PT1648922E - Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos - Google Patents

Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos Download PDF

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Publication number
PT1648922E
PT1648922E PT04761605T PT04761605T PT1648922E PT 1648922 E PT1648922 E PT 1648922E PT 04761605 T PT04761605 T PT 04761605T PT 04761605 T PT04761605 T PT 04761605T PT 1648922 E PT1648922 E PT 1648922E
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PT
Portugal
Prior art keywords
compound
λλγ
quot
figura
formula
Prior art date
Application number
PT04761605T
Other languages
English (en)
Portuguese (pt)
Inventor
Pierre Deslongchamps
Yves Dory
Mark Peterson
Kamel Benakli
Eric Marsault
Luc Ouellet
Mahesh Ramaseshan
Martin Vezina
Daniel Fortin
Ruoxi Lan
Shigui Li
Gerald Villeneuve
Hamid Hoveyda
Sylvie Beaubien
Graeme Fraser
Original Assignee
Tranzyme Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc
Publication of PT1648922E publication Critical patent/PT1648922E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
PT04761605T 2003-07-31 2004-08-02 Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos PT1648922E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49124803P 2003-07-31 2003-07-31

Publications (1)

Publication Number Publication Date
PT1648922E true PT1648922E (pt) 2011-01-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PT04761605T PT1648922E (pt) 2003-07-31 2004-08-02 Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos

Country Status (15)

Country Link
US (3) US7452862B2 (de)
EP (3) EP2316846B1 (de)
JP (1) JP4928262B2 (de)
AT (1) ATE490264T1 (de)
AU (1) AU2004261329B2 (de)
CA (1) CA2533818C (de)
CY (1) CY1111901T1 (de)
DE (1) DE602004030344D1 (de)
DK (1) DK1648922T3 (de)
ES (1) ES2357235T7 (de)
IL (1) IL173312A0 (de)
PL (1) PL1648922T3 (de)
PT (1) PT1648922E (de)
SI (1) SI1648922T1 (de)
WO (1) WO2005012331A1 (de)

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EA025380B1 (ru) 2011-02-25 2016-12-30 Мерк Шарп Энд Домэ Корп. Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов
KR20150036245A (ko) 2012-08-02 2015-04-07 머크 샤프 앤드 돔 코포레이션 항당뇨병 트리시클릭 화합물
CN103113404B (zh) * 2013-02-22 2015-09-23 广州巨元生化有限公司 一种制备4-二烃氧基膦酰基-2-甲基-2-丁烯酸烃基酯的方法
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Also Published As

Publication number Publication date
EP1648922B3 (de) 2012-08-15
EP1648922A4 (de) 2006-08-23
JP4928262B2 (ja) 2012-05-09
ES2357235T3 (es) 2011-04-20
CY1111901T1 (el) 2015-11-04
EP2316846B1 (de) 2019-10-02
DK1648922T3 (da) 2011-03-14
US8440851B2 (en) 2013-05-14
DE602004030344D1 (de) 2011-01-13
EP2319859B1 (de) 2013-03-27
AU2004261329B2 (en) 2011-10-27
PL1648922T3 (pl) 2011-05-31
ES2357235T7 (es) 2013-02-14
CA2533818C (en) 2015-03-17
EP2316846A2 (de) 2011-05-04
IL173312A0 (en) 2009-02-11
AU2004261329A1 (en) 2005-02-10
SI1648922T1 (sl) 2011-03-31
WO2005012331A1 (en) 2005-02-10
EP1648922A1 (de) 2006-04-26
US20090137817A1 (en) 2009-05-28
ES2357235T8 (es) 2011-06-06
EP2316846A3 (de) 2012-04-04
EP2319859A2 (de) 2011-05-11
EP1648922B9 (de) 2013-04-03
ATE490264T1 (de) 2010-12-15
US20050137127A1 (en) 2005-06-23
EP2319859A3 (de) 2011-12-21
US20110237785A1 (en) 2011-09-29
CA2533818A1 (en) 2005-02-10
EP1648922B1 (de) 2010-12-01
US8022252B2 (en) 2011-09-20
US7452862B2 (en) 2008-11-18
JP2007527863A (ja) 2007-10-04

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