MA29374B1 - Anticorps anti-ccr5 et leurs utilisations - Google Patents

Anticorps anti-ccr5 et leurs utilisations

Info

Publication number
MA29374B1
MA29374B1 MA30257A MA30257A MA29374B1 MA 29374 B1 MA29374 B1 MA 29374B1 MA 30257 A MA30257 A MA 30257A MA 30257 A MA30257 A MA 30257A MA 29374 B1 MA29374 B1 MA 29374B1
Authority
MA
Morocco
Prior art keywords
seq
constituted
cdr1
cdr2
group
Prior art date
Application number
MA30257A
Other languages
English (en)
Inventor
Michael Brandt
Suryanarayana Sankuratri
Ralf Schumacher
Stefan Seeber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29374B1 publication Critical patent/MA29374B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'INVENTION CONCERNE UN ANTICORPS SE LIANT AU CCR5 HUMAIN, COMPRENANT UNE CHAÎNE LOURDE VARIABLE ET UNE CHAÎNE LÉGÈRE VARIABLE, SE CARACTÉRISANT EN CE QUE LA CHAÎNE LOURDE VARIABLE COMPREND DES SÉQUENCES CDR, CDR1, CDR2 ET CDR3, CDR1 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 9, 10, 11, 12, CDR2 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 13, 14, 15, CDR3 ÉTANT SÉLECTIONNÉE DANS LE GROUPE CONSTITUÉ PAR SEQ ID NO: 16, 17, LESDITES CDR ÉTANT SÉLECTIONNÉES INDÉPENDAMMENT LES UNES DES AUTRES, OU EST UN VARIANT HUMANISÉ CHIMÉRIQUE OU UN FRAGMENT DUDIT ANTICORPS. L'ANTICORPS SELON L'INVENTION PRÉSENTE DES PROPRIÉTÉS AVANTAGEUSES DANS LE TRAITEMENT DES MALADIES IMMUNOSUPPRESSIVES.
MA30257A 2005-04-01 2007-09-27 Anticorps anti-ccr5 et leurs utilisations MA29374B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05007138 2005-04-01

Publications (1)

Publication Number Publication Date
MA29374B1 true MA29374B1 (fr) 2008-04-01

Family

ID=34934663

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30257A MA29374B1 (fr) 2005-04-01 2007-09-27 Anticorps anti-ccr5 et leurs utilisations

Country Status (19)

Country Link
US (1) US7615216B2 (fr)
EP (2) EP1869087A2 (fr)
JP (2) JP4733736B2 (fr)
KR (1) KR20070116136A (fr)
CN (1) CN101175771A (fr)
AR (1) AR052959A1 (fr)
AU (1) AU2006228663A1 (fr)
BR (1) BRPI0609792A2 (fr)
CA (1) CA2603692A1 (fr)
CR (1) CR9393A (fr)
IL (1) IL186071A0 (fr)
MA (1) MA29374B1 (fr)
MX (1) MX2007011842A (fr)
NO (1) NO20074867L (fr)
RU (1) RU2007139953A (fr)
SG (1) SG151284A1 (fr)
TW (1) TW200720289A (fr)
WO (1) WO2006103100A2 (fr)
ZA (1) ZA200708332B (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1981911A2 (fr) * 2006-01-30 2008-10-22 F.Hoffmann-La Roche Ag Compositions synergiques destinees au traitement du vih
TW200817438A (en) * 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
EP2074147B1 (fr) 2006-09-29 2012-03-21 F. Hoffmann-La Roche AG Anticorps diriges contre le ccr5 et leurs utilisations
CL2008000707A1 (es) 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
CA2710912A1 (fr) * 2008-01-15 2009-07-23 F. Hoffmann-La Roche Ag Anticorps afucosyles contre ccr5 et leurs utilisations
WO2010028796A1 (fr) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Anticorps hexavalents trispécifiques
WO2010028798A1 (fr) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Anticorps multivalents
US9631008B2 (en) 2008-12-22 2017-04-25 Hoffmann-La Roche Inc. Immunoglobulin purification
SG175004A1 (en) 2009-04-02 2011-11-28 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
WO2010115589A1 (fr) 2009-04-07 2010-10-14 Roche Glycart Ag Anticorps trivalents bispécifiques
PE20120540A1 (es) 2009-05-27 2012-05-09 Hoffmann La Roche Anticuerpos triespecificos o tetraespecificos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
TWI412375B (zh) 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體
TW201113037A (en) 2009-08-28 2011-04-16 Hoffmann La Roche Antibodies against CDCP1 for the treatment of cancer
CN102483408A (zh) 2009-09-07 2012-05-30 弗·哈夫曼-拉罗切有限公司 用于糖基化分析的糖肽的es-ms
RU2573915C2 (ru) 2009-09-16 2016-01-27 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применение
NZ600262A (en) 2009-12-22 2013-06-28 Roche Glycart Ag Anti-her3 antibodies and uses thereof
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
WO2012010582A1 (fr) 2010-07-21 2012-01-26 Roche Glycart Ag Anticorps anti-cxcr5 et leurs méthodes d'utilisation
CA2807278A1 (fr) 2010-08-24 2012-03-01 F. Hoffmann - La Roche Ag Anticorps bispecifiques comprenant un fragment fv stabilise par bisulfure
US9187564B2 (en) 2010-10-05 2015-11-17 Hoffmann-La Roche Inc. Antibodies against human TWEAK and uses thereof
EP2655413B1 (fr) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
WO2012113813A1 (fr) * 2011-02-23 2012-08-30 F. Hoffmann-La Roche Ag Anticorps contre il33r humain et ses utilisations
RU2607038C2 (ru) 2011-02-28 2017-01-10 Ф. Хоффманн-Ля Рош Аг Антигенсвязывающие белки
CA2824824A1 (fr) 2011-02-28 2012-09-07 F. Hoffmann-La Roche Ag Proteines monovalentes de liaison a l'antigene
WO2013024022A1 (fr) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire
BR112014006537A2 (pt) 2011-09-23 2017-11-28 Roche Glycart Ag anticorpos biespecíficos, formulação farmacêutica, usos de um anticorpo biespecífico, método de tratamento, ácido nucleico, vetores de expressão, célula hospedeira e método para a produção de um anticorpo biespecífico
US9365881B2 (en) 2011-10-05 2016-06-14 Hoffmann-La Roche Inc. Process for antibody G1 glycoform production
JP6486686B2 (ja) 2012-02-10 2019-03-20 ジェネンテック， インコーポレイテッド 単鎖抗体及び他のヘテロ多量体
KR20150013188A (ko) 2012-05-24 2015-02-04 에프. 호프만-라 로슈 아게 다중특이적 항체
CA2871882A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Methode de fabrication de conjugues d'anticorps a region fc comprenant au moins une entite de liaison qui se lie specifiquement a une cible et leurs utilisations
CN104395339A (zh) 2012-06-27 2015-03-04 弗·哈夫曼-拉罗切有限公司 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
EP3055329B1 (fr) 2013-10-11 2018-06-13 F. Hoffmann-La Roche AG Anticorps à chaîne variable légère commune échangés dans un domaine multispécifique
WO2015082446A1 (fr) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps anti-cdcp1 et d'un taxane
UA117289C2 (uk) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
JP6721590B2 (ja) 2014-12-03 2020-07-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性抗体
EP3551046B1 (fr) 2016-12-07 2023-07-19 Biora Therapeutics, Inc. Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal
CA3045310A1 (fr) 2016-12-14 2018-06-21 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal avec une chimoikine/un inhibiteur du recepteur de chimiokine
AU2019302603A1 (en) 2018-07-13 2021-01-14 Nanjing Legend Biotech Co., Ltd. Co-receptor systems for treating infectious diseases
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
CN114901700A (zh) * 2019-11-21 2022-08-12 尤尼蒂生物技术公司 针对tie-2的抗体及其使用方法
CN115666704A (zh) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 用于将治疗剂递送至胃肠道的可摄取装置
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DE3675588D1 (de) * 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・２・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5202238A (en) * 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US6743594B1 (en) * 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
WO1997045543A2 (fr) 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Recepteur 5 de cc chemokine, anticorps diriges contre ce dernier et animaux transgeniques
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
DE69833755T2 (de) 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
US20030099645A1 (en) 2000-10-10 2003-05-29 Lobo Peter Isaac Naturally occuring IgM antibodies that bind to membrane receptors on lymphocytes
US6610834B1 (en) 1998-11-18 2003-08-26 Peter I. Lobo Human IgM antibodies to chemokine receptors
JP2002534959A (ja) 1998-12-08 2002-10-22 バイオベーション リミテッド 免疫原性タンパク質の改変方法
EP2088158A3 (fr) 1998-12-16 2010-01-20 Progenics Pharmaceuticals, Inc. Anticorp monoclonal contre le récepteur CCR5 de chimokine.
CN1345336A (zh) 1999-03-11 2002-04-17 麦克美特股份公司 抗体和趋化因子构建物及其在自身免疫疾病治疗中的用途
WO2001042308A2 (fr) * 1999-12-08 2001-06-14 Novartis Ag Methodes et compositions utiles pour l'inhibition de l'infection, dependante de ccr5, de cellules par vhi-1
AU2265701A (en) 1999-12-16 2001-06-25 Tanox, Inc. Anti-hiv-1 conjugates for treatment of hiv disease
WO2001058915A2 (fr) 2000-02-09 2001-08-16 Human Genome Sciences, Inc. Recepteur humain de chimiokines couple aux proteines g (ccr5) hdgnr10
US20040043033A1 (en) 2000-05-01 2004-03-04 Green Lorrence H. Method and vaccine for the prevention of AIDS
US7138119B2 (en) 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US20030165988A1 (en) * 2002-02-08 2003-09-04 Shaobing Hua High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
US7005503B2 (en) 2002-02-08 2006-02-28 Genetastix Corporation Human monoclonal antibody against coreceptors for human immunodeficiency virus
US20020147147A1 (en) 2000-11-16 2002-10-10 Karin Molling Nucleic acid molecules encoding a protein interacting with the chemokine receptor CCR5 or other chemokine receptor family members
EP1207202A1 (fr) 2000-11-16 2002-05-22 Mölling, Karin, Inst. für med. Virologie der Uni. Zürich Molécules d'acide nucléique interagissant avec le récepteur de chémokines et d'autres membres de la famille de récepteurs de chémokines
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US20030003440A1 (en) 2001-03-14 2003-01-02 Lucia Lopalco Novel CCR5 epitope and antibodies against it
US20020146415A1 (en) 2001-04-06 2002-10-10 Olson William C. Methods for inhibiting HIV-1 infection
US7060273B2 (en) 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
AU2002337885B1 (en) 2001-10-16 2003-04-28 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Broadly cross-reactive neutralizing antibodies against human ummunodeficiency virus selected by Env-CD4-co-receptor complexes
AU2003209059A1 (en) 2002-02-08 2003-09-02 Genetastix Corporation Human monoclonal antibodies against membrane proteins
RU2322454C2 (ru) * 2002-02-22 2008-04-20 Проджиникс Фармасьютикалз, Инк. Антитело против ccr5
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody

Also Published As

Publication number Publication date
KR20070116136A (ko) 2007-12-06
TW200720289A (en) 2007-06-01
ZA200708332B (en) 2009-04-29
EP1869087A2 (fr) 2007-12-26
AR052959A1 (es) 2007-04-11
IL186071A0 (en) 2008-01-20
AU2006228663A1 (en) 2006-10-05
RU2007139953A (ru) 2009-05-10
EP2336183A2 (fr) 2011-06-22
US20070036796A1 (en) 2007-02-15
EP2336183A3 (fr) 2011-10-12
MX2007011842A (es) 2007-10-11
SG151284A1 (en) 2009-04-30
BRPI0609792A2 (pt) 2010-04-27
CA2603692A1 (fr) 2006-10-05
JP2008533998A (ja) 2008-08-28
WO2006103100A2 (fr) 2006-10-05
CR9393A (es) 2008-02-20
JP2011079836A (ja) 2011-04-21
JP4733736B2 (ja) 2011-07-27
CN101175771A (zh) 2008-05-07
US7615216B2 (en) 2009-11-10
WO2006103100A3 (fr) 2006-12-28
NO20074867L (no) 2007-12-07

Similar Documents

Publication Publication Date Title
MA29374B1 (fr) Anticorps anti-ccr5 et leurs utilisations
NZ623319A (en) Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
RU2376316C2 (ru) Человеческие антитела против человеческого 4-1вв (cd137)
RU2505603C2 (ru) Антитело против рецептора il-6
MA35345B1 (fr) Proteines de liaisons a un antigene ayant une liaison accrue a fcrn
RS54393B1 (en) HUMAN MONOCLONAL ANTIBODIES ON KINASE-1 SIMILAR TO ACTIVE RECEPTOR
NZ604090A (en) Human anti-b7rp1 neutralizing antibodies
PE20141398A1 (es) Anticuerpos neutralizantes de citomegalovirus humano
MA42542B1 (fr) Molécules se liant à pd-1 et méthodes d'utilisation correspondantes
NZ599683A (en) Anti-ilt7 antibody
NZ611387A (en) Selected antibodies binding to anionic phospholipids and aminophospholipids and their use in treatment
TNSN04078A1 (fr) Antibodies to cd40
PE20121552A1 (es) Anticuerpos monoclonales anti cea humanizados de afinidad madura
HRP20090527T1 (en) Nogo-a neutralising immunoglobulins for treatment of neurological diseases
EA200970879A1 (ru) Связывающие белки, включающие антитела, производные антител и фрагменты антител, которые специфически связываются с cd154, и их применения
NZ594466A (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
TW200738748A (en) Human monoclonal antibody human CD134 (OX40) and methods of making and using same
WO2005110474A3 (fr) ANTICORPS SPÉCIFIQUES FcϜRIIB HUMANISÉS ET MÉTHODES D’UTILISATION
PE20120079A1 (es) Moleculas de anticuerpos mejoradas
RS80704A (en) ANTI- av?6.ANTIBODIES
KR101155294B1 (ko) 면역특이적으로 ＢＬｙＳ에 결합하는 항체
PE20120343A1 (es) Anticuerpo anti-cmet que comprende una region bisagra
UA90457C2 (ru) Человеческое моноклональное антитело, которое специфически связывается с м-csf человека и блокирует связывание м-csf с с-fms
MA29226B1 (fr) Anticorps diriges contre le recepteur alpha 1 de il-13 et leurs utilisations
MA33387B1 (fr) Polypeptides et procede de traitement