CY1110843T1 - Αντισωματα εναντι il-22ra και εταιροι δεσμευσης και μεθοδοι χρησης σε φλεγμονη - Google Patents

Αντισωματα εναντι il-22ra και εταιροι δεσμευσης και μεθοδοι χρησης σε φλεγμονη

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Publication number
CY1110843T1
CY1110843T1 CY20101100932T CY101100932T CY1110843T1 CY 1110843 T1 CY1110843 T1 CY 1110843T1 CY 20101100932 T CY20101100932 T CY 20101100932T CY 101100932 T CY101100932 T CY 101100932T CY 1110843 T1 CY1110843 T1 CY 1110843T1
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CY
Cyprus
Prior art keywords
methods
binding
catalogs
partnership
use inflammation
Prior art date
Application number
CY20101100932T
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English (en)
Inventor
Wenfeng Xu
Wayne R Kindsvogel
Yasmin A Chandrasekher
Stacey R Dillon
Joyce M Lehner
Anthony W Siadak
Pallavur V Sivakumar
Margaret D Moore
Original Assignee
Zymogenetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Zymogenetics, Inc. filed Critical Zymogenetics, Inc.
Publication of CY1110843T1 publication Critical patent/CY1110843T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με τον αποκλεισμό, αναστολή, περιορισμό, ανταγωνισμό ή εξουδετέρωση της ενεργότητας των IL-22, IL-20, ή αμφοτέρων των IL-20 και IL-22 πολυπεπτιδικών μορίων. Οι IL-20 και IL-22 είναι κυτοκίνες που συμμετέχουν σε φλεγμονώδεις εξεργασίες και σε ανθρώπινες παθήσεις. Ο IL-22RA (zcytor11) είναι κοινός υποδοχέας για IL-20 και IL-22. Η παρούσα εφεύρεση περιλαμβάνει αντισώματα έναντι IL-22RA και εταίρους δέσμευσης, καθώς και μεθόδους για τον ανταγωνισμό της IL-22 ή αμφοτέρων των IL-20 και IL-22 με χρήση τέτοιων αντισωμάτων και εταίρων δέσμευσης.
CY20101100932T 2004-10-22 2010-10-18 Αντισωματα εναντι il-22ra και εταιροι δεσμευσης και μεθοδοι χρησης σε φλεγμονη CY1110843T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62155304P 2004-10-22 2004-10-22
EP05816060A EP1812476B1 (en) 2004-10-22 2005-10-21 Anti-il-22ra antibodies and binding partners and methods of using in inflammation

Publications (1)

Publication Number Publication Date
CY1110843T1 true CY1110843T1 (el) 2015-06-10

Family

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Family Applications (1)

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CY20101100932T CY1110843T1 (el) 2004-10-22 2010-10-18 Αντισωματα εναντι il-22ra και εταιροι δεσμευσης και μεθοδοι χρησης σε φλεγμονη

Country Status (22)

Country Link
US (5) US7537761B2 (el)
EP (1) EP1812476B1 (el)
JP (1) JP4898691B2 (el)
KR (1) KR101238684B1 (el)
CN (1) CN101198625A (el)
AT (1) ATE474856T1 (el)
AU (1) AU2005299809B2 (el)
BR (1) BRPI0516975A (el)
CA (1) CA2584157C (el)
CY (1) CY1110843T1 (el)
DE (1) DE602005022475D1 (el)
DK (1) DK1812476T3 (el)
EA (1) EA015706B1 (el)
ES (1) ES2347672T3 (el)
HK (1) HK1110333A1 (el)
IL (2) IL182503A (el)
MX (1) MX2007004770A (el)
NO (1) NO20072602L (el)
PT (1) PT1812476E (el)
UA (1) UA96122C2 (el)
WO (1) WO2006047249A1 (el)
ZA (1) ZA200704125B (el)

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US8124088B2 (en) 2012-02-28
AU2005299809A1 (en) 2006-05-04
US20060141582A1 (en) 2006-06-29
CN101198625A (zh) 2008-06-11
DE602005022475D1 (de) 2010-09-02
JP2008517922A (ja) 2008-05-29
EP1812476B1 (en) 2010-07-21
PT1812476E (pt) 2010-11-08
WO2006047249A1 (en) 2006-05-04
IL182503A (en) 2012-01-31
US20130315919A1 (en) 2013-11-28
UA96122C2 (ru) 2011-10-10
IL207146A (en) 2012-06-28
KR20070084486A (ko) 2007-08-24
IL207146A0 (en) 2010-12-30
AU2005299809A2 (en) 2006-05-04
KR101238684B1 (ko) 2013-03-04
EP1812476A1 (en) 2007-08-01
JP4898691B2 (ja) 2012-03-21
US8536309B2 (en) 2013-09-17
US20090220519A1 (en) 2009-09-03
DK1812476T3 (da) 2010-10-25
EA200700916A1 (ru) 2007-10-26
US7537761B2 (en) 2009-05-26
US20100210825A1 (en) 2010-08-19
MX2007004770A (es) 2007-11-22
CA2584157A1 (en) 2006-05-04
ES2347672T3 (es) 2010-11-03
HK1110333A1 (en) 2008-07-11
ATE474856T1 (de) 2010-08-15
BRPI0516975A (pt) 2008-09-30
ZA200704125B (en) 2008-09-25
IL182503A0 (en) 2007-09-20
EA015706B1 (ru) 2011-10-31
US7871616B2 (en) 2011-01-18
CA2584157C (en) 2014-10-14
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AU2005299809B2 (en) 2010-12-02
US20120156210A1 (en) 2012-06-21

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