BRPI0606368A2 - anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma - Google Patents
anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridomaInfo
- Publication number
- BRPI0606368A2 BRPI0606368A2 BRPI0606368-3A BRPI0606368A BRPI0606368A2 BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2 BR PI0606368 A BRPI0606368 A BR PI0606368A BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- pharmaceutical composition
- antibodies against
- host cell
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ANTICORPOS CONTRA RECEPTOR ALFA1 DE IL-13, USOS DOS MESMOS, COMPOSIçãO FARMACêUTICA, E MéTODO PARA FABRICAçãO DA MESMA, CéLULA HOSPEDEIRA RECOMBINANTE, áCIDO NUCLéICO, VETOR DE EXPRESSãO, MéTODO PARA A PRODUçãO DE UM POLIPEPTIDEO, BEM COMO LINHAGEM CELULAR DE HIBRIDOMA. A presente invenção refere-se a um anticorpo que se liga a IL-l3Ral, inibe a bioatividade de IL-13 e compreende uma cadeia pesada variável e leve variável, caracterizado pelo fato de que a seqúência de aminoácido de cadeia pesada variável CDR3 do dito anticorpo é selecionada a partir do grupo que consiste nas seqúências de CDR3 de cadeia pesada de SEQ ID NO: 1, 3, 5, 7 ou 9 é útil no tratamento de asma e doenças alérgicas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05000003 | 2005-01-03 | ||
| EP05002229 | 2005-02-03 | ||
| PCT/EP2006/000005 WO2006072564A1 (en) | 2005-01-03 | 2006-01-02 | Antibodies against il-13 receptor alpha 1 and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606368A2 true BRPI0606368A2 (pt) | 2009-06-23 |
Family
ID=36199730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606368-3A BRPI0606368A2 (pt) | 2005-01-03 | 2006-01-02 | anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7807158B2 (pt) |
| EP (1) | EP1836226B1 (pt) |
| JP (1) | JP5086098B2 (pt) |
| KR (1) | KR100934894B1 (pt) |
| AR (1) | AR051888A1 (pt) |
| AT (1) | ATE513855T1 (pt) |
| AU (1) | AU2006204480B2 (pt) |
| BR (1) | BRPI0606368A2 (pt) |
| CA (1) | CA2592614C (pt) |
| CR (1) | CR9209A (pt) |
| HK (1) | HK1112006A1 (pt) |
| IL (1) | IL184205A0 (pt) |
| MA (1) | MA29226B1 (pt) |
| MX (1) | MX2007008128A (pt) |
| NO (1) | NO20073655L (pt) |
| NZ (1) | NZ556126A (pt) |
| RU (1) | RU2413736C2 (pt) |
| SG (1) | SG172504A1 (pt) |
| TW (2) | TW200902555A (pt) |
| WO (1) | WO2006072564A1 (pt) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| CN101522716B (zh) * | 2006-10-02 | 2013-03-20 | 瑞泽恩制药公司 | 抗人il-4受体的高亲和力人抗体 |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| JP5238710B2 (ja) | 2006-10-19 | 2013-07-17 | シーエスエル、リミテッド | インターロイキン−１３レセプターアルファ１の高親和性抗体アンタゴニスト |
| US8207304B2 (en) | 2006-10-19 | 2012-06-26 | Csl Limited | Antibody antagonists of interleukin-13 receptor α1 |
| US8613925B2 (en) | 2006-10-19 | 2013-12-24 | Csl Limited | Anti-IL-13Rα1 antibodies and their uses thereof |
| AU2008256411B2 (en) | 2007-06-01 | 2013-08-22 | F. Hoffmann-La Roche Ag | Immunoglobulin purification |
| WO2009007272A1 (en) * | 2007-07-10 | 2009-01-15 | F. Hoffmann-La Roche Ag | Novel formulation |
| WO2009046978A1 (en) * | 2007-10-12 | 2009-04-16 | F. Hoffmann-La Roche Ag | Protein expression from multiple nucleic acids |
| EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| US8227195B2 (en) | 2007-12-15 | 2012-07-24 | Hoffman-La Roche Inc. | Distinguishing assay |
| HUE061117T2 (hu) * | 2009-03-25 | 2023-05-28 | Genentech Inc | Anti-FGFR3 antitestek és eljárások alkalmazásukra |
| EP2431463A4 (en) * | 2009-05-13 | 2012-12-26 | Shionogi & Co | TESTS FOR VISCERAL ADIPOSITAS AND ITS USE |
| SI2459291T1 (en) | 2009-07-30 | 2018-06-29 | F. Hoffmann-La Roche Ag | Portable separator for chromatographic columns |
| MX342442B (es) | 2009-10-01 | 2016-09-29 | F Hoffmann-La Roche Ag * | Filtracion final en multiples pasos. |
| WO2011038894A1 (en) | 2009-10-01 | 2011-04-07 | F. Hoffmann-La Roche Ag | Protein a chromatography |
