peptidicos contra acinetobacter baumannii.

Country Status (26)

Country Link
US (3) US10030047B2 (es)
EP (1) EP3368544B1 (es)
JP (2) JP7286317B2 (es)
KR (1) KR102701379B1 (es)
CN (1) CN108350028B (es)
AU (1) AU2016347456B2 (es)
CL (1) CL2018000978A1 (es)
CO (1) CO2017013708A2 (es)
CR (1) CR20180232A (es)
DK (1) DK3368544T3 (es)
ES (1) ES2811911T3 (es)
HR (1) HRP20201273T1 (es)
HU (1) HUE050053T2 (es)
IL (1) IL258060B (es)
MX (2) MX2018005236A (es)
MY (1) MY193014A (es)
PE (1) PE20180796A1 (es)
PH (1) PH12018500904A1 (es)
PL (1) PL3368544T3 (es)
PT (1) PT3368544T (es)
RS (1) RS60662B1 (es)
RU (1) RU2729609C2 (es)
SI (1) SI3368544T1 (es)
TW (1) TWI720042B (es)
UA (1) UA124303C2 (es)
WO (1) WO2017072062A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY192108A (en) * 2014-08-13 2022-07-27 Huawei Tech Co Ltd Fbmc signal transmitting method and receiving method, transmitter and receiver
PE20180796A1 (es) 2015-10-27 2018-05-09 Hoffmann La Roche Macrociclos peptidicos contra acinetobacter baumannii
JP6931058B2 (ja) 2016-12-21 2021-09-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗体のインビトロ糖鎖工学における酵素の再使用
MX2019006123A (es) 2016-12-21 2019-08-12 Hoffmann La Roche Metodo para glicomanipulacion in vitro de anticuerpos.
EP3388444A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) * 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
CN113164771A (zh) * 2018-12-17 2021-07-23 豪夫迈·罗氏有限公司 咪唑并吡嗪衍生物作为抗菌剂
JP7715634B2 (ja) 2019-03-08 2025-07-30 エフ． ホフマン－ラ ロシュ アーゲー 新規イミダゾール－ピラゾール誘導体
EP4093734A1 (en) 2020-01-22 2022-11-30 F. Hoffmann-La Roche AG Novel heterocyclic compounds
WO2021219578A1 (en) 2020-04-29 2021-11-04 F. Hoffmann-La Roche Ag Antibacterial 8-phenylamino-3-(pyrazol-4-yl)imidazo[1,2-a]pyrazine derivatives
EP4157846A1 (en) 2020-06-01 2023-04-05 F. Hoffmann-La Roche AG Novel imidazopyrazne derivatives
EP4161930A1 (en) 2020-06-08 2023-04-12 F. Hoffmann-La Roche AG Novel imidazo-pyrazine derivatives
WO2021249896A1 (en) 2020-06-09 2021-12-16 F. Hoffmann-La Roche Ag Novel imidazopyrazine derivatives
WO2022043486A1 (en) 2020-08-31 2022-03-03 F. Hoffmann-La Roche Ag Imidazole-pyrazole derivatives as antibacterials
WO2022049011A1 (en) 2020-09-01 2022-03-10 F. Hoffmann-La Roche Ag Imidazole-pyrazole derivatives with anti-bacterial properties
JP2023539782A (ja) 2020-09-07 2023-09-19 エフ． ホフマン－ラ ロシュ アーゲー 新規複素環式抗生物質
WO2022167631A1 (en) 2021-02-07 2022-08-11 F. Hoffmann-La Roche Ag Novel heteroaryl-substituted imidazole derivatives
CN117715892A (zh) 2021-07-06 2024-03-15 豪夫迈·罗氏有限公司 用于治疗细菌感染的季铵阳离子取代化合物
JP2024525793A (ja) 2021-07-15 2024-07-12 エフ． ホフマン－ラ ロシュ アーゲー イミダゾール誘導体及びその抗生物質としての使用
CN118632842A (zh) 2022-02-25 2024-09-10 豪夫迈·罗氏有限公司 两性离子抗细菌化合物
IL317277A (en) * 2022-08-09 2025-01-01 Hoffmann La Roche Process for producing a macrocyclic antibiotic peptide
WO2025067477A1 (zh) * 2023-09-27 2025-04-03 武汉人福创新药物研发中心有限公司 抗鲍曼不动杆菌的环肽及其应用
CN120424159A (zh) * 2024-02-02 2025-08-05 武汉人福创新药物研发中心有限公司 抗鲍曼不动杆菌的含羧酸取代的环肽及其应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660832B1 (en) * 1999-08-20 2003-12-09 Isis Pharmaceuticals, Inc. Macrocyclic compounds and preparation methods thereof
DE10226921A1 (de) 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10234422A1 (de) 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
RU2311415C2 (ru) * 2002-08-23 2007-11-27 Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения
SI1767535T1 (sl) 2002-08-23 2010-03-31 Sloan Kettering Inst Cancer Sinteza epotilonov njihovih intermediatov analogov in uporaba le teh
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
EP2210612B1 (en) 2003-06-18 2016-10-05 Ocera Therapeutics, Inc. Macrocyclic antagonists of the motilin receptor
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
EP1498422A1 (de) 2003-07-17 2005-01-19 Jerini AG C5a-Rezeptor-Antagonisten
ATE490264T1 (de) 2003-07-31 2010-12-15 Tranzyme Pharma Inc Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen
US7550431B2 (en) 2003-07-31 2009-06-23 Tranzyme Pharma Inc. Spatially-defined macrocycles incorporating peptide bond surrogates
CA2540646A1 (en) 2003-10-01 2005-04-14 Bayer Healthcare Ag Antibacterial amide macrocycles
US8193310B2 (en) 2004-03-19 2012-06-05 The University Of Queensland Alpha helical mimics, their uses and methods for their production
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
US20080161232A1 (en) 2005-01-17 2008-07-03 Jerini Ag C5a Receptor Antagonist
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
MX2009008540A (es) 2007-02-08 2009-08-18 Tibotec Pharm Ltd Inhibidores de virus de hepatitis c macrociclicos sustituidos con pirimidina.
CN104474529A (zh) 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
WO2010022249A2 (en) 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
EP2491020A4 (en) 2009-10-23 2013-04-24 Tranzyme Pharma Inc PROCESS FOR USE OF MACROCYCLIC INHIBITORS OF SERIN PROTEASE CYMS
CA2778990A1 (en) 2009-10-30 2011-05-05 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
US20130123196A1 (en) 2011-08-31 2013-05-16 New York University Thioether-, ether-, and alkylamine-linked hydrogen bond surrogate peptidomimetics
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CN103387601B (zh) 2012-05-11 2017-01-11 南开大学 抗登革热病毒(denv)杂环肽类化合物及其制备方法和用途
CN104903302B (zh) 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
US9493510B2 (en) 2013-01-10 2016-11-15 Noliva Therapeutics Llc Peptidomimetic compounds
PL3174852T3 (pl) 2014-07-30 2018-11-30 ABAC Therapeutics, S.L. Arylohydrazydy zawierające ugrupowanie 2-pirydonu jako selektywne środki przeciwbakteryjne
PE20180796A1 (es) 2015-10-27 2018-05-09 Hoffmann La Roche Macrociclos peptidicos contra acinetobacter baumannii
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Also Published As

