ATE412649T1 - Substituierte heteroarylbenzofuransäuren - Google Patents
Substituierte heteroarylbenzofuransäurenInfo
- Publication number
- ATE412649T1 ATE412649T1 AT04784968T AT04784968T ATE412649T1 AT E412649 T1 ATE412649 T1 AT E412649T1 AT 04784968 T AT04784968 T AT 04784968T AT 04784968 T AT04784968 T AT 04784968T AT E412649 T1 ATE412649 T1 AT E412649T1
- Authority
- AT
- Austria
- Prior art keywords
- acids
- substituted
- heteroarylbenzofuranic
- methods
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50601203P | 2003-09-25 | 2003-09-25 | |
US10/947,840 US7446201B2 (en) | 2003-09-25 | 2004-09-23 | Substituted heteroaryl benzofuran acids |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE412649T1 true ATE412649T1 (de) | 2008-11-15 |
Family
ID=34396284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04784968T ATE412649T1 (de) | 2003-09-25 | 2004-09-24 | Substituierte heteroarylbenzofuransäuren |
Country Status (13)
Country | Link |
---|---|
US (2) | US7446201B2 (de) |
EP (1) | EP1668001B1 (de) |
JP (1) | JP2007506760A (de) |
AT (1) | ATE412649T1 (de) |
AU (1) | AU2004276305A1 (de) |
BR (1) | BRPI0414463A (de) |
CA (1) | CA2538711A1 (de) |
DE (1) | DE602004017486D1 (de) |
DK (1) | DK1668001T3 (de) |
ES (1) | ES2315711T3 (de) |
MX (1) | MXPA06003249A (de) |
PL (1) | PL1668001T3 (de) |
WO (1) | WO2005030760A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60221391T2 (de) * | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
DE60306547T2 (de) * | 2002-12-10 | 2007-06-28 | Wyeth | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator |
EP1569901B1 (de) * | 2002-12-10 | 2008-10-15 | Wyeth | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
UA80453C2 (en) * | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
DE60306548T2 (de) * | 2002-12-10 | 2007-06-21 | Wyeth | Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7342039B2 (en) * | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7442805B2 (en) * | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7163954B2 (en) * | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
US7265148B2 (en) * | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
CN101039936A (zh) * | 2004-08-23 | 2007-09-19 | 惠氏公司 | 作为i-型纤溶酶原激活剂抑制剂(pai-1)调节剂用于治疗血栓形成和心血管疾病的唑基-萘基酸 |
JP2008510816A (ja) * | 2004-08-23 | 2008-04-10 | ワイス | チアゾロ−ナフチル酸 |
BRPI0514549A (pt) * | 2004-08-23 | 2008-06-17 | Wyeth Corp | ácidos de pirrol-naftila como inibidores de pai-1 |
EP1919866A2 (de) * | 2005-08-17 | 2008-05-14 | Wyeth a Corporation of the State of Delaware | Substituierte indole und deren verwendung |
AU2007217363A1 (en) * | 2006-02-27 | 2007-08-30 | Wyeth | Inhibitors of PAI-1 for treatment of muscular conditions |
CA2644929A1 (en) * | 2006-03-13 | 2008-05-02 | Merck & Co., Inc. | Somatostatin agonists |
CN105294662B (zh) * | 2015-09-11 | 2018-04-20 | 中山大学 | 苯并呋喃喹啉衍生物及其在制备治疗阿尔茨海默病症的药品中的应用 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3026325A (en) | 1959-01-26 | 1962-03-20 | Upjohn Co | 5-hydroxy-alpha-alkyltryptophans |
US3476770A (en) | 1967-04-14 | 1969-11-04 | Parke Davis & Co | 2-methyl-7-phenylindole-3-acetic acid compounds |
GB1321433A (en) | 1968-01-11 | 1973-06-27 | Roussel Uclaf | 1,2,3,6-tetrasubstituted indoles |
US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
DE3147276A1 (de) | 1981-11-28 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole |
FR2525474A1 (fr) | 1982-04-26 | 1983-10-28 | Roussel Uclaf | Nouvelle forme pharmaceutique orale de clometacine |
US4863958A (en) | 1984-06-20 | 1989-09-05 | Merck Frosst Canada, Inc. | Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis |
CA1281325C (en) | 1984-06-20 | 1991-03-12 | Patrice C. Belanger | Benzofuran derivatives |
DE3531658A1 (de) | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
US5164372A (en) | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
IL95584A (en) | 1989-09-07 | 1995-03-15 | Abbott Lab | Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them |
US5420289A (en) | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
DE4035961A1 (de) | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5151435A (en) | 1991-04-08 | 1992-09-29 | Merck & Co., Inc. | Angiotensin ii antagonists incorporating an indole or dihydroindole |
IL101785A0 (en) | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
GB9123396D0 (en) | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
