ES452361A1 - Process for manufacture of 9-amino-9-deoxyclavulanates - Google Patents

Process for manufacture of 9-amino-9-deoxyclavulanates

Info

Publication number
ES452361A1
ES452361A1 ES452361A ES452361A ES452361A1 ES 452361 A1 ES452361 A1 ES 452361A1 ES 452361 A ES452361 A ES 452361A ES 452361 A ES452361 A ES 452361A ES 452361 A1 ES452361 A1 ES 452361A1
Authority
ES
Spain
Prior art keywords
carbon atoms
deoxyclavulanates
amino
manufacture
inert organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452361A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES452361A1 publication Critical patent/ES452361A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

The compounds of the formula (II): < IMAGE > (II) and salts and esters thereof wherein R1 is an inert organic group of up to 14 carbon atoms and R2 is an inert organic group of up to 16 carbon atoms, the group NR1R2 containing up to 22 carbon atoms, are antibacterial agents able to enhance the effectiveness of penicillins and cephalosporins against certain beta -lactamase producing bacteria.
ES452361A 1975-10-13 1976-10-13 Process for manufacture of 9-amino-9-deoxyclavulanates Expired ES452361A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB41887/75A GB1566706A (en) 1975-10-13 1975-10-13 Clavulanic acid derivatives

Publications (1)

Publication Number Publication Date
ES452361A1 true ES452361A1 (en) 1978-01-01

Family

ID=10421810

Family Applications (2)

Application Number Title Priority Date Filing Date
ES452361A Expired ES452361A1 (en) 1975-10-13 1976-10-13 Process for manufacture of 9-amino-9-deoxyclavulanates
ES463974A Expired ES463974A1 (en) 1975-10-13 1977-11-08 Process for manufacture of 9-amino-9-deoxyclavulanates

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES463974A Expired ES463974A1 (en) 1975-10-13 1977-11-08 Process for manufacture of 9-amino-9-deoxyclavulanates

Country Status (28)

Country Link
US (3) US4256638A (en)
JP (1) JPS5248686A (en)
AR (1) AR213294A1 (en)
AT (1) AT352874B (en)
AU (1) AU503489B2 (en)
BE (1) BE847044A (en)
CA (1) CA1094563A (en)
CH (2) CH634323A5 (en)
DD (1) DD126929A5 (en)
DE (1) DE2646003A1 (en)
DK (1) DK457676A (en)
ES (2) ES452361A1 (en)
FI (1) FI762895A (en)
FR (1) FR2327775A1 (en)
GB (1) GB1566706A (en)
GR (1) GR61674B (en)
HU (1) HU175046B (en)
IE (1) IE43840B1 (en)
IL (1) IL50618A (en)
MX (1) MX4688E (en)
NL (1) NL7611206A (en)
NO (3) NO763472L (en)
NZ (1) NZ182190A (en)
PT (1) PT65707B (en)
SE (3) SE7611047L (en)
SU (1) SU639454A3 (en)
ZA (1) ZA765901B (en)
ZM (1) ZM12276A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK471577A (en) * 1976-10-25 1978-04-26 Glaxo Lab Ltd PROCEDURE FOR PREPARING CLAVAM DERIVATIVES
US4359473A (en) 1977-04-22 1982-11-16 Beecham Group Limited α-Amino deoxy clavulanic acid antibacterial agents
GB1604822A (en) * 1977-04-22 1981-12-16 Beecham Group Ltd N-monosubstituted-9-amino-9-deoxyclavulanic acid derivative
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
EP0005014A1 (en) * 1978-04-22 1979-10-31 Beecham Group Plc Clavulanic acid derivatives, preparation and compositions
DE2963534D1 (en) * 1978-07-29 1982-10-07 Beecham Group Plc Clavulanic acid derivatives, a process for their preparation, their use, and pharmaceutical compositions containing them
EP0008884B1 (en) * 1978-09-09 1983-08-17 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their compositions
DE2966347D1 (en) * 1978-09-09 1983-12-01 Beecham Group Plc Clavulanic acid derivatives and process for their preparation
EP0008877B1 (en) * 1978-09-09 1983-10-26 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use
DE2965938D1 (en) 1978-10-25 1983-08-25 Beecham Group Plc Clavulanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them
IL60343A0 (en) * 1979-07-02 1980-09-16 Beecham Group Ltd Clavulanic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
DE3066511D1 (en) * 1979-10-26 1984-03-15 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and pharmaceutical compositions containing them
EP0053893B1 (en) * 1980-12-09 1985-03-20 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
NZ199200A (en) * 1980-12-23 1984-07-31 Beecham Group Ltd Clavulanic acid derivatives and pharmaceutical compositions
JPS57143194A (en) * 1981-02-27 1982-09-04 Matsushita Electric Ind Co Ltd Blower
EP0062407A1 (en) * 1981-03-10 1982-10-13 Beecham Group Plc Therapeutic compounds containing beta-lactams
JPH0495698U (en) * 1991-01-21 1992-08-19
GB9518917D0 (en) * 1995-09-15 1995-11-15 Smithkline Beecham Plc Compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1424186A (en) * 1971-10-08 1976-02-11 Beecham Group Ltd Penicillins
US3925363A (en) * 1974-01-17 1975-12-09 Merck & Co Inc Process for epimerizing penicillin compounds, and related products
US4051132A (en) * 1974-01-23 1977-09-27 Merck & Co., Inc. Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench
GB1585165A (en) * 1976-06-29 1981-02-25 Leo Pharm Prod Ltd Derivatives of 6-amidino penicillanic acid
IL54859A (en) * 1977-06-21 1982-01-31 Rech Applications Therap Derivatives of amidinopenicillanic acid,their production and pharmaceutical compositions containing them
EP0005348B1 (en) * 1978-05-06 1982-09-22 Beecham Group Plc Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them
US4244965A (en) * 1978-06-15 1981-01-13 Beecham Group Limited Azetidinoyl ethers
US4252722A (en) * 1979-08-08 1981-02-24 Merck & Co., Inc. Process for the preparation of 6-hydroxymethyl-2-(β-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acid
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
US4231928A (en) * 1979-04-24 1980-11-04 Bristol-Myers Company Antibacterial agents

Also Published As

Publication number Publication date
MX4688E (en) 1982-08-02
SE8004329L (en) 1980-06-10
SU639454A3 (en) 1978-12-25
AU503489B2 (en) 1979-09-06
CH639665A5 (en) 1983-11-30
US4438101A (en) 1984-03-20
JPS612670B2 (en) 1986-01-27
NL7611206A (en) 1977-04-15
PT65707A (en) 1976-11-01
GB1566706A (en) 1980-05-08
PT65707B (en) 1978-04-17
FR2327775A1 (en) 1977-05-13
IL50618A (en) 1979-09-30
NO802661L (en) 1977-04-14
ZM12276A1 (en) 1977-07-21
BE847044A (en) 1977-04-07
FR2327775B1 (en) 1978-11-17
GR61674B (en) 1978-12-05
NO802662L (en) 1977-04-14
CH634323A5 (en) 1983-01-31
DK457676A (en) 1977-04-14
NO763472L (en) 1977-04-14
ES463974A1 (en) 1978-12-16
AU1858276A (en) 1978-04-20
IE43840B1 (en) 1981-06-03
US4256638A (en) 1981-03-17
SE7611047L (en) 1977-04-14
IL50618A0 (en) 1976-12-31
AR213294A1 (en) 1979-01-15
NZ182190A (en) 1979-03-16
HU175046B (en) 1980-05-28
ATA753476A (en) 1979-03-15
DE2646003A1 (en) 1977-04-21
IE43840L (en) 1977-04-13
JPS5248686A (en) 1977-04-18
AT352874B (en) 1979-10-10
FI762895A (en) 1977-04-14
SE8004330L (en) 1980-06-10
DD126929A5 (en) 1977-08-24
US4382084A (en) 1983-05-03
CA1094563A (en) 1981-01-27
ZA765901B (en) 1977-09-28

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