BRPI0606368A2 - anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma - Google Patents
anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridomaInfo
- Publication number
- BRPI0606368A2 BRPI0606368A2 BRPI0606368-3A BRPI0606368A BRPI0606368A2 BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2 BR PI0606368 A BRPI0606368 A BR PI0606368A BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- pharmaceutical composition
- antibodies against
- host cell
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ANTICORPOS CONTRA RECEPTOR ALFA1 DE IL-13, USOS DOS MESMOS, COMPOSIçãO FARMACêUTICA, E MéTODO PARA FABRICAçãO DA MESMA, CéLULA HOSPEDEIRA RECOMBINANTE, áCIDO NUCLéICO, VETOR DE EXPRESSãO, MéTODO PARA A PRODUçãO DE UM POLIPEPTIDEO, BEM COMO LINHAGEM CELULAR DE HIBRIDOMA. A presente invenção refere-se a um anticorpo que se liga a IL-l3Ral, inibe a bioatividade de IL-13 e compreende uma cadeia pesada variável e leve variável, caracterizado pelo fato de que a seqúência de aminoácido de cadeia pesada variável CDR3 do dito anticorpo é selecionada a partir do grupo que consiste nas seqúências de CDR3 de cadeia pesada de SEQ ID NO: 1, 3, 5, 7 ou 9 é útil no tratamento de asma e doenças alérgicas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05000003 | 2005-01-03 | ||
EP05002229 | 2005-02-03 | ||
PCT/EP2006/000005 WO2006072564A1 (en) | 2005-01-03 | 2006-01-02 | Antibodies against il-13 receptor alpha 1 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0606368A2 true BRPI0606368A2 (pt) | 2009-06-23 |
Family
ID=36199730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0606368-3A BRPI0606368A2 (pt) | 2005-01-03 | 2006-01-02 | anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma |
Country Status (20)
Country | Link |
---|---|
US (2) | US7807158B2 (pt) |
EP (1) | EP1836226B1 (pt) |
JP (1) | JP5086098B2 (pt) |
KR (1) | KR100934894B1 (pt) |
AR (1) | AR051888A1 (pt) |
AT (1) | ATE513855T1 (pt) |
AU (1) | AU2006204480B2 (pt) |
BR (1) | BRPI0606368A2 (pt) |
CA (1) | CA2592614C (pt) |
CR (1) | CR9209A (pt) |
HK (1) | HK1112006A1 (pt) |
IL (1) | IL184205A0 (pt) |
MA (1) | MA29226B1 (pt) |
MX (1) | MX2007008128A (pt) |
NO (1) | NO20073655L (pt) |
NZ (1) | NZ556126A (pt) |
RU (1) | RU2413736C2 (pt) |
SG (1) | SG172504A1 (pt) |
TW (2) | TW200902555A (pt) |
WO (1) | WO2006072564A1 (pt) |
Families Citing this family (59)
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AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
EP2769992B1 (en) * | 2006-10-02 | 2020-12-30 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
WO2008049098A2 (en) | 2006-10-19 | 2008-04-24 | Merck & Co., Inc. | ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR α1 |
ES2388567T3 (es) | 2006-10-19 | 2012-10-16 | Csl Limited | Anticuerpos anti-il-13r alfa 1 y usos de los mismos |
PL2068921T3 (pl) | 2006-10-19 | 2014-12-31 | Csl Ltd | Przeciwciała o dużym powinowactwie będące antagonistami receptora alfa1 interleukiny 13 |
JP5064558B2 (ja) | 2007-06-01 | 2012-10-31 | エフ.ホフマン−ラ ロシュ アーゲー | 免疫グロブリン精製 |
WO2009007272A1 (en) * | 2007-07-10 | 2009-01-15 | F. Hoffmann-La Roche Ag | Novel formulation |
EP2592147A1 (en) | 2007-10-12 | 2013-05-15 | F. Hoffmann-La Roche AG | Protein expression from multiple nucleic acids |
EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
BRPI0821267A2 (pt) | 2007-12-15 | 2015-06-16 | Hoffmann La Roche | Ensaio distintivo |
LT3702371T (lt) * | 2009-03-25 | 2023-01-10 | Genentech, Inc. | Anti-fgfr3 antikūnai ir jų panaudojimo būdai |
JP5804599B2 (ja) * | 2009-05-13 | 2015-11-04 | 国立研究開発法人理化学研究所 | 内臓脂肪型肥満の検査薬およびその利用 |
MX2012000735A (es) | 2009-07-30 | 2012-01-27 | Hoffmann La Roche | Separador de columna de cromatografia movible. |
WO2011038894A1 (en) | 2009-10-01 | 2011-04-07 | F. Hoffmann-La Roche Ag | Protein a chromatography |
MX342442B (es) | 2009-10-01 | 2016-09-29 | F Hoffmann-La Roche Ag * | Filtracion final en multiples pasos. |