| JP5715634B2 (ja) | 2009-10-19 | 2015-05-13 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 非交差反応性抗ＩｇＧ抗体 |
| BR112012012873B1 (pt) | 2009-12-22 | 2021-08-31 | F.Hoffmann-La Roche Ag | Método para fornecer uma sequência de ácido nucleico que codifica uma imunoglobulina e método para produzir uma imunoglobulina |
| CN103068852B (zh) | 2010-08-17 | 2016-04-20 | 弗·哈夫曼-拉罗切有限公司 | 抗人IgG1抗体 |
| KR101951965B1 (ko) | 2011-02-02 | 2019-02-25 | 에프. 호프만-라 로슈 아게 | 크로마토그래피 칼럼 지지체 |
| JP6152090B2 (ja) | 2011-04-21 | 2017-06-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 視神経脊髄炎を処置するための組成物および方法 |
| EP4324479A3 (en) | 2012-08-21 | 2024-04-24 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| RS59354B1 (sr) | 2013-06-21 | 2019-10-31 | Sanofi Biotechnology | Postupci lečenja nosne polipoze davanjem il-4r antagonista |
| BR112015032960B1 (pt) | 2013-07-04 | 2021-01-05 | F. Hoffmann-La Roche Ag | imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| CA2932515C (en) | 2013-12-20 | 2023-08-01 | Intervet International B.V. | Caninized antibodies |
| KR20230167770A (ko) | 2014-02-21 | 2023-12-11 | 사노피 바이오테크놀로지 | Ｉｌ-4ｒ 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| ES2973858T3 (es) | 2014-02-28 | 2024-06-24 | Regeneron Pharma | Métodos para tratar infecciones cutáneas mediante la administración de un antagonista de IL-4R |
| RU2722562C2 (ru) | 2014-09-30 | 2020-06-01 | Интервет Интернэшнл Б.В. | Антитела к pd-l1, связывающие pd-l1 собаки |
| JP6861630B2 (ja) | 2014-11-14 | 2021-04-21 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| SI3337817T1 (sl) | 2015-08-21 | 2021-12-31 | F. Hoffmann - La Roche Ag | Postopek za redukcijo beljakovin gostiteljske celice pri afinitetni kromatografiji |
| WO2017032686A1 (en) | 2015-08-21 | 2017-03-02 | F. Hoffmann-La Roche Ag | Method for the reduction of host cell proteins in affinity chromatography |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| WO2018011405A1 (en) * | 2016-07-15 | 2018-01-18 | Universität Zürich | Il-13ralpha1 antibodies for use in treatment of atopic inflammation, sepsis and neutropenia |
| MA46098A (fr) | 2016-09-01 | 2019-07-10 | Regeneron Pharma | Méthodes de prévention ou de traitement de l'allergie par administration d'un antagoniste d'il-4 r |
| JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
| TW202332696A (zh) | 2016-12-01 | 2023-08-16 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| EP4252629A3 (en) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| MA46269B1 (fr) | 2017-08-18 | 2024-05-31 | Regeneron Pharma | Méthodes de traitement d'une dermatite atopique sévère par administration d'un inhibiteur des il-4r |
| CN111526920A (zh) | 2017-10-30 | 2020-08-11 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂来治疗或预防哮喘的方法 |
| MX2020009774A (es) | 2018-03-21 | 2020-10-08 | Alx Oncology Inc | Anticuerpos contra proteína alfa reguladora de señal y métodos de uso. |
| BR112020020387A2 (pt) | 2018-05-13 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Métodos para o tratamento de dermatite atópica por administração de um inibidor de il-4r |
| KR20210095165A (ko) | 2018-11-19 | 2021-07-30 | 프로제너티, 인크. | 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스 |
| AU2020240132A1 (en) | 2019-03-21 | 2021-09-16 | Regeneron Pharmaceuticals, Inc. | Combination of IL-4/IL-13 pathway inhibitors and plasma cell ablation for treating allergy |
| AU2020247175A1 (en) | 2019-03-26 | 2021-10-14 | Aslan Pharmaceuticals Pte Ltd | Treatment employing anti-IL-13R antibody or binding fragment thereof |
| CN114173819A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法 |
| CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2022186773A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION |
| WO2022186772A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
| WO2023048651A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | Method for treatment of moderate to severe atoptic dematitis |
| WO2023048650A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
| TW202333784A (zh) | 2021-10-29 | 2023-09-01 | 新加坡商亞獅康私人有限公司 | 抗ｉｌ１３ｒ抗體調配物 |
| WO2024043837A1 (en) | 2022-08-26 | 2024-02-29 | Aslan Pharmaceuticals Pte Ltd | High concentration anti-il13r antibody formulation |
| WO2024054157A1 (en) | 2022-09-06 | 2024-03-14 | Aslan Pharmaceuticals Pte Ltd | Treatment for sleep loss or sleep disturbance in patients with dermatitis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5614191A (en) | 1995-03-15 | 1997-03-25 | The United States Of America As Represented By The Department Of Health And Human Services | IL-13 receptor specific chimeric proteins and uses thereof |
| AU718899C (en) | 1995-10-23 | 2004-01-29 | Amrad Operations Pty. Limited | A novel haemopoietin receptor and genetic sequences encoding same |
| US5843659A (en) * | 1996-03-21 | 1998-12-01 | Apoptosis Technology, Inc. | Apoptosis gene EI24, compositions, and methods of use |
| EP1449851A4 (en) | 2001-11-27 | 2005-11-16 | Mochida Pharm Co Ltd | NEUTRALIZING ANTIBODIES OF IL13 ALPHA RECEPTOR 1 |
| AR037756A1 (es) * | 2001-12-17 | 2004-12-01 | Bayer Corp | Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma. |
| JP4432031B2 (ja) * | 2002-03-22 | 2010-03-17 | ズィナイス オペレーションズ ピーティーワイ．エルティーディー． | インターロイキン１３受容体α１（ＩＬ−１３Ｒα１）に対するモノクローナル抗体 |
| US7625699B2 (en) * | 2003-03-10 | 2009-12-01 | Celera Corporation | Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof |
| EA013614B1 (ru) * | 2003-07-15 | 2010-06-30 | Амджен Инк. | Изолированное антитело к фактору роста нервов (ngf) и способы его применения |
-
2005
- 2005-12-30 TW TW097137970A patent/TW200902555A/zh unknown
- 2005-12-30 TW TW094147847A patent/TWI306862B/zh not_active IP Right Cessation
-
2006
- 2006-01-02 KR KR1020077015296A patent/KR100934894B1/ko not_active IP Right Cessation
- 2006-01-02 BR BRPI0606368-3A patent/BRPI0606368A2/pt not_active IP Right Cessation
- 2006-01-02 AU AU2006204480A patent/AU2006204480B2/en not_active Expired - Fee Related
- 2006-01-02 AT AT06706157T patent/ATE513855T1/de not_active IP Right Cessation
- 2006-01-02 NZ NZ556126A patent/NZ556126A/en not_active IP Right Cessation
- 2006-01-02 RU RU2007129676/10A patent/RU2413736C2/ru not_active IP Right Cessation
- 2006-01-02 WO PCT/EP2006/000005 patent/WO2006072564A1/en active Application Filing
- 2006-01-02 EP EP06706157A patent/EP1836226B1/en active Active
- 2006-01-02 SG SG2009087206A patent/SG172504A1/en unknown
- 2006-01-02 MX MX2007008128A patent/MX2007008128A/es active IP Right Grant
- 2006-01-02 JP JP2007548835A patent/JP5086098B2/ja not_active Expired - Fee Related
- 2006-01-02 CA CA2592614A patent/CA2592614C/en not_active Expired - Fee Related
- 2006-01-03 AR ARP060100010A patent/AR051888A1/es unknown
- 2006-01-03 US US11/325,197 patent/US7807158B2/en not_active Expired - Fee Related
-
2007
- 2007-06-25 IL IL184205A patent/IL184205A0/en unknown
- 2007-06-26 CR CR9209A patent/CR9209A/es not_active Application Discontinuation
- 2007-07-06 MA MA30048A patent/MA29226B1/fr unknown
- 2007-07-17 NO NO20073655A patent/NO20073655L/no not_active Application Discontinuation
-
2008
- 2008-06-23 HK HK08106940.0A patent/HK1112006A1/xx not_active IP Right Cessation
-
2010
- 2010-07-26 US US12/843,225 patent/US20110086026A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006072564A1 (en) | 2006-07-13 |
| TWI306862B (en) | 2009-03-01 |
| EP1836226B1 (en) | 2011-06-22 |
| JP2008526187A (ja) | 2008-07-24 |
| HK1112006A1 (en) | 2008-08-22 |
| ATE513855T1 (de) | 2011-07-15 |
| US7807158B2 (en) | 2010-10-05 |
| MX2007008128A (es) | 2007-07-20 |
| CR9209A (es) | 2007-08-28 |
| AU2006204480B2 (en) | 2011-06-09 |
| CA2592614C (en) | 2015-04-14 |
| KR20070091180A (ko) | 2007-09-07 |
| NZ556126A (en) | 2008-09-26 |
| AR051888A1 (es) | 2007-02-14 |
| AU2006204480A1 (en) | 2006-07-13 |
| CA2592614A1 (en) | 2006-07-13 |
