DE602004030344D1 - Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen - Google Patents

Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen

Info

Publication number
DE602004030344D1
DE602004030344D1 DE602004030344T DE602004030344T DE602004030344D1 DE 602004030344 D1 DE602004030344 D1 DE 602004030344D1 DE 602004030344 T DE602004030344 T DE 602004030344T DE 602004030344 T DE602004030344 T DE 602004030344T DE 602004030344 D1 DE602004030344 D1 DE 602004030344D1
Authority
DE
Germany
Prior art keywords
discovery
macrocyclic compounds
compounds suitable
medicinal products
spatially defined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004030344T
Other languages
English (en)
Inventor
Pierre Deslongchamps
Yves Dory
Mark Peterson
Kamel Benakli
Eric Marsault
Luc Ouellet
Mahesh Ramaseshan
Martin Vezina
Daniel Fortin
Ruoxi Lan
Shigui Li
Gerald Villeneuve
Hamid Hoveyda
Sylvie Beaubien
Graeme Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tranzyme Pharma Inc
Original Assignee
Tranzyme Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc
Publication of DE602004030344D1 publication Critical patent/DE602004030344D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
DE602004030344T 2003-07-31 2004-08-02 Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen Active DE602004030344D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49124803P 2003-07-31 2003-07-31
PCT/CA2004/001439 WO2005012331A1 (en) 2003-07-31 2004-08-02 Spatially-defined macrocyclic compounds useful for drug discovery

Publications (1)

Publication Number Publication Date
DE602004030344D1 true DE602004030344D1 (de) 2011-01-13

Family

ID=34115484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004030344T Active DE602004030344D1 (de) 2003-07-31 2004-08-02 Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen

Country Status (15)

Country Link
US (3) US7452862B2 (de)
EP (3) EP1648922B9 (de)
JP (1) JP4928262B2 (de)
AT (1) ATE490264T1 (de)
AU (1) AU2004261329B2 (de)
CA (1) CA2533818C (de)
CY (1) CY1111901T1 (de)
DE (1) DE602004030344D1 (de)
DK (1) DK1648922T3 (de)
ES (1) ES2357235T7 (de)
IL (1) IL173312A0 (de)
PL (1) PL1648922T3 (de)
PT (1) PT1648922E (de)
SI (1) SI1648922T1 (de)
WO (1) WO2005012331A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE42624E1 (en) 2003-06-18 2011-08-16 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
US7476653B2 (en) * 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
DK1633774T3 (da) * 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
US8921521B2 (en) 2003-06-18 2014-12-30 Ocera Therapeutics, Inc. Macrocyclic modulators of the Ghrelin receptor
USRE42013E1 (en) 2003-06-18 2010-12-28 Tranzyme Pharma Inc. Macrocyclic modulators of the ghrelin receptor
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
WO2005012332A1 (en) * 2003-07-31 2005-02-10 Tranzyme Pharma Spatially-defined macrocycles incorporating peptide bond surrogates
JP5739766B2 (ja) * 2004-06-18 2015-06-24 オセラ セラピューティクス， インコーポレイテッド グレリン受容体の大環状モジュレーターの使用方法
WO2006046977A1 (en) * 2004-10-26 2006-05-04 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and methods of using the same
CA2583345A1 (en) * 2005-06-13 2006-12-28 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
PL1907374T3 (pl) * 2005-07-26 2012-12-31 Glaxo Group Ltd Pochodne benzylopiperazyny użyteczne do leczenia zaburzeń układu pokarmowego
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
EP2054429B1 (de) 2006-09-11 2013-11-06 Tranzyme Pharma, Inc. Makrozyklische motilinrezeptor antagonisten zur behandlung von gastro-intestinaler störungen
CN101657436A (zh) 2007-02-09 2010-02-24 特兰齐姆制药公司 大环生长素释放肽受体调节剂及其使用方法
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
WO2010098145A1 (en) 2009-02-27 2010-09-02 Raqualia Pharma Inc. Oxyindole derivatives with motilin receptor agonistic activity
US9662126B2 (en) 2009-04-17 2017-05-30 Arthrosurface Incorporated Glenoid resurfacing system and method
JP2013509434A (ja) 2009-10-30 2013-03-14 トランザイム・ファーマ，インコーポレイテッド 大環状グレリン受容体アンタゴニストおよびインバースアゴニストならびにその使用方法
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011105310A1 (en) * 2010-02-26 2011-09-01 Semiconductor Energy Laboratory Co., Ltd. Semiconductor device
EP2659404B1 (de) 2010-12-29 2018-08-08 Sigma-Aldrich Co., LLC Zellen mit gestörter expression von in adme und toxikologieverfahren involvierten proteinen
MY159058A (en) 2011-02-25 2016-12-15 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
MX2015001500A (es) 2012-08-02 2015-04-08 Merck Sharp & Dohme Compuestos antidiabeticos triciclicos.
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
CN103113404B (zh) * 2013-02-22 2015-09-23 广州巨元生化有限公司 一种制备4-二烃氧基膦酰基-2-甲基-2-丁烯酸烃基酯的方法
EP2970119B1 (de) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Neuartige indolderivate als antidiabetika
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US10407442B2 (en) 2015-09-24 2019-09-10 Cyclenium Pharma Inc. Libraries of heteroaryl-containing macrocyclic compounds and methods of making and using the same
RU2729609C2 (ru) 2015-10-27 2020-08-11 Ф. Хоффманн-Ля Рош Аг Пептидные макроциклы против acinetobacter baumannii
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
WO2017197488A1 (en) * 2016-05-16 2017-11-23 Cyclenium Pharma Inc. Libraries of diverse macrocyclic compounds and methods of making and using the same
US20180110824A1 (en) * 2016-10-21 2018-04-26 Ocera Therapeutics, Inc. Macrocyclic Modulators of the Ghrelin Receptor
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
WO2018118670A1 (en) 2016-12-20 2018-06-28 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
EP3388444A1 (de) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Antibakterielle peptidmakrozyklen und verwendung davon
US11524979B2 (en) 2017-06-15 2022-12-13 University Of Washington Macrocyclic polypeptides
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
CA3127387A1 (en) * 2019-02-08 2020-08-13 Eric Marsault Neurotensinergic agonists and methods of using same preventing or treating pain

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2235377A1 (de) * 1971-07-30 1973-02-08 Banyu Pharma Co Ltd 2,4-thiazol-dimethanol-carbamat und verfahren zu dessen herstellung
GB1365201A (en) 1971-07-30 1974-08-29 Banyu Pharma Co Ltd 2 4 thiazoledimethanol carbamates and 2 4-thiazoledimethanol
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
EP0804460A1 (de) * 1995-01-20 1997-11-05 Molecumetics, Ltd. Konformationsbeschränkte bibliothek mit umgekehrter diehung und dazu beziehende verfahren
US5891737A (en) 1995-06-07 1999-04-06 Zymogenetics, Inc. Combinatorial non-peptide libraries
US5646285A (en) 1995-06-07 1997-07-08 Zymogenetics, Inc. Combinatorial non-peptide libraries
IL117426A (en) * 1996-03-10 2005-09-25 Yissum Res Dev Co Synthetic pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
US6011155A (en) 1996-11-07 2000-01-04 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
WO1998046631A1 (en) 1997-04-11 1998-10-22 Eli Lilly And Company Combinatorial libraries of peptidomimetic macrocycles and processes therefor
US20020068301A1 (en) 1997-05-28 2002-06-06 Hung-Sen Lai Cyclic peptide libraries and methods of use thereof to identify binding motifs
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
CA2284459C (en) * 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
ES2333097T3 (es) * 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
KR20030033002A (ko) * 2000-07-24 2003-04-26 아다나 바이오싸이언스 리미티드 그렐린 길항제
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
US7476653B2 (en) * 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
DK1633774T3 (da) * 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
US7491695B2 (en) * 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
WO2005012332A1 (en) * 2003-07-31 2005-02-10 Tranzyme Pharma Spatially-defined macrocycles incorporating peptide bond surrogates
NZ545692A (en) 2003-09-03 2009-02-28 Kowa Co PPAR-activating compound and pharmaceutical composition containing same

Also Published As

Publication number Publication date
EP2316846A2 (de) 2011-05-04
EP1648922B9 (de) 2013-04-03
SI1648922T1 (sl) 2011-03-31
CY1111901T1 (el) 2015-11-04
ES2357235T8 (es) 2011-06-06
ATE490264T1 (de) 2010-12-15
ES2357235T3 (es) 2011-04-20
US7452862B2 (en) 2008-11-18
EP2316846A3 (de) 2012-04-04
JP4928262B2 (ja) 2012-05-09
CA2533818A1 (en) 2005-02-10
EP1648922B3 (de) 2012-08-15
US20110237785A1 (en) 2011-09-29
EP1648922B1 (de) 2010-12-01
WO2005012331A1 (en) 2005-02-10
JP2007527863A (ja) 2007-10-04
EP1648922A4 (de) 2006-08-23
EP1648922A1 (de) 2006-04-26
IL173312A0 (en) 2009-02-11
PL1648922T3 (pl) 2011-05-31
DK1648922T3 (da) 2011-03-14
EP2316846B1 (de) 2019-10-02
US20090137817A1 (en) 2009-05-28
AU2004261329A1 (en) 2005-02-10
AU2004261329B2 (en) 2011-10-27
EP2319859A2 (de) 2011-05-11
EP2319859A3 (de) 2011-12-21
CA2533818C (en) 2015-03-17
ES2357235T7 (es) 2013-02-14
US8022252B2 (en) 2011-09-20
PT1648922E (pt) 2011-01-04
US20050137127A1 (en) 2005-06-23
EP2319859B1 (de) 2013-03-27
US8440851B2 (en) 2013-05-14

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