Publication number Publication date
PL3368544T3 (pl) 2020-11-16
HRP20201273T1 (hr) 2020-11-13
CO2017013708A2 (es) 2018-03-20
MY193014A (en) 2022-09-22
IL258060A (en) 2018-05-31
PE20180796A1 (es) 2018-05-09
RU2018113426A3 (es) 2020-01-31
JP2022024009A (ja) 2022-02-08
AU2016347456B2 (en) 2018-12-13
KR20180063138A (ko) 2018-06-11
MX2018005236A (es) 2018-08-15
EP3368544B1 (en) 2020-06-17
CL2018000978A1 (es) 2018-08-24
NZ738307A (en) 2024-02-23
US12012466B2 (en) 2024-06-18
US20180362578A1 (en) 2018-12-20
AU2016347456A1 (en) 2018-01-18
SI3368544T1 (sl) 2020-10-30
HK1258443A1 (zh) 2019-11-15
TW201718565A (zh) 2017-06-01
US20220411468A1 (en) 2022-12-29
RS60662B1 (sr) 2020-09-30
JP2018535960A (ja) 2018-12-06
ES2811911T3 (es) 2021-03-15
HUE050053T2 (hu) 2020-11-30
JP7286317B2 (ja) 2023-06-05
KR102701379B1 (ko) 2024-09-02
IL258060B (en) 2021-05-31
UA124303C2 (uk) 2021-08-25
TWI720042B (zh) 2021-03-01
US11098080B2 (en) 2021-08-24
PT3368544T (pt) 2020-08-20
RU2729609C2 (ru) 2020-08-11
DK3368544T3 (da) 2020-08-24
RU2018113426A (ru) 2019-11-28
EP3368544A1 (en) 2018-09-05
CN108350028A (zh) 2018-07-31
CR20180232A (es) 2018-05-31
CN108350028B (zh) 2021-12-07
US10030047B2 (en) 2018-07-24
PH12018500904A1 (en) 2018-11-05
CA2992926A1 (en) 2017-05-04
WO2017072062A1 (en) 2017-05-04
US20170233437A1 (en) 2017-08-17

Similar Documents

Publication Publication Date Title
MX2022010520A (es) Macrociclos peptidicos contra acinetobacter baumannii.
PH12020551762A1 (en) Peptide macrocycles against acinetobacter baumannii
PH12020551089A1 (en) Pyrrolopyrimidine compounds used as tlr7 agonist
MX384868B (es) Composiciones para tratar atrofia muscular espinal.
MX375925B (es) Compuestos imidazo[1,2-a]pirazin-1-il-benzamida para tratar atrofia muscular espinal.
PH12016502081A1 (en) Compounds for treating spinal muscular atrophy
MX390302B (es) Oxiesteroles y metodos de uso de los mismos
NZ708593A (en) Novel pyrazole derivative
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
MX2015017345A (es) Compuestos para tratar atrofia muscular espinal.
MX2022013612A (es) Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas.
EP4252848A3 (en) Oxysterols and methods of use thereof
MX2016013529A (es) Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos.
MX2020010690A (es) Oxiesteroles y metodos de uso de los mismos.
MX2018005041A (es) Compuestos para tratar la esclerosis lateral amiotrofica.
TN2017000485A1 (en) Tricyclic compounds and their use as phosphodiesterase inhibitors
PH12018500378B1 (en) Novel annelated phenoxyacetamides
EA201691058A1 (ru) Производные пирролопирролона и их применение для лечения заболеваний
PH12019500849A1 (en) Naphthyridinone derivatives and their use inthe treatment of arrhythmia
MX2017013099A (es) Metodos para el tratamiento de trastornos inflamatorios.
MX379373B (es) Derivado de sulfonamida heterocíclico y medicina que contiene el mismo.
MX386902B (es) Metodos para el tratamiento de trastornos cardiovasculares.
EA201990656A1 (ru) Пирролопиримидиновые соединения, используемые в качестве агониста tlr7