MA29226B1 - Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations - Google Patents

Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations

Info

Publication number
MA29226B1
MA29226B1 MA30048A MA30048A MA29226B1 MA 29226 B1 MA29226 B1 MA 29226B1 MA 30048 A MA30048 A MA 30048A MA 30048 A MA30048 A MA 30048A MA 29226 B1 MA29226 B1 MA 29226B1
Authority
MA
Morocco
Prior art keywords
receptor
heavy chain
alpha
antibodies against
variable
Prior art date
Application number
MA30048A
Other languages
English (en)
Inventor
Josef Endl
Maria Fuentes
Yvo Graus
Adelbert Grossmann
Sebastian Neumann
Paul Parren
Frank Rebers
Joerg Regula
Ralf Schumacher
Stefan Seeber
Jan Stracke
Kay-Gunnar Stubenrauch
De Winkel Jan Van
Vugt Martine Van
Sandra Vereecken-Verploegen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29226B1 publication Critical patent/MA29226B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRÉSENTE INVENTION DÉCRIT UN ANTICORPS SE LIANT AU RÉCEPTEUR $G(A)1 DE L'IL-13, INHIBANT LA BIO-ACTIVITÉ DE L'IL-13 ET COMPRENANT UNE CHAÎNE LOURDE VARIABLE ET UNE CHAÎNE LÉGÈRE VARIABLE, CARACTÉRISÉ EN CE QUE LA SÉQUENCE CDR3 D'ACIDES AMINÉS DE LA CHAÎNE LOURDE VARIABLE DUDIT ANTICORPS EST CHOISIE DANS LE GROUPE SE COMPOSANT DES SÉQUENCES CDR3 DE LA CHAÎNE LOURDE TELLES QUE SEQ ID N°: 1, 3, 5, 7 OU 9 ET EST UTILE DANS LE TRAITEMENT DE L'ASTHME ET DE MALADIES ALLERGIQUES.
MA30048A 2005-01-03 2007-07-06 Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations MA29226B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05000003 2005-01-03
EP05002229 2005-02-03

Publications (1)

Publication Number Publication Date
MA29226B1 true MA29226B1 (fr) 2008-02-01

Family

ID=36199730

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30048A MA29226B1 (fr) 2005-01-03 2007-07-06 Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations

Country Status (20)

