EA200701040A1 - Способ очистки fsh - Google Patents

Способ очистки fsh

Info

Publication number
EA200701040A1
EA200701040A1 EA200701040A EA200701040A EA200701040A1 EA 200701040 A1 EA200701040 A1 EA 200701040A1 EA 200701040 A EA200701040 A EA 200701040A EA 200701040 A EA200701040 A EA 200701040A EA 200701040 A1 EA200701040 A1 EA 200701040A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fsh
cleaning method
chromatography
dye
steps
Prior art date
Application number
EA200701040A
Other languages
English (en)
Other versions
EA011673B1 (ru
Inventor
Паскаль Вала
Пьер Венгер
Анн Стэнли
Лидия Делегранж
Лучано Каппони
Original Assignee
Арес Трейдинг С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арес Трейдинг С.А. filed Critical Арес Трейдинг С.А.
Publication of EA200701040A1 publication Critical patent/EA200701040A1/ru
Publication of EA011673B1 publication Critical patent/EA011673B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу очистки рекомбинантного человеческого FSH или варианта FSH, начиная с неочищенного FSH, включающему следующие стадии:(1) аффинная хроматография с красителем;(2) хроматография гидрофобного взаимодействия и(3) хроматография с обращенной фазой.
EA200701040A 2004-11-09 2005-11-08 Способ очистки fsh EA011673B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04105639 2004-11-09
US62871704P 2004-11-17 2004-11-17
PCT/EP2005/055815 WO2006051070A1 (en) 2004-11-09 2005-11-08 Method for purifying fsh

Publications (2)

Publication Number Publication Date
EA200701040A1 true EA200701040A1 (ru) 2007-10-26
EA011673B1 EA011673B1 (ru) 2009-04-28

Family

ID=39560952

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701040A EA011673B1 (ru) 2004-11-09 2005-11-08 Способ очистки fsh

Country Status (22)

