DK1606317T3 - Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammation - Google Patents
Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammationInfo
- Publication number
- DK1606317T3 DK1606317T3 DK04749427.3T DK04749427T DK1606317T3 DK 1606317 T3 DK1606317 T3 DK 1606317T3 DK 04749427 T DK04749427 T DK 04749427T DK 1606317 T3 DK1606317 T3 DK 1606317T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- binding partners
- methods
- well
- inflammation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45748103P | 2003-03-24 | 2003-03-24 | |
US52329503P | 2003-11-17 | 2003-11-17 | |
PCT/US2004/008956 WO2004085476A2 (en) | 2003-03-24 | 2004-03-24 | Anti-il-22ra antibodies and binding partners and methods of using in inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1606317T3 true DK1606317T3 (da) | 2010-10-25 |
Family
ID=33101289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04749427.3T DK1606317T3 (da) | 2003-03-24 | 2004-03-24 | Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammation |
Country Status (16)
Country | Link |
---|---|
US (6) | US20040209330A1 (da) |
EP (2) | EP1606317B1 (da) |
JP (2) | JP2007525438A (da) |
KR (3) | KR20110091598A (da) |
CN (2) | CN102690350A (da) |
AT (1) | ATE475673T1 (da) |
AU (2) | AU2004223837C1 (da) |
BR (2) | BRPI0408705A (da) |
CA (2) | CA2519089C (da) |
DE (1) | DE602004028347D1 (da) |
DK (1) | DK1606317T3 (da) |
EA (2) | EA009124B1 (da) |
ES (1) | ES2347657T3 (da) |
MX (2) | MXPA05010134A (da) |
NO (1) | NO20054892L (da) |
WO (2) | WO2004085475A2 (da) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
EP2177616B1 (en) * | 2000-08-08 | 2012-02-29 | ZymoGenetics, Inc. | Soluble zcytor 11 cytokine receptors |
EP1351703B1 (en) | 2000-09-15 | 2006-07-26 | ZymoGenetics, Inc. | Use of a polypeptide comprising the extracellular domains of il-20ra and il-20rb for the treatment of inflammation |
US7582287B2 (en) | 2001-12-17 | 2009-09-01 | Zymogenetics, Inc. | Method for treating cervical cancer |
ES2347657T3 (es) * | 2003-03-24 | 2010-11-03 | Zymogenetics, Inc. | Anticuerpos dirigidos contra il-22ra y asociados de union y procedimiento de uso en inflamacion. |
JP2007537993A (ja) * | 2003-11-21 | 2007-12-27 | ザイモジェネティクス, インコーポレイテッド | 抗il−20受容体抗体および結合パートナーならびに炎症において用いる方法 |
CA2583202A1 (en) * | 2004-10-04 | 2006-04-27 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of macromolecules |
DE602005022475D1 (de) * | 2004-10-22 | 2010-09-02 | Zymogenetics Inc | Anti-il-22ra-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
CN100515491C (zh) * | 2005-01-04 | 2009-07-22 | 健能隆医药技术(上海)有限公司 | 白介素-22的医药用途 |
CA2596390A1 (en) * | 2005-02-08 | 2006-08-17 | Zymogenetics, Inc. | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation |
EP1954719A2 (en) * | 2005-12-02 | 2008-08-13 | Genentech Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
WO2007067596A2 (en) * | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of antibodies |
US20070148131A1 (en) * | 2005-12-05 | 2007-06-28 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of binding partners |
JP2009521503A (ja) * | 2005-12-22 | 2009-06-04 | ディー・エイチ・ワイ・アンド・カンパニー・リミテッド | インターロイキン−22結合タンパク質に対する抗体と、代謝性疾患の処置のためのその使用 |
WO2007109110A2 (en) * | 2006-03-16 | 2007-09-27 | Trinity Biosystems, Inc. | Methods for increasing the size of animals using needleless delivery constructs |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
DK2047863T3 (da) | 2006-06-08 | 2013-09-16 | Chugai Pharmaceutical Co Ltd | Middel til forebyggelse eller behandling af inflammatoriske sygdomme |
US20090092660A1 (en) * | 2006-08-09 | 2009-04-09 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of particles |
