ES452361A1 - Process for manufacture of 9-amino-9-deoxyclavulanates - Google Patents
Process for manufacture of 9-amino-9-deoxyclavulanatesInfo
- Publication number
- ES452361A1 ES452361A1 ES452361A ES452361A ES452361A1 ES 452361 A1 ES452361 A1 ES 452361A1 ES 452361 A ES452361 A ES 452361A ES 452361 A ES452361 A ES 452361A ES 452361 A1 ES452361 A1 ES 452361A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- deoxyclavulanates
- amino
- manufacture
- inert organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
The compounds of the formula (II): < IMAGE > (II) and salts and esters thereof wherein R1 is an inert organic group of up to 14 carbon atoms and R2 is an inert organic group of up to 16 carbon atoms, the group NR1R2 containing up to 22 carbon atoms, are antibacterial agents able to enhance the effectiveness of penicillins and cephalosporins against certain beta -lactamase producing bacteria.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB41887/75A GB1566706A (en) | 1975-10-13 | 1975-10-13 | Clavulanic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES452361A1 true ES452361A1 (en) | 1978-01-01 |
Family
ID=10421810
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES452361A Expired ES452361A1 (en) | 1975-10-13 | 1976-10-13 | Process for manufacture of 9-amino-9-deoxyclavulanates |
ES463974A Expired ES463974A1 (en) | 1975-10-13 | 1977-11-08 | Process for manufacture of 9-amino-9-deoxyclavulanates |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES463974A Expired ES463974A1 (en) | 1975-10-13 | 1977-11-08 | Process for manufacture of 9-amino-9-deoxyclavulanates |
Country Status (28)
Country | Link |
---|---|
US (3) | US4256638A (en) |
JP (1) | JPS5248686A (en) |
AR (1) | AR213294A1 (en) |
AT (1) | AT352874B (en) |
AU (1) | AU503489B2 (en) |
BE (1) | BE847044A (en) |
CA (1) | CA1094563A (en) |
CH (2) | CH634323A5 (en) |
DD (1) | DD126929A5 (en) |
DE (1) | DE2646003A1 (en) |
DK (1) | DK457676A (en) |
ES (2) | ES452361A1 (en) |
FI (1) | FI762895A (en) |
FR (1) | FR2327775A1 (en) |
GB (1) | GB1566706A (en) |
GR (1) | GR61674B (en) |
HU (1) | HU175046B (en) |
IE (1) | IE43840B1 (en) |
IL (1) | IL50618A (en) |
MX (1) | MX4688E (en) |
NL (1) | NL7611206A (en) |
NO (3) | NO763472L (en) |
NZ (1) | NZ182190A (en) |
PT (1) | PT65707B (en) |
SE (3) | SE7611047L (en) |
SU (1) | SU639454A3 (en) |
ZA (1) | ZA765901B (en) |
ZM (1) | ZM12276A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK471577A (en) * | 1976-10-25 | 1978-04-26 | Glaxo Lab Ltd | PROCEDURE FOR PREPARING CLAVAM DERIVATIVES |
US4359473A (en) | 1977-04-22 | 1982-11-16 | Beecham Group Limited | α-Amino deoxy clavulanic acid antibacterial agents |
GB1604822A (en) * | 1977-04-22 | 1981-12-16 | Beecham Group Ltd | N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative |
GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
EP0005014A1 (en) * | 1978-04-22 | 1979-10-31 | Beecham Group Plc | Clavulanic acid derivatives, preparation and compositions |
DE2963534D1 (en) * | 1978-07-29 | 1982-10-07 | Beecham Group Plc | Clavulanic acid derivatives, a process for their preparation, their use, and pharmaceutical compositions containing them |
EP0008884B1 (en) * | 1978-09-09 | 1983-08-17 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their compositions |
DE2966347D1 (en) * | 1978-09-09 | 1983-12-01 | Beecham Group Plc | Clavulanic acid derivatives and process for their preparation |
EP0008877B1 (en) * | 1978-09-09 | 1983-10-26 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and their use |
DE2965938D1 (en) | 1978-10-25 | 1983-08-25 | Beecham Group Plc | Clavulanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them |
IL60343A0 (en) * | 1979-07-02 | 1980-09-16 | Beecham Group Ltd | Clavulanic acid derivatives,their preparation and pharmaceutical compositions containing them |
ZA804670B (en) * | 1979-08-03 | 1981-07-29 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
DE3066511D1 (en) * | 1979-10-26 | 1984-03-15 | Beecham Group Plc | Derivatives of clavulanic acid, a process for their preparation and pharmaceutical compositions containing them |
EP0053893B1 (en) * | 1980-12-09 | 1985-03-20 | Beecham Group Plc | Derivatives of clavulanic acid, their preparation and their use |
NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
JPS57143194A (en) * | 1981-02-27 | 1982-09-04 | Matsushita Electric Ind Co Ltd | Blower |
EP0062407A1 (en) * | 1981-03-10 | 1982-10-13 | Beecham Group Plc | Therapeutic compounds containing beta-lactams |
JPH0495698U (en) * | 1991-01-21 | 1992-08-19 | ||
GB9518917D0 (en) * | 1995-09-15 | 1995-11-15 | Smithkline Beecham Plc | Compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1424186A (en) * | 1971-10-08 | 1976-02-11 | Beecham Group Ltd | Penicillins |
US3925363A (en) * | 1974-01-17 | 1975-12-09 | Merck & Co Inc | Process for epimerizing penicillin compounds, and related products |
US4051132A (en) * | 1974-01-23 | 1977-09-27 | Merck & Co., Inc. | Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench |
GB1585165A (en) * | 1976-06-29 | 1981-02-25 | Leo Pharm Prod Ltd | Derivatives of 6-amidino penicillanic acid |
IL54859A (en) * | 1977-06-21 | 1982-01-31 | Rech Applications Therap | Derivatives of amidinopenicillanic acid,their production and pharmaceutical compositions containing them |
EP0005348B1 (en) * | 1978-05-06 | 1982-09-22 | Beecham Group Plc | Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them |
US4244965A (en) * | 1978-06-15 | 1981-01-13 | Beecham Group Limited | Azetidinoyl ethers |
US4252722A (en) * | 1979-08-08 | 1981-02-24 | Merck & Co., Inc. | Process for the preparation of 6-hydroxymethyl-2-(β-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid |
US4237051A (en) * | 1979-04-19 | 1980-12-02 | Schering Corporation | Stereospecific production of 6- or 7-carbon-substituted-β-lactams |
US4231928A (en) * | 1979-04-24 | 1980-11-04 | Bristol-Myers Company | Antibacterial agents |
-
1975
- 1975-10-12 AU AU18582/76A patent/AU503489B2/en not_active Expired
- 1975-10-13 GB GB41887/75A patent/GB1566706A/en not_active Expired
-
1976
- 1976-09-28 IE IE2142/76A patent/IE43840B1/en unknown
- 1976-10-05 SE SE7611047A patent/SE7611047L/en not_active Application Discontinuation
- 1976-10-05 ZM ZM122/76A patent/ZM12276A1/en unknown
- 1976-10-06 IL IL50618A patent/IL50618A/en unknown
- 1976-10-07 BE BE171321A patent/BE847044A/en not_active IP Right Cessation
- 1976-10-11 NL NL7611206A patent/NL7611206A/en not_active Application Discontinuation
- 1976-10-11 FI FI762895A patent/FI762895A/fi not_active Application Discontinuation
- 1976-10-11 FR FR7630454A patent/FR2327775A1/en active Granted
- 1976-10-11 AT AT753476A patent/AT352874B/en active
- 1976-10-11 GR GR51907A patent/GR61674B/en unknown
- 1976-10-12 NO NO763472A patent/NO763472L/no unknown
- 1976-10-12 DE DE19762646003 patent/DE2646003A1/en not_active Withdrawn
- 1976-10-12 DK DK457676A patent/DK457676A/en unknown
- 1976-10-12 CA CA263,103A patent/CA1094563A/en not_active Expired
- 1976-10-12 DD DD195241A patent/DD126929A5/xx unknown
- 1976-10-12 JP JP51122727A patent/JPS5248686A/en active Granted
- 1976-10-13 PT PT65707A patent/PT65707B/en unknown
- 1976-10-13 CH CH1296176A patent/CH634323A5/en not_active IP Right Cessation
- 1976-10-13 SU SU762412359A patent/SU639454A3/en active
- 1976-10-13 MX MX764975U patent/MX4688E/en unknown
- 1976-10-13 HU HU76BE1274A patent/HU175046B/en unknown
- 1976-10-13 ES ES452361A patent/ES452361A1/en not_active Expired
- 1976-10-13 NZ NZ182190A patent/NZ182190A/en unknown
- 1976-10-13 AR AR265083A patent/AR213294A1/en active
-
1977
- 1977-08-12 ZA ZA765901A patent/ZA765901B/en unknown
- 1977-11-08 ES ES463974A patent/ES463974A1/en not_active Expired
-
1978
- 1978-09-14 US US05/942,156 patent/US4256638A/en not_active Expired - Lifetime
- 1978-09-22 US US05/944,808 patent/US4438101A/en not_active Expired - Lifetime
-
1980
- 1980-03-10 US US06/129,188 patent/US4382084A/en not_active Expired - Lifetime
- 1980-06-10 SE SE8004330A patent/SE8004330L/en not_active Application Discontinuation
- 1980-06-10 SE SE8004329A patent/SE8004329L/en not_active Application Discontinuation
- 1980-09-09 NO NO802661A patent/NO802661L/en unknown
- 1980-09-09 NO NO802662A patent/NO802662L/en unknown
-
1982
- 1982-11-12 CH CH661582A patent/CH639665A5/en not_active IP Right Cessation
Also Published As
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