Country Link
US (1) US7741455B2 (ru)
EP (1) EP1809663B1 (ru)
KR (1) KR101173717B1 (ru)
CN (1) CN101087805B (ru)
AT (1) ATE408624T1 (ru)
AU (1) AU2005303818B2 (ru)
BR (1) BRPI0517973B8 (ru)
CA (1) CA2579131A1 (ru)
CY (1) CY1108602T1 (ru)
DE (1) DE602005009856D1 (ru)
DK (1) DK1809663T3 (ru)
EA (1) EA011673B1 (ru)
ES (1) ES2312037T3 (ru)
HK (1) HK1108704A1 (ru)
HR (1) HRP20080464T3 (ru)
IL (1) IL182716A (ru)
MX (1) MX2007005327A (ru)
NO (1) NO340811B1 (ru)
PL (1) PL1809663T3 (ru)
PT (1) PT1809663E (ru)
SI (1) SI1809663T1 (ru)
WO (1) WO2006051070A1 (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100554277C (zh) * 2003-12-22 2009-10-28 阿雷斯贸易股份有限公司 Fsh的纯化方法
EA015901B1 (ru) 2005-08-26 2011-12-30 Арес Трейдинг С.А. Способ получения гликозилированного интерферона бета
US8604175B2 (en) * 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
WO2008150488A1 (en) * 2007-06-01 2008-12-11 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
UA103598C2 (ru) 2007-06-28 2013-11-11 Биодженерикс Аг Клон клеток, которые продуцируют fsh
JP2011500757A (ja) * 2007-10-22 2011-01-06 メルク セローノ ソシエテ アノニム Ｆｃ含有タンパク質の精製方法
EP2203474A1 (en) * 2007-10-22 2010-07-07 Merck Serono S.A. Method for purifying fc-fusion proteins
NZ586588A (en) 2008-02-08 2012-10-26 Biogenerix Ag Formulation of ( follice stimulating hormone) fsh and varients with benzalkonium chloride and benzyl alcohol
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
UA106369C2 (ru) * 2009-04-01 2014-08-26 Рациофарм Гмбх Способ очистки рекомбинантного фсг
CN101519445B (zh) * 2009-04-08 2013-03-27 上海天伟生物制药有限公司 一种高比活尿促卵泡刺激素及其制备方法
CN101555279B (zh) * 2009-05-19 2013-03-27 上海天伟生物制药有限公司 一种高纯度尿促卵泡刺激素及其制备方法
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
EP2325194A1 (en) * 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CN103570820B (zh) * 2012-08-06 2015-11-18 齐鲁制药有限公司 一种重组人促卵泡激素的纯化方法
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
WO2015159309A1 (en) 2014-04-18 2015-10-22 Cadila Healthcare Limited Novel purification process of gonadotropin
CN104961821A (zh) * 2014-07-28 2015-10-07 厦门欧瑞捷生物科技有限公司 一种从人尿中提取促性腺激素的方法
WO2016116966A1 (en) * 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
CN105461799A (zh) * 2015-12-31 2016-04-06 哈药集团技术中心 一种重组人促卵泡生成素的纯化方法
CN107698676B (zh) * 2017-11-07 2020-07-14 江西浩然生物医药有限公司 一种高纯度尿促性素的提取制备方法
CN110563832A (zh) * 2019-07-31 2019-12-13 江苏璟泽生物医药有限公司 一种高纯度重组促卵泡刺激素纯化方法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
EP0475779A1 (en) 1990-09-14 1992-03-18 Vittal Mallya Scientific Research Foundation Process for the separation of proteins, polypeptides or metals using immobilized, optionally modified, phosvitin
SE9201073D0 (sv) 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
CA2223125A1 (en) * 1995-02-17 1996-08-22 Stichting Instituut Voor Dierhouderij En Diergezondheid Production of biologically active recombinant bovine follicle stimulating hormone (recbfsh) in the baculovirus expression system
AUPN801296A0 (en) 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
US6162905A (en) 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IT1287138B1 (it) * 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
US5990288A (en) 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
PT1169349E (pt) * 1999-04-16 2007-06-18 Inst Massone S A Composições de gonadotropina de altamente purificada e processo para a sua preparação
DE60127100T2 (de) 2000-02-22 2007-06-28 Applied Research Systems Ars Holding N.V. Gereinigtes recombinantes hlh mit spezifischer bioaktivität und verfahren zu dessen reinigung
AU2001266557A1 (en) * 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
AU784808B2 (en) * 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
CN100554277C (zh) * 2003-12-22 2009-10-28 阿雷斯贸易股份有限公司 Fsh的纯化方法
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily

Also Published As

Publication number Publication date
NO20072863L (no) 2007-06-05
HK1108704A1 (en) 2008-05-16
CN101087805B (zh) 2012-05-23
PL1809663T3 (pl) 2009-01-30
US20080070832A1 (en) 2008-03-20
NO340811B1 (no) 2017-06-19
BRPI0517973B8 (pt) 2021-05-25
WO2006051070A1 (en) 2006-05-18
DK1809663T3 (da) 2008-11-17
AU2005303818B2 (en) 2011-06-23
MX2007005327A (es) 2007-08-02
EA011673B1 (ru) 2009-04-28
HRP20080464T3 (en) 2008-10-31
ES2312037T3 (es) 2009-02-16
KR101173717B1 (ko) 2012-08-13
KR20070083618A (ko) 2007-08-24
IL182716A (en) 2010-12-30
CY1108602T1 (el) 2014-04-09
IL182716A0 (en) 2007-07-24
AU2005303818A1 (en) 2006-05-18
CN101087805A (zh) 2007-12-12
SI1809663T1 (sl) 2009-02-28
ATE408624T1 (de) 2008-10-15
DE602005009856D1 (de) 2008-10-30
BRPI0517973A (pt) 2008-10-21
PT1809663E (pt) 2008-10-02
CA2579131A1 (en) 2006-05-18
US7741455B2 (en) 2010-06-22
EP1809663A1 (en) 2007-07-25
EP1809663B1 (en) 2008-09-17
BRPI0517973B1 (pt) 2018-02-14

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM