ATE510534T1 - Naltrexonhydrochlorid-zusammensetzungen - Google Patents
Naltrexonhydrochlorid-zusammensetzungenInfo
- Publication number
- ATE510534T1 ATE510534T1 AT03716588T AT03716588T ATE510534T1 AT E510534 T1 ATE510534 T1 AT E510534T1 AT 03716588 T AT03716588 T AT 03716588T AT 03716588 T AT03716588 T AT 03716588T AT E510534 T1 ATE510534 T1 AT E510534T1
- Authority
- AT
- Austria
- Prior art keywords
- naltrexone hydrochloride
- hydrochloride compositions
- compositions
- naltrexone
- stabilizing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36452102P | 2002-03-14 | 2002-03-14 | |
PCT/US2003/007932 WO2003077867A2 (en) | 2002-03-14 | 2003-03-14 | Naltrexone hydrochloride compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE510534T1 true ATE510534T1 (de) | 2011-06-15 |
Family
ID=28041930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03716588T ATE510534T1 (de) | 2002-03-14 | 2003-03-14 | Naltrexonhydrochlorid-zusammensetzungen |
Country Status (15)
Country | Link |
---|---|
US (2) | US20030229111A1 (de) |
EP (2) | EP1482912B1 (de) |
JP (2) | JP4683842B2 (de) |
KR (1) | KR20040098660A (de) |
CN (1) | CN1652752A (de) |
AT (1) | ATE510534T1 (de) |
AU (1) | AU2003220290B2 (de) |
BR (1) | BR0308452A (de) |
CA (2) | CA2478558C (de) |
CO (1) | CO5611137A2 (de) |
ES (1) | ES2616981T3 (de) |
IL (1) | IL163911A0 (de) |
MX (1) | MXPA04008772A (de) |
RU (1) | RU2004130441A (de) |
WO (1) | WO2003077867A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE323491T1 (de) | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Peroral zu verabreichende arzneiform enthaltend eine kombination von einem opioid agonisten und naltrexon |
ES2539904T3 (es) | 2000-02-08 | 2015-07-07 | Euro-Celtique S.A. | Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas |
DE60238756D1 (de) | 2001-05-11 | 2011-02-10 | Endo Pharmaceuticals Inc | Opioid enthaltende arzneiform gegen missbrauch |
EP2316428A1 (de) | 2002-04-05 | 2011-05-04 | Euro-Celtique S.A. | Matrix für die modifizierte Freigabe von aktiven Substanzen |
EP1894562B1 (de) * | 2002-08-15 | 2010-12-15 | Euro-Celtique S.A. | Pharmazeutische Zusammensetzungen enthaltend einen Opioidantagonisten |
ES2528669T3 (es) † | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
TWI347201B (en) * | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
JP4758897B2 (ja) * | 2003-09-25 | 2011-08-31 | ユーロ−セルティーク エス.エイ. | ヒドロコドンとナルトレキソンとの併用医薬 |
CN1938004B (zh) * | 2004-03-30 | 2011-12-21 | 欧洲凯尔特公司 | 包含吸附剂和不利剂的抗篡改剂型 |
EP1604666A1 (de) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
WO2008015220A1 (en) | 2006-08-04 | 2008-02-07 | Ethypharm | Granule and orally disintegrating tablet comprising oxycodone |
TWI489984B (zh) * | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
AU2008233133B2 (en) | 2007-03-29 | 2014-03-27 | Progenics Pharmaceuticals, Inc. | Crystal forms of (R) -N-methylnaltrexone bromide and uses thereof |
PE20130480A1 (es) | 2007-03-29 | 2013-05-08 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
EP2565195B1 (de) | 2007-03-29 | 2015-05-06 | Wyeth LLC | Peripherer Opioid-Rezeptor sowie Antagonisten und Verwendungen davon |
WO2008133330A1 (ja) | 2007-04-26 | 2008-11-06 | Toray Industries, Inc. | 4,5-エポキシモルヒナン誘導体を含有する安定な固形製剤 |
EP2168579B1 (de) * | 2007-05-21 | 2017-10-11 | Toray Industries, Inc. | Orale zubereitung mit einer spezifischen orgnanischen säure und verfahren zur verbesserung der auflösungseigenschaft und chemischen stabilität der oralen zubereitung |
EP2065038A1 (de) | 2007-11-30 | 2009-06-03 | Pharnext | Neue therapeutische Ansätze zur Behandlung der Charcot-Marie-Tooth Krankheit |
AU2008349873B2 (en) | 2008-02-06 | 2014-02-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone |
US20110250278A1 (en) * | 2008-07-01 | 2011-10-13 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
CN101658489B (zh) * | 2008-08-27 | 2011-11-23 | 海南四环心脑血管药物研究院有限公司 | 一种盐酸纳美芬注射液及其制备方法 |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
CA2740476C (en) | 2008-10-24 | 2016-04-05 | Toray Industries, Inc. | Stable tablet containing 4,5-epoxymorphinan derivative |
WO2010103039A1 (en) | 2009-03-10 | 2010-09-16 | Euro-Celtique S.A. | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