DK2202245T3 (da) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til modificering af et antistofs isoelektriske punkt via aminosyresubstitution i cdr |
KR102467302B1 (ko) | 2007-09-26 | 2022-11-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
CA2708065C (en) | 2007-12-05 | 2015-02-24 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for pruritus |
MY177564A (en) | 2007-12-05 | 2020-09-20 | Chugai Pharmaceutical Co Ltd | Anti-nr10 antibody and use thereof |
EP3521311A1 (en) | 2008-04-11 | 2019-08-07 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
JP2011526591A (ja) | 2008-06-30 | 2011-10-13 | ノボ・ノルデイスク・エー/エス | 抗ヒトインターロイキン−20抗体 |
JP2010210772A (ja) * | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
US20120071634A1 (en) | 2009-03-19 | 2012-03-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody Constant Region Variant |
US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
CA2819356C (en) | 2010-11-30 | 2023-01-24 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
ES2670874T3 (es) | 2011-03-16 | 2018-06-01 | Argenx Bvba | Anticuerpos contra CD70 |
DK2739748T3 (da) | 2011-08-05 | 2019-06-24 | Univ Aix Marseille | Il22ra2-gen med fibrosefølsomhed og anvendelser deraf |
US8597647B1 (en) | 2012-05-22 | 2013-12-03 | National Cheng Kung University | Humanized anti-IL-20 antibody and uses thereof |
WO2014006230A1 (en) * | 2012-07-06 | 2014-01-09 | Novo Nordisk A/S | Il-20 epitopes and il-20 ligands |
WO2014015133A1 (en) | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
CN104583238A (zh) * | 2012-08-31 | 2015-04-29 | 阿尔金-X有限公司 | 用于产生具有物种间、靶标内交叉反应性之抗体分子的方法 |
US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
RU2683020C2 (ru) * | 2014-11-11 | 2019-03-26 | Петр Иванович Никитин | Субстанция и способ для модуляции активности агента в организме |
EP3284480A4 (en) | 2015-04-14 | 2018-12-05 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing il-31 antagonist as active ingredient |
CN105601739B (zh) * | 2016-02-22 | 2019-01-18 | 王晨辉 | 一种人源化抗白介素22基因工程抗体及其应用 |
WO2017202813A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections |
GB201612337D0 (en) * | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
JOP20190155A1 (ar) | 2016-12-21 | 2019-06-23 | Novartis Ag | مترافقات عقار جسم مضاد لإزالة خلايا جذعية مكونة للدم |
US20220177912A1 (en) * | 2019-04-12 | 2022-06-09 | The Methodist Hospital | Therapeutic particles that enable antigen presenting cells to attack cancer cells |
EP3984553A4 (en) * | 2019-06-12 | 2023-07-19 | Acurasysbio Co., Ltd. | COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER |
WO2021100794A1 (ja) | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
NZ212437A (en) * | 1985-06-17 | 1992-06-25 | Mark Philip Best | Site-directed antibody conjugates, and their preparation |
WO1989004838A1 (en) * | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
US5789192A (en) * | 1992-12-10 | 1998-08-04 | Schering Corporation | Mammalian receptors for interleukin-10 (IL-10) |
JPH09509054A (ja) | 1994-02-01 | 1997-09-16 | アメリカ合衆国 | 抗体部分および非抗体部分を含む融合タンパク質 |
JP3713074B2 (ja) * | 1995-08-30 | 2005-11-02 | 栄研化学株式会社 | 血清アミロイドaを認識するモノクローナル抗体 |
US5843697A (en) | 1996-07-17 | 1998-12-01 | University Of Medicine And Dentistry Of New Jersey | Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein |
US5985614A (en) * | 1996-08-30 | 1999-11-16 | Human Genome Sciences, Inc. | Polynucleotides encoding interleukin-19 |
US5945511A (en) * | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
US6133426A (en) * | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