KR101536388B1 (ko) | 2009-10-19 | 2015-07-22 | 에프. 호프만-라 로슈 아게 | 비-교차반응성 항-IgG 항체 |
JP5686817B2 (ja) | 2009-12-22 | 2015-03-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 配列依存性の凝集 |
CA3043423A1 (en) | 2010-08-17 | 2012-02-23 | F. Hoffmann-La Roche Ag | Anti-human igg1 antibody |
MX347297B (es) | 2011-02-02 | 2017-04-21 | Hoffmann La Roche | Soporte para columna de cromatografía. |
AU2012245205B2 (en) * | 2011-04-21 | 2017-06-01 | The Regents Of The University Of California, A California Corporation | Compositions and methods for the treatment of neuromyelitis optica |
PL3470432T3 (pl) | 2012-08-21 | 2022-02-07 | Sanofi Biotechnology | Sposoby leczenia lub zapobiegania astmie przez podawanie antagonisty IL-4R |
TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
EP3010539B1 (en) | 2013-06-21 | 2019-07-24 | Sanofi Biotechnology | Methods for treating nasal polyposis by administering an il-4r antagonist |
RU2674996C2 (ru) | 2013-07-04 | 2018-12-14 | Ф. Хоффманн-Ля Рош Аг | Иммуноферментный анализ с подавлением интерференции для определения антител к лекарствам в образцах сыворотки |
TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
CN117603354A (zh) | 2013-12-20 | 2024-02-27 | 英特维特国际股份有限公司 | 具有经修饰的ch2-ch3序列的犬抗体 |
EP3107575B1 (en) | 2014-02-21 | 2021-09-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
KR20220070544A (ko) | 2014-02-28 | 2022-05-31 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법 |
DK3201230T3 (da) | 2014-09-30 | 2021-02-15 | Intervet Int Bv | Canine pd-l1-bindende pd-l1-antistoffer |
CA2967602A1 (en) | 2014-11-14 | 2016-05-19 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
ES2897965T3 (es) | 2015-08-21 | 2022-03-03 | Hoffmann La Roche | Procedimiento para la reducción de proteínas de célula huésped en cromatografía de afinidad |
EP3337812B1 (en) | 2015-08-21 | 2021-04-28 | F. Hoffmann-La Roche AG | Method for the reduction of host cell proteins in affinity chromatography |
US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
WO2018011405A1 (en) * | 2016-07-15 | 2018-01-18 | Universität Zürich | Il-13ralpha1 antibodies for use in treatment of atopic inflammation, sepsis and neutropenia |
MA46098A (fr) | 2016-09-01 | 2019-07-10 | Regeneron Pharma | Méthodes de prévention ou de traitement de l'allergie par administration d'un antagoniste d'il-4 r |
JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
TW202332696A (zh) | 2016-12-01 | 2023-08-16 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
HUE064655T2 (hu) | 2017-10-30 | 2024-04-28 | Sanofi Biotechnology | IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban |
WO2019183266A1 (en) | 2018-03-21 | 2019-09-26 | ALX Oncology Inc. | Antibodies against signal-regulatory protein alpha and methods of use |
CN112153982A (zh) | 2018-05-13 | 2020-12-29 | 瑞泽恩制药公司 | 用于通过施用il-4r抑制剂治疗特应性皮炎的方法 |
CN113348011B (zh) | 2018-11-19 | 2023-04-18 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
CA3132587A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
AU2020247175A1 (en) | 2019-03-26 | 2021-10-14 | Aslan Pharmaceuticals Pte Ltd | Treatment employing anti-IL-13R antibody or binding fragment thereof |
SG11202113312VA (en) | 2019-08-05 | 2021-12-30 | Regeneron Pharma | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist |
CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
WO2022186773A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION |
WO2022186772A1 (en) | 2021-03-01 | 2022-09-09 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
WO2023048651A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | Method for treatment of moderate to severe atoptic dematitis |
WO2023048650A1 (en) | 2021-09-27 | 2023-03-30 | Aslan Pharmaceuticals Pte Ltd | TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF |
TW202333784A (zh) | 2021-10-29 | 2023-09-01 | 新加坡商亞獅康私人有限公司 | 抗il13r抗體調配物 |