US5502187A (en) | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
DE4242675A1 (de) | 1992-12-17 | 1994-06-23 | Basf Ag | Neue Hydroxyiminoalkylindolcarbonsäure-Derivate, ihre Herstellung und Verwendung |
ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
IL109568A0 (en) | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
CA2134192A1 (en) | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
IL117208A0 (en) | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
ES2175079T3 (es) | 1995-04-10 | 2002-11-16 | Fujisawa Pharmaceutical Co | Derivados de indol utiles como inhibidores de cgmp-pde. |
US5728724A (en) | 1995-08-17 | 1998-03-17 | Eli Lilly And Company | Benzothiophene compounds |
CA2203912A1 (en) | 1995-09-01 | 1997-03-13 | Dennis Michael Zimmerman | Indolyl neuropeptide y receptor antagonists |
DE19543639A1 (de) | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
GB9609641D0 (en) | 1996-05-09 | 1996-07-10 | Pfizer Ltd | Compounds useful in therapy |
EP0934307B1 (de) | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituierte azabicyclische verbindungen und ihre verwendung als inhibitoren des tnf und der cyclischen amp phosphodiestrase |
CA2207083A1 (en) | 1996-07-15 | 1998-01-15 | Brian William Grinnell | Benzothiophene compounds, and uses and formulations thereof |
CA2207141A1 (en) | 1996-07-15 | 1998-01-15 | David Thompson Berg | Benzothiophene compounds, and uses and formulations thereof |
EP0822185A1 (de) | 1996-07-31 | 1998-02-04 | Pfizer Inc. | Beta-3-adrenergische Agonisten als antidiabetische Mittel und als Mittel gegen Fettsucht |
JP2000516958A (ja) | 1996-08-26 | 2000-12-19 | ジェネティックス・インスチチュート・インコーポレーテッド | ホスホリパーゼ酵素の阻害剤 |
DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
SK12782000A3 (sk) | 1998-02-25 | 2001-04-09 | Genetics Institute, Inc. | Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie |
IL137719A0 (en) | 1998-02-25 | 2001-10-31 | Genetics Inst | Inhibitors of phospholipase enzymes |
CA2322161A1 (en) | 1998-02-25 | 1999-09-02 | Yibin Xiang | Inhibitors of phospholipase enzymes |
SE9800836D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
ATE269861T1 (de) | 1998-03-31 | 2004-07-15 | Inst For Pharm Discovery Inc | Substituierte indolalkansäure |
FR2777886B1 (fr) | 1998-04-27 | 2002-05-31 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6251936B1 (en) | 1998-05-12 | 2001-06-26 | American Home Products Corporation | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia |
US6110963A (en) | 1998-05-12 | 2000-08-29 | American Home Products Corporation | Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
EP1077969A1 (de) | 1998-05-12 | 2001-02-28 | American Home Products Corporation | Für die behandlung von insulinresistenz und hyperglycemie verwendbare benzothiophene, benzofurane und indole |
US6232322B1 (en) | 1998-05-12 | 2001-05-15 | American Home Products Corporation | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
US6166069A (en) | 1998-05-12 | 2000-12-26 | American Home Products Corporation | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
CA2331120A1 (en) | 1998-05-12 | 1999-11-18 | Iwan Gunawan | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
DE59908916D1 (de) | 1998-12-16 | 2004-04-22 | Boehringer Ingelheim Pharma | Substituierte aryl- und heteroarylamidinderivate, deren herstellung und deren verwendung als arzneimittel |
GB9827882D0 (en) | 1998-12-17 | 1999-02-10 | Smithkline Beecham Plc | Novel compounds |
WO2000044743A1 (fr) | 1999-01-28 | 2000-08-03 | Nippon Shinyaku Co., Ltd. | Derives d'amides et compositions de medicaments |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
ATE323678T1 (de) | 1999-04-28 | 2006-05-15 | Aventis Pharma Gmbh | Tri-aryl-säurederivate als ppar rezeptor liganden |
DE60035682T2 (de) | 1999-04-28 | 2008-04-30 | Sanofi-Aventis Deutschland Gmbh | Di-aryl-säurederivate als ppar rezeptor liganden |
GB9919413D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
FR2799756B1 (fr) | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE19963178A1 (de) | 1999-12-27 | 2001-07-05 | Gruenenthal Gmbh | Substituierte Indol-Mannichbasen |
US6787651B2 (en) | 2000-10-10 | 2004-09-07 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents |
WO2002072549A1 (en) | 2001-03-12 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
TW591020B (en) * | 2001-06-20 | 2004-06-11 | Wyeth Corp | 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
