BRPI0812288A2 - Purificação de imunoglobulina. - Google Patents

Purificação de imunoglobulina.

Info

Publication number
BRPI0812288A2
BRPI0812288A2 BRPI0812288-1A2A BRPI0812288A BRPI0812288A2 BR PI0812288 A2 BRPI0812288 A2 BR PI0812288A2 BR PI0812288 A BRPI0812288 A BR PI0812288A BR PI0812288 A2 BRPI0812288 A2 BR PI0812288A2
Authority
BR
Brazil
Prior art keywords
immunoglobulin purification
immunoglobulin
purification
Prior art date
Application number
BRPI0812288-1A2A
Other languages
English (en)
Inventor
Roberto Falkenstein
Claudia Giessel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38440174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0812288(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0812288A2 publication Critical patent/BRPI0812288A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
BRPI0812288-1A2A 2007-06-01 2008-05-28 Purificação de imunoglobulina. BRPI0812288A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07010840 2007-06-01
PCT/EP2008/004231 WO2008145351A1 (en) 2007-06-01 2008-05-28 Immunoglobulin purification

Publications (1)

Publication Number Publication Date
BRPI0812288A2 true BRPI0812288A2 (pt) 2014-11-25

Family

ID=38440174

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812288-1A2A BRPI0812288A2 (pt) 2007-06-01 2008-05-28 Purificação de imunoglobulina.

Country Status (14)

Country Link
US (3) US9493548B2 (pt)
EP (1) EP2152745B2 (pt)
JP (1) JP5064558B2 (pt)
KR (1) KR101226353B1 (pt)
CN (1) CN101679509A (pt)
AU (1) AU2008256411B2 (pt)
BR (1) BRPI0812288A2 (pt)
CA (1) CA2687837A1 (pt)
ES (1) ES2449148T5 (pt)
IL (1) IL201388A0 (pt)
MX (1) MX2009012786A (pt)
RU (1) RU2009148891A (pt)
TW (1) TWI395609B (pt)
WO (1) WO2008145351A1 (pt)

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RU2009148891A (ru) * 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
US20110105725A1 (en) * 2008-05-15 2011-05-05 Novo Nordisk A/S Antibody purification process
BRPI0923541A2 (pt) 2008-12-22 2016-01-26 Hoffmann La Roche purificação de imunoglobulina
WO2011073389A1 (en) 2009-12-18 2011-06-23 Novartis Ag Wash solution and method for affinity chromatography
WO2011090719A2 (en) * 2009-12-29 2011-07-28 Dr. Reddy's Laboratories Ltd. Protein purification by ion exchange
KR101555740B1 (ko) 2010-03-10 2015-09-25 에프. 호프만-라 로슈 아게 면역글로불린 용액 정제 방법
MX2012011737A (es) 2010-04-14 2012-11-16 Hoffmann La Roche Remocion de agregado de inmunoglobulina.
WO2011159074A2 (ko) * 2010-06-17 2011-12-22 Jeon Sook Yeong 치료용 면역글로불린 제제 제조장치 및 이를 이용한 제조방법
WO2012030512A1 (en) * 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
US20130289247A1 (en) * 2010-11-01 2013-10-31 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
US8911992B2 (en) * 2011-04-28 2014-12-16 Bio-Rad Laboratories, Inc. DNA removal in target molecule purification
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
EP2726496B1 (en) 2011-07-01 2018-04-04 F.Hoffmann-La Roche Ag Method for separation of monomeric polypeptides from aggregated polypeptides
WO2013028330A2 (en) * 2011-08-19 2013-02-28 Emd Millipore Corporation Methods of reducing level of one of more impurities in a sample during protein purification
JP6356607B2 (ja) 2011-11-02 2018-07-11 ジェネンテック， インコーポレイテッド オーバーロード／溶出クロマトグラフィー
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
ES2381828B1 (es) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
CN110054661A (zh) 2013-12-12 2019-07-26 Emd密理博公司 使用含丙烯酰胺的过滤器分离蛋白
EP3102589A1 (en) * 2014-02-04 2016-12-14 Biogen MA Inc. Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
CN106414476B (zh) * 2014-03-11 2019-12-31 株式会社绿十字控股 用于纯化免疫球蛋白的方法
CA2960797A1 (en) 2014-11-06 2016-05-12 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding and methods of use
WO2016093251A1 (ja) * 2014-12-08 2016-06-16 旭化成メディカル株式会社 生理活性物質の精製方法
EP3773969A1 (en) * 2018-04-03 2021-02-17 Merck Patent GmbH Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds
CN109336970A (zh) * 2018-11-09 2019-02-15 杭州奕安济世生物药业有限公司 阳离子交换层析法纯化抗体的方法
US20220324945A1 (en) 2019-07-31 2022-10-13 Kyowa Kirin Co., Ltd. Method for purifying antibody using adsorbent

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GB2201904B (en) 1987-02-14 1990-12-19 Domnick Hunter Filters Ltd Device for liquid chromatography or immobilised enzyme reaction
US5118796A (en) 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
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WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
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WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
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IT1271461B (it) 1993-12-01 1997-05-28 Menarini Ricerche Sud Spa Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
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US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5610285A (en) * 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
AU735883C (en) 1997-06-13 2002-02-07 Genentech Inc. Protein recovery by chromatography followed by filtration upon a charged layer
ATE321066T1 (de) * 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
WO1999062936A1 (en) * 1998-06-01 1999-12-09 Genentech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
AU1344102A (en) * 2000-10-12 2002-04-22 Genentech Inc Reduced-viscosity concentrated protein formulations
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ES2629602T5 (es) 2002-09-11 2021-06-08 Genentech Inc Purificación de proteínas
EP1601697B1 (en) 2003-02-28 2007-05-30 Lonza Biologics plc Antibody purification by Protein A and ion exchange chromatography
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WO2006024497A1 (en) * 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
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TWI306862B (en) 2005-01-03 2009-03-01 Hoffmann La Roche Antibodies against il-13 receptor alpha 1 and uses thereof
JP2006249082A (ja) 2005-03-08 2006-09-21 Pharmacia & Upjohn Co Llc 低減レベルの内毒素を有する抗ｍ−ｃｓｆ抗体組成物
TWI320788B (en) 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
WO2007075283A2 (en) * 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
US20100069617A1 (en) * 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
EP2726496B1 (en) 2011-07-01 2018-04-04 F.Hoffmann-La Roche Ag Method for separation of monomeric polypeptides from aggregated polypeptides

Also Published As

Publication number Publication date
US20170137497A1 (en) 2017-05-18
US9493548B2 (en) 2016-11-15
CA2687837A1 (en) 2008-12-04
AU2008256411B2 (en) 2013-08-22
RU2009148891A (ru) 2011-07-20
ES2449148T3 (es) 2014-03-18
US20100311952A1 (en) 2010-12-09
KR20100028064A (ko) 2010-03-11
JP2010528076A (ja) 2010-08-19
EP2152745B2 (en) 2023-03-15
TW200904503A (en) 2009-02-01
EP2152745A1 (en) 2010-02-17
EP2152745B1 (en) 2014-01-08
TWI395609B (zh) 2013-05-11
IL201388A0 (en) 2010-05-31
US20200377574A1 (en) 2020-12-03
JP5064558B2 (ja) 2012-10-31
CN101679509A (zh) 2010-03-24
MX2009012786A (es) 2009-12-10
WO2008145351A1 (en) 2008-12-04
US10590186B2 (en) 2020-03-17
KR101226353B1 (ko) 2013-01-24
ES2449148T5 (es) 2023-06-14
AU2008256411A1 (en) 2008-12-04
US11261238B2 (en) 2022-03-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.