WO2000078961A1 (en) | 1999-06-23 | 2000-12-28 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
WO1999003982A1 (en) | 1997-07-16 | 1999-01-28 | Human Genome Sciences, Inc. | Interleukin-20 |
US6486301B1 (en) | 1997-07-16 | 2002-11-26 | Human Genome Sciences, Inc. | Interleukin-20 |
KR100236609B1 (ko) * | 1997-08-01 | 2000-02-01 | 박호군 | 클로로하이드로실란 유도체 및 이의 제조방법 |
US5965704A (en) * | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
US6020163A (en) * | 1997-08-06 | 2000-02-01 | Zymogenetics, Inc. | Lipocalin homolog |
US6551799B2 (en) * | 1999-12-07 | 2003-04-22 | Genentech, Inc. | Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders |
EP1719780A3 (en) * | 1997-11-26 | 2006-12-20 | ZymoGenetics, Inc. | Mammalian cytokine-like polypeptide-10 |
US6576743B1 (en) * | 1997-11-26 | 2003-06-10 | Zymogenetics, Inc. | Mammalian cytokine-like polypeptide-10 |
NZ505880A (en) | 1998-01-23 | 2003-06-30 | Immunex Corp | IL-18 receptor polypeptides |
AU2871899A (en) | 1998-03-09 | 1999-09-27 | Schering Corporation | Human receptor proteins; related reagents and methods |
PT1490386E (pt) | 1998-03-10 | 2008-11-24 | Genentech Inc | Novos polipéptidos e ácidos nucleicos que os codificam |
US6197582B1 (en) * | 1998-03-18 | 2001-03-06 | The Trustees Of Columbia University In The City Of New York | Development of human monoclonal antibodies and uses thereof |
US6982320B2 (en) | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
WO1999061630A2 (en) | 1998-05-26 | 1999-12-02 | Regeneron Pharmaceuticals, Inc. | Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system |
NZ531664A (en) | 1998-09-01 | 2005-07-29 | Genentech Inc | Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family |
CA2347066C (en) | 1998-10-26 | 2011-05-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules which encode t cell inducible factors (tifs), the proteins encoded, and uses thereof |
US6274710B1 (en) * | 1998-10-26 | 2001-08-14 | Ludwig Institute For Cancer Research | Antibodies which specifically bind T Cell inducible factors (TIFs) |
EP1141008A1 (en) | 1998-12-31 | 2001-10-10 | Millennium Pharmaceuticals, Inc. | Class ii cytokine receptor-like proteins and nucleic acids encoding them |
NZ515678A (en) | 1999-04-28 | 2004-01-30 | Genetics Inst | Human GIL-19/AE289 proteins and polynucleotides encoding same |
AU5151100A (en) | 1999-05-19 | 2000-12-05 | Incyte Genomics, Inc. | Extracellular signaling molecules |
AU5047600A (en) | 1999-05-27 | 2000-12-18 | Schering Corporation | Mammalian interleukin-10 homologs: il-d110 and il-d210 |
ATE449109T1 (de) | 1999-06-15 | 2009-12-15 | Genentech Inc | Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung |
DE60045931D1 (de) | 1999-07-07 | 2011-06-16 | Zymogenetics Inc | Menschliches Rezeptor für Zytokine |
EP1208202A2 (en) | 1999-09-01 | 2002-05-29 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP1230368A2 (en) | 1999-11-18 | 2002-08-14 | Schering Corporation | Mammalian receptor proteins; related reagents and methods |
CA2393369A1 (en) | 1999-12-03 | 2001-06-07 | Zymogenetics, Inc. | Human cytokine receptor |
EP1242600B1 (en) | 1999-12-23 | 2010-03-03 | ZymoGenetics, Inc. | Cytokine zcyto18 |
CA2395539C (en) | 1999-12-23 | 2009-08-25 | Zymogenetics, Inc. | Soluble interleukin-20 receptor |
EP2295079A3 (en) * | 1999-12-23 | 2011-03-23 | ZymoGenetics, L.L.C. | Method for treating inflammation |
US6610286B2 (en) * | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
NZ523122A (en) | 2000-06-22 | 2004-06-25 | Smithkline Beecham Corp | Polypeptides and polynucleotides and methods of identifying agonists and antagonists in relation to treatment of diseases |