TWI224101B (en) * | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
DE60221391T2 (de) | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
KR100810468B1 (ko) | 2001-10-10 | 2008-03-07 | 씨제이제일제당 (주) | 사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난1h-인돌 유도체 |
ES2325071T3 (es) | 2002-12-10 | 2009-08-25 | Wyeth | Derivados del acido indol-oxo-acetilaminoacetico sustituido como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1). |
DE60306547T2 (de) | 2002-12-10 | 2007-06-28 | Wyeth | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator |
EP1569901B1 (de) | 2002-12-10 | 2008-10-15 | Wyeth | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
DE60306548T2 (de) | 2002-12-10 | 2007-06-21 | Wyeth | Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
US7446201B2 (en) * | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
US20050215626A1 (en) | 2003-09-25 | 2005-09-29 | Wyeth | Substituted benzofuran oximes |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
-
2004
- 2004-09-23 US US10/947,840 patent/US7446201B2/en not_active Expired - Fee Related
- 2004-09-24 BR BRPI0414463-5A patent/BRPI0414463A/pt not_active IP Right Cessation
- 2004-09-24 WO PCT/US2004/031364 patent/WO2005030760A1/en active Search and Examination
- 2004-09-24 MX MXPA06003249A patent/MXPA06003249A/es unknown
- 2004-09-24 ES ES04784968T patent/ES2315711T3/es active Active
- 2004-09-24 DK DK04784968T patent/DK1668001T3/da active
- 2004-09-24 JP JP2006528204A patent/JP2007506760A/ja not_active Withdrawn
- 2004-09-24 AT AT04784968T patent/ATE412649T1/de not_active IP Right Cessation
- 2004-09-24 AU AU2004276305A patent/AU2004276305A1/en not_active Withdrawn
- 2004-09-24 DE DE602004017486T patent/DE602004017486D1/de active Active
- 2004-09-24 PL PL04784968T patent/PL1668001T3/pl unknown
- 2004-09-24 EP EP04784968A patent/EP1668001B1/de active Active
- 2004-09-24 CA CA002538711A patent/CA2538711A1/en not_active Abandoned
-
2008
- 2008-10-27 US US12/258,968 patent/US20090054484A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005030760A1 (en) | 2005-04-07 |
DK1668001T3 (da) | 2009-02-16 |
JP2007506760A (ja) | 2007-03-22 |
EP1668001B1 (de) | 2008-10-29 |
US7446201B2 (en) | 2008-11-04 |
DE602004017486D1 (de) | 2008-12-11 |
MXPA06003249A (es) | 2006-06-08 |
CA2538711A1 (en) | 2005-04-07 |
ES2315711T3 (es) | 2009-04-01 |
PL1668001T3 (pl) | 2009-04-30 |
US20090054484A1 (en) | 2009-02-26 |
EP1668001A1 (de) | 2006-06-14 |
AU2004276305A1 (en) | 2005-04-07 |
US20050119296A1 (en) | 2005-06-02 |
BRPI0414463A (pt) | 2006-11-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1668001T3 (da) | Substituerede heteroarylbenzofuransyrer | |
BRPI0414599A (pt) | pirrol-indóis substituìdos | |
NO20091976L (no) | Nye forbindelser | |
EA200700702A1 (ru) | Аналоги локсапина и способы их применения | |
DE602004031372D1 (de) | Nachweis von staphylococcus | |
ECSP056111A (es) | Derivados de 2-acilamino-4-feniltiazol, su preparación y aplicación en terapeutica | |
BR0308452A (pt) | composições farmacêuticas e métodos de preparação de composição farmacêutica | |
DK1633697T3 (da) | Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser | |
ITMO20050067A1 (it) | Mezzi di illuminazione e metodo per ottenere mezzi di illuminazione. | |
DE602004006618D1 (de) | Azaindolverbindungen als kinaseinhibitoren | |
DK1485360T3 (da) | Natriumkanalblokkere | |
SG10201809390QA (en) | Modulators of indoleamine 2,3-dioxygenase and methods of using the same | |
DE60321324D1 (de) | Sulfonylaminoderivate als neue inhibitoren von histondeacetylase | |
FI20020078A (fi) | Immuunijärjestelmän stimulointi polydextroosilla | |
MXPA05013553A (es) | Pirrolodihidroisoquinolinas como inhibidores de pde10. | |
BRPI0414598A (pt) | indóis substituìdos | |
IS8094A (is) | Notkun 10-hýdroxý-10,11-díhýdrókarbamasepínafleiða til að meðhöndla geðbrigðasýki | |
CO5660287A2 (es) | Derivados de tetrahidrocarbazol y su uso farmaceutico | |
BRPI0414809A (pt) | ácidos de benzotiofeno de naftila substituìdos | |
DK1519944T3 (da) | Fremgangsmåder til fremstilling af fibrinogen | |
DE60316984D1 (de) | Benzoylsulfonamide als antitumor-mittel | |
ATE549024T1 (de) | Chinazolin-kaliumkanalhemmer | |
DE602004028493D1 (de) | Isochinolinon-kaliumkanalinhibitoren | |
DE60316128D1 (de) | N-sulfonylurea-apoptosis-förderer | |
DE602004024651D1 (de) | Verbesserungen von dampfinjektoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |