BRPI0606368A2 - anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma - Google Patents

anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma

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Publication number
BRPI0606368A2
BRPI0606368A2 BRPI0606368-3A BRPI0606368A BRPI0606368A2 BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2 BR PI0606368 A BRPI0606368 A BR PI0606368A BR PI0606368 A2 BRPI0606368 A2 BR PI0606368A2
Authority
BR
Brazil
Prior art keywords
nucleic acid
pharmaceutical composition
antibodies against
host cell
polypeptide
Prior art date
Application number
BRPI0606368-3A
Other languages
English (en)
Inventor
Josef Endl
Maria Elena Fuentes
Yvo Graus
Adelbert Grossmann
Sebastian Neumann
Paul Parren
Frank Rebers
Joerg Regula
Ralf Schumacher
Stefan Seeber
Jan Stracke
Kay-Gunnar Stubenrauch
Jan Van De Winkel
Vugt Martine Van
Sandra Vereecken-Verploegen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0606368A2 publication Critical patent/BRPI0606368A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

ANTICORPOS CONTRA RECEPTOR ALFA1 DE IL-13, USOS DOS MESMOS, COMPOSIçãO FARMACêUTICA, E MéTODO PARA FABRICAçãO DA MESMA, CéLULA HOSPEDEIRA RECOMBINANTE, áCIDO NUCLéICO, VETOR DE EXPRESSãO, MéTODO PARA A PRODUçãO DE UM POLIPEPTIDEO, BEM COMO LINHAGEM CELULAR DE HIBRIDOMA. A presente invenção refere-se a um anticorpo que se liga a IL-l3Ral, inibe a bioatividade de IL-13 e compreende uma cadeia pesada variável e leve variável, caracterizado pelo fato de que a seqúência de aminoácido de cadeia pesada variável CDR3 do dito anticorpo é selecionada a partir do grupo que consiste nas seqúências de CDR3 de cadeia pesada de SEQ ID NO: 1, 3, 5, 7 ou 9 é útil no tratamento de asma e doenças alérgicas.
BRPI0606368-3A 2005-01-03 2006-01-02 anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma BRPI0606368A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05000003 2005-01-03
EP05002229 2005-02-03
PCT/EP2006/000005 WO2006072564A1 (en) 2005-01-03 2006-01-02 Antibodies against il-13 receptor alpha 1 and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0606368A2 true BRPI0606368A2 (pt) 2009-06-23

Family

ID=36199730

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606368-3A BRPI0606368A2 (pt) 2005-01-03 2006-01-02 anticorpos contra receptor alfa1 de il-13, usos dos mesmos, composição farmacêitica, e método para fabricação da mesma, célula hospedeira recombinante, ácido nucléico, vetor de expressão, método para a produção de um polipeptìdeo , bem como linhagem celular de hibridoma

Country Status (20)