| JP5086098B2 (ja) | 2012-11-28 |
| KR100934894B1 (ko) | 2010-01-07 |
| US20110086026A1 (en) | 2011-04-14 |
| RU2007129676A (ru) | 2009-02-10 |
| TW200902555A (en) | 2009-01-16 |
| RU2413736C2 (ru) | 2011-03-10 |
| MA29226B1 (fr) | 2008-02-01 |
| NO20073655L (no) | 2007-08-02 |
| IL184205A0 (en) | 2007-10-31 |
| EP1836226A1 (en) | 2007-09-26 |
| TW200635945A (en) | 2006-10-16 |
| US20060263356A1 (en) | 2006-11-23 |
| SG172504A1 (en) | 2011-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0606368A2 (pt) | anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma | |
| HRP20171765T1 (hr) | Protutijela koja vežu il-4 i/ili il-13 i njihova uporaba | |
| AR124240A2 (es) | Un anticuerpo biespecífico anti-vegf / anti-ang-2, ácido nucleico, vector de expresión, célula huésped y un método de preparación del anticuerpo | |
| BRPI0914319B8 (pt) | imunoligante que se liga especificamente ao tnf alfa humano e composição | |
| BR112012007821A2 (pt) | polipeptídeos para ligação ao "receptor de produtos finais de glicação avançada" bem como composições e métodos envolvendo os mesmos | |
| HRP20150776T1 (hr) | Humanizirana protutijela koja su specifiäśna za protofibrilarni oblik beta-amiloidnog peptida | |
| CL2018000537A1 (es) | Anticuerpo anti-factor d del complemento; polinucleótido codificante; vector que comprende dicho polinucleótido; célula húesped que comprende dicho vector; método de fabricación de anticuerpo; composición farmacéutica que lo comprende; uso del anticuerpo para tratar trastornos inflamatorios o trastornos oculares (divisional de cl 1001-2009). | |
| BRPI0713000A8 (pt) | Proteína de ligação multiespecífica de cadeia simples, composição farmacêutica e uso da referida proteína de ligação multiespecífica de cadeia simples | |
| AR080794A1 (es) | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 | |
| BR112019025904A2 (pt) | método de fabricação de anticorpos biespecíficos, anticorpos biespecíficos e uso terapêutico de tais anticorpos | |
| PE20121646A1 (es) | Anticuerpo anti-tslp modificado por tecnicas de ingeneria genetica | |
| AR080942A1 (es) | Produccion de proteinas heteromultimericas | |
| PE20181044A1 (es) | Anticuerpos anti-pd-1 y composiciones | |
| RU2015150149A (ru) | Составы на основе биспецифических антител к il-4/il-13 | |
| BRPI1012321A8 (pt) | Anticorpos anti-vegf e seus usos | |
| NO20092121L (no) | Humaniserte anti-faktor D-antistoffer og anvendelser derav | |
| BRPI0821168B8 (pt) | anticorpo isolado que se liga ao il-21 humano, ou um fragmento deste, usos de dito anticorpo ou fragmento, e, hibridoma | |
| BRPI0815370B8 (pt) | anticorpos humanos de alta afinidade contra o fator de crescimento neural humano e seu uso, molécula de ácido nucleico, vetor de expressão, método para produção de um anticorpo anti-ngf humano e composiçao farmacêutica | |
| AR077931A2 (es) | Anticuerpos contra la interleuquina-13 humana y usos de los mismos | |
| BR112015014751A8 (pt) | anti-corpos anti-tau humanos e fragmento de ligação a tau dos mesmo, seu uso na preparação de um medicamento, bem como polipeptídeos codificando os mesmos. | |
| AR085138A1 (es) | VARIANTES DE Fc Y METODOS PARA SU PRODUCCION | |
| AR064333A1 (es) | Anticuerpo anti-tslp de diseno | |
| RU2012129735A (ru) | Антитела к her3 и их применения | |
| HRP20240102T1 (hr) | Monoklonsko protutijelo koje antagonizira i inhibira vezanje između humanog pd-1 antigena i njegovog liganda, postupak njegove priprave i primjena | |
| CL2011001431A1 (es) | Molecula de anticuerpo humano que se une al factor de crecimiento insulinico tipo 1 (igf-1) y tipo 2 (igf-2) humano, de raton y rata, y no se enlaza a insulina humana; molecula de adn que la codifica; vector, celula hospedante; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar cancer. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUI DADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013. |