JP2002015498A (ja) * | 2000-06-29 | 2002-01-18 | Fujitsu Ltd | センス電流の設定方法 |
EP2177616B1 (en) | 2000-08-08 | 2012-02-29 | ZymoGenetics, Inc. | Soluble zcytor 11 cytokine receptors |
ATE549347T1 (de) | 2000-09-08 | 2012-03-15 | Schering Corp | Gene von säugetiere, und damit verbundene reagentien, methoden |
EP1351703B1 (en) | 2000-09-15 | 2006-07-26 | ZymoGenetics, Inc. | Use of a polypeptide comprising the extracellular domains of il-20ra and il-20rb for the treatment of inflammation |
US7268223B2 (en) | 2000-09-22 | 2007-09-11 | Wyeth | Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof |
US20030022827A1 (en) | 2000-09-25 | 2003-01-30 | Bertram Weiss | Three new members of the cytokine receptor family class 2 |
NZ527087A (en) | 2001-01-12 | 2008-09-26 | Genetics Inst Llc | Type 2 cytokine receptor and nucleic acids encoding same |
WO2002058724A2 (en) | 2001-01-26 | 2002-08-01 | Eli Lilly And Company | Use of lp82 to treat body weight disorders |
NZ527396A (en) | 2001-02-23 | 2007-12-21 | Genetics Inst Llc | Antibodies and fragments thereof for the binding of IL-22 and use therefore for treating inflammatory disorders |
CA2433933A1 (en) * | 2001-02-28 | 2002-09-12 | Eli Lilly And Company | Use of lp82 to treat hematopoietic disorders |
EP1370676A4 (en) | 2001-03-02 | 2004-09-22 | Zymogenetics Inc | CYTOKIN RECEPTOR FROM MOUSE |
WO2002072607A2 (en) * | 2001-03-09 | 2002-09-19 | Zymogenetics, Inc. | Soluble heterodimeric cytokine receptor |
EP1373508B1 (en) | 2001-03-27 | 2013-04-24 | ZymoGenetics, Inc. | Human cytokine receptor |
DK2163256T3 (da) * | 2001-05-11 | 2015-12-07 | Ludwig Inst For Cancer Res Ltd | Specifikke bindende proteiner og anvendelse deraf |
US20040204351A1 (en) | 2001-10-22 | 2004-10-14 | Rowlinson Scott William | Soluble proteins that inhibit cytokine signal transduction pathways |
DE10154579A1 (de) | 2001-11-07 | 2003-05-28 | Medigene Ag | Topikale Verwendung von Cytokinen und Chemokinen zur Behandlung von viralen oder mykotischen Hauterkrankungen oder Tumorerkrankungen |
US7582287B2 (en) | 2001-12-17 | 2009-09-01 | Zymogenetics, Inc. | Method for treating cervical cancer |
US20040236075A1 (en) | 2002-07-24 | 2004-11-25 | Laure Dumoutier | Novel glass II cytokine receptors, and uses thereof |
UA93179C2 (ru) * | 2003-03-24 | 2011-01-25 | Займоджинетикс, Инк. | Антитело, kotopoe специфически связывается c il-22ra, и способы его применения |
ES2347657T3 (es) | 2003-03-24 | 2010-11-03 | Zymogenetics, Inc. | Anticuerpos dirigidos contra il-22ra y asociados de union y procedimiento de uso en inflamacion. |
JP2007537993A (ja) | 2003-11-21 | 2007-12-27 | ザイモジェネティクス, インコーポレイテッド | 抗il−20受容体抗体および結合パートナーならびに炎症において用いる方法 |
DE602005022475D1 (de) * | 2004-10-22 | 2010-09-02 | Zymogenetics Inc | Anti-il-22ra-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
-
2004
- 2004-03-24 ES ES04749427T patent/ES2347657T3/es not_active Expired - Lifetime
- 2004-03-24 CN CN2011101100944A patent/CN102690350A/zh active Pending
- 2004-03-24 CN CN201310173876.1A patent/CN103864934A/zh active Pending
- 2004-03-24 DK DK04749427.3T patent/DK1606317T3/da active
- 2004-03-24 WO PCT/US2004/008955 patent/WO2004085475A2/en active Application Filing
- 2004-03-24 MX MXPA05010134A patent/MXPA05010134A/es unknown
- 2004-03-24 EA EA200501506A patent/EA009124B1/ru not_active IP Right Cessation
- 2004-03-24 EP EP04749427A patent/EP1606317B1/en not_active Revoked
- 2004-03-24 KR KR1020117017412A patent/KR20110091598A/ko not_active Application Discontinuation
- 2004-03-24 EP EP04758097A patent/EP1606316A2/en not_active Withdrawn
- 2004-03-24 JP JP2006507520A patent/JP2007525438A/ja active Pending
- 2004-03-24 KR KR1020057017960A patent/KR20050116392A/ko not_active Application Discontinuation
- 2004-03-24 JP JP2006507519A patent/JP2007525437A/ja active Pending
- 2004-03-24 CA CA2519089A patent/CA2519089C/en not_active Expired - Fee Related
- 2004-03-24 MX MXPA05010136A patent/MXPA05010136A/es active IP Right Grant
- 2004-03-24 AT AT04749427T patent/ATE475673T1/de active
- 2004-03-24 US US10/807,837 patent/US20040209330A1/en not_active Abandoned
- 2004-03-24 AU AU2004223837A patent/AU2004223837C1/en not_active Ceased
- 2004-03-24 BR BRPI0408705-4A patent/BRPI0408705A/pt not_active Application Discontinuation
- 2004-03-24 US US10/807,997 patent/US20060134756A1/en not_active Abandoned
- 2004-03-24 CA CA002519057A patent/CA2519057A1/en not_active Abandoned
- 2004-03-24 AU AU2004223836A patent/AU2004223836A1/en not_active Abandoned
- 2004-03-24 BR BRPI0408683-0A patent/BRPI0408683A/pt not_active Application Discontinuation
- 2004-03-24 DE DE602004028347T patent/DE602004028347D1/de not_active Expired - Lifetime
- 2004-03-24 WO PCT/US2004/008956 patent/WO2004085476A2/en active Application Filing
- 2004-03-24 KR KR1020057017908A patent/KR20050116390A/ko not_active Application Discontinuation
- 2004-03-24 EA EA200501505A patent/EA009026B1/ru not_active IP Right Cessation
-
2005
- 2005-10-21 NO NO20054892A patent/NO20054892L/no not_active Application Discontinuation
-
2007
- 2007-11-27 US US11/945,975 patent/US20080233115A1/en not_active Abandoned
-
2008
- 2008-07-21 US US12/177,029 patent/US20090074661A1/en not_active Abandoned
-
2009
- 2009-10-16 US US12/580,987 patent/US8163286B2/en not_active Expired - Fee Related
-
2012
- 2012-03-22 US US13/427,077 patent/US20120207761A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1606317T3 (da) | Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammation | |
DK1812476T3 (da) | Anti-IL-22RA-antistoffer og bindingspartnere samt fremgangsmåder til anvendelse ved inflammation | |
WO2006086396A3 (en) | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation | |
WO2005052000A3 (en) | Anti-il-20 antibodies and binding partners and methods of using in inflammation | |
MXPA06014465A (es) | Zcytor14 soluble, anticuerpos anti-zcytor14 y moleculas de union y metodos de uso en inflamacion. | |
BR0314814A (pt) | Variantes otimizadas de fc e métodos para sua geração | |
DK1931697T3 (da) | IL-17A og IL-17F-antagonister og fremgangsmåder til anvendelse af disse | |
WO2004045525A3 (en) | Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation. | |
EP1603949B8 (en) | Antibodies against human il-21 receptor and uses therefor | |
DK1368060T3 (da) | HMGB1-proteininhibitorer og/eller antagonister til behandlingen af vaskulære sygdomme | |
MA29226B1 (fr) | Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations | |
WO2003101401A3 (en) | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer | |
ATE408624T1 (de) | Verfahren zur reinigung von fsh | |
IL192950A0 (en) | Soluble il-17rcx4 and methods of using in inflammation | |
EA200700823A1 (ru) | Растворимый zcytor21, анти-zcytor21 антитела и связывающие партнёры и способы применения при воспалении | |
DE60040089D1 (de) | Menschliches homolog aus der familie der metalloproteasen | |
EA200600314A1 (ru) | Использование растворимого cd164 при воспалительных и/или аутоимунных нарушениях | |
DK1196188T3 (da) | VGF-selektive monoklonale antistoffer og deres anvendelse til behandling af VGF-relaterede lidelser | |
EA200500624A1 (ru) | Промотор для il-18bp, его получение и применение |