Country Link
US (2) US7807158B2 (pt)
EP (1) EP1836226B1 (pt)
JP (1) JP5086098B2 (pt)
KR (1) KR100934894B1 (pt)
AR (1) AR051888A1 (pt)
AT (1) ATE513855T1 (pt)
AU (1) AU2006204480B2 (pt)
BR (1) BRPI0606368A2 (pt)
CA (1) CA2592614C (pt)
CR (1) CR9209A (pt)
HK (1) HK1112006A1 (pt)
IL (1) IL184205A0 (pt)
MA (1) MA29226B1 (pt)
MX (1) MX2007008128A (pt)
NO (1) NO20073655L (pt)
NZ (1) NZ556126A (pt)
RU (1) RU2413736C2 (pt)
SG (1) SG172504A1 (pt)
TW (2) TW200902555A (pt)
WO (1) WO2006072564A1 (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
EP2769992B1 (en) * 2006-10-02 2020-12-30 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
WO2008049098A2 (en) 2006-10-19 2008-04-24 Merck & Co., Inc. ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR α1
ES2388567T3 (es) 2006-10-19 2012-10-16 Csl Limited Anticuerpos anti-il-13r alfa 1 y usos de los mismos
PL2068921T3 (pl) 2006-10-19 2014-12-31 Csl Ltd Przeciwciała o dużym powinowactwie będące antagonistami receptora alfa1 interleukiny 13
JP5064558B2 (ja) 2007-06-01 2012-10-31 エフ.ホフマン−ラ ロシュ アーゲー 免疫グロブリン精製
WO2009007272A1 (en) * 2007-07-10 2009-01-15 F. Hoffmann-La Roche Ag Novel formulation
EP2592147A1 (en) 2007-10-12 2013-05-15 F. Hoffmann-La Roche AG Protein expression from multiple nucleic acids
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
BRPI0821267A2 (pt) 2007-12-15 2015-06-16 Hoffmann La Roche Ensaio distintivo
LT3702371T (lt) * 2009-03-25 2023-01-10 Genentech, Inc. Anti-fgfr3 antikūnai ir jų panaudojimo būdai
JP5804599B2 (ja) * 2009-05-13 2015-11-04 国立研究開発法人理化学研究所 内臓脂肪型肥満の検査薬およびその利用
MX2012000735A (es) 2009-07-30 2012-01-27 Hoffmann La Roche Separador de columna de cromatografia movible.
WO2011038894A1 (en) 2009-10-01 2011-04-07 F. Hoffmann-La Roche Ag Protein a chromatography
MX342442B (es) 2009-10-01 2016-09-29 F Hoffmann-La Roche Ag * Filtracion final en multiples pasos.
KR101536388B1 (ko) 2009-10-19 2015-07-22 에프. 호프만-라 로슈 아게 비-교차반응성 항-IgG 항체
JP5686817B2 (ja) 2009-12-22 2015-03-18 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 配列依存性の凝集
CA3043423A1 (en) 2010-08-17 2012-02-23 F. Hoffmann-La Roche Ag Anti-human igg1 antibody
MX347297B (es) 2011-02-02 2017-04-21 Hoffmann La Roche Soporte para columna de cromatografía.
AU2012245205B2 (en) * 2011-04-21 2017-06-01 The Regents Of The University Of California, A California Corporation Compositions and methods for the treatment of neuromyelitis optica
PL3470432T3 (pl) 2012-08-21 2022-02-07 Sanofi Biotechnology Sposoby leczenia lub zapobiegania astmie przez podawanie antagonisty IL-4R
TWI633891B (zh) 2013-06-04 2018-09-01 再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
EP3010539B1 (en) 2013-06-21 2019-07-24 Sanofi Biotechnology Methods for treating nasal polyposis by administering an il-4r antagonist
RU2674996C2 (ru) 2013-07-04 2018-12-14 Ф. Хоффманн-Ля Рош Аг Иммуноферментный анализ с подавлением интерференции для определения антител к лекарствам в образцах сыворотки
TWI682781B (zh) 2013-07-11 2020-01-21 美商再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
CN117603354A (zh) 2013-12-20 2024-02-27 英特维特国际股份有限公司 具有经修饰的ch2-ch3序列的犬抗体
EP3107575B1 (en) 2014-02-21 2021-09-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
KR20220070544A (ko) 2014-02-28 2022-05-31 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
DK3201230T3 (da) 2014-09-30 2021-02-15 Intervet Int Bv Canine pd-l1-bindende pd-l1-antistoffer
CA2967602A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
ES2897965T3 (es) 2015-08-21 2022-03-03 Hoffmann La Roche Procedimiento para la reducción de proteínas de célula huésped en cromatografía de afinidad
EP3337812B1 (en) 2015-08-21 2021-04-28 F. Hoffmann-La Roche AG Method for the reduction of host cell proteins in affinity chromatography
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
WO2018011405A1 (en) * 2016-07-15 2018-01-18 Universität Zürich Il-13ralpha1 antibodies for use in treatment of atopic inflammation, sepsis and neutropenia
MA46098A (fr) 2016-09-01 2019-07-10 Regeneron Pharma Méthodes de prévention ou de traitement de l'allergie par administration d'un antagoniste d'il-4 r
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
TW202332696A (zh) 2016-12-01 2023-08-16 美商再生元醫藥公司 治療發炎症狀的方法
EP3551034A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
HUE064655T2 (hu) 2017-10-30 2024-04-28 Sanofi Biotechnology IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban
WO2019183266A1 (en) 2018-03-21 2019-09-26 ALX Oncology Inc. Antibodies against signal-regulatory protein alpha and methods of use
CN112153982A (zh) 2018-05-13 2020-12-29 瑞泽恩制药公司 用于通过施用il-4r抑制剂治疗特应性皮炎的方法
CN113348011B (zh) 2018-11-19 2023-04-18 比奥拉治疗股份有限公司 用生物治疗剂治疗疾病的方法和装置
CA3132587A1 (en) 2019-03-21 2020-09-24 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
AU2020247175A1 (en) 2019-03-26 2021-10-14 Aslan Pharmaceuticals Pte Ltd Treatment employing anti-IL-13R antibody or binding fragment thereof
SG11202113312VA (en) 2019-08-05 2021-12-30 Regeneron Pharma Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
CN115666704A (zh) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 用于将治疗剂递送至胃肠道的可摄取装置
WO2022186773A1 (en) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION
WO2022186772A1 (en) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF
WO2023048651A1 (en) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd Method for treatment of moderate to severe atoptic dematitis
WO2023048650A1 (en) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF
TW202333784A (zh) 2021-10-29 2023-09-01 新加坡商亞獅康私人有限公司 抗il13r抗體調配物
WO2024043837A1 (en) 2022-08-26 2024-02-29 Aslan Pharmaceuticals Pte Ltd High concentration anti-il13r antibody formulation
WO2024054157A1 (en) 2022-09-06 2024-03-14 Aslan Pharmaceuticals Pte Ltd Treatment for sleep loss or sleep disturbance in patients with dermatitis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
AU718899C (en) 1995-10-23 2004-01-29 Amrad Operations Pty. Limited A novel haemopoietin receptor and genetic sequences encoding same
US5843659A (en) * 1996-03-21 1998-12-01 Apoptosis Technology, Inc. Apoptosis gene EI24, compositions, and methods of use
EP1449851A4 (en) 2001-11-27 2005-11-16 Mochida Pharm Co Ltd NEUTRALIZING ANTIBODIES OF IL13 ALPHA RECEPTOR 1
AR037756A1 (es) * 2001-12-17 2004-12-01 Bayer Corp Anticuerpo que inhibe la actividad del factor de las celulas precursoras y su uso para el tratamiento del asma.
CA2480059C (en) * 2002-03-22 2015-11-24 Amrad Operations Pty. Ltd. Monoclonal antibody against interleukin-13 receptor alpha 1 (il-13r.alpha.1)
US7625699B2 (en) * 2003-03-10 2009-12-01 Celera Corporation Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
CN102408483B (zh) * 2003-07-15 2016-06-08 安姆根有限公司 作为选择性ngf途径抑制剂的人抗ngf中和抗体