EP2263665A1 (de) | 2009-06-02 | 2010-12-22 | Pharnext | Neue Zusammensetzungen zur Behandlung von CMT und verwandten Erkrankungen |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
WO2011052499A1 (ja) * | 2009-10-28 | 2011-05-05 | 第一三共株式会社 | 貯蔵安定性が改善された医薬組成物 |
TWI589293B (zh) | 2010-03-11 | 2017-07-01 | 惠氏有限責任公司 | 甲基拿淬松(methylnaltrexone)之口服製劑及親脂性鹽 |
EP2568968B1 (de) | 2010-05-10 | 2017-07-12 | Euro-Celtique S.A. | Herstellung von Wirkstoff-freiem Granulat und dieses enthaltende Tabletten |
JP5840201B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス.エイ. | 活性剤を負荷した顆粒と追加の活性剤の組合せ |
TWI560170B (en) * | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
CA2795324C (en) * | 2012-11-09 | 2015-07-14 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
HUE040023T2 (hu) | 2013-06-05 | 2019-02-28 | Pharnext | Stabil orális oldatok kombinált API-hoz |
CA2918004C (en) | 2013-07-23 | 2018-11-20 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
JP6232135B2 (ja) | 2013-11-13 | 2017-11-15 | ユーロ−セルティーク エス.エイ. | 疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン |
CN105582011A (zh) * | 2014-10-24 | 2016-05-18 | 江苏国丹生物制药有限公司 | 溴甲纳曲酮固体组合物及其制备方法 |
EP3352823B1 (de) | 2015-09-24 | 2021-04-21 | Pain Therapeutics, Inc. | Kristalline salze von naloxon und naltrexon |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
KR20190084262A (ko) * | 2016-10-18 | 2019-07-16 | 앤테이아 인코포레이티드 | 노르-오피오이드 및 날-오피오이드 벤질이소퀴놀린 알칼로이드를 생산하는 방법 |
US11185540B2 (en) * | 2017-04-12 | 2021-11-30 | Pardon My Scotch Llc. | Extended release compositions of opioid antagonists and phosphodiesterase 5 inhibitors |
WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
US10975099B2 (en) | 2018-11-05 | 2021-04-13 | Alkermes Pharma Ireland Limited | Thiophene compounds for long-acting injectable compositions and related methods |
BR112022000218A2 (pt) | 2019-07-10 | 2022-02-22 | Intas Pharmaceuticals Ltd | Composição farmacêutica estável livre de lactose e processo para a preparação de uma composição farmacêutica estável livre de lactose |
JPWO2021100728A1 (de) * | 2019-11-20 | 2021-05-27 | ||
EP4039252A1 (de) * | 2021-02-09 | 2022-08-10 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Filmbeschichtete tablette mit naltrexon-hydrochlorid |
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US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
US4587118A (en) * | 1981-07-15 | 1986-05-06 | Key Pharmaceuticals, Inc. | Dry sustained release theophylline oral formulation |
FR2609632B1 (fr) * | 1987-01-21 | 1991-03-29 | Shelly Marc | Nouvelle application therapeutique de la 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinon-6-one et les compositions pharmaceutiques destinees a cet usage |
US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
US5994392A (en) * | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
AU2571092A (en) * | 1991-09-27 | 1993-04-27 | Fujisawa Pharmaceutical Co., Ltd. | Long-acting preparation |
US6271239B1 (en) * | 1992-04-13 | 2001-08-07 | Regents Of The University Of Minnesota | Delta opioid receptor-selective benzylidene-substituted morphinans |
US5512578A (en) | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
US5472943A (en) | 1992-09-21 | 1995-12-05 | Albert Einstein College Of Medicine Of Yeshiva University, | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists |
US5580876A (en) | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
US5697282A (en) * | 1994-03-15 | 1997-12-16 | Schuller International, Inc. | Apparatus for and method of forming large diameter duct with liner and the product formed thereby |
PT914097E (pt) * | 1996-03-12 | 2002-06-28 | Alza Corp | Composicao e forma de dosagem compreendendo antagonista de opioide |
SK282549B6 (sk) | 1997-02-14 | 2002-10-08 | G�decke Aktiengesellschaft | Spôsob stabilizácie naloxonhydrochloridu |
US5980882A (en) * | 1997-04-16 | 1999-11-09 | Medeva Pharmaceuticals Manufacturing | Drug-resin complexes stabilized by chelating agents |
ATE323491T1 (de) | 1997-12-22 | 2006-05-15 | Euro Celtique Sa | Peroral zu verabreichende arzneiform enthaltend eine kombination von einem opioid agonisten und naltrexon |
