ATE537259T1 - Modifizierte beta-lactamasen und deren verwendung - Google Patents

Modifizierte beta-lactamasen und deren verwendung

Info

Publication number
ATE537259T1
ATE537259T1 AT04723149T AT04723149T ATE537259T1 AT E537259 T1 ATE537259 T1 AT E537259T1 AT 04723149 T AT04723149 T AT 04723149T AT 04723149 T AT04723149 T AT 04723149T AT E537259 T1 ATE537259 T1 AT E537259T1
Authority
AT
Austria
Prior art keywords
lactamases
beta
omega
loop
modified beta
Prior art date
Application number
AT04723149T
Other languages
English (en)
Inventor
Kwokyin Wong
Thomas Y Leung
Pakho Chan
Original Assignee
Univ Hong Kong Polytechnic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Polytechnic filed Critical Univ Hong Kong Polytechnic
Application granted granted Critical
Publication of ATE537259T1 publication Critical patent/ATE537259T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04723149T 2003-03-31 2004-03-25 Modifizierte beta-lactamasen und deren verwendung ATE537259T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/401,867 US7323303B2 (en) 2003-03-31 2003-03-31 Modified β-lactamases and uses thereof
PCT/CN2004/000253 WO2004087925A1 (en) 2003-03-31 2004-03-25 Modified beta-lactamases and uses thereof

Publications (1)

Publication Number Publication Date
ATE537259T1 true ATE537259T1 (de) 2011-12-15

Family

ID=33130436

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04723149T ATE537259T1 (de) 2003-03-31 2004-03-25 Modifizierte beta-lactamasen und deren verwendung

Country Status (5)

Country Link
US (1) US7323303B2 (de)
EP (1) EP1608757B1 (de)
CN (1) CN1784493B (de)
AT (1) ATE537259T1 (de)
WO (1) WO2004087925A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
US8005280B2 (en) * 2007-12-12 2011-08-23 Jadak, Llc Optical imaging clinical sampler
FI20105572A0 (fi) * 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
WO2013053953A1 (en) * 2011-10-14 2013-04-18 Université de Liège Method for measuring beta-lactam antibiotics
WO2017161183A1 (en) 2016-03-16 2017-09-21 The Regents Of The University Of California Covalent peptide binders
WO2020018462A1 (en) 2018-07-16 2020-01-23 Brown University A chromogenic beta-lactamase substrate
WO2020206341A1 (en) * 2019-04-04 2020-10-08 The Regents Of The University Of California Method to generate biochemically reactive amino acids
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
US12509559B2 (en) 2019-10-28 2025-12-30 Brown University Bacterial beta-lactamase responsive hydrogels
WO2024012487A1 (en) * 2022-07-14 2024-01-18 The Hong Kong Polytechnic University Biosensor comprising a modified beta-lactamase and uses thereof
CN116597904B (zh) * 2023-02-02 2026-03-24 中国人民解放军陆军特色医学中心 基于抗生素与金属β-内酰胺酶作用机理研发抑制剂的模拟方法
CN117701543A (zh) * 2023-12-15 2024-03-15 四川省固体废物与化学品管理中心 一种b家族内酰胺酶突变体及其固定化方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5371190A (en) * 1984-05-29 1994-12-06 Genencor International, Inc. Substrate assisted catalysis
US4792523A (en) * 1984-08-31 1988-12-20 Cetus Corporation 3'Expression enhancing fragments and method
US5824469A (en) * 1986-07-17 1998-10-20 University Of Washington Method for producing novel DNA sequences with biological activity
CA2094495C (en) * 1990-10-22 2007-04-03 David Botstein Methods for modifying and detecting the effects on the interaction of modified polypeptides and target substrates
US5508192A (en) * 1990-11-09 1996-04-16 Board Of Regents, The University Of Texas System Bacterial host strains for producing proteolytically sensitive polypeptides
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5741657A (en) * 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
JP2002250730A (ja) 2001-02-27 2002-09-06 Shinwa Kako Kk 分子センサー及びその製造方法

Also Published As

Publication number Publication date
EP1608757B1 (de) 2011-12-14
EP1608757A1 (de) 2005-12-28
EP1608757A4 (de) 2006-09-06
CN1784493B (zh) 2010-12-01
WO2004087925A1 (en) 2004-10-14
US7323303B2 (en) 2008-01-29
US20050261270A1 (en) 2005-11-24
CN1784493A (zh) 2006-06-07

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