KR102112373B1

KR102112373B1 - 펩티드모방체 마크로사이클

Info

Publication number: KR102112373B1
Application number: KR1020147025489A
Authority: KR
Inventors: 빈센트 구에르라바이스; 카를 엘킨; 후우 엠. 나쉬; 토미 케이. 소이어; 브래드포드 제이. 그라비스; 에릭 페이팡트
Original assignee: 에일러론 테라퓨틱스 인코포레이티드
Priority date: 2012-02-15
Filing date: 2013-02-14
Publication date: 2020-05-18
Also published as: JP2015509940A; SG11201404648PA; PH12014501844A1; AU2013221432A1; US20220000968A1; PH12014501844B1; ES2817877T3; BR112014020103A2; EP2822572A4; IL233710B; KR20140122759A; US20150051155A1; SG10201606775YA; AU2013221432B2; RU2014137107A; US10967042B2; MX362492B; IL233710A0; EP3769776A1; CN112500466B

Abstract

본원에서는 펩티드모방체 마크로사이클, 및 질환을 치료하기 위해 상기 펩티드모방체 마크로사이클을 사용하는 방법을 제공한다.

Description

펩티드모방체 마크로사이클{PEPTIDOMIMETIC MACROCYCLES}

서열 목록

본 출원은 EFS-Web을 통해 ASCII 포맷으로 제출된 서열 목록을 포함한다. 2013년 3월 20일 작성된 상기 ASCII 사본의 명칭은 35224-766.601_SL.txt이고, 크기는 1,201,625 바이트이다.

인간 전사 인자 단백질인 p53은 DNA 손상 및 세포 스트레스에 대한 반응으로 세포 주기 정지 및 아폽토시스를 유도하여 세포를 세포를 악성 형질전환으로부터 보호하는 데 있어 중요한 역할을 한다. (HDM2로도 알려져 있는) E3 유비퀴틴 리가제 MDM2는 p53 트랜스활성화 활성을 중화시키고, p53 단백질의 핵으로부터의 외수송을 유도하고, 유비퀴틴화 프로테아좀 경로를 통한 분해로 p53을 표적화하는 직접적인 결합 상호작용을 통해 p53을 음성적으로 조절한다. 결실, 돌연변이, 또는 MDM2 과다발현에 의한 p53 활성 손실이 인간 암에 있어 가장 일반적인 결함이다. 야생형 p53을 발현하는 종양은 활성 p53의 농도를 안정화시키거나, 증가시키는 약리 작용제에 영향을 받기 쉽다. 이와 관련하여, MDM2의 활성을 억제시키는 것이 시험관내 및 생체내에서 p53 활성을 회복시키고, 암 세포를 아폽토시스에 대해 재감작화시키는 입증된 접근법으로서 부상하였다. 더욱 최근에는 MDMX (MDM4)가 p53의 유사한 음성 조절 인자인 것으로서 확인되었으며, 연구를 통해 MDM2의 p53 결합 계면과 MDMX의 것 사이의 유의적인 구조상의 상동성이 밝혀졌다. p53-MDM2 및 p53-MDMX 단백질-단백질 상호작용은, MDM2 및 MDMX의 표면상의 틈새 내로 삽입되는, p53의 동일한 15개의 잔기로된 알파 나선형 트랜스활성화 도메인에 의해 매개된다. p53의 상기 도메인 내의 3개의 잔기(F19, W23, 및 L26)가 MDM2 및 MDMX에의 결합에 필수적이다.

p53, MDM2 및/또는 MDMX에 결합하여 그의 활성을 조절할 수 있는 화합물이 여전히 상당히 요구되고 있다. 본원에서는 p53의 활성을 조절하는 p53 기반 펩티드모방체 마크로사이클을 제공한다. 본원에서는 p53, MDM2 및/또는 MDMX 단백질 사이의 상호작용을 억제시키는 p53 기반 펩티드모방체 마크로사이클 또한 제공한다. 추가로, 본원에서는 암 및 다른 과증식성 질환을 포함하나, 이에 한정되지 않는 질환을 치료하는 데 사용될 수 있는 p53 기반 펩티드모방체 마크로사이클을 제공한다.

본 발명의 요약

본원에서는 인간 p53의 일부와 관련된 안정하게 가교 결합된 펩티드("p53 펩티드모방체 마크로사이클)를 기술한다. 상기 가교 결합된 펩티드는 p53의 MDM2에의 결합, 및 p53의 MDMX에의 결합에 중요한 것으로 간주되는 p53의 일부의 알파 나선형 2차 구주를 안정화시키는 데 도움을 줄 수 있는 분자내 가교 결합을 함께 형성하는 2개 이상의 변형된 아미노산을 포함한다. 따라서, 본원에 기술된 가교 결합된 폴리펩티드는 가교 결합되지 않은 상응하는 폴리펩티드에 비해 개선된 생물학적 활성을 가질 수 있다. p53 펩티드모방체 마크로사이클은 p53의 MDM2에의 결합, 및/또는 p53의 MDMX에의 결합을 방해하여 작용성 p53을 유리시키고, 그의 파괴를 억제시키는 것으로 것으로 간주된다. 본원에 기술된 p53 펩티드모방체 마크로사이클은 치료학적으로, 예를 들어, 바람직하지 않게 낮은 p53 수준 또는 낮은 p53 활성을 특징으로 하는 암 및 다른 장애를 치료하고/거나, 바람직하지 않게 높은 MDM2 또는 MDMX 활성 수준을 특징으로 하는 암 및 다른 장애를 치료하는 데 사용될 수 있다. p53 펩티드모방체 마크로사이클은 또한 p53 전사 경로 조절 파괴와 관련이 되며, 이를 통해 부적절한 세포 주기 정지 및 아폽토시스의 병증, 예컨대, 신경퇴행 및면역 결핍 이외에도, 과도한 세포 생존 및 증식의 병증, 예컨대, 암 및 자가면역을 유도하는 임의의 장애를 치료하는 데 유용할 수 있다. 일부 실시양태에서, p53 펩티드모방체 마크로사이클은 MDM2(예컨대, 진뱅크(GenBank)® 수탁 번호: 228952; GL228952) 및/또는 MDMX(MDM4로도 지칭된다; 진뱅크® 수탁 번호: 88702791; GL88702791)에 결합한다.

한 측면에서, 본원에서는 표 1, 표 1a, 표 1b, 또는 표 1c 중의 아미노산 서열로 이루어진 군으로부터 선택되는 아미노산 서열과 약 60%, 80%, 90%, 또는 95% 이상 동일한 아미노산 서열을 포함하는 펩티드모방체 마크로사이클을 제공한다. 별법으로, 상기 펩티드모방체 마크로사이클의 아미노산 서열은 표 4 중의 아미노산 서열로 이루어진 군으로부터 선택된다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 표 2a 또는 2b에 제시되어 있는 펩티드는 아니다. 다른 경우에서, 펩티드모방체 마크로사이클은 표 2a 또는 2b에 제시되어 있는 것과 같은 구조를 포함하지 않는다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 표 1로부터 선택된 아미노산 서열을 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 표 1a로부터 선택된 아미노산 서열을 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 표 1b로부터 선택된 아미노산 서열을 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 표 1c로부터 선택된 아미노산 서열을 가진다.

별법으로, 상기 펩티드모방체 마크로사이클의 아미노산 서열은 상기와 같이 선택되며, 추가로, 여기서, 마크로사이클은 티오에테르 또는 트리아졸을 포함하지 않는다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 나선부(helix), 예컨대, α 나선부를 포함한다. 다른 실시양태에서, 펩티드모방체 마크로사이클은 α,α-이치환된 아미노산을 포함한다. 펩티드모방체 마크로사이클은 2개 이상의 아미노산의 α 위치를 연결하는 가교제를 포함할 수 있다. 상기 두 아미노산 중 적어도 하나는 α,α-이치환된 아미노산일 수 있다.

일부 실시양태에서, 하기 화학식 I의 펩티드모방체 마크로사이클을 제공한다:

<화학식 I>

상기 식에서,

각각의 A, C, D, 및 E는 독립적으로 아미노산이고;

B는 아미노산,

, [-NH-L₃-CO-], [-NH-L₃-SO₂-], 또는 [-NH-L₃-]이고;

R₁ 및 R₂는 독립적으로 비치환되거나 또는 할로로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 사이클로알킬알킬, 헤테로알킬, 또는 헤테로사이클로알킬이거나; 또는 R₁ 및 R₂ 중 하나 이상이 상기 D 또는 E 아미노산 중 하나의 알파 위치에 연결된 마크로사이클 형성 링커 L'을 형성하고;

R₃은 임의적으로 R₅로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 헤테로알킬, 사이클로알킬, 헤테로사이클로알킬, 사이클로알킬알킬, 사이클로아릴, 또는 헤테로사이클로아릴이고;

각각의 L 또는 L'은 독립적으로 식 -L₁-L₂-의 마크로사이클 형성 링커이고;

L₁ 및 L₂ 및 L₃은 독립적으로, 각각 임의적으로 R₅로 치환된, 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 사이클로알킬렌, 헤테로사이클로알킬렌, 사이클로아릴렌, 헤테로사이클로아릴렌, 또는 [-R₄-K-R₄-]_n이고;

각각의 R₄는 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 사이클로알킬렌, 헤테로사이클로알킬렌, 아릴렌, 또는 헤테로아릴렌이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

각각의 R₅는 독립적으로 할로겐, 알킬, -OR₆, -N(R₆)₂, -SR₆, -SOR₆, -SO₂R₆, -CO₂R₆, 형광성 모이어티, 방사성 동위원소 또는 치료제이고;

각각의 R₆은 독립적으로 -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 형광성 모이어티, 방사성 동위원소 또는 치료제이고;

R₇은 임의적으로 R₅로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 사이클로아릴, 또는 헤테로사이클로아릴, 또는 D 잔기를 포함하는 사이클릭 구조의 일부이고;

R₈은 임의적으로 R₅로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 사이클로아릴, 또는 헤테로사이클로아릴, 또는 E 잔기를 포함하는 사이클릭 구조의 일부이고;

v 및 w는 독립적으로 정수 1-1,000, 예를 들어, 1-500, 1-200, 1-100, 1-50, 1-30, 1-20, 또는 1-10이고;

u는 정수 1-10, 예를 들어, 1-5, 1-3 또는 1-2이고;

x, y 및 z는 독립적으로 정수 0-10이고, 예를 들어, x+y+z의 합계는 2, 3, 또는 6이고;

n은 정수 1-5이다.

일부 실시양태에서, w>2이고, E로 나타낸 처음 2개의 아미노산은 각각 비하전된 측쇄 또는 음으로 하전된 측쇄를 포함한다.

일부 실시양태에서, E로 나타낸 첫번째 C 말단 아미노산 및/또는 두번째 C 말단 아미노산은 소수성 측쇄를 포함한다. 예를 들어, E로 나타낸 첫번째 C 말단 아미노산 및/또는 두번째 C 말단 아미노산은 소수성 측쇄, 예를 들어, 큰(large) 소수성 측쇄를 포함한다.

일부 실시양태에서, w는 3 내지 1,000이다. 예를 들어, E로 나타낸 세번째 아미노산은 큰 소수성 측쇄를 포함한다.

다른 실시양태에서, 청구되는 바와 같은 펩티드모방체 마크로사이클은

Ac-RTQATF$r8NQWAibANle$TNAibTR-NH₂(서열 번호 1)_,

Ac-RTQATF$r8NQWAibANle$TNAibTR-NH₂(서열 번호 2),

Ac-$r8SQQTFS$LWRLLAibQN-NH₂(서열 번호 3),

Ac-QSQ$r8TFSNLW$LLAibQN-NH₂(서열 번호 4),

Ac-QS$r5QTFStNLW$LLAibQN-NH₂(서열 번호 5), 또는

Ac-QSQQ$r8FSNLWR$LAibQN-NH₂(서열 번호 6)의 서열을 배제한다.

Ac-Q$r8QQTFSN$WRLLAibQN-NH₂(서열 번호 7)의 서열을 배제한다.

하기 화학식의 펩티드모방체 마크로사이클 또한 제공한다:

상기 식에서,

각각의 Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀은 개별적으로 아미노산이고, 여기서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 3개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)(여기서, 각각의 X는 아미노산이다)의 상응하는 위치의 아미노산과 동일한 아미노산이고;

각각의 D 및 E는 독립적으로 아미노산이고;

L₁ 및 L₂는 독립적으로, 각각 임의적으로 R₅로 치환된, 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 사이클로알킬렌, 헤테로사이클로알킬렌, 사이클로아릴렌, 헤테로사이클로아릴렌, 또는 [-R₄-K-R₄-]_n이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

v는 정수 1-1,000, 예를 들어, 1-500, 1-200, 1-100, 1-50, 1-30, 1-20, 또는 1-10이고;

w는 정수 3-1,000, 예를 들어, 3-500, 3-200, 3-100, 3-50, 3-30, 3-20, 또는 3-10이고;

n은 정수 1-5이다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 하기 화학식을 가진다:

상기 식에서,

각각의 Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀은 개별적으로 아미노산이고, 여기서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 3개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)(여기서, 각각의 X는 아미노산이다)의 상응하는 위치의 아미노산과 동일한 아미노산이고;

각각의 D는 독립적으로 아미노산이고;

각각의 E는 독립적으로 아미노산, 예를 들어, Ala(알라닌), D-Ala(D-알라닌), Aib(α-아미노이소부티르산), Sar(N-메틸 글리신), 및 Ser(세린)으로부터 선택되는 아미노산이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

n은 정수 1-5이다.

상기 식에서,

각각의 Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀은 개별적으로 아미노산이고, 여기서, Xaa₃, Xaa₅, Xaa₆, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 2개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)(여기서, 각각의 X는 아미노산이다)의 상응하는 위치의 아미노산과 동일한 아미노산이고;

각각의 D 및 E는 독립적으로 아미노산이고;

각각의 L 또는 L'은 독립적으로 식 -L₁-L₂-의 마크로사이클 형성 링커이고, 여기서, L은 E 배위(configuration)로 하나 이상의 이중 결합을 포함하고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

v는 정수 1-1,000이고;

w는 정수 3-1,000이고;

n는 정수 1-5이고;

Xaa₇은 Boc 보호된 트립토판이다.

본원에 기술된 화학식 중 임의의 것의 일부 실시양태에서, [D]_v는 -Leu₁-Thr ₂이다. 본원에 기술된 화학식의 다른 실시양태에서, E로 나타낸 세번째 아미노산 이외의 각각의 E는 Ala(알라닌), D-Ala(D-알라닌), Aib(α-아미노이소부티르산), Sar(N-메틸 글리신), 및 Ser(세린)으로부터 선택되는 아미노산이다.

일부 실시양태에서, w는 정수 3-10, 예를 들어, 3-6, 3-8, 6-8, 또는 6-10이다. 일부 실시양태에서, w는 3이다. 다른 실시양태에서, w는 6이다. 일부 실시양태에서, v는 정수 1-10, 예를 들어, 2-5이다. 일부 실시양태에서, v는 2이다.

일부 실시양태에서, 본원에 개시된 펩티드는 적어도 부분적으로는 L17, V46, M50, (포켓의 테두리를 형성하는) Y96 및 L99의 MDMX 아미노산 측쇄에 의해 정의되는 결합 부위에 결합한다. 이론으로 제한하지 않으면서, 상기 결합 부위에의 결합을 통해 하나 이상의 특성, 예컨대, 결합 친화도, 아폽토시스 유도, 시험관내 또는 생체내 항종양 효능은 개선되거나, 또는 MDMX 대 MDM2에의 결합 친화도 비는 감소된다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 MDM2 또는 MDMX에의 개선된 결합 친화도를 가진다. 다른 경우에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 MDMX 대 MDM2에의 결합 친화도 비가 감소된다. 추가의 다른 경우에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 p53 양성 종양 세포주에 대해 개선된 시험관내 항종양 효능을 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 p53 양성 종양 세포주에서 개선된 시험관내 아폽토시스 유도를 보인다. 다른 경우에서, 제1항의 펩티드모방체 마크로사이클인 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 p53 양성 대 p53 음성 또는 돌연변이체 종양 세포주에 대해 개선된 시험관내 항종양 효능 비를 가진다. 일부 경우에서, 개선된 시험관내 효능 비는 1-29, ≥30-49, 또는 ≥50이다. 추가의 다른 경우에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 p53 양성 종양에 대해 개선된 생체내 항종양 효능을 가진다. 일부 경우에서, 개선된 생체내 효능 비 -29, ≥30-49, 또는 ≥50이다. 추가의 다른 경우에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 p53 양성 종양에서 개선된 생체내 아폽토시스 유도를 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 개선된 세포 투과성을 가진다. 다른 경우에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, w는 0, 1 또는 2이다)에 비하여 개선된 용해도를 가진다.

일부 실시양태에서, Xaa₅는 Glu 또는 그의 아미노산 유사체이다. 일부 실시양태에서, Xaa₅는 Glu 또는 그의 아미노산 유사체이고, 여기서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 개선된 특성, 예컨대, 개선된 결합 친화도, 개선된 용해도, 개선된 세포 효능, 개선된 세포 투과성, 개선된 생체내 또는 시험관내 항종양 효능, 또는 개선된 아폽토시스 유도를 가진다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 MDM2 또는 MDMX에의 개선된 결합 친화도를 가진다. 다른 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 MDMX vs MDM2에의 결합 친화도 비가 감소된다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 개선된 용해도를 가지거나, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 개선된 세포 효능을 가진다.

일부 실시양태에서, Xaa₅는 Glu 또는 그의 아미노산 유사체이고, 여기서, 펩티드모방체 마크로사이클은 상응하는 펩티드모방체 마크로사이클(여기서, Xaa₅는 Ala이다)에 비하여 개선된 생물학적 활성, 예컨대, 개선된 결합 친화도, 개선된 용해도, 개선된 세포 효능, 개선된 나선도(helicity), 개선된 세포 투과성, 개선된 생체내 또는 시험관내 항종양 효능, 또는 개선된 아폽토시스 유도를 가진다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 p53-/- 세포주에 대한 그의 결합 친화도보다 2배, 3배, 5배, 10배, 20배, 30배, 50배, 70배, 또는 100배 이상 더 큰 활성을 p53+/+ 세포주에 대하여 가진다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 p53-/- 세포주에 대한 그의 결합 친화도보다 1 내지 29배, 30 내지 49배, 또는 ≥50배 더 큰 활성을 p53+/+ 세포주에 대하여 가진다. 활성은 예를 들어, IC₅₀ 값으로서 측정될 수 있다. 예를 들어, p53+/+ 세포주는 SJSA-1, RKO, HCT-116, 또는 MCF-7이고, p53-/- 세포주는 RKO-E6 또는 SW-480이다. 일부 실시양태에서, 펩티드는 p53+/+ 세포주에 대하여 1 μM 미만의 IC₅₀을 가진다.

일부 실시양태에서, Xaa₅는 Glu 또는 그의 아미노산 유사체이고, 펩티드모방체 마크로사이클은 p53-/- 세포주에 대한 그의 결합 친화도보다 10배 이상 더 큰 활성을 p53+/+ 세포주에 대하여 가진다.

추가로, 피험체에게 펩티드모방체 마크로사이클을 투여하는 단계를 포함하는, 피험체에서 암을 치료하는 방법을 제공한다. 일부 실시양태에서, 암은 두경부암, 흑색종, 폐암, 유방암, 또는 신경교종이다.

피험체에게 펩티드모방체 마크로사이클을 투여하는 단계를 포함하는, 피험체에서 p53 또는 MDM2 또는 MDMX의 활성을 조절하는 방법, 또는 피험체에게 상기 펩티드모방체 마크로사이클을 투여하는 단계를 포함하는, 피험체에서 p53과 MDM2 및/또는 MDMX 단백질 사이의 상호작용을 길항시키는 방법 또한 제공한다.

본원에서는 하기 화학식 II의 화합물을 촉매로 처리하여 화학식 I의 화합물을 수득하는 단계를 포함하는, 표 1, 표 1a, 표 1b, 또는 표 1c 중의 아미노산 서열로 이루어진 군으로부터 선택되는 아미노산 서열과 약 60% 내지 약 100% 동일한 아미노산 서열을 포함하는, 하기 화학식 I의 펩티드모방체 마크로사이클을 포함하는 조성물을 제조하는 방법을 제공한다:

<화학식 I>

<화학식 II>

화학식 I 및 II의 화합물(들)에서,

각각의 A, C, D, 및 E는 독립적으로 아미노산이고;

각각의 B는 독립적으로 아미노산,

, [-NH-L₃-CO-], [-NH-L₃-SO₂-], 또는 [-NH-L₃-]이고;

각각의 R₁ 및 R₂는 독립적으로 비치환되거나 또는 할로로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 사이클로알킬알킬, 헤테로알킬, 또는 헤테로사이클로알킬이거나; 또는 R₁ 및 R₂ 중 하나 이상이 D 또는 E 아미노산 중 하나의 알파 위치에 연결된 마크로사이클 형성 링커 L'을 형성하고;

각각의 R₃은 독립적으로 임의적으로 R₅로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 헤테로알킬, 사이클로알킬, 헤테로사이클로알킬, 사이클로알킬알킬, 사이클로아릴, 또는 헤테로사이클로아릴이고;

각각의 L'은 독립적으로 식 -L₁-L₂-의 마크로사이클 형성 링커이고;

각각의 L₁, L₂ 및 L₃은 독립적으로, 각각 임의적으로 R₅로 치환된, 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 사이클로알킬렌, 헤테로사이클로알킬렌, 사이클로아릴렌, 헤테로사이클로아릴렌, 또는 [-R₄-K-R_4'-]_n이고;

각각의 R₄ 및 R_4'는 독립적으로 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 사이클로알킬렌, 헤테로사이클로알킬렌, 아릴렌, 또는 헤테로아릴렌이고;

각각의 K는 독립적으로 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

각각의 R₆은 독립적으로 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 형광성 모이어티, 방사성 동위원소 또는 치료제이고;

각각의 R₇은 독립적으로 임의적으로 R₅로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 사이클로아릴, 또는 헤테로사이클로아릴, 또는 D 잔기를 포함하는 사이클릭 구조의 일부이고;

각각의 R₈은 독립적으로 임의적으로 R₅로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 사이클로아릴, 또는 헤테로사이클로아릴, 또는 E 잔기를 포함하는 사이클릭 구조의 일부이고;

각각의 v 및 w는 독립적으로 정수 1-1,000이고;

u는 정수 1-10이고;

각각의 x, y 및 z는 독립적으로 정수 0-10이고;

각각의 n은 독립적으로 정수 1-5이고;

각각의 o는 독립적으로 정수 1 내지 15이고;

각각의 p는 독립적으로 정수 1 내지 15이고;

"(E)"는 트랜스 이중 결합을 나타내고;

화학식 I 및 II의 화합물에 존재하는 아미노산 A, C 및/또는 B(B가 아미노산일 때) 중 하나 이상은 보호기를 보유하는 측쇄를 가진다.

일부 실시양태에서, 보호기는 질소 원자 보호기이다.

일부 실시양태에서, 보호기는 Boc 기이다.

일부 실시양태에서, 보호기를 보유하는 아미노산의 측쇄는 보호된 인돌을 포함한다.

일부 실시양태에서, 그의 측쇄 상의 보호기를 보유하는 아미노산은 그의 인돌 질소 상에서 보호기에 의해 보호된 트립토판(W)이다. 예를 들어, 보호기는 Boc 기이다.

일부 실시양태에서, 화학식 II의 화합물을 촉매와 접촉시키는 단계 후, 화학식 I의 화합물을 Z 이성체인 상응하는 화합물과 동량으로, 또는 그보다 많은 양으로 수득된다. 예를 들어, 화학식 II의 화합물을 촉매와 접촉시키는 단계 후, 화학식 I의 화합물을 Z 이성체인 상응하는 화합물보다 2, 3, 4, 5, 6, 7, 8, 9, 또는 10배 더 많은 양으로 수득된다.

일부 실시양태에서, 촉매는 루테늄 촉매이다.

일부 실시양태에서, 본 방법은 화학식 I의 화합물을 환원제 또는 산화제로 처리하는 단계를 추가로 포함한다.

일부 실시양태에서, 화학식 II의 화합물을 고체 지지체에 부착시킨다. 다른 실시양태에서, 화학식 II의 화합물을 고체 지지체에 부착시키지 않는다.

일부 실시양태에서, 본 방법은 화학식 I의 화합물로부터 보호기(들)를 제거하는 단계를 추가로 포함한다.

일부 실시양태에서, 폐환 복분해(ring closing metathesis)는 약 20℃ 내지 약 80℃ 범위의 온도에서 수행된다.

일부 실시양태에서, 화학식 I의 펩티드모방체 마크로사이클은 하기 화학식을 가진다:

상기 식에서,

각각의 Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀은 개별적으로 아미노산이고, 여기서, Xaa₃, Xaa₅, Xaa₆, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 2개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)(여기서, 각각의 X는 아미노산이다)의 상응하는 위치의 아미노산과 동일한 아미노산이고;

각각의 D 및 E는 독립적으로 아미노산이고;

각각의 L 또는 L'은 독립적으로 식 -L₁-L₂-의 마크로사이클 형성 링커이고, 여기서, L은 E 배위로 하나 이상의 이중 결합을 포함하고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

v는 정수 1-1,000이고;

w는 정수 3-1,000이고;

n은 정수 1-5이고;

Xaa₇은 Boc 보호된 트립토판이다.

일부 실시양태에서, 화학식 I의 펩티드모방체 마크로사이클은 α 나선부를 포함한다.

본 발명의 신규한 특징은 특히 첨부된 특허청구범위에 기술되어 있다. 본 발명의 원리가 사용되는, 예시적인 실시양태를 기술하는 하기의 상세한 설명, 및 첨부된 도면을 참조하면 본 발명의 특징 및 이점을 잘 이해될 것이다:
도 1은 MDMX(프라이머리 스위스프로트(Primary SwissProt) 수탁 번호 Q7ZUW7; 엔트리 MDM4_DANRE)와 복합체를 형성하고 있는, 펩티드모방체 마크로사이클 46(표 2b)인 p53 펩티드모방체 마크로사이클의 구조를 보여주는 것이다.
도 2는 MDMX(프라이머리 스위스프로트 수탁 번호 Q7ZUW7; 엔트리 MDM4_DANRE)에 결합된 p53 펩티드모방체 마크로사이클 142(표 2b) 및 SP43의 중첩된 구조를 보여주는 것이다.
도 3은 마우스 MCF-7 이종이식편 모델에서 SP154인 펩티드모방체 마크로사이클이 종양 성장에 미치는 효과를 보여주는 것이다.
도 4는 마우스 MCF-7 이종이식편 모델에서 SP249인 펩티드모방체 마크로사이클이 종양 성장에 미치는 효과를 보여주는 것이다.
도 5는 마우스 MCF-7 이종이식편 모델에서 SP315인 펩티드모방체 마크로사이클이 종양 성장에 미치는 효과를 보여주는 것이다.
도 6은 마우스 MCF-7 이종이식편 모델에서 SP252인 SP154의 점 돌연변이가 종양 성장에 미치는 효과를 보여주는 것이다.
도 7은 다양한 C 말단 연장부를 가지는 펩티드모방체 마크로사이클에 대한 용해도 플롯을 보여주는 것이다.

본원에서 사용되는 바, "마크로사이클(macrocycle)"이라는 용어는 9개 이상의 공유 결합된 원자에 의해 형성된 고리 또는 사이클을 포함하는 화학 구조를 가지는 분자를 의미한다.

본원에서 사용되는 바, "펩티드모방체 마크로사이클(peptidomimetic macrocycle)" 또는 "가교 결합된 폴리펩티드"라는 용어는 같은 복수 개의 펩티드 결합에 의해 결합된 복수 개의 아미노산 잔기, 및 분자 내의 제1 자연적으로 발생된 또는 비자연적으로 발생된 아미노산 잔기(또는 유사체)와 제2 자연적으로 발생된 or 비자연적으로 발생된 아미노산 잔기(또는 유사체) 사이에 마크로사이클을 형성하는 하나 이상의 마크로사이클 형성 링커를 포함하는 화합물을 의미한다. 펩티드모방체 마크로사이클은, 마크로사이클 형성 링커가 제1 아미노산 잔기(또는 유사체)의 α 탄소를 제2 아미노산 잔기(또는 유사체)의 α 탄소에 연결하는 것인 실시양태를 포함한다. 펩티드모방체 마크로사이클은 임의적으로 하나 이상의 아미노산 잔기 및/또는 아미노산 유사체 잔기 사이에 하나 이상의 비펩티드 결합을 포함하고, 임의적으로 마크로사이클을 형성하는 임의의 것 이외에도, 하나 이상의 비자연적으로 발생된 아미노산 잔기 또는 아미노산 유사체 잔기를 포함한다. 펩티드모방체 마크로사이클과 관련하여 언급될 때, "상응하는 비가교 결합된 폴리펩티드"란 마크로사이클과 길이가 동일하고, 마크로사이클에 상응하는 야생형 서열의 등가인 천연 아미노산을 포함하는 폴리펩티드에 관한 것으로 이해된다.

본원에서 사용되는 바, "안정성"이라는 용어는 원편광 이색성, NMR 또는 또 다른 생물리학적 척도, 또는 시험관내 또는 생체내 단백질분해성 분해에 대한 저항성에 의해 측정된 바, 용액 중 정의된 2차 구조가 펩티드모방체 마크로사이클에 의해 유지된다는 것을 의미한다. 본원에서 고려되는 2차 구조에 관한 비제한적인 예로는 α 나선부, 3₁₀ 나선부, β 선회부, 및 β 병풍 구조가 있다.

본원에서 사용되는 바, "나선 안정성"이라는 용어는 원편광 이색성 또는 NMR에 의해 측정된 바, 나선 구조가 펩티드모방체 마크로사이클에 의해 유지된다는 것을 의미한다. 예를 들어, 일부 실시양태에서, 원편광 이색성에 의해 측정된 바, 펩티드모방체 마크로사이클은 상응하는 비가교 결합된 마크로사이클과 비교하여 1.25, 1.5, 1.75 또는 2배 이상 증가된 α 나선도를 보인다.

"아미노산"이라는 용어는 아미노 기 및 카복실 기, 둘 모두를 함유하는 분자를 의미한다. 적합한 아미노산으로는 제한 없이, 유기 합성 또는 다른 대사 경로에 의해 제조된, 자연적으로 발생된 아미노산 뿐만 아니라, 비-자연적으로 발생된 아미노산의 D 및 L 이성체, 둘 모두를 포함한다. 본원에서 사용되는 바, 아미노산이라는 용어는 제한 없이, α-아미노산, 천연 아미노산, 비천연 아미노산, 및 아미노산 유사체를 포함한다.

"α-아미노산"이라는 용어는 α-탄소로 지정된 탄소에 결합된, 아미노 기 및 카복실 기, 둘 모두를 함유하는 분자를 의미한다.

"β-아미노산"이라는 용어는 β 배위로 아미노 기 및 카복실 기, 둘 모두를 함유하는 분자를 의미한다.

"자연적으로 발생된 아미노산"이라는 용어는 자연상에서 합성된 펩티드 중에서 통상 발견되며, 1문자 약어 A, R, N, C, D, Q, E, G, H, I, L, K, M, F, P, S, T, W, Y 및 V로 공지된, 20종의 아미노산 중 어느 하나를 의미한다.

하기 표에는 천연 아미노산의 특성에 관한 요약이 제시되어 있다:

"소수성 아미노산"은 작은 소수성 아미노산 및 큰 소수성 아미노산을 포함한다. "작은 소수성 아미노산"은 글리신, 알라닌, 프롤린, 및 그의 유사체이다. "큰 소수성 아미노산"은 발린, 류신, 이소류신, 페닐알라닌, 메티오닌, 트립토판, 및 그의 유사체이다. "극성 아미노산"은 세린, 트레오닌, 아스파라긴, 글루타민, 시스테인, 티로신, 및 그의 유사체이다. "하전된 아미노산"은 리신, 아르기닌, 히스티딘, 아스파테이트, 글루타메이트, 및 그의 유사체이다.

"아미노산 유사체"라는 용어는 아미노산과 구조상 유사하고, 펩티드모방체 마크로사이클에서 아미노산 대신으로 치환될 수 있는 분자를 의미한다. 아미노산 유사체는 제한 없이, β-아미노산, 및 아미노 기 또는 카복시 기가 유사한 반응성을 가진 기로 치환된 아미노산(예컨대, 1차 아민을 2차 또는 3차 아민으로 치환, 또는 카복시 기를 에스테르로 치환)을 포함한다.

"비천연 아미노산"이라는 용어는 자연상에서 합성된 펩티드 중에서 통상 발견되며, 1문자 약어 A, R, N, C, D, Q, E, G, H, I, L, K, M, F, P, S, T, W, Y 및 V로 공지된, 20종의 아미노산 중 하나가 아닌 아미노산을 의미한다. 비천연 아미노산 유사체은 제한 없이, 하기에 따른 구조를 포함한다:

아미노산 유사체는 β-아미노산 유사체를 포함한다. β-아미노산 유사체의 예로는 하기를 포함하나, 이에 한정되지 않는다: 사이클릭 β-아미노산 유사체; β-알라닌; (R)-β-페닐알라닌; (R)-1,2,3,4-테트라하이드로-이소퀴놀린-3-아세트산; (R)-3-아미노-4-(1-나프틸)-부티르산; (R)-3-아미노-4-(2,4-디클로로페닐)부티르산; (R)-3-아미노-4-(2-클로로페닐)-부티르산; (R)-3-아미노-4-(2-시아노페닐)-부티르산; (R)-3-아미노-4-(2-플루오로페닐)-부티르산; (R)-3-아미노-4-(2-푸릴)-부티르산; (R)-3-아미노-4-(2-메틸페닐)-부티르산; (R)-3-아미노-4-(2 나프틸)-부티르산; (R)-3-아미노-4-(2-티에닐)-부티르산; (R)-3-아미노-4-(2-트리플루오로메틸페닐)-부티르산; (R)-3-아미노-4-(3,4-디클로로페닐)부티르산; (R)-3-아미노-4-(3,4-디플루오로페닐)부티르산; (R)-3-아미노-4-(3-벤조티에닐)-부티르산; (R)-3-아미노-4-(3-클로로페닐)-부티르산; (R)-3-아미노-4-(3-시아노페닐)-부티르산; (R)-3-아미노-4-(3-플루오로페닐)-부티르산; (R)-3-아미노-4-(3-메틸페닐)-부티르산; (R)-3-아미노-4-(3-피리딜)-부티르산; (R)-3-아미노-4-(3-티에닐)-부티르산; (R)-3-아미노-4-(3-트리플루오로메틸페닐)-부티르산; (R)-3-아미노-4-(4-브로모페닐)-부티르산; (R)-3-아미노-4-(4-클로로페닐)-부티르산; (R)-3-아미노-4-(4-시아노페닐)-부티르산; (R)-3-아미노-4-(4-플루오로페닐)-부티르산; (R)-3-아미노-4-(4-요오도페닐)-부티르산; (R)-3-아미노-4-(4-메틸페닐)-부티르산; (R)-3-아미노-4-(4-니트로페닐)-부티르산; (R)-3-아미노-4-(4-피리딜)-부티르산; (R)-3-아미노-4-(4-트리플루오로메틸페닐)-부티르산; (R)-3-아미노-4-펜타플루오로-페닐부티르산; (R)-3-아미노-5-헥세노익산; (R)-3-아미노-5-헥시노익산; (R)-3-아미노-5-페닐펜탄산; (R)-3-아미노-6-페닐-5-헥세노익산; (S)-1,2,3,4-테트라하이드로-이소퀴놀린-3-아세트산; (S)-3-아미노-4-(1 나프틸)-부티르산; (S)-3-아미노-4-(2,4-디클로로페닐)부티르산; (S)-3-아미노-4-(2-클로로페닐)-부티르산; (S)-3-아미노-4-(2-시아노페닐)-부티르산; (S)-3-아미노-4-(2-플루오로페닐)-부티르산; (S)-3-아미노-4-(2-푸릴)-부티르산; (S)-3-아미노-4-(2-메틸페닐)-부티르산; (S)-3-아미노-4-(2 나프틸)-부티르산; (S)-3-아미노-4-(2-티에닐)-부티르산; (S)-3-아미노-4-(2-트리플루오로메틸페닐)-부티르산; (S)-3-아미노-4-(3,4-디클로로페닐)부티르산; (S)-3-아미노-4-(3,4-디플루오로페닐)부티르산; (S)-3-아미노-4-(3-벤조티에닐)-부티르산; (S)-3-아미노-4-(3-클로로페닐)-부티르산; (S)-3-아미노-4-(3-시아노페닐)-부티르산; (S)-3-아미노-4-(3-플루오로페닐)-부티르산; (S)-3-아미노-4-(3-메틸페닐)-부티르산; (S)-3-아미노-4-(3-피리딜)-부티르산; (S)-3-아미노-4-(3-티에닐)-부티르산; (S)-3-아미노-4-(3-트리플루오로메틸페닐)-부티르산; (S)-3-아미노-4-(4-브로모페닐)-부티르산; (S)-3-아미노-4-(4-클로로페닐)-부티르산; (S)-3-아미노-4-(4-시아노페닐)-부티르산; (S)-3-아미노-4-(4-플루오로페닐)-부티르산; (S)-3-아미노-4-(4-요오도페닐)-부티르산; (S)-3-아미노-4-(4-메틸페닐)-부티르산; (S)-3-아미노-4-(4-니트로페닐)-부티르산; (S)-3-아미노-4-(4-피리딜)-부티르산; (S)-3-아미노-4-(4-트리플루오로메틸페닐)-부티르산; (S)-3-아미노-4-펜타플루오로-페닐부티르산; (S)-3-아미노-5-헥세노익산; (S)-3-아미노-5-헥시노익산; (S)-3-아미노-5-페닐펜탄산; (S)-3-아미노-6-페닐-5-헥세노익산; 1,2,5,6-테트라하이드로피리딘-3-카복실산; 1,2,5,6-테트라하이드로피리딘-4-카복실산; 3-아미노-3-(2-클로로페닐)-프로피온산; 3-아미노-3-(2-티에닐)-프로피온산; 3-아미노-3-(3-브로모페닐)-프로피온산; 3-아미노-3-(4-클로로페닐)-프로피온산; 3-아미노-3-(4-메톡시페닐)-프로피온산; 3-아미노-4,4,4-트리플루오로-부티르산; 3-아미노아디프산; D-β-페닐알라닌; β-류신; L-β-호모알라닌; L-β-호모아스파르트산 γ-벤질 에스테르; L-β-호모글루탐산δ-벤질 에스테르; L-β-호모이소류신; L-β-호모류신; L-β-호모메티오닌; L-β-호모페닐알라닌; L-β-호모프롤린; L-β-호모트립토판; L-β-호모발린; L-Nω-벤질옥시카보닐-β-호모리신; Nω-L-β-호모아르기닌; O-벤질-L-β-호모하이드록시프롤린; O-벤질-L-β-호모세린; O-벤질-L-β-호모트레오닌; O-벤질-L-β-호모티로신; γ-트리틸-L-β-호모아스파라긴; (R)-β-페닐알라닌; L-β-호모아스파르트산 γ-1-부틸 에스테르; L-β-호모글루탐산δ-1-부틸 에스테르; L-Nω-β-호모리신; Nδ-트리틸-L-β-호모글루타민; Nω-2,2,4,6,7-펜타메틸-디하이드로벤조푸란-5-술포닐-L-β-호모아르기닌; 0-1-부틸-L-β-호모하이드록시-프롤린; O-1-부틸-L-β-호모세린; O-1-부틸-L-β-호모트레오닌; O-1-부틸-L-β-호모티로신; 2-아미노사이클로펜탄 카복실산; 및 2-아미노사이클로헥산 카복실산.

아미노산 유사체로는 알라닌, 발린, 글리신 또는 류신의 유사체를 포함한다. 알라닌, 발린, 글리신, 및 류신의 아미노산 유사체의 예로는 하기: α-메톡시글리신; α-알릴-L-알라닌; α-아미노이소부티르산; α-메틸-류신; β-(1 나프틸)-D-알라닌; β-(1 나프틸)-L-알라닌; β-(2 나프틸)-D-알라닌; β-(2 나프틸)-L-알라닌; β-(2-피리딜)-D-알라닌; β-(2-피리딜)-L-알라닌; β-(2-티에닐)-D-알라닌; β-(2-티에닐)-L-알라닌; β-(3-벤조티에닐)-D-알라닌; β-(3-벤조티에닐)-L-알라닌; β-(3-피리딜)-D-알라닌; β-(3-피리딜)-L-알라닌; β-(4-피리딜)-D-알라닌; β-(4-피리딜)-L-알라닌; β-클로로-L-알라닌; β-시아노-L-알라닌; β-사이클로헥실-D-알라닌; β-사이클로헥실-L-알라닌; β-사이클로펜텐-1-일-알라닌; β-사이클로펜틸-알라닌; β-사이클로프로필-L-Ala-OH·디사이클로헥실암모늄 염; β-1-부틸-D-알라닌; β-1-부틸-L-알라닌; γ-아미노부티르산; L-α,β-디아미노프로피온산; 2,4-디니트로-페닐글리신; 2,5-디하이드로-D-페닐글리신; 2-아미노-4,4,4-트리플루오로부티르산; 2-플루오로-페닐글리신; 3-아미노-4,4,4-트리플루오로-부티르산; 3-플루오로-발린; 4,4,4-트리플루오로-발린; 4,5-데하이드로-L-leu-OH·디사이클로헥실암모늄 염; 4-플루오로-D-페닐글리신; 4-플루오로-L-페닐글리신; 4-하이드록시-D-페닐글리신; 5,5,5-트리플루오로-류신; 6-아미노헥사노산; 사이클로펜틸-D-Gly-OH·디사이클로헥실암모늄 염; 사이클로펜틸-Gly-OH·디사이클로헥실암모늄 염; D-,β-디아미노프로피온산; D-α-아미노부티르산; D-α-1-부틸글리신; D-(2-티에닐) 글리신; D-(3-티에닐) 글리신; D-2-아미노카프로산; D-2-인다닐글리신; D-알릴글리신'디사이클로헥실암모늄 염; D-사이클로헥실글리신; D-노르발린; D-페닐글리신; β-아미노부티르산; β-아미노이소부티르산; (2-브로모페닐)글리신; (2-메톡시페닐)글리신; (2-메틸페닐)글리신; (2-티아졸릴)글리신; (2-티에닐)글리신; 2-아미노-3-(디메틸아미노)-프로피온산; L-α,β-디아미노프로피온산; L-α-아미노부티르산; L-α-1-부틸글리신; L-(3-티에닐)글리신; L-2-아미노-3-(디메틸아미노)-프로피온산; L-2-아미노카프로산 디사이클로헥실-암모늄 염; L-2-인다닐글리신; L-알릴글리신·디사이클로헥실 암모늄 염; L-사이클로헥실글리신; L-페닐글리신; L-프로파길글리신; L-노르발린; N-α-아미노메틸-L-알라닌; D-α,γ-디아미노부티르산; L-α,γ-디아미노부티르산; β-사이클로프로필-L-알라닌; (N-β-(2,4-디니트로페닐))-L-α,β-디아미노프로피온산; (N-β-1-(4,4-디메틸-2,6-디옥소사이클로헥스-1-일리덴)에틸)-D-α,β-디아미노프로피온산; (N-β-1-(4,4-디메틸-2,6-디옥소사이클로헥스-1-일리덴)에틸)-L-α,β-디아미노프로피온산; (N-β-4-메틸트리틸)-L-α,β-디아미노프로피온산; (N-β-알릴옥시카보닐)-L-α,β-디아미노프로피온산; (N-γ-1-(4,4-디메틸-2,6-디옥소사이클로헥스-1-일리덴)에틸)-D-α,γ-디아미노부티르산; (N-γ-1-(4,4-디메틸-2,6-디옥소사이클로헥스-1-일리덴)에틸)-L-α,γ-디아미노부티르산; (N-γ-4-메틸트리틸)-D-α,γ-디아미노부티르산; (N-γ-4-메틸트리틸)-L-α,γ-디아미노부티르산; (N-γ-알릴옥시카보닐)-L-α,γ-디아미노부티르산; L-α,γ-디아미노부티르산; 4,5-데하이드로-L-류신; 사이클로펜틸-D-Gly-OH; 사이클로펜틸-Gly-OH; D-알릴글리신; D-호모사이클로헥실알라닌; L-1-피레닐알라닌; L-2-아미노카프로산; L-알릴글리신; L-호모사이클로헥실알라닌; 및 N-(2-하이드록시-4-메톡시-Bzl)-Gly-OH를 포함하나, 이에 한정되지 않는다.

아미노산 유사체로는 아르기닌 또는 리신의 유사체를 포함한다. 아르기닌 및 리신의 아미노산 유사체의 예로는 하기: 시트룰린; L-2-아미노-3-구아니디노프로피온산; L-2-아미노-3-우레이도프로피온산; L-시트룰린; Lys(Me)₂- OH; Lys(N₃)-OH; Nδ-벤질옥시카보닐-L-오르니틴; Nω-니트로-D-아르기닌; Nω-니트로-L-아르기닌; α-메틸-오르니틴; 2,6-디아미노헵탄디오산; L-오르니틴; (Nδ-1-(4,4-디메틸-2,6-디옥소-사이클로헥스-1-일리덴)에틸)-D-오르니틴; (Nδ-1-(4,4-디메틸-2,6-디옥소-사이클로헥스-1-일리덴)에틸)-L-오르니틴; (Nδ-4-메틸트리틸)-D-오르니틴; (Nδ-4-메틸트리틸)-L-오르니틴; D-오르니틴; L-오르니틴; Arg(Me)(Pbf)-OH; Arg(Me)₂- OH(비대칭); Arg(Me)2-OH(대칭); Lys(ivDde)-OH; Lys(Me)2-OH·HCl; Lys(Me3)-OH 클로라이드; Nω-니트로-D-아르기닌; 및 Nω-니트로-L-아르기닌을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 아스파르트산 또는 글루탐산의 유사체를 포함한다. 아스파르트산 및 글루탐산의 아미노산 유사체의 예로는 하기: α-메틸-D-아스파르트산; α-메틸-글루탐산; α-메틸-L-아스파르트산; γ-메틸렌-글루탐산; (N-γ-에틸)-L-글루타민; [N-α-(4-아미노벤조일)]-L-글루탐산; 2,6-디아미노피멜산; L-α-아미노수베르산; D-2-아미노아디프산; D-α-아미노수베르산; α-아미노피멜산; 이미노디아세트산; L-2-아미노아디프산; 트레오-β-메틸-아스파르트산; γ-카복시-D-글루탐산 γ,γ-디-1-부틸 에스테르; γ-카복시-L-글루탐산 γ,γ-디-1-부틸 에스테르; Glu(OAll)-OH; L-Asu(OtBu)-OH; 및 피로글루탐산을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 시스테인 및 메티오닌의 유사체를 포함한다. 시스테인 및 메티오닌의 아미노산 유사체의 예로는 Cys(파네실)-OH, Cys(파네실)-OMe, α-메틸-메티오닌, Cys(2-하이드록시에틸)-OH, Cys(3-아미노프로필)-OH, 2-아미노-4-(에틸티오)부티르산, 부티오닌, 부티오닌술폭시민, 에티오닌, 메티오닌 메틸술포늄 클로라이드, 셀레노메티오닌, 시스테인산, [2-(4-피리딜)에틸]-DL-페니실라민, [2-(4-피리딜)에틸]-L-시스테인, 4-메톡시벤질-D-페니실라민, 4-메톡시벤질-L-페니실라민, 4-메틸벤질-D-페니실라민, 4-메틸벤질-L-페니실라민, 벤질-D-시스테인, 벤질-L-시스테인, 벤질-DL-호모시스테인, 카바모일-L-시스테인, 카복시에틸-L-시스테인, 카복시메틸-L-시스테인, 디페닐메틸-L-시스테인, 에틸-L-시스테인, 메틸-L-시스테인, t-부틸-D-시스테인, 트리틸-L-호모시스테인, 트리틸-D-페니실라민, 시스타티오닌, 호모시스틴, L-호모시스틴, (2-아미노에틸)-L-시스테인, 셀레노-L-시스틴, 시스타티오닌, Cys(StBu)-OH, 및 아세트아미도메틸-D-페니실라민을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 페닐알라닌 및 티로신의 유사체를 포함한다. 페닐알라닌 및 티로신의 아미노산 유사체의 예로는 β-메틸-페닐알라닌, β-하이드록시페닐알라닌, α-메틸-3-메톡시-DL-페닐알라닌, α-메틸-D-페닐알라닌, α-메틸-L-페닐알라닌, 1,2,3,4-테트라하이드로이소퀴놀린-3-카복실산, 2,4-디클로로-페닐알라닌, 2-(트리플루오로메틸)-D-페닐알라닌, 2-(트리플루오로메틸)-L-페닐알라닌, 2-브로모-D-페닐알라닌, 2-브로모-L-페닐알라닌, 2-클로로-D-페닐알라닌, 2-클로로-L-페닐알라닌, 2-시아노-D-페닐알라닌, 2-시아노-L-페닐알라닌, 2-플루오로-D-페닐알라닌, 2-플루오로-L-페닐알라닌, 2-메틸-D-페닐알라닌, 2-메틸-L-페닐알라닌, 2-니트로-D-페닐알라닌, 2-니트로-L-페닐알라닌, 2;4;5-트리하이드록시-페닐알라닌, 3,4,5-트리플루오로-D-페닐알라닌, 3,4,5-트리플루오로-L-페닐알라닌, 3,4-디클로로-D 페닐알라닌, 3,4-디클로로-L-페닐알라닌, 3,4-디플루오로-D-페닐알라닌, 3,4-디플루오로-L-페닐알라닌, 3,4-디하이드록시-L-페닐알라닌, 3,4-디메톡시-L-페닐알라닌, 3,5,3'-트리요오도-L-티로닌, 3,5-디요오도-D-티로신, 3,5-디요오도-L-티로신, 3,5-디요오도-L-티로닌, 3-(트리플루오로메틸)-D-페닐알라닌, 3-(트리플루오로메틸)-L-페닐알라닌, 3-아미노-L-티로신, 3-브로모-D-페닐알라닌, 3-브로모-L-페닐알라닌, 3-클로로-D-페닐알라닌, 3-클로로-L-페닐알라닌, 3-클로로-L-티로신, 3-시아노-D-페닐알라닌, 3-시아노-L-페닐알라닌, 3-플루오로-D-페닐알라닌, 3-플루오로-L-페닐알라닌, 3-플루오로-티로신, 3-요오도-D-페닐알라닌, 3-요오도-L-페닐알라닌, 3-요오도-L-티로신, 3-메톡시-L-티로신, 3-메틸-D-페닐알라닌, 3-메틸-L-페닐알라닌, 3-니트로-D-페닐알라닌, 3-니트로-L-페닐알라닌, 3-니트로-L-티로신, 4-(트리플루오로메틸)-D-페닐알라닌, 4-(트리플루오로메틸)-L-페닐알라닌, 4-아미노-D-페닐알라닌, 4-아미노-L-페닐알라닌, 4-벤조일-D-페닐알라닌, 4-벤조일-L-페닐알라닌, 4-비스(2-클로로에틸)아미노-L-페닐알라닌, 4-브로모-D-페닐알라닌, 4-브로모-L-페닐알라닌, 4-클로로-D-페닐알라닌, 4-클로로-L-페닐알라닌, 4-시아노-D-페닐알라닌, 4-시아노-L-페닐알라닌, 4-플루오로-D-페닐알라닌, 4-플루오로-L-페닐알라닌, 4-요오도-D-페닐알라닌, 4-요오도-L-페닐알라닌, 호모페닐알라닌, 티록신, 3,3-디페닐알라닌, 티로닌, 에틸-티로신, 및 메틸-티로신을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 프롤린의 유사체를 포함한다. 프롤린의 아미노산 유사체의 예로는 3,4-데하이드로-프롤린, 4-플루오로-프롤린, 시스-4-하이드록시-프롤린, 티아졸리딘-2 -카복실산, 및 트랜스-4 -플루오로-프롤린을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 세린 및 트레오닌의 유사체를 포함한다. 세린 및 트레오닌의 아미노산 유사체의 예로는 3-아미노-2-하이드록시-5-메틸헥사노산, 2-아미노-3-하이드록시-4-메틸펜탄산, 2-아미노-3-에톡시부탄산, 2-아미노-3-메톡시부탄산, 4-아미노-3-하이드록시-6-메틸헵탄산, 2-아미노-3-벤질옥시프로피온산, 2-아미노-3-벤질옥시프로피온산, 2-아미노-3-에톡시프로피온산, 4-아미노-3-하이드록시부탄산, 및 α-메틸세린을 포함하나, 이에 한정되지 않는다.

아미노산 유사체는 트립토판의 유사체를 포함한다. 트립토판의 아미노산 유사체의 예로는 하기: α-메틸-트립토판; β-(3-벤조티에닐)-D-알라닌; β-(3-벤조티에닐)-L-알라닌; 1-메틸-트립토판; 4-메틸-트립토판; 5-벤질옥시-트립토판; 5-브로모-트립토판; 5-클로로-트립토판; 5-플루오로-트립토판; 5-하이드록시-트립토판; 5-하이드록시-L-트립토판; 5-메톡시-트립토판; 5-메톡시-L-트립토판; 5-메틸-트립토판; 6-브로모-트립토판; 6-클로로-D-트립토판; 6-클로로-트립토판; 6-플루오로-트립토판; 6-메틸-트립토판; 7-벤질옥시-트립토판; 7-브로모-트립토판; 7-메틸-- 트립토판; D-1,2,3,4-테트라하이드로-노르하만-3-카복실산; 6-메톡시-1,2,3,4-테트라하이드로노르하만-1-카복실산; 7-아자트립토판; L-1,2,3,4-테트라하이드로-노르하만-3-카복실산; 5-메톡시-2-메틸-트립토판; 및 6-클로로-L-트립토판을 포함하나, 이에 한정되지 않는다.

일부 실시양태에서, 아미노산 유사체는 라세믹이다. 일부 실시양태에서, 아미노산 유사체의 D 이성체가 사용된다. 일부 실시양태에서, 아미노산 유사체의 L 이성체가 사용된다. 다른 실시양태에서, 아미노산 유사체는 R 또는 S 배위의 키랄 중심을 포함한다. 추가의 다른 실시양태에서, β-아미노산 유사체의 아미노 기(들)는 보호기, 예컨대, tert-부틸옥시카보닐(BOC 기), 9-플루오레닐메틸옥시카보닐 (FMOC), 토실 등으로 치환된다. 추가의 다른 실시양태에서, β-아미노산 유사체의 카복실산 작용기는 예컨대, 그의 에스테르 유도체와 같이 보호된다. 일부 실시양태에서, 아미노산 유도체의 염이 사용된다.

"비필수" 아미노산 잔기는 폴리펩티드의 야생형 서열의 필수적인 생물학적 또는 생화학적 활성(예컨대, 수용체 결합 또는 활성화)를 제거하거나, 또는 실질적으로 변경시키지 않으면서 폴리펩티드의 야생형 서열로부터 변경될 수 있는 잔기이다. "필수" 아미노산 잔기는 폴리펩티드의 야생형 서열로부터 변경되었을 때, 그로 인해 폴리펩티드의 필수적인 생물학적 또는 생화학적 활성이 제거되거나, 또는 실질적으로 변경되는 것인 잔기이다.

"보존적 아미노산 치환"은 아미노산 잔기가 유사한 측쇄를 가지는 아미노산 잔기로 치환되는 것이다. 유사한 측쇄를 가지는 아미노산 잔기의 패밀리는 본 분야에서 정의되어 있다. 상기 패밀리는 염기성 측쇄(예컨대, K, R, H), 산성 측쇄(예컨대, D, E), 비하전된 극성 측쇄(예컨대, G, N, Q, S, T, Y, C), 비극성 측쇄(예컨대, A, V, L, I, P, F, M, W), 베타 분지형 측쇄(예컨대, T, V, I) 및 방향족 측쇄(예컨대, Y, F, W, H)를 가지는 아미노산을 포함한다. 따라서, 폴리펩티드 중의 예측 비필수 아미노산 잔기는 예를 들어, 동일한 측쇄 패밀리로부터의 또 다른 아미노산 잔기로 치환된다. 허용되는 치환의 다른 예는 등전자 고려사항(예컨대, 메티오닌에 대해 노르류신) 또는 다른 특성(예컨대, 페닐알라닌에 대해 2-티에닐알라닌, 또는 트립토판에 대해 6-Cl-트립토판)을 근거로 한 치환된다.

"캡핑 기"라는 용어는 대상 펩티드모방체 마크로사이클의 폴리펩티드 쇄의 카복시 또는 아미노 말단 중 한 말단에 존재하는 화학적 모이어티를 의미한다. 카복시 말단의 캡핑 기로는 비변형된 카복실산(즉, -COOH), 또는 치환기를 가지는 카복실산을 포함한다. 예를 들어, 카복시 말단은 아미노 기로 치환될 수 있고, 이로써, C 말단에 카복스아미드를 얻을 수 있다. 다양한 치환으로는 페길화된 2급 아민을 비롯한, 1급 및 2급 아민을 포함하나, 이에 한정되지 않는다. C 말단에 대한, 대표적인 2급 아민 캡핑 기로는 하기를 포함한다:

아미노 말단의 캡핑 기로는 비변형된 아민(즉, -NH₂), 또는 치환기를 가지는 아민을 포함한다. 예를 들어, 아미노 말단은 아실 기로 치환될 수 있고, 이로써, N 말단에 카복스아미드를 얻을 수 있다. 다양한 치환으로는 C₁-C₆ 카보닐, C₇-C₃₀ 카보닐, 및 페길화된 카바메이트를 비롯한, 1급 및 2급 아민을 포함하나, 이에 한정되지 않는다. N 말단에 대한, 대표적인 캡핑 기로는 4-FBzl(4-플루오로-벤질) 및 하기를 포함하나, 이에 한정되지 않는다:

본원에서 사용되는 바, 마크로사이클 또는 마크로사이클 형성 링커와 관련하여 "구성원(member)"이라는 용어는 마크로사이클을 형성하거나, 형성할 수 있는 원자를 의미하며, 치환기 또는 측쇄 원자는 배제된다. 유추해 볼 때, 수소 또는 플루오로 치환기 또는 메틸 측쇄는 마크로사이클을 형성하는 데에는 참여하지 않는 바, 사이클로데칸, 1,2-디플루오로-데칸 및 1,3-디메틸 사이클로데칸은 모두 10원 마크로사이클인 것으로 간주된다.

기호

는 분자 구조의 일부로서 사용될 때, 단일 결합 또는 트랜스 또는 시스 이중 결합을 의미한다.

"아미노산 측쇄(side chain)"라는 용어는 아미노산 중 α 탄소(또는 또 다른 골격 원자)에 부착된 모이어티를 의미한다. 예를 들어, 알라닌에 대한 아미노산 측쇄는 메틸이고, 페닐알라닌에 대한 아미노산 측쇄는 페닐메틸이고, 시스테인에 대한 아미노산 측쇄는 티오메틸, 아스파테이트에 대한 아미노산 측쇄는 카복시메틸이고, 티로신에 대한 아미노산 측쇄는 4-하이드록시페닐메틸 등이다. 다른 비자연적으로 발생된 아미노산 측쇄, 예를 들어, 자연 중에 존재하는 것(예컨대, 아미노산 대사산물), 또는 합성적으로 제조된 것(예컨대, α,α-이치환된 아미노산) 또한 포함된다.

"α,α-이치환된 아미노산"이라는 용어는 2개의 천연 또는 비천연 아미노산 측쇄에 부착된 탄소(α 탄소)에 결합된 아미노 기 및 카복실 기, 둘 모두를 함유하는 분자 또는 모이어티를 의미한다.

"폴리펩티드"라는 용어는 공유 결합(예컨대, 아미드 결합)에 의해 연결된, 2개 이상의 자연적으로 또는 비자연적으로 발생된 아미노산을 포함한다. 본원에 기술된 바와 같은 폴리펩티드로는 전장의 단백질(예컨대, 완전하게 프로세싱된 단백질) 뿐만 아니라, 보다 짧은 아미노산 서열(예컨대, 자연적으로 발생된 단백질의 단편 또는 합성 폴리펩티드 단편)을 포함한다.

"첫번째 C 말단 아미노산"이라는 용어는 C 말단에 가장 가깝게 위치하는 아미노산을 의미한다. "두번째 C 말단 아미노산"이라는 용어는 첫번째 C 말단 아미노산의 N 말단에 부착된 아미노산을 의미한다.

본원에서 사용되는 바, "마크로고리화 시약(reagent)" 또는 "마크로사이클 형성 시약"이라는 용어는 두 반응성 기 사이의 반응을 마크로고리화 반응을 매개함으로써 펩티드모방체 마크로사이클을 제조하는 데 사용될 수 있는 임의의 시약을 의미한다. 반응성 기는 예를 들어, 아지드 및 알킨일 수 있고, 이 경우, 마크로고리화 시약으로는 제한 없이, Cu 시약, 예컨대, 반응성 Cu(I) 종을 제공하는 시약, 예컨대, CuBr, CuI 또는 CuOTf 뿐만 아니라, 환원제, 예컨대, 아스코르브산 또는 아스코르브산 나트륨의 첨가에 의해 계내에서 활성 Cu(I) 시약으로 전환될 수 있는 Cu(II) 염, 예컨대, Cu(CO₂CH₃)₂, CuSO₄, 및 CuCl₂를 포함한다. 마크로고리화 시약은 추가로 예를 들어, 당업계에 공지된 Ru 시약, 예컨대, Cp*RuCl(PPh₃)₂, [Cp*RuCl]₄ 또는 반응성 Ru(II) 종을 제공할 수 있는 다른 Ru 시약을 포함할 수 있다. 다른 경우에서, 반응성 기는 말단 올레핀이다. 상기 실시양태에서, 마크로고리화 시약 또는 마크로사이클 형성 시약은 안정화된 후지 전이 금속 카르벤 복합체 촉매, 예컨대, VIII 족 전이 금속 카르벤 촉매를 포함하나, 이에 한정되지 않는, 복분해 촉매이다. 예를 들어, 상기 촉매는 전자 카운트가 16기이고, 5배위인, +2 산화 상태를 가지는 Ru 및 Os 금속 중심이다. 다른 예에서, 촉매는 W 또는 Mo 중심을 가진다. 다양한 촉매가 문헌 [Grubbs et al., "Ring Closing Metathesis and Related Processes in Organic Synthesis" Acc. Chem. Res. 1995, 28, 446-452], 미국 특허 번호 제5,811,515호; 미국 특허 번호 제7,932,397호; 미국 출원 번호 2011/0065915; 미국 출원 번호 2011/0245477; [Yu et al., "Synthesis of Macrocyclic Natural Products by Catalyst-Controlled Stereoselective Ring-Closing Metathesis," Nature 2011, 479, 88]; 및 [Peryshkov et al., "Z-Selective Olefin Metathesis Reactions Promoted by Tungsten Oxo Alkylidene Complexes," J. Am. Chem. Soc. 2011, 133, 20754]에 개시되어 있다. 추가의 다른 경우에서, 반응성 기는 티올 기이다. 상기 실시양태에서, 마크로고리화 시약은 예를 들어, 2개의 티올 반응성 기, 예컨대, 할로겐 기로 작용화된 링커이다.

"할로" 또는 "할로겐"이라는 용어는 불소, 염소, 브롬, 또는 요오드 또는 그의 라디칼을 의미한다.

"알킬"이라는 용어는 명시된 개수의 탄소 원자를 함유하는, 직쇄 또는 분지쇄인 탄화수소 쇄를 의미한다. 예를 들어, C₁-C₁₀은 기가 그 안에 1 내지 10개(1개 및 10개 포함)의 탄소 원자를 가진다는 것을 나타낸다. 개수가 명시되지 않은 경우, "알킬"은 그 안에 1 내지 20개(1개 및 10개 포함)의 탄소 원자를 가지는 쇄(직쇄 또는 분지쇄)이다.

"알킬렌"이라는 용어는 2가 알킬(즉, -R-)을 의미한다.

"알케닐"이라는 용어는 하나 이상의 탄소-탄소 이중 결합을 가지는, 직쇄 또는 분지쇄인 탄화수소 쇄를 의미한다. 알케닐 모이어티는 명시된 개수의 탄소 원자를 함유한다. 예를 들어, C₂-C₁₀은 기가 그 안에 2 내지 10개(2개 및 10개 포함)의 탄소 원자를 가진다는 것을 나타낸다. "저급 알케닐"이라는 용어는 C₂-C₆ 알케닐 쇄를 의미한다. 개수가 명시되지 않은 경우, "알케닐"은 그 안에 2 내지 20개(2개 및 10개 포함)의 탄소 원자를 가지는 쇄(직쇄 또는 분지쇄)이다.

"알키닐"이라는 용어는 하나 이상의 탄소-탄소 삼중 결합을 가지는, 직쇄 또는 분지쇄인 탄화수소 쇄를 의미한다. 알키닐 모이어티는 명시된 개수의 탄소 원자를 함유한다. 예를 들어, C₂-C₁₀은 기가 그 안에 2 내지 10개(2개 및 10개 포함)의 탄소 원자를 가진다는 것을 나타낸다. "저급 알키닐"이라는 용어는 C₂-C₆ 알키닐 쇄를 의미한다. 개수가 명시되지 않은 경우, "알키닐"은 그 안에 2 내지 20개(2개 및 10개 포함)의 탄소 원자를 가지는 쇄(직쇄 또는 분지쇄)이다.

"아릴"이라는 용어는 각 고리의 0, 1, 2, 3, 또는 4개의 원자가 치환기에 의해 치환되어 있는, 6 탄소 모노사이클릭 또는 10 탄소 비사이클릭방향족 고리 시스템을 의미한다. 아릴 기의 예로는 페닐, 나프틸 등을 포함한다. "아릴 알콕시"이라는 용어는 아릴로 치환된 알콕시를 의미한다.

"아릴알킬"이란 아릴 기의 수소 원자 중 하나가 상기 정의된 바와 같은 C₁-C₅ 알킬 기로 치환된, 상기 정의된 바와 같은 아릴 기를 의미한다. 아릴알킬 기의 대표적인 예로는 2-메틸페닐, 3-메틸페닐, 4-메틸페닐, 2-에틸페닐, 3-에틸페닐, 4-에틸페닐, 2-프로필페닐, 3-프로필페닐, 4-프로필페닐, 2-부틸페닐, 3-부틸페닐, 4-부틸페닐, 2-펜틸페닐, 3-펜틸페닐, 4-펜틸페닐, 2-이소프로필페닐, 3-이소프로필페닐, 4-이소프로필페닐, 2-이소부틸페닐, 3-이소부틸페닐, 4-이소부틸페닐, 2-sec-부틸페닐, 3-sec-부틸페닐, 4-sec-부틸페닐, 2-t-부틸페닐, 3-t-부틸페닐 및 4-t-부틸페닐을 포함하나, 이에 한정되지 않는다.

"아릴아미도"란 아릴 기의 수소 원자 중 하나가 하나 이상의 -C(O)NH₂ 기로 치환된, 상기 정의된 바와 같은 아릴 기를 의미한다. 아릴아미도 기의 대표적인 예로는 2-C(O)NH₂-페닐, 3-C(O)NH₂-페닐, 4-C(O)NH₂-페닐, 2-C(O)NH₂-피리딜, 3-C(O)NH₂-피리딜, 및 4-C(O)NH₂-피리딜을 포함한다.

"알킬헤테로사이클"이란 C₁-C₅ 알킬 기의 수소 원자 중 하나가 헤테로사이클로 치환된, 상기 정의된 바와 같은 C₁-C₅ 알킬 기를 의미한다. 알킬헤테로사이클 기의 대표적인 예로는 -CH₂CH₂-모르폴린, -CH₂CH₂-피페리딘, -CH₂CH₂CH₂-모르폴린, 및 -CH₂CH₂CH₂-이미다졸을 포함하나, 이에 한정되지 않는다.

"알킬아미도"란 C₁-C₅ 알킬 기의 수소 원자 중 하나가 -C(O)NH₂ 기로 치환된, 상기 정의된 바와 같은 C₁-C₅ 알킬 기를 의미한다. 알킬아미도 기의 대표적인 예로는 -CH₂-C(O)NH₂, -CH₂CH₂-C(O)NH₂, -CH₂CH₂CH₂C(O)NH₂, -CH₂CH₂CH₂CH₂C(O)NH₂, -CH₂CH₂CH₂CH₂CH₂C(O)NH₂, -CH₂CH(C(O)NH₂)CH₃, -CH₂CH(C(O)NH₂)CH₂CH₃, -CH(C(O)NH₂)CH₂CH₃, -C(CH₃)₂CH₂C(O)NH₂, -CH₂-CH₂-NH-C(O)-CH₃, -CH₂-CH₂-NH-C(O)-CH₃-CH3, 및 -CH₂-CH₂-NH-C(O)-CH=CH₂를 포함하나, 이에 한정되지 않는다.

"알카놀"이란 C₁-C₅ 알킬 기의 수소 원자 중 하나가 하이드록실 기로 치환된, 상기 정의된 바와 같은 C₁-C₅ 알킬 기를 의미한다. 알카놀 기의 대표적인 예로 -CH₂OH, -CH₂CH₂OH, -CH₂CH₂CH₂OH, -CH₂CH₂CH₂CH₂OH, -CH₂CH₂CH₂CH₂CH₂OH, -CH₂CH(OH)CH₃, -CH₂CH(OH)CH₂CH₃, -CH(OH)CH₃ 및 -C(CH₃)₂CH₂OH를 포함하나, 이에 한정되지 않는다.

"알킬카복시"란 C₁-C₅ 알킬 기의 수소 원자 중 하나가 --COOH 기로 치환된, 상기 정의된 바와 같은 C₁-C₅ 알킬 기를 의미한다. 알킬카복시의 대표적인 예로는 -CH₂COOH, -CH₂CH₂COOH, -CH₂CH₂CH₂COOH, -CH₂CH₂CH₂CH₂COOH, -CH₂CH(COOH)CH₃, -CH₂CH₂CH₂CH₂CH₂COOH, -CH₂CH(COOH)CH₂CH₃, -CH(COOH)CH₂CH₃ 및 -C(CH₃)₂CH₂COOH를 포함하나, 이에 한정되지 않는다.

본원에서 사용되는 바, "사이클로알킬"이라는 용어는 3 내지 12개의 탄소, 바람직하게, 3 내지 8개의 탄소, 및 더욱 바람직하게, 3 내지 6개의 탄소를 가지는 포화된 및 부분적으로 불포화된 사이클릭 탄화수소 기를 포함하며, 여기서, 사이클로알킬 기는 추가로 임의적으로 치환된다. 일부 사이클로알킬 기로는 제한 없이, 사이클로프로필, 사이클로부틸, 사이클로펜틸, 사이클로펜테닐, 사이클로헥실, 사이클로헥세닐, 사이클로헵틸, 및 사이클로옥틸을 포함한다.

"헤테로아릴"이라는 용어는 모노사이클릭일 경우, 1-3개의 헤테로원자를 가지거나, 비사이클릭일 경우, 1-6개의 헤테로원자를 가지거나, 트리사이클릭일 경우, 1-9개의 헤테로원자를 가지며, 상기 헤테로원자는 O, N, 또는 S로부터 선택되며(예컨대, 모노사이클릭, 비사이클릭, 또는 트리사이클릭일 경우, 각각 탄소 원자 및 O, N, 또는 S로 된 1-3, 1-6, 또는 1-9개의 헤테로원자), 여기서, 각 고리의 0, 1, 2, 3, 또는 4개의 원자가 치환기에 의해 치환되는 것인, 방향족 5-8원 모노사이클릭, 8-12원 비사이클릭, 또는 11-14원 트리사이클릭 고리 시스템을 의미한다. 헤테로아릴 기의 예로는 피리딜, 푸릴 또는 푸라닐, 이미다졸릴, 벤즈이미다졸릴, 피리미디닐, 티오페닐 또는 티에닐, 퀴놀리닐, 인돌릴, 티아졸릴 등을 포함한다.

"헤테로아릴알킬"이라는 용어 또는 "헤테로아르알킬"이라는 용어는 헤테로아릴로 치환된 알킬을 의미한다. "헤테로아릴알콕시"라는 용어는 헤테로아릴로 치환된 알콕시를 의미한다.

"헤테로사이클릴"이라는 용어는 모노사이클릭일 경우, 1-3개의 헤테로원자를 가지거나, 비사이클릭일 경우, 1-6개의 헤테로원자를 가지거나, 트리사이클릭일 경우, 1-9개의 헤테로원자를 가지며, 상기 헤테로원자는 O, N, 또는 S로부터 선택되며(예컨대, 모노사이클릭, 비사이클릭, 또는 트리사이클릭일 경우, 각각 탄소 원자 및 O, N, 또는 S로 된 1-3, 1-6, 또는 1-9개의 헤테로원자), 여기서, 각 고리의 0, 1, 2 또는 3개의 원자가 치환기에 의해 치환되는 것인, 비방향족 5-8원 모노사이클릭, 8-12원 비사이클릭, 또는 11-14원 트리사이클릭 고리 시스템을 의미한다. 헤테로사이클릴 기의 예로는 피페라지닐, 피롤리디닐, 디옥사닐, 모르폴리닐, 테트라하이드로푸라닐 등을 포함한다.

"치환기"라는 용어는 임의의 분자, 화합물 또는 모이어티 상의 수소 원자와 같은 제2 원자 또는 기를 치환하는 기를 의미한다. 적합한 치환기로는 제한 없이, 할로, 하이드록시, 머캅토, 옥소, 니트로, 할로알킬, 알킬, 알크아릴, 아릴, 아르알킬, 알콕시, 티오알콕시, 아릴옥시, 아미노, 알콕시카보닐, 아미도, 카복시, 알칸술포닐, 알킬카보닐, 및 시아노 기를 포함한다.

일부 실시양태에서, 본원에 개시된 화합물은 하나 이상의 비대칭 중심을 함유하며, 따라서, 라세메이트 및 라세믹 혼합물, 단일 거울상이성체, 개별 부분입체이성체 및 부분입체이성체 혼합물로서 존재한다. 달리 명확하게 제공되지 않는 한, 본 화합물의 상기와 같은 이성체 형태들 모두 포함된다. 일부 실시양태에서, 본원에 개시된 화합물은 또한 다중 호변이성체 형태로 존재하며, 상기와 같은 경우에, 화합물은 본원에 기술된 화합물의 호변이성체 형태 모두를 포함한다(예컨대, 고리 시스템의 알킬화를 통해 다중 부위에서 알킬화가 이루어지게 되면, 본 발명은 상기 반응 생성물을 모두를 포함한다). 달리 명확하게 제공되지 않는 한, 본 화합물의 상기와 같은 이성체 형태들 모두 포함된다. 달리 명확하게 제공되지 않는 한, 본원에 기술된 화합물의 결정 형태들 모두 포함된다.

본원에서 사용되는 바, "증가시키다" 및 "감소시키다"라는 용어는 각각 5% 이상의 통계학적 유의적인 (즉, p < 0.1) 증가 또는 감소를 유발하는 것을 의미한다.

본원에서 사용되는 바, 변수에 대하여 수치 범위로 언급하는 것은 상기 범위 내의 값 중 임의 값과 동일하다는 것을 의미하는 것으로 한다. 따라서, 본질적으로 불연속적인 변수인 경우, 변수는 수치 범위(그 범위의 종점을 포함) 내의 임의의 정수 값과 동일한 것이다. 유사하게, 본질적으로 연속적인 변수인 경우, 변수는 수치 범위(그 범위의 종점을 포함) 내의 임의의 실제 값과 동일한 것이다. 일례에서서, 및 제한 없이, 0 내지 2의 값을 가지는 것으로 기술된 값은, 변수가 본질적으로 불연속적인 변수일 경우, 값 0, 1, 또는 2를 취하고, 변수가 본질적으로 연속적인 변수일 경우, 값 0.0, 0.1, 0.01, 0.001, 또는 ≥ 0 내지 ≤ 2인 임의의 다른 실제 값을 취한다.

본원에서 사용되는 바, 달리 구체적으로 언급되지 않는 한, "또는"이라는 단어는 "둘 중 어느 하나/또는"이라는 배타적 의미가 아닌, "및/또는"이라는 포괄적인 의미로 사용된다.

"평균적으로"라는 용어는 각 데이터 점에 대해 3회 이상의 독립된 반복을 수행함으로써 그로부터 도출된 평균 값을 나타낸다.

"생물학적 활성"이라는 용어는 마크로사이클의 구조적 및 기능적 특성을 포함한다. 생물학적 활성은 예를 들어, 구조적 안정성, 알파 나선도, 표적에 대한 친화도, 단백질분해성 분해에 대한 저항성, 세포 투과성, 세포내 안정성, 생체내 안정성, 또는 그의 임의 조합이다.

"결합 친화도"라는 용어는 예를 들어, 펩티드모방체 마크로사이클과 표적 사이의 결합 상호작용 강도를 의미한다. 결합 친화도는 예를 들어, 농도 척도 단위(예컨대, M, mM, μM, nM 등)로 표시되는 평형 해리 상수("K_D")로서 표현될 수 있다. 수치상, 결합 친화도 및 K_D 값은 역변하며, 따라서, 더 낮은 결합 친화도는 더 높은 K_D 값에 상응하는 반면, 더 높은 결합 친화도는 더 낮은 K_D 값에 상응한다. 높은 결합 친화도가 바람직할 경우, "개선된" 결합 친화도란 더 높은 결합 친화도, 및 따라서, 더 낮은 K_D 값을 의미한다.

"시험관내 효능(efficacy)"이라는 용어는 테스트 화합물, 예컨대, 펩티드모방체 마크로사이클이 시험관내 테스트 시스템 또는 검정에서 유익한 결과를 산출하는 정도를 의미한다. 시험관내 효능은 예를 들어, 테스트 시스템에서 최대 효과의 50%를 산출해 내는 테스트 화합물의 농도를 나타내는 "IC₅₀" 또는 "EC₅₀" 값으로 측정될 수 있다.

"시험관내 효능의 비" 또는 "시험관내 효능 비"라는 용어는 제1 검정(분자) 대 제2 검정(분모)으로부터 얻은 IC₅₀ 또는 EC₅₀의 비를 의미한다. 결과적으로, 검정 1 대 검정 2에 대한 개선된 시험관내 효능 비란, IC₅₀(검정 1)/IC₅₀(검정 2) 또는 별법으로 as EC₅₀(검정 l)/EC₅₀(검정 2)으로 표현되는 비의 값이 감소하였음을 의미한다. 상기 개념은 또한 표적 1에 대한 IC₅₀ 또는 EC₅₀ 값의 감소, 또는 표적 2에 대한 IC₅₀ 또는 EC₅₀ 값의 증가에 기인하는 것일 수 있는, 검정 1 대 검정 2에서의 "개선된 선택성"을 특징으로 할 수 있다.

본 발명의 하나 이상의 측정 실시양태에 대한 상세한 설명은 첨부된 도면 및 하기의 상세한 설명에 기술되어 있다. 본 발명의 다른 특징, 목적, 및 장점은 상세한 설명 및 도면으로부터, 및 특허청구범위로부터 자명해질 것이다.

펩티드모방체 마크로사이클

일부 실시양태에서, 펩티드모방체 마크로사이클은 하기 화학식 I을 가진다:

<화학식 I>

상기 식에서,

각각의 A, C, D, 및 E는 독립적으로 아미노산(천연 또는 비천연 아미노산, 및 아미노산 유사체 포함)이고, 말단 D 및 E는 독립적으로 임의적으로 캡핑 기를 포함하고;

B는 아미노산 (천연 또는 비천연 아미노산, 및 아미노산 유사체 포함),

, [-NH-L₃-CO-], [-NH-L₃-SO₂-], 또는 [-NH-L₃-]이고;

R₁ 및 R₂는 독립적으로 비치환되거나 또는 할로로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 사이클로알킬알킬, 헤테로알킬, 또는 헤테로사이클로알킬이고;

L은 식 -L₁-L₂-의 마크로사이클 형성 링커이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

u는 정수 1-10, 예를 들어, 1-5, 1-3 또는 1-2이고;

n은 정수 1-5이다.

일부 실시양태에서, v 및 w는 정수 1-30이다. 일부 실시양태에서, w는 정수 3-1,000, 예를 들어, 3-500, 3-200, 3-100, 3-50, 3-30, 3-20, 또는 3-10이다. 일부 실시양태에서, x+y+z의 합계는 3 또는 6이다. 일부 실시양태에서, x+y+z의 합계는 3이다. 다른 실시양태에서, x+y+z의 합계는 6이다.

일부 실시양태에서, 하기 화학식의 펩티드모방체 마크로사이클 또한 제공한다:

상기 식에서,

각각의 D 및 E는 독립적으로 아미노산이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

v는 정수 1-1,000, 예를 들어, 1-500, 1-200, 1-100, 1-50, 1-30, 1-20 또는 1-10이고;

n은 정수 1-5이다.

본원에 기술된 화학식 중 임의의 것의 일부 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 3개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 4개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 5개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 6개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 7개 이상은 서열 Phe₃-X₄-His₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀-X₁₁-Ser₁₂(서열 번호 8)의 상응하는 위치의 아미노산과 동일한 아미노산이다.

상기 식에서,

각각의 D는 독립적으로 아미노산이고;

각각의 E는 독립적으로 아미노산, 예를 들어, Ala(알라닌), D-Ala(D-알라닌), Aib(α-아미노이소부티르산), Sar(N-메틸 글리신), 및 Ser(세린)로부터 선택되는 아미노산이고;

각각의 K는 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이고;

n은 정수 1-5이다.

상기 화학식의 일부 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 3개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 상기 화학식의 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 4개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 상기 화학식의 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 5개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 상기 화학식의 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 6개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)의 상응하는 위치의 아미노산과 동일한 아미노산이다. 상기 화학식의 다른 실시양태에서, Xaa₃, Xaa₅, Xaa₆, Xaa₇, Xaa₈, Xaa₉, 및 Xaa₁₀ 중 7개 이상은 서열 Phe₃-X₄-Glu₅-Tyr₆-Trp₇-Ala₈-Gln₉-Leu₁₀/Cba₁₀-X₁₁-Ala₁₂(서열 번호 9)의 상응하는 위치의 아미노산과 동일한 아미노산이다.

본원에 기술된 화학식 중 임의의 것의 한 실시양태에서, L₁ 및 L₂는 단독으로 또는 조합하여 트리아졸 또는 티오에테르를 형성하지 않는다.

일례에서, R₁ 및 R₂ 중 하나 이상은 비치환되거나 또는 할로로 치환된 알킬이다. 또 다른 일례에서, R₁ 및 R₂, 둘 모두 독립적으로 비치환되거나 또는 할로로 치환된 알킬이다. 일부 실시양태에서, R₁ 및 R₂ 중 하나 이상은 메틸이다. 다른 실시양태에서, R₁ 및 R₂는 메틸이다.

일부 실시양태에서, x+y+z는 3 이상이다. 다른 실시양태에서, x+y+z는 1, 2, 3, 4, 5, 6, 7, 8, 9 또는 10이다. 일부 실시양태에서, x+y+z의 합계는 3 또는 6이다. 일부 실시양태에서, x+y+z의 합계는 3이다. 다른 실시양태에서, x+y+z의 합계는 6이다. 마크로사이클 또는 마크로사이클 전구체 중의 A, B, C, D 또는 E는 각각의 경우에 독립적으로 선택된다. 예를 들어, 화학식 [A]_x(x가 3일 때)로 나타낸 서열은 아미노산이 동일하지 않은, 예컨대, Gln-Asp-Ala인 실시양태 뿐만 아니라, 아미노산이 동일한, 예컨대, Gln-Gln-Gln인 실시양태를 포함한다. 이는 명시된 범위의 x, y, 또는 z의 임의 값에 적용된다. 유사하게, u가 1 초과일 경우, 각 화합물은 동일하거나, 상이한 펩티드모방체 마크로사이클을 포함할 수 있다. 예를 들어, 화합물은 다른 링커 길이 또는 화학 조성물을 포함하는 펩티드모방체 마크로사이클을 포함할 수 있다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 α 나선부이고, R₈은 -H인, 나선내 수소 결합을 허용하는, 2차 구조를 포함한다. 일부 실시양태에서, A, B, C, D 또는 E 중 하나 이상이 α,α-이치환된 아미노산이다. 일례에서, B는 α,α- 이치환된 아미노산이다. 예를 들어, A, B, C, D 또는 E 중 하나 이상은 2-아미노이소부티르산이다. 다른 실시양태에서, A, B, C, D 또는 E 중 하나 이상은

이다.

다른 실시양태에서, 제1 Cα부터 제2 Cα까지로 측정된, 마크로사이클 형성 링커 L의 길이는 원하는 2차 펩티드 구조, 예컨대, 반드시 제한하는 것은 아니지만, 제1 Cα와 제2 Cα 사이의 것인, 펩티드모방체 마크로사이클의 잔기에 의해 형성된 α 나선부를 안정화시키도록 선택된다.

한 실시양태에서, 화학식 I의 펩티드모방체는

이다:

상기 식에서, 각각의 R₁ 및 R₂는 독립적으로 비치환되거나 또는 할로로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 사이클로알킬알킬, 헤테로알킬, 또는 헤테로사이클로알킬이다.

관련된 실시양태에서, 화학식 I의 펩티드모방체는

이다:

상기 식에서, 각각의 R₁ ^' 및 R₂ ^'는 독립적으로 아미노산이다.

다른 실시양태에서, 화학식 I의 펩티드모방체 마크로사이클은 하기 제시된 화학식들 중 임의 화학식의 화합물이다:

상기 식에서, "AA"는 임의의 천연 또는 비천연 아미노산 측쇄를 나타내고,

는 상기 정의된 바와 같은 [D]_v, [E]_w이고, n은 0 내지 20, 50, 100, 200, 300, 400 또는 500인 정수이다. 일부 실시양태에서, n은 0이다. 다른 실시양태에서