US6166211A (en) * | 1999-03-19 | 2000-12-26 | Endo Pharmaceuticals, Inc. | Sequential benzylic oxidations of the naloxone ring system |
GB9908921D0 (en) * | 1999-04-19 | 1999-06-16 | Britannia Pharmaceuticals Ltd | Spray dispenser for opiod antagonists |
US6071918A (en) * | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
ES2539904T3 (es) * | 2000-02-08 | 2015-07-07 | Euro-Celtique S.A. | Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas |
WO2001085257A2 (en) * | 2000-05-05 | 2001-11-15 | Pain Therapeutics, Inc. | Opioid antagonist compositions and dosage forms |
DE60232417D1 (de) * | 2001-08-06 | 2009-07-02 | Euro Celtique Sa | Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist |
US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
TWI347201B (en) * | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
-
2003
- 2003-03-14 EP EP03716588A patent/EP1482912B1/de not_active Expired - Lifetime
- 2003-03-14 WO PCT/US2003/007932 patent/WO2003077867A2/en active IP Right Grant
- 2003-03-14 BR BRPI0308452-3A patent/BR0308452A/pt not_active IP Right Cessation
- 2003-03-14 US US10/389,238 patent/US20030229111A1/en not_active Abandoned
- 2003-03-14 JP JP2003575921A patent/JP4683842B2/ja not_active Expired - Lifetime
- 2003-03-14 KR KR10-2004-7013905A patent/KR20040098660A/ko not_active Application Discontinuation
- 2003-03-14 AT AT03716588T patent/ATE510534T1/de not_active IP Right Cessation
- 2003-03-14 RU RU2004130441/15A patent/RU2004130441A/ru not_active Application Discontinuation
- 2003-03-14 CA CA2478558A patent/CA2478558C/en not_active Expired - Lifetime
- 2003-03-14 MX MXPA04008772A patent/MXPA04008772A/es unknown
- 2003-03-14 IL IL16391103A patent/IL163911A0/xx unknown
- 2003-03-14 EP EP10010921.4A patent/EP2289492B1/de not_active Expired - Lifetime
- 2003-03-14 CA CA2748620A patent/CA2748620C/en not_active Expired - Lifetime
- 2003-03-14 CN CNA038103737A patent/CN1652752A/zh active Pending
- 2003-03-14 AU AU2003220290A patent/AU2003220290B2/en not_active Expired
- 2003-03-14 ES ES10010921.4T patent/ES2616981T3/es not_active Expired - Lifetime
-
2004
- 2004-09-13 CO CO04090752A patent/CO5611137A2/es not_active Application Discontinuation
-
2009
- 2009-02-12 JP JP2009029529A patent/JP5291483B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-20 US US15/298,483 patent/US20170100337A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20040098660A (ko) | 2004-11-20 |
JP2005531515A (ja) | 2005-10-20 |
US20170100337A1 (en) | 2017-04-13 |
EP1482912A2 (de) | 2004-12-08 |
AU2003220290B2 (en) | 2007-06-14 |
CA2748620C (en) | 2014-03-11 |
EP1482912A4 (de) | 2006-11-15 |
EP2289492A3 (de) | 2011-12-21 |
CA2478558C (en) | 2012-09-11 |
JP2009143948A (ja) | 2009-07-02 |
CO5611137A2 (es) | 2006-02-28 |
RU2004130441A (ru) | 2005-05-20 |
CN1652752A (zh) | 2005-08-10 |
IL163911A0 (en) | 2005-12-18 |
EP1482912B1 (de) | 2011-05-25 |
CA2748620A1 (en) | 2003-09-25 |
WO2003077867A3 (en) | 2004-09-02 |
CA2478558A1 (en) | 2003-09-25 |
JP5291483B2 (ja) | 2013-09-18 |
AU2003220290A1 (en) | 2003-09-29 |
US20030229111A1 (en) | 2003-12-11 |
WO2003077867A2 (en) | 2003-09-25 |
EP2289492A2 (de) | 2011-03-02 |
MXPA04008772A (es) | 2004-12-06 |
ES2616981T3 (es) | 2017-06-15 |
EP2289492B1 (de) | 2016-12-07 |
JP4683842B2 (ja) | 2011-05-18 |
BR0308452A (pt) | 2006-06-06 |
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FI20010780A0 (fi) | Parannetut koostumukset | |
DE10393374D2 (de) | Zusammensetzung | |
DE60335716D1 (de) | Beschleuniger-zusammensetzung | |
SE0500163L (sv) | Sammansättning | |
DE10290365T1 (de) | Gummizusammensetzung | |
DE60212442D1 (de) | Kautschukzusammensetzung | |
DE50302630D1 (de) | Verstellantrieb | |
DE10238843B8 (de) | Halbleiterbauelement | |
DE60237109D1 (de) | Rbesserte transistoreigenschaften | |
DE60129749D1 (de) | Kautschukzusammensetzung | |
ITMI20022022A1 (it) | Analoghi di nocicettina. | |
DE60326190D1 (de) | des Körpers | |
DE60236587D1 (de) | Latexzusammensetzung | |
NO20020524D0 (no) | Stabiliserte organisk-peroksid sammensetninger | |
FR2843451B1 (fr) | Fronde du type lance-pierres |
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