GB1365201A - 2 4 thiazoledimethanol carbamates and 2 4-thiazoledimethanol - Google Patents
2 4 thiazoledimethanol carbamates and 2 4-thiazoledimethanolInfo
- Publication number
- GB1365201A GB1365201A GB3551472A GB3551472A GB1365201A GB 1365201 A GB1365201 A GB 1365201A GB 3551472 A GB3551472 A GB 3551472A GB 3551472 A GB3551472 A GB 3551472A GB 1365201 A GB1365201 A GB 1365201A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thiazoledimethanol
- july
- carbamates
- formula
- thiazole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
Abstract
1365201 Thiazole derivatives BANYU PHARMACEUTICAL CO Ltd and H HIDAKA 28 July 1972 [30 July 1971 (3)] 35514/72 Heading C2C Novel thiazole derivatives of the formula wherein R is C 1-4 alkyl or phenyl are prepared by reacting isocyanates of the formula RNCO with 2,4-thiazoledimethanol, which is obtained by reducing diesters of 2,4-thiazoledicarboxylic acid or by hydrolysing 2,4-diacetoxymethylthiazole resulting from the reaction between 1-acetoxy-3-chloroacetone and 2-acetoxythioacetamide, obtained by reacting 2-acetoxyacetonitrile with hydrogen sulphide. Ethyl 2-hydroxymethyl-4-thiazolecarboxylate is obtained by reducing diethyl 2,4-thiazoledicarboxylate. Pharmaceutical compositions contain the above novel carbamates in admixture with pharma. ceutically acceptable carriers or diluents. The compositions are used in the treatment of diseases of the circulatory, cardiovascular and central nervous systems.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5676771A JPS5533434B1 (en) | 1971-07-30 | 1971-07-30 | |
| JP5676671A JPS5758344B1 (en) | 1971-07-30 | 1971-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1365201A true GB1365201A (en) | 1974-08-29 |
Family
ID=26397753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3551472A Expired GB1365201A (en) | 1971-07-30 | 1972-07-28 | 2 4 thiazoledimethanol carbamates and 2 4-thiazoledimethanol |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1365201A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7452862B2 (en) | 2003-07-31 | 2008-11-18 | Tranzyme Pharma, Inc. | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists |
| US8088733B2 (en) | 2006-07-06 | 2012-01-03 | Tranzyme Pharma Inc. | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders |
-
1972
- 1972-07-28 GB GB3551472A patent/GB1365201A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7452862B2 (en) | 2003-07-31 | 2008-11-18 | Tranzyme Pharma, Inc. | Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists |
| US8022252B2 (en) | 2003-07-31 | 2011-09-20 | Tranzyme Pharma Inc. | Spatially-defined macrocyclic compounds useful for drug discovery |
| US8440851B2 (en) | 2003-07-31 | 2013-05-14 | Tranzyme Pharma, Inc. | Spatially-defined macrocyclic compounds useful for drug discovery |
| US8088733B2 (en) | 2006-07-06 | 2012-01-03 | Tranzyme Pharma Inc. | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |