ATE272114T1 - Rezeptoren für il-18 - Google Patents

Rezeptoren für il-18

Info

Publication number
ATE272114T1
ATE272114T1 AT99904222T AT99904222T ATE272114T1 AT E272114 T1 ATE272114 T1 AT E272114T1 AT 99904222 T AT99904222 T AT 99904222T AT 99904222 T AT99904222 T AT 99904222T AT E272114 T1 ATE272114 T1 AT E272114T1
Authority
AT
Austria
Prior art keywords
receptor
polypeptide
receptors
multimeric
fragment
Prior art date
Application number
AT99904222T
Other languages
English (en)
Inventor
John E Sims
Teresa L Born
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE272114T1 publication Critical patent/ATE272114T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT99904222T 1998-01-23 1999-01-22 Rezeptoren für il-18 ATE272114T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7230198P 1998-01-23 1998-01-23
US7883598P 1998-03-20 1998-03-20
US9446998P 1998-07-28 1998-07-28
PCT/US1999/001419 WO1999037772A1 (en) 1998-01-23 1999-01-22 Il-18 receptors

Publications (1)

Publication Number Publication Date
ATE272114T1 true ATE272114T1 (de) 2004-08-15

Family

ID=27372056

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904222T ATE272114T1 (de) 1998-01-23 1999-01-22 Rezeptoren für il-18

Country Status (13)