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WO2024054157A1 (en) | 2022-09-06 | 2024-03-14 | Aslan Pharmaceuticals Pte Ltd | Treatment for sleep loss or sleep disturbance in patients with dermatitis |
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AU718899C (en) | 1995-10-23 | 2004-01-29 | Amrad Operations Pty. Limited | A novel haemopoietin receptor and genetic sequences encoding same |
US5843659A (en) * | 1996-03-21 | 1998-12-01 | Apoptosis Technology, Inc. | Apoptosis gene EI24, compositions, and methods of use |
EP1449851A4 (en) | 2001-11-27 | 2005-11-16 | Mochida Pharm Co Ltd | NEUTRALIZING ANTIBODIES OF IL13 ALPHA RECEPTOR 1 |
AR037756A1 (es) * | 2001-12-17 | 2004-12-01 | Bayer Corp | Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma. |
CA2480059C (en) * | 2002-03-22 | 2015-11-24 | Amrad Operations Pty. Ltd. | Monoclonal antibody against interleukin-13 receptor alpha 1 (il-13r.alpha.1) |
US7625699B2 (en) * | 2003-03-10 | 2009-12-01 | Celera Corporation | Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof |
CN102408483B (zh) * | 2003-07-15 | 2016-06-08 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
-
2005
- 2005-12-30 TW TW097137970A patent/TW200902555A/zh unknown
- 2005-12-30 TW TW094147847A patent/TWI306862B/zh not_active IP Right Cessation
-
2006
- 2006-01-02 MX MX2007008128A patent/MX2007008128A/es active IP Right Grant
- 2006-01-02 BR BRPI0606368-3A patent/BRPI0606368A2/pt not_active IP Right Cessation
- 2006-01-02 SG SG2009087206A patent/SG172504A1/en unknown
- 2006-01-02 AU AU2006204480A patent/AU2006204480B2/en not_active Expired - Fee Related
- 2006-01-02 EP EP06706157A patent/EP1836226B1/en active Active
- 2006-01-02 KR KR1020077015296A patent/KR100934894B1/ko not_active IP Right Cessation
- 2006-01-02 RU RU2007129676/10A patent/RU2413736C2/ru not_active IP Right Cessation
- 2006-01-02 AT AT06706157T patent/ATE513855T1/de not_active IP Right Cessation
- 2006-01-02 CA CA2592614A patent/CA2592614C/en not_active Expired - Fee Related
- 2006-01-02 WO PCT/EP2006/000005 patent/WO2006072564A1/en active Application Filing
- 2006-01-02 JP JP2007548835A patent/JP5086098B2/ja not_active Expired - Fee Related
- 2006-01-02 NZ NZ556126A patent/NZ556126A/en not_active IP Right Cessation
- 2006-01-03 AR ARP060100010A patent/AR051888A1/es unknown
- 2006-01-03 US US11/325,197 patent/US7807158B2/en not_active Expired - Fee Related
-
2007
- 2007-06-25 IL IL184205A patent/IL184205A0/en unknown
- 2007-06-26 CR CR9209A patent/CR9209A/es not_active Application Discontinuation
- 2007-07-06 MA MA30048A patent/MA29226B1/fr unknown
- 2007-07-17 NO NO20073655A patent/NO20073655L/no not_active Application Discontinuation
-
2008
- 2008-06-23 HK HK08106940.0A patent/HK1112006A1/xx not_active IP Right Cessation
-
2010
- 2010-07-26 US US12/843,225 patent/US20110086026A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20073655L (no) | 2007-08-02 |
NZ556126A (en) | 2008-09-26 |
AU2006204480A1 (en) | 2006-07-13 |
KR100934894B1 (ko) | 2010-01-07 |
US20110086026A1 (en) | 2011-04-14 |
US20060263356A1 (en) | 2006-11-23 |
CA2592614C (en) | 2015-04-14 |
EP1836226B1 (en) | 2011-06-22 |
WO2006072564A1 (en) | 2006-07-13 |
JP2008526187A (ja) | 2008-07-24 |
TW200635945A (en) | 2006-10-16 |
SG172504A1 (en) | 2011-07-28 |
ATE513855T1 (de) | 2011-07-15 |
KR20070091180A (ko) | 2007-09-07 |
CR9209A (es) | 2007-08-28 |
HK1112006A1 (en) | 2008-08-22 |
AU2006204480B2 (en) | 2011-06-09 |
TWI306862B (en) | 2009-03-01 |
IL184205A0 (en) | 2007-10-31 |
CA2592614A1 (en) | 2006-07-13 |
TW200902555A (en) | 2009-01-16 |
US7807158B2 (en) | 2010-10-05 |
AR051888A1 (es) | 2007-02-14 |
RU2007129676A (ru) | 2009-02-10 |
JP5086098B2 (ja) | 2012-11-28 |
RU2413736C2 (ru) | 2011-03-10 |
MA29226B1 (fr) | 2008-02-01 |
MX2007008128A (es) | 2007-07-20 |
EP1836226A1 (en) | 2007-09-26 |
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