Country Link
US (2) US7807158B2 (fr)
EP (1) EP1836226B1 (fr)
JP (1) JP5086098B2 (fr)
KR (1) KR100934894B1 (fr)
AR (1) AR051888A1 (fr)
AT (1) ATE513855T1 (fr)
AU (1) AU2006204480B2 (fr)
BR (1) BRPI0606368A2 (fr)
CA (1) CA2592614C (fr)
CR (1) CR9209A (fr)
HK (1) HK1112006A1 (fr)
IL (1) IL184205A0 (fr)
MA (1) MA29226B1 (fr)
MX (1) MX2007008128A (fr)
NO (1) NO20073655L (fr)
NZ (1) NZ556126A (fr)
RU (1) RU2413736C2 (fr)
SG (1) SG172504A1 (fr)
TW (2) TWI306862B (fr)
WO (1) WO2006072564A1 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
CA2664343C (fr) * 2006-10-02 2016-04-26 Regeneron Pharmaceuticals, Inc. Anticorps humains a haute affinite vis-a-vis du recepteur il-4 humain
PL2829551T3 (pl) 2006-10-19 2018-04-30 Csl Limited Antagonisty przeciwciała o wysokim powinowactwie wobec receptora alfa 1 interleukiny-13
WO2008049098A2 (fr) 2006-10-19 2008-04-24 Merck & Co., Inc. Antagonistes d'anticorps du récepteur α1 de l'interleukine-13
DK2068922T3 (da) * 2006-10-19 2012-10-08 Csl Ltd Anti-IL-13Ralfa1-antistoffer samt deres anvendelser
BRPI0812288A2 (pt) 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
WO2009007272A1 (fr) * 2007-07-10 2009-01-15 F. Hoffmann-La Roche Ag Nouvelle formulation
WO2009046978A1 (fr) * 2007-10-12 2009-04-16 F. Hoffmann-La Roche Ag Expression de protéine à partir d'acides nucléiques multiples
EP2050764A1 (fr) * 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
PL2573568T3 (pl) 2007-12-15 2015-05-29 Hoffmann La Roche Próba rozróżniająca
BRPI1006448B1 (pt) * 2009-03-25 2021-08-17 Genentech, Inc Anticorpo antagonista anti-fgfr3, anticorpo monoclonal, polinucleotídeo, vetor, micro­organismo transgênico, método para produção de um anticorpo anti-fgfr3, formulação farmacêutica e usos do anticorpo antagonista anti-fgfr3
US8530392B2 (en) * 2009-05-13 2013-09-10 Shionogi & Co., Ltd. Test agent for visceral obesity and use thereof
JP5813638B2 (ja) 2009-07-30 2015-11-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 可動クロマトグラフィーカラムセパレータ
WO2011038894A1 (fr) 2009-10-01 2011-04-07 F. Hoffmann-La Roche Ag Chromatographie sur protéine a
LT2483305T (lt) 2009-10-01 2016-11-25 F.Hoffmann-La Roche Ag Daugiakopis galutinis imunoglobulino filtravimas
MX337290B (es) 2009-10-19 2016-02-24 Hoffmann La Roche Anticuerpos anti igg reactivos no cruzados.
NZ599840A (en) 2009-12-22 2014-06-27 Hoffmann La Roche Sequence dependent aggregation
CA3043423A1 (fr) 2010-08-17 2012-02-23 F. Hoffmann-La Roche Ag Anticorps anti-igg1 humaine
CN103339502B (zh) 2011-02-02 2016-02-17 霍夫曼-拉罗奇有限公司 色谱柱支撑体
KR20140059168A (ko) 2011-04-21 2014-05-15 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 시신경 척수염 치료용 조성물 및 치료 방법
PT3470432T (pt) 2012-08-21 2021-12-14 Regeneron Pharma Métodos para tratamento ou prevenção da asma por meio de administração de um antagonista de il-4r
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
AU2014284235B2 (en) 2013-06-21 2019-11-21 Regeneron Pharmaceuticals, Inc. Methods for treating nasal polyposis by administering an IL-4R antagonist
JP6563910B2 (ja) 2013-07-04 2019-08-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
TWI682781B (zh) 2013-07-11 2020-01-21 美商再生元醫藥公司 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
CN113173993B (zh) 2013-12-20 2024-03-08 英特维特国际股份有限公司 拮抗性抗犬pd-1抗体
WO2015127229A1 (fr) 2014-02-21 2015-08-27 Sanofi Méthodes de traitement ou de prévention de l'asthme par administration d'un antagoniste d'il-4 r
CN106062000B (zh) 2014-02-28 2021-05-28 瑞泽恩制药公司 通过施用il-4r拮抗剂治疗皮肤感染的方法
AU2015326996B2 (en) 2014-09-30 2021-05-20 Intervet International B.V. PD-L1 antibodies binding canine PD-L1
US10066017B2 (en) 2014-11-14 2018-09-04 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist
SI3337817T1 (sl) 2015-08-21 2021-12-31 F. Hoffmann - La Roche Ag Postopek za redukcijo beljakovin gostiteljske celice pri afinitetni kromatografiji
CN107849087B (zh) 2015-08-21 2022-09-06 豪夫迈·罗氏有限公司 在亲和层析中减少宿主细胞蛋白的方法
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
WO2018011405A1 (fr) * 2016-07-15 2018-01-18 Universität Zürich Anticorps il-13r alpha1 pour dans le traitement de l'inflammation atopique, de la septicémie et de la neutropénie.
KR102462039B1 (ko) 2016-09-01 2022-11-02 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
TWI784988B (zh) 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
US20180193003A1 (en) 2016-12-07 2018-07-12 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018183932A1 (fr) 2017-03-30 2018-10-04 Progenity Inc. Traitement d'une maladie du tractus gastro-intestinal à l'aide d'un inhibiteur d'il-13
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
MA46269B1 (fr) 2017-08-18 2024-05-31 Regeneron Pharma Méthodes de traitement d'une dermatite atopique sévère par administration d'un inhibiteur des il-4r
EP4344706A3 (fr) 2017-10-30 2024-05-22 Sanofi Biotechnology Méthodes de traitement ou de prévention de l'asthme par administration d'un antagoniste de l'il-4r
EP3768314A4 (fr) 2018-03-21 2022-01-05 ALX Oncology Inc. Anticorps contre la protéine régulatrice de signal alpha et procédés d'utilisation
BR112020020387A2 (pt) 2018-05-13 2021-01-19 Regeneron Pharmaceuticals, Inc. Métodos para o tratamento de dermatite atópica por administração de um inibidor de il-4r
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
BR112021018627A2 (pt) 2019-03-21 2021-11-23 Regeneron Pharma Combinação de inibidores da via de il-4/il-13 e ablação de células plasmáticas para o tratamento de alergia
SG11202109545VA (en) 2019-03-26 2021-10-28 Aslan Pharmaceuticals Pte Ltd Treatment employing anti-il-13r antibody or binding fragment thereof
AU2020325021B2 (en) 2019-08-05 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
EP3870261B1 (fr) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Dispositif ingestible pour la livraison d'un agent thérapeutique au système gastro-intestinal
WO2022186772A1 (fr) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DE LA DERMATITE ATOPIQUE À L'AIDE D'UN ANTICORPS ANTI-IL-13Rα1 OU D'UN FRAGMENT DE LIAISON ASSOCIÉ
WO2022186773A1 (fr) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DE LA DERMATITE ATOPIQUE À L'AIDE D'UN ANTICORPS ANTI-IL-13Rα1 OU D'UN FRAGMENT DE LIAISON ASSOCIÉ CHEZ UNE POPULATION ALLERGIQUE
WO2023048650A1 (fr) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd TRAITEMENT DU PRURIT FAISANT INTERVENIR UN ANTICORPS ANTI-IL13Rα1 OU UN FRAGMENT DE LIAISON DE CELUI-CI
WO2023048651A1 (fr) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd Procédé de traitement de la dermatite atoptique modérée à grave
TW202333784A (zh) 2021-10-29 2023-09-01 新加坡商亞獅康私人有限公司 抗ｉｌ１３ｒ抗體調配物
WO2024043837A1 (fr) 2022-08-26 2024-02-29 Aslan Pharmaceuticals Pte Ltd Formulation d'anticorps anti-il13r à haute concentration
WO2024054157A1 (fr) 2022-09-06 2024-03-14 Aslan Pharmaceuticals Pte Ltd Traitement de la perte de sommeil ou des troubles du sommeil chez des patients atteints de dermatite

