DE69918946D1 - Rezeptoren für il-18 - Google Patents

Rezeptoren für il-18

Info

Publication number
DE69918946D1
DE69918946D1 DE69918946T DE69918946T DE69918946D1 DE 69918946 D1 DE69918946 D1 DE 69918946D1 DE 69918946 T DE69918946 T DE 69918946T DE 69918946 T DE69918946 T DE 69918946T DE 69918946 D1 DE69918946 D1 DE 69918946D1
Authority
DE
Germany
Prior art keywords
receptor
polypeptide
receptors
multimeric
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69918946T
Other languages
English (en)
Other versions
DE69918946T2 (de
Inventor
E Sims
L Born
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunex Corp
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DE69918946D1 publication Critical patent/DE69918946D1/de
Publication of DE69918946T2 publication Critical patent/DE69918946T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69918946T 1998-01-23 1999-01-22 Rezeptoren für il-18 Expired - Lifetime DE69918946T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7230198P 1998-01-23 1998-01-23
US72301P 1998-01-23
US7883598P 1998-03-20 1998-03-20
US78835P 1998-03-20
US9446998P 1998-07-28 1998-07-28
US94469P 1998-07-28
PCT/US1999/001419 WO1999037772A1 (en) 1998-01-23 1999-01-22 Il-18 receptors

Publications (2)

Publication Number Publication Date
DE69918946D1 true DE69918946D1 (de) 2004-09-02
DE69918946T2 DE69918946T2 (de) 2005-07-28

Family

ID=27372056

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69918946T Expired - Lifetime DE69918946T2 (de) 1998-01-23 1999-01-22 Rezeptoren für il-18

Country Status (13)

Country Link
US (4) US6589764B1 (de)
EP (1) EP1047781B1 (de)
JP (1) JP4271850B2 (de)
AT (1) ATE272114T1 (de)
AU (1) AU737592B2 (de)
CA (1) CA2318482C (de)
DE (1) DE69918946T2 (de)
DK (1) DK1047781T3 (de)
ES (1) ES2226335T3 (de)
IL (2) IL137178A0 (de)
NZ (1) NZ505880A (de)
PT (1) PT1047781E (de)
WO (1) WO1999037772A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326472B1 (en) 1997-10-15 2001-12-04 Schering Corporation Human receptor proteins; related reagents and methods
US6472179B2 (en) * 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US7083949B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US20020155526A1 (en) 1998-09-30 2002-10-24 Busfield Samantha J. Novel secreted immunomodulatory proteins and uses thereof
US6610286B2 (en) 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
ATE485306T1 (de) * 1999-12-23 2010-11-15 Zymogenetics Inc Löslicher interleukin-20-rezeptor
US7122632B2 (en) 1999-12-23 2006-10-17 Zymogenetics, Inc. Soluble Interleukin-20 receptor
CN102504024A (zh) * 2000-02-10 2012-06-20 雅培制药有限公司 结合人白介素-18的抗体及制备和使用方法
US20020052475A1 (en) * 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor
US20020025317A1 (en) * 2000-07-20 2002-02-28 Schering Ag Bispecific monoclonal antibodies to IL-12 and IL-18
JP5015404B2 (ja) 2000-08-08 2012-08-29 ザイモジェネティクス， インコーポレイテッド 可溶性ｚｃｙｔｏｒ１１サイトカイン受容体
JP4908723B2 (ja) 2000-09-15 2012-04-04 ザイモジェネティクス， インコーポレイテッド 炎症を治療するための方法
JP2004528010A (ja) 2000-10-11 2004-09-16 バイロン・セラピューティックス・インコーポレーテッド 免疫モジュレーションのための核酸およびポリペプチド
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
GB2375604A (en) * 2001-05-18 2002-11-20 Warner Lambert Co Methods for screening using interleukin soluble trimolecular complex
CN103232539B (zh) 2001-06-26 2015-06-03 安姆根弗里蒙特公司 抗opgl抗体
EP1293566A1 (de) * 2001-09-17 2003-03-19 Societe Des Produits Nestle S.A. Ein löslicher Toll-ähnlicher Rezeptor
WO2003051384A1 (en) 2001-12-17 2003-06-26 Zymogenetics, Inc. Method for treating cervical cancer
US20040136992A1 (en) 2002-08-28 2004-07-15 Burton Paul B. J. Compositions and method for treating cardiovascular disease
CA2500577C (en) 2002-10-08 2013-12-17 Charles A. Dinarello The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine
DK1606317T3 (da) 2003-03-24 2010-10-25 Zymogenetics Inc Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammation
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
WO2005052000A2 (en) 2003-11-21 2005-06-09 Zymogenetics, Inc. Anti-il-20 antibodies and binding partners and methods of using in inflammation
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
CN101198625A (zh) 2004-10-22 2008-06-11 津莫吉尼蒂克斯公司 抗il-22ra抗体和结合伴侣及其在炎症中的使用方法
CN101146823A (zh) * 2005-02-15 2008-03-19 阿波罗生命科学有限公司 分子及其嵌合分子
WO2007096398A1 (en) * 2006-02-22 2007-08-30 University Of Zurich Soluble receptors and methods for treating autoimmune or demyelinating diseases
ATE555383T1 (de) 2006-06-22 2012-05-15 Novo Nordisk As Lösliche heterodimere rezeptoren und ihre verwendung
NZ581395A (en) * 2007-05-14 2012-08-31 Biogen Idec Inc Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
RS61082B1 (sr) 2010-02-26 2020-12-31 Novo Nordisk As Stabilno antitelo koje sadrži kompozicije
KR20130086144A (ko) 2010-05-28 2013-07-31 노보 노르디스크 에이/에스 항체 및 보존제를 포함하는 안정한 다중-투여 조성물
PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
MX340555B (es) 2010-08-25 2016-07-14 F Hoffmann-La Roche Ag * Anticuerpos contra il-18r1 y usos de los mismos.
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989004838A1 (en) 1987-11-25 1989-06-01 Immunex Corporation Interleukin-1 receptors
EP0533006A1 (de) * 1991-09-18 1993-03-24 F.Hoffmann-La Roche & Co. Aktiengesellschaft Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
WO1996013593A2 (en) * 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
US5853721A (en) 1995-01-31 1998-12-29 Hoffmann-La Roche Inc. Antibody to interleukin-12 receptor
ES2255067T3 (es) * 1995-08-01 2006-06-16 F. Hoffmann-La Roche Ag Receptores para la interleucina-12 humana.
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
US6326472B1 (en) 1997-10-15 2001-12-04 Schering Corporation Human receptor proteins; related reagents and methods
US6280955B1 (en) * 1997-12-16 2001-08-28 Tularik Inc. Interleukin-1 receptor accessory proteins, nucleic acids and methods
US6472179B2 (en) 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20020052475A1 (en) 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor

Also Published As

Publication number Publication date
AU737592B2 (en) 2001-08-23
US20030199040A1 (en) 2003-10-23
AU2466899A (en) 1999-08-09
US7169581B2 (en) 2007-01-30
ATE272114T1 (de) 2004-08-15
EP1047781A1 (de) 2000-11-02
DK1047781T3 (da) 2004-12-06
DE69918946T2 (de) 2005-07-28
IL137178A0 (en) 2001-07-24
JP4271850B2 (ja) 2009-06-03
CA2318482C (en) 2010-04-13
NZ505880A (en) 2003-06-30
EP1047781B1 (de) 2004-07-28
ES2226335T3 (es) 2005-03-16
US6589764B1 (en) 2003-07-08
US20100190211A1 (en) 2010-07-29
WO1999037772A1 (en) 1999-07-29
US20070135625A1 (en) 2007-06-14
IL137178A (en) 2007-06-17
JP2002500886A (ja) 2002-01-15
CA2318482A1 (en) 1999-07-29
US7704945B2 (en) 2010-04-27
US8053233B2 (en) 2011-11-08
PT1047781E (pt) 2004-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOCKHORNI & KOLLEGEN, 80687 MUENCHEN