ES436198A1 - Substituted cephalosporin antibiotics - Google Patents
Substituted cephalosporin antibioticsInfo
- Publication number
- ES436198A1 ES436198A1 ES436198A ES436198A ES436198A1 ES 436198 A1 ES436198 A1 ES 436198A1 ES 436198 A ES436198 A ES 436198A ES 436198 A ES436198 A ES 436198A ES 436198 A1 ES436198 A1 ES 436198A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- cephalosporin antibiotics
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 cephalosporin compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
- C07C273/1863—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety from urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process is described for the preparation of novel cephalosporin compounds of the formula I, which are substituted by a ureido radical, by reaction of a compound of the formula II with a compound of the formula (III) R''-NH-CO-N(R')-CO-A. These can be converted into the esters of the formula IV which are likewise new. The substituents in the compounds of the formula I and IV have the meanings stated in Claim 1 and Claim 10 respectively. The compounds of the formula I and IV have a high activity and a broad spectrum of action as antibiotics and are particularly suitable for the treatment of infections caused by Gram-negative microorganisms.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45651674A | 1974-04-01 | 1974-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES436198A1 true ES436198A1 (en) | 1977-01-01 |
Family
ID=23813076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES436198A Expired ES436198A1 (en) | 1974-04-01 | 1975-04-01 | Substituted cephalosporin antibiotics |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS614837B2 (en) |
| AR (1) | AR210258A1 (en) |
| AT (1) | AT337896B (en) |
| BE (1) | BE827408A (en) |
| BG (1) | BG27376A3 (en) |
| CA (1) | CA1096373A (en) |
| CH (1) | CH627471A5 (en) |
| CS (1) | CS196261B2 (en) |
| DD (1) | DD118648A5 (en) |
| DE (1) | DE2514019A1 (en) |
| DK (1) | DK130375A (en) |
| ES (1) | ES436198A1 (en) |
| FR (1) | FR2265394B1 (en) |
| GB (1) | GB1504589A (en) |
| HU (1) | HU170816B (en) |
| IE (1) | IE42705B1 (en) |
| IL (1) | IL46956A (en) |
| NL (1) | NL7503883A (en) |
| PH (1) | PH13642A (en) |
| PL (1) | PL101400B1 (en) |
| RO (1) | RO67392A (en) |
| SE (1) | SE423392B (en) |
| ZA (1) | ZA752004B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4063019A (en) | 1976-03-30 | 1977-12-13 | E. R. Squibb & Sons, Inc. | [[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]-acetylcephalosporin derivatives |
| CN1069639C (en) * | 1998-06-19 | 2001-08-15 | 山东沂蒙新华制药厂 | Preparation process of 1-chloroformyl-3-mesyl imidazolyl alkyl ketone |
-
1975
- 1975-03-26 DK DK130375A patent/DK130375A/da not_active Application Discontinuation
- 1975-03-28 IL IL46956A patent/IL46956A/en unknown
- 1975-03-28 HU HU75EI00000607A patent/HU170816B/en unknown
- 1975-03-29 BG BG7529484A patent/BG27376A3/en unknown
- 1975-03-29 PL PL1975179227A patent/PL101400B1/en unknown
- 1975-03-29 DE DE19752514019 patent/DE2514019A1/en not_active Ceased
- 1975-03-31 PH PH16988A patent/PH13642A/en unknown
- 1975-03-31 RO RO7581853A patent/RO67392A/en unknown
- 1975-04-01 GB GB13383/75A patent/GB1504589A/en not_active Expired
- 1975-04-01 CA CA223,530A patent/CA1096373A/en not_active Expired
- 1975-04-01 NL NL7503883A patent/NL7503883A/en not_active Application Discontinuation
- 1975-04-01 SE SE7503707-7A patent/SE423392B/en unknown
- 1975-04-01 CH CH411575A patent/CH627471A5/en not_active IP Right Cessation
- 1975-04-01 AT AT247675A patent/AT337896B/en not_active IP Right Cessation
- 1975-04-01 ES ES436198A patent/ES436198A1/en not_active Expired
- 1975-04-01 CS CS752206A patent/CS196261B2/en unknown
- 1975-04-01 ZA ZA752004A patent/ZA752004B/en unknown
- 1975-04-01 FR FR7510143A patent/FR2265394B1/fr not_active Expired
- 1975-04-01 DD DD185120A patent/DD118648A5/xx unknown
- 1975-04-01 JP JP50040203A patent/JPS614837B2/ja not_active Expired
- 1975-04-01 BE BE1006559A patent/BE827408A/en not_active IP Right Cessation
- 1975-04-02 IE IE705/75A patent/IE42705B1/en unknown
- 1975-04-10 AR AR258200A patent/AR210258A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| SE7503707L (en) | 1975-10-02 |
| SE423392B (en) | 1985-05-03 |
| HU170816B (en) | 1977-09-28 |
| NL7503883A (en) | 1975-10-03 |
| ATA247675A (en) | 1976-11-15 |
| DD118648A5 (en) | 1976-03-12 |
| AR210258A1 (en) | 1977-07-15 |
| IE42705L (en) | 1975-10-01 |
| IE42705B1 (en) | 1980-10-08 |
| IL46956A0 (en) | 1975-05-22 |
| IL46956A (en) | 1979-10-31 |
| GB1504589A (en) | 1978-03-22 |
| ZA752004B (en) | 1976-11-24 |
| PL101400B1 (en) | 1978-12-30 |
| FR2265394A1 (en) | 1975-10-24 |
| PH13642A (en) | 1980-08-18 |
| CA1096373A (en) | 1981-02-24 |
| BG27376A3 (en) | 1979-10-12 |
| CH627471A5 (en) | 1982-01-15 |
| AU7963775A (en) | 1976-09-30 |
| FR2265394B1 (en) | 1978-07-28 |
| JPS614837B2 (en) | 1986-02-13 |
| JPS50137995A (en) | 1975-11-01 |
| CS196261B2 (en) | 1980-03-31 |
| DE2514019A1 (en) | 1975-10-02 |
| DK130375A (en) | 1975-10-02 |
| RO67392A (en) | 1981-04-30 |
| AT337896B (en) | 1977-07-25 |
| BE827408A (en) | 1975-10-01 |
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