Country Link
US (4) US6589764B1 (de)
EP (1) EP1047781B1 (de)
JP (1) JP4271850B2 (de)
AT (1) ATE272114T1 (de)
AU (1) AU737592B2 (de)
CA (1) CA2318482C (de)
DE (1) DE69918946T2 (de)
DK (1) DK1047781T3 (de)
ES (1) ES2226335T3 (de)
IL (2) IL137178A0 (de)
NZ (1) NZ505880A (de)
PT (1) PT1047781E (de)
WO (1) WO1999037772A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326472B1 (en) 1997-10-15 2001-12-04 Schering Corporation Human receptor proteins; related reagents and methods
US6472179B2 (en) * 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7083949B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20020155526A1 (en) 1998-09-30 2002-10-24 Busfield Samantha J. Novel secreted immunomodulatory proteins and uses thereof
US7122632B2 (en) 1999-12-23 2006-10-17 Zymogenetics, Inc. Soluble Interleukin-20 receptor
US6610286B2 (en) 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
DE60045139D1 (de) 1999-12-23 2010-12-02 Zymogenetics Inc Löslicher Interleukin-20-Rezeptor
PL356836A1 (en) 2000-02-10 2004-07-12 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
US20020052475A1 (en) * 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor
US20020025317A1 (en) * 2000-07-20 2002-02-28 Schering Ag Bispecific monoclonal antibodies to IL-12 and IL-18
EP2177616B1 (de) 2000-08-08 2012-02-29 ZymoGenetics, Inc. Lösliche Zcyctor 11 Cytokinrezeptoren
EP1803733B1 (de) 2000-09-15 2010-03-10 ZymoGenetics, Inc. Polypeptide enthaltend extrazellulären Domäne von IL-20RA und/oderr IL-20RB
AU1174402A (en) 2000-10-11 2002-04-22 Viron Therapeutics Inc Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
GB2375604A (en) * 2001-05-18 2002-11-20 Warner Lambert Co Methods for screening using interleukin soluble trimolecular complex
CA2451955C (en) 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
EP1293566A1 (de) * 2001-09-17 2003-03-19 Societe Des Produits Nestle S.A. Ein löslicher Toll-ähnlicher Rezeptor
IL161978A0 (en) 2001-12-17 2005-11-20 Zymogenetics Inc Method for treating cervical cancer
MXPA05002219A (es) 2002-08-28 2005-07-05 Immunex Corp Composiciones y metodos para tratar una enfermedad cardiovascular.
US7279155B2 (en) * 2002-10-08 2007-10-09 Ares Trading S.A. Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
EP1606317B1 (de) 2003-03-24 2010-07-28 ZymoGenetics, Inc. Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
EP2143733A1 (de) 2003-11-21 2010-01-13 ZymoGenetics, Inc. Anti-il-20-Rezeptor-Antikörper und Bindungspartner und Verfahren zur Anwendung bei Entzündungen
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
EA015706B1 (ru) 2004-10-22 2011-10-31 Займоджинетикс, Инк. Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела
CN101146823A (zh) * 2005-02-15 2008-03-19 阿波罗生命科学有限公司 分子及其嵌合分子
JP2009527535A (ja) * 2006-02-22 2009-07-30 ユニバーシティ オブ チューリッヒ 自己免疫疾患又は脱髄疾患を処置するための可溶性受容体及び方法
ATE555383T1 (de) 2006-06-22 2012-05-15 Novo Nordisk As Lösliche heterodimere rezeptoren und ihre verwendung
EP2158318A2 (de) * 2007-05-14 2010-03-03 Biogen Idec MA, Inc. Scfc-(single-chain fc-)bereiche, diese enthaltende bindungspolypeptide und verfahren in verbindung damit
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
EP3409289B1 (de) 2010-02-26 2020-09-30 Novo Nordisk A/S Stabile, antikörperhaltige zusammensetzungen
RU2012153786A (ru) 2010-05-28 2014-07-10 Ново Нордиск А/С Стабильные многодозовые композиции, содержащие антитело и консервант
HRP20191305T1 (hr) 2010-07-09 2019-10-18 Bioverativ Therapeutics Inc. Preradive jednolančane molekule i polipeptidi izrađeni koristeći iste
AR082518A1 (es) 2010-08-25 2012-12-12 Hoffmann La Roche Anticuerpos contra il-18r1 y usos de los mismos
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004838A1 (en) 1987-11-25 1989-06-01 Immunex Corporation Interleukin-1 receptors
EP0533006A1 (de) * 1991-09-18 1993-03-24 F.Hoffmann-La Roche & Co. Aktiengesellschaft Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
WO1996013593A2 (en) * 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
US5853721A (en) 1995-01-31 1998-12-29 Hoffmann-La Roche Inc. Antibody to interleukin-12 receptor
ES2305024T3 (es) * 1995-08-01 2008-11-01 F. Hoffmann-La Roche Ag Receptores para interleuquina-12 humana.
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
US6326472B1 (en) 1997-10-15 2001-12-04 Schering Corporation Human receptor proteins; related reagents and methods
US6280955B1 (en) * 1997-12-16 2001-08-28 Tularik Inc. Interleukin-1 receptor accessory proteins, nucleic acids and methods
US6472179B2 (en) 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20020052475A1 (en) 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor

Also Published As

Publication number Publication date
ES2226335T3 (es) 2005-03-16
CA2318482C (en) 2010-04-13
DE69918946T2 (de) 2005-07-28
US7704945B2 (en) 2010-04-27
US20070135625A1 (en) 2007-06-14
NZ505880A (en) 2003-06-30
DE69918946D1 (de) 2004-09-02
US20030199040A1 (en) 2003-10-23
AU2466899A (en) 1999-08-09
US8053233B2 (en) 2011-11-08
US7169581B2 (en) 2007-01-30
AU737592B2 (en) 2001-08-23
CA2318482A1 (en) 1999-07-29
US6589764B1 (en) 2003-07-08
WO1999037772A1 (en) 1999-07-29
US20100190211A1 (en) 2010-07-29
IL137178A (en) 2007-06-17
EP1047781A1 (de) 2000-11-02
JP2002500886A (ja) 2002-01-15
IL137178A0 (en) 2001-07-24
DK1047781T3 (da) 2004-12-06
EP1047781B1 (de) 2004-07-28
JP4271850B2 (ja) 2009-06-03
PT1047781E (pt) 2004-11-30

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