PL1648922T3 - Przestrzennie określone związki makrocykliczne użyteczne w dziedzinie odkrywania leków - Google Patents

Przestrzennie określone związki makrocykliczne użyteczne w dziedzinie odkrywania leków

Info

Publication number
PL1648922T3
PL1648922T3 PL04761605T PL04761605T PL1648922T3 PL 1648922 T3 PL1648922 T3 PL 1648922T3 PL 04761605 T PL04761605 T PL 04761605T PL 04761605 T PL04761605 T PL 04761605T PL 1648922 T3 PL1648922 T3 PL 1648922T3
Authority
PL
Poland
Prior art keywords
spatially
macrocyclic compounds
compounds useful
drug discovery
defined macrocyclic
Prior art date
Application number
PL04761605T
Other languages
English (en)
Inventor
Pierre Deslongchamps
Yves Dory
Mark Peterson
Kamel Benakli
Eric Marsault
Luc Ouellet
Mahesh Ramaseshan
Martin Vezina
Daniel Fortin
Ruoxi Lan
Shigui Li
Gérald Villeneuve
Hamid Hoveyda
Sylvie Beaubien
Graeme Fraser
Original Assignee
Tranzyme Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc
Publication of PL1648922T3 publication Critical patent/PL1648922T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL04761605T 2003-07-31 2004-08-02 Przestrzennie określone związki makrocykliczne użyteczne w dziedzinie odkrywania leków PL1648922T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49124803P 2003-07-31 2003-07-31
EP04761605A EP1648922B9 (en) 2003-07-31 2004-08-02 Spatially-defined macrocyclic compounds useful for drug discovery
PCT/CA2004/001439 WO2005012331A1 (en) 2003-07-31 2004-08-02 Spatially-defined macrocyclic compounds useful for drug discovery

Publications (1)

Publication Number Publication Date
PL1648922T3 true PL1648922T3 (pl) 2011-05-31

Family

ID=34115484

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04761605T PL1648922T3 (pl) 2003-07-31 2004-08-02 Przestrzennie określone związki makrocykliczne użyteczne w dziedzinie odkrywania leków

Country Status (15)

Country Link
US (3) US7452862B2 (pl)
EP (3) EP1648922B9 (pl)
JP (1) JP4928262B2 (pl)
AT (1) ATE490264T1 (pl)
AU (1) AU2004261329B2 (pl)
CA (1) CA2533818C (pl)
CY (1) CY1111901T1 (pl)
DE (1) DE602004030344D1 (pl)
DK (1) DK1648922T3 (pl)
ES (1) ES2357235T7 (pl)
IL (1) IL173312A0 (pl)
PL (1) PL1648922T3 (pl)
PT (1) PT1648922E (pl)
SI (1) SI1648922T1 (pl)
WO (1) WO2005012331A1 (pl)

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CA2533820C (en) * 2003-07-31 2016-12-13 Tranzyme Pharma Spatially-defined macrocycles incorporating peptide bond surrogates
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WO2006046977A1 (en) * 2004-10-26 2006-05-04 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and methods of using the same
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RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
CN103113404B (zh) * 2013-02-22 2015-09-23 广州巨元生化有限公司 一种制备4-二烃氧基膦酰基-2-甲基-2-丁烯酸烃基酯的方法
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WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
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US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
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US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
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Also Published As

Publication number Publication date
DK1648922T3 (da) 2011-03-14
EP1648922B1 (en) 2010-12-01
EP2319859A3 (en) 2011-12-21
US7452862B2 (en) 2008-11-18
ES2357235T3 (es) 2011-04-20
WO2005012331A1 (en) 2005-02-10
EP1648922A1 (en) 2006-04-26
US20110237785A1 (en) 2011-09-29
CA2533818A1 (en) 2005-02-10
US8440851B2 (en) 2013-05-14
IL173312A0 (en) 2009-02-11
CY1111901T1 (el) 2015-11-04
CA2533818C (en) 2015-03-17
EP2319859B1 (en) 2013-03-27
AU2004261329A1 (en) 2005-02-10
JP2007527863A (ja) 2007-10-04
ATE490264T1 (de) 2010-12-15
US20090137817A1 (en) 2009-05-28
EP2316846A3 (en) 2012-04-04
SI1648922T1 (sl) 2011-03-31
EP1648922B9 (en) 2013-04-03
EP1648922B3 (en) 2012-08-15
EP2316846B1 (en) 2019-10-02
JP4928262B2 (ja) 2012-05-09
EP2316846A2 (en) 2011-05-04
US20050137127A1 (en) 2005-06-23
EP2319859A2 (en) 2011-05-11
EP1648922A4 (en) 2006-08-23
ES2357235T7 (es) 2013-02-14
ES2357235T8 (es) 2011-06-06
US8022252B2 (en) 2011-09-20
PT1648922E (pt) 2011-01-04
AU2004261329B2 (en) 2011-10-27
DE602004030344D1 (de) 2011-01-13

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