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
DE69638050D1 (de) 1995-10-23 2009-11-19 Zenyth Operations Pty Ltd Hemopoietin-rezeptor und dafür kodierende genetische sequenzen
US5843659A (en) * 1996-03-21 1998-12-01 Apoptosis Technology, Inc. Apoptosis gene EI24, compositions, and methods of use
US20050154192A1 (en) * 2001-11-27 2005-07-14 Kamon Shirakawa Anti-il13 receptor alpha1 neutralizing antibody
AR037756A1 (es) * 2001-12-17 2004-12-01 Bayer Corp Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma.
CA2480059C (fr) 2002-03-22 2015-11-24 Amrad Operations Pty. Ltd. Anticorps monoclonal contre le recepteur alpha1 de l'interleukine 13 (il-13ra1)
WO2004081186A2 (fr) * 2003-03-10 2004-09-23 Applera Corporation Polymorphismes genetiques associes a la stenose, procedes de detection et utilisations associees
MEP31508A (en) * 2003-07-15 2010-10-10 Amgen Inc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

Also Published As

Publication number Publication date
EP1836226B1 (fr) 2011-06-22
KR20070091180A (ko) 2007-09-07
MX2007008128A (es) 2007-07-20
NZ556126A (en) 2008-09-26
IL184205A0 (en) 2007-10-31
AU2006204480A1 (en) 2006-07-13
TW200902555A (en) 2009-01-16
KR100934894B1 (ko) 2010-01-07
WO2006072564A1 (fr) 2006-07-13
NO20073655L (no) 2007-08-02
CR9209A (es) 2007-08-28
HK1112006A1 (en) 2008-08-22
JP2008526187A (ja) 2008-07-24
AU2006204480B2 (en) 2011-06-09
CA2592614A1 (fr) 2006-07-13
US7807158B2 (en) 2010-10-05
EP1836226A1 (fr) 2007-09-26
JP5086098B2 (ja) 2012-11-28
TW200635945A (en) 2006-10-16
RU2007129676A (ru) 2009-02-10
RU2413736C2 (ru) 2011-03-10
SG172504A1 (en) 2011-07-28
ATE513855T1 (de) 2011-07-15
US20110086026A1 (en) 2011-04-14
US20060263356A1 (en) 2006-11-23
TWI306862B (en) 2009-03-01
BRPI0606368A2 (pt) 2009-06-23
AR051888A1 (es) 2007-02-14
CA2592614C (fr) 2015-04-14

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