Also Published As

Publication number Publication date
NO20073655L (no) 2007-08-02
NZ556126A (en) 2008-09-26
AU2006204480A1 (en) 2006-07-13
KR100934894B1 (ko) 2010-01-07
US20110086026A1 (en) 2011-04-14
US20060263356A1 (en) 2006-11-23
CA2592614C (en) 2015-04-14
EP1836226B1 (en) 2011-06-22
WO2006072564A1 (en) 2006-07-13
JP2008526187A (ja) 2008-07-24
TW200635945A (en) 2006-10-16
SG172504A1 (en) 2011-07-28
ATE513855T1 (de) 2011-07-15
KR20070091180A (ko) 2007-09-07
CR9209A (es) 2007-08-28
HK1112006A1 (en) 2008-08-22
AU2006204480B2 (en) 2011-06-09
TWI306862B (en) 2009-03-01
IL184205A0 (en) 2007-10-31
CA2592614A1 (en) 2006-07-13
TW200902555A (en) 2009-01-16
US7807158B2 (en) 2010-10-05
AR051888A1 (es) 2007-02-14
RU2007129676A (ru) 2009-02-10
JP5086098B2 (ja) 2012-11-28
RU2413736C2 (ru) 2011-03-10
MA29226B1 (fr) 2008-02-01
MX2007008128A (es) 2007-07-20
EP1836226A1 (en) 2007-09-26

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