ATE408624T1 - Verfahren zur reinigung von fsh - Google Patents

Verfahren zur reinigung von fsh

Info

Publication number
ATE408624T1
ATE408624T1 AT05815953T AT05815953T ATE408624T1 AT E408624 T1 ATE408624 T1 AT E408624T1 AT 05815953 T AT05815953 T AT 05815953T AT 05815953 T AT05815953 T AT 05815953T AT E408624 T1 ATE408624 T1 AT E408624T1
Authority
AT
Austria
Prior art keywords
fsh
chromatography
purifying fsh
purifying
dye
Prior art date
Application number
AT05815953T
Other languages
English (en)
Inventor
Pascal Valax
Pierre Wenger
Anne Stanley
Lydia Delegrange
Luciano Capponi
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of ATE408624T1 publication Critical patent/ATE408624T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Detergent Compositions (AREA)
AT05815953T 2004-11-09 2005-11-08 Verfahren zur reinigung von fsh ATE408624T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04105639 2004-11-09
US62871704P 2004-11-17 2004-11-17

Publications (1)

Publication Number Publication Date
ATE408624T1 true ATE408624T1 (de) 2008-10-15

Family

ID=39560952

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05815953T ATE408624T1 (de) 2004-11-09 2005-11-08 Verfahren zur reinigung von fsh

Country Status (21)

Country Link
US (1) US7741455B2 (de)
EP (1) EP1809663B1 (de)
KR (1) KR101173717B1 (de)
CN (1) CN101087805B (de)
AT (1) ATE408624T1 (de)
AU (1) AU2005303818B2 (de)
BR (1) BRPI0517973B8 (de)
CA (1) CA2579131A1 (de)
CY (1) CY1108602T1 (de)
DE (1) DE602005009856D1 (de)
DK (1) DK1809663T3 (de)
EA (1) EA011673B1 (de)
ES (1) ES2312037T3 (de)
HR (1) HRP20080464T3 (de)
IL (1) IL182716A (de)
MX (1) MX2007005327A (de)
NO (1) NO340811B1 (de)
PL (1) PL1809663T3 (de)
PT (1) PT1809663E (de)
SI (1) SI1809663T1 (de)
WO (1) WO2006051070A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004309040B2 (en) * 2003-12-22 2010-12-16 Ares Trading S.A. Method for purifying FSH
CN101282990B (zh) 2005-08-26 2013-04-03 阿雷斯贸易股份有限公司 糖基化干扰素-β的制备方法
EP1960419B1 (de) * 2005-12-09 2016-03-16 Ares Trading S.A. Verfahren zur aufreinigung von fsh oder einer fsh-mutante
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
US8318457B2 (en) 2007-06-28 2012-11-27 Biogenerix Ag FSH producing cell clone
AU2008314689A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying an Fc-containing protein
US20100249381A1 (en) * 2007-10-22 2010-09-30 David Delvaille Method for Purifying FC-Fusion Proteins
DE202009009905U1 (de) 2008-02-08 2009-10-29 Biogenerix Ag Flüssig-Formulierung von FSH
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
MX2011010480A (es) * 2009-04-01 2012-09-07 Biogenerix Ag Metodo para purificar una fsh recombinante.
CN101519445B (zh) * 2009-04-08 2013-03-27 上海天伟生物制药有限公司 一种高比活尿促卵泡刺激素及其制备方法
CN101555279B (zh) * 2009-05-19 2013-03-27 上海天伟生物制药有限公司 一种高纯度尿促卵泡刺激素及其制备方法
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
EP2325194A1 (de) * 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CN103570820B (zh) * 2012-08-06 2015-11-18 齐鲁制药有限公司 一种重组人促卵泡激素的纯化方法
EP2968391A1 (de) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Langlebige polynukleotidmoleküle
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
EA201691834A1 (ru) 2014-04-18 2017-02-28 Кадила Хелзкэр Лимитед Новый способ очистки гонадотропина
CN104961821A (zh) * 2014-07-28 2015-10-07 厦门欧瑞捷生物科技有限公司 一种从人尿中提取促性腺激素的方法
WO2016116966A1 (en) 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
CN105461799A (zh) * 2015-12-31 2016-04-06 哈药集团技术中心 一种重组人促卵泡生成素的纯化方法
CN107698676B (zh) * 2017-11-07 2020-07-14 江西浩然生物医药有限公司 一种高纯度尿促性素的提取制备方法
CN110563832B (zh) * 2019-07-31 2025-11-14 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5665868A (en) 1990-09-14 1997-09-09 Vittal Mallya Scientific Research Foundation Chromatographic agent and its use for the separation or proteins, polypeptides of metals
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
EP0842275A1 (de) 1995-02-17 1998-05-20 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) HERSTELLUNG EINES BIOLOGISCH AKTIVEM,REKOMBINANTEN RINDER FOLLIKEL STIMULIERENDEN HORMONS(REC bFSH) IM BACULOVIRUS EXPRESSIONS-SYSTEM
AUPN801296A0 (en) 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IT1287138B1 (it) 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
PT1169349E (pt) 1999-04-16 2007-06-18 Inst Massone S A Composições de gonadotropina de altamente purificada e processo para a sua preparação
HU227007B1 (en) * 2000-02-22 2010-04-28 Serono Lab Purified lh
EP2275557A1 (de) * 2000-04-12 2011-01-19 Human Genome Sciences, Inc. Albuminfusionsproteine
AU784808B2 (en) * 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
AU2004309040B2 (en) 2003-12-22 2010-12-16 Ares Trading S.A. Method for purifying FSH
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily

Also Published As

Publication number Publication date
PT1809663E (pt) 2008-10-02
DK1809663T3 (da) 2008-11-17
EP1809663A1 (de) 2007-07-25
NO340811B1 (no) 2017-06-19
BRPI0517973B8 (pt) 2021-05-25
BRPI0517973A (pt) 2008-10-21
IL182716A (en) 2010-12-30
CA2579131A1 (en) 2006-05-18
CN101087805A (zh) 2007-12-12
EP1809663B1 (de) 2008-09-17
PL1809663T3 (pl) 2009-01-30
NO20072863L (no) 2007-06-05
HK1108704A1 (en) 2008-05-16
US20080070832A1 (en) 2008-03-20
KR101173717B1 (ko) 2012-08-13
AU2005303818B2 (en) 2011-06-23
EA200701040A1 (ru) 2007-10-26
AU2005303818A1 (en) 2006-05-18
KR20070083618A (ko) 2007-08-24
MX2007005327A (es) 2007-08-02
CY1108602T1 (el) 2014-04-09
US7741455B2 (en) 2010-06-22
BRPI0517973B1 (pt) 2018-02-14
ES2312037T3 (es) 2009-02-16
CN101087805B (zh) 2012-05-23
SI1809663T1 (sl) 2009-02-28
IL182716A0 (en) 2007-07-24
DE602005009856D1 (de) 2008-10-30
HRP20080464T3 (en) 2008-10-31
WO2006051070A1 (en) 2006-05-18
EA011673B1 (ru) 2009-04-28

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