DE60042066D1 - Chimärische dr4 antikörper und ihre verwendung - Google Patents
Chimärische dr4 antikörper und ihre verwendungInfo
- Publication number
- DE60042066D1 DE60042066D1 DE60042066T DE60042066T DE60042066D1 DE 60042066 D1 DE60042066 D1 DE 60042066D1 DE 60042066 T DE60042066 T DE 60042066T DE 60042066 T DE60042066 T DE 60042066T DE 60042066 D1 DE60042066 D1 DE 60042066D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- chimeric
- kits
- diagnosis
- articles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32287599A | 1999-05-28 | 1999-05-28 | |
PCT/US2000/014599 WO2000073349A1 (en) | 1999-05-28 | 2000-05-25 | Dr4 antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60042066D1 true DE60042066D1 (de) | 2009-06-04 |
Family
ID=23256824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60042066T Expired - Lifetime DE60042066D1 (de) | 1999-05-28 | 2000-05-25 | Chimärische dr4 antikörper und ihre verwendung |
Country Status (12)
Country | Link |
---|---|
EP (2) | EP1181319B1 (de) |
JP (1) | JP4589586B2 (de) |
AT (1) | ATE429450T1 (de) |
AU (3) | AU781952B2 (de) |
CA (1) | CA2374599A1 (de) |
CY (1) | CY1109151T1 (de) |
DE (1) | DE60042066D1 (de) |
DK (1) | DK1181319T3 (de) |
ES (1) | ES2325305T3 (de) |
IL (1) | IL146448A0 (de) |
PT (1) | PT1181319E (de) |
WO (1) | WO2000073349A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1624128A (zh) | 1997-03-17 | 2005-06-08 | 人类基因组科学公司 | 包含死亡结构域的受体-5 |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
EP1196191A4 (de) * | 1999-05-04 | 2004-03-24 | Human Genome Sciences Inc | Death domain enthaltenden rezeptor 5 |
DE60042066D1 (de) * | 1999-05-28 | 2009-06-04 | Genentech Inc | Chimärische dr4 antikörper und ihre verwendung |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
US7115717B2 (en) * | 2001-05-18 | 2006-10-03 | Kirin Beer Kabushiki Kaisha | Anti-TRAIL-R antibodies |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
KR100942393B1 (ko) | 2001-05-25 | 2010-02-17 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Trail 수용체에 면역특이적으로 결합하는 항체 |
JP4509570B2 (ja) | 2001-07-03 | 2010-07-21 | ジェネンテック, インコーポレイテッド | ヒトdr4抗体及びその使用法 |
WO2003013584A1 (en) * | 2001-08-09 | 2003-02-20 | Genset S.A. | Xafinix agonists and antagonists for use in the treatment of metabolic disorders |
ES2357225T3 (es) * | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
RU2395294C2 (ru) * | 2004-06-18 | 2010-07-27 | Дженентек, Инк. | Способы применения агонистов аро-2l-рецепторов и активаторов nk-клеток |
EP1778871B1 (de) | 2004-08-06 | 2011-05-04 | Genentech, Inc. | Tests und verfahren unter verwendung von biomarkern |
KR101235479B1 (ko) | 2004-08-06 | 2013-02-20 | 제넨테크, 인크. | 바이오마커를 사용한 분석 및 방법 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
BRPI0606791A2 (pt) | 2005-02-02 | 2010-02-09 | Uab Research Foundation | métodos de reverter ou prevenir a resistência de uma célula a um agonista do receptor da morte, de triar uma célula quanto a um biomarcador da resistência a um agonista do receptor da morte, de monitorar a resistência a um agonista do receptor da morte em um indivìduo, de induzir seletivamente a apoptose em uma célula alvo expressando um receptor da morte, de tratar de um indivìduo com cáncer, de tratar de um indivìduo com uma doença inflamatória ou autoimune, de bloquear a ligação da proteìna contendo card a um receptor da morte em uma célula, de bloquear a associação de um iap com o receptor da morte e de triar um modulador de uma proteìna contendo card, composição, ácido nucleico isolado, vetor, célula, e, polipeptìdeo isolado |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
ZA200800974B (en) * | 2005-08-16 | 2009-11-25 | Genentech Inc | Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues |
WO2008066854A2 (en) * | 2006-11-28 | 2008-06-05 | Novartis Ag | Methods and compositions for inducing apoptosis in cancer cells |
CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
EP2430047B1 (de) | 2009-05-13 | 2018-03-28 | i2 Pharmaceuticals, Inc. | Neutralisierende moleküle gegen influenza-viren |
CA2834776A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies |
EP2736928B1 (de) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Gegen erbb3-gerichtete sur-bindende proteine |
US9975956B2 (en) | 2011-12-22 | 2018-05-22 | I2 Pharmaceuticals, Inc. | Surrogate binding proteins which bind DR4 and/or DR5 |
CN110305874A (zh) * | 2019-06-19 | 2019-10-08 | 浙江省肿瘤医院 | 长爪沙鼠免疫球蛋白IgG1、IgG2重组蛋白、基因及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
ATE244763T1 (de) | 1992-02-11 | 2003-07-15 | Cell Genesys Inc | Erzielen von homozygotem durch zielgerichtete genetische ereignisse |
DE69837806T3 (de) * | 1997-01-28 | 2012-01-05 | Human Genome Sciences, Inc. | "death-domain"-enthaltender rezeptor 4 (dr4), ein mitglied der tnf-rezeptor superfamilie, welcher an trail (apo-2l) bindet |
PT1860187E (pt) * | 1997-05-15 | 2011-10-04 | Genentech Inc | Receptor apo-2 |
CA2318405C (en) * | 1998-01-26 | 2014-01-07 | Genentech, Inc. | Antibodies to death receptor 4(dr4) and uses thereof |
JP2002517223A (ja) * | 1998-06-12 | 2002-06-18 | ジェネンテック・インコーポレーテッド | モノクローナル抗体、交叉反応性抗体およびそれを生成する方法 |
DE60042066D1 (de) * | 1999-05-28 | 2009-06-04 | Genentech Inc | Chimärische dr4 antikörper und ihre verwendung |
-
2000
- 2000-05-25 DE DE60042066T patent/DE60042066D1/de not_active Expired - Lifetime
- 2000-05-25 DK DK00937844T patent/DK1181319T3/da active
- 2000-05-25 WO PCT/US2000/014599 patent/WO2000073349A1/en active IP Right Grant
- 2000-05-25 JP JP2001500673A patent/JP4589586B2/ja not_active Expired - Lifetime
- 2000-05-25 ES ES00937844T patent/ES2325305T3/es not_active Expired - Lifetime
- 2000-05-25 EP EP00937844A patent/EP1181319B1/de not_active Expired - Lifetime
- 2000-05-25 CA CA002374599A patent/CA2374599A1/en not_active Abandoned
- 2000-05-25 AU AU52967/00A patent/AU781952B2/en not_active Expired
- 2000-05-25 EP EP09004554A patent/EP2213302A3/de not_active Withdrawn
- 2000-05-25 PT PT00937844T patent/PT1181319E/pt unknown
- 2000-05-25 AT AT00937844T patent/ATE429450T1/de active
- 2000-05-25 IL IL14644800A patent/IL146448A0/xx unknown
-
2005
- 2005-05-05 AU AU2005201915A patent/AU2005201915B2/en not_active Expired
-
2009
- 2009-04-20 AU AU2009201670A patent/AU2009201670A1/en not_active Abandoned
- 2009-06-16 CY CY20091100634T patent/CY1109151T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1181319E (pt) | 2009-07-14 |
AU2009201670A1 (en) | 2009-05-21 |
AU2005201915A1 (en) | 2005-06-02 |
EP2213302A2 (de) | 2010-08-04 |
IL146448A0 (en) | 2002-07-25 |
JP4589586B2 (ja) | 2010-12-01 |
ATE429450T1 (de) | 2009-05-15 |
WO2000073349A9 (en) | 2002-05-10 |
EP1181319B1 (de) | 2009-04-22 |
EP2213302A3 (de) | 2010-11-03 |
CA2374599A1 (en) | 2000-12-07 |
DK1181319T3 (da) | 2009-08-17 |
JP2003503017A (ja) | 2003-01-28 |
WO2000073349A1 (en) | 2000-12-07 |
ES2325305T3 (es) | 2009-09-01 |
AU5296700A (en) | 2000-12-18 |
AU781952B2 (en) | 2005-06-23 |
AU2005201915B2 (en) | 2009-01-22 |
CY1109151T1 (el) | 2014-07-02 |
EP1181319A1 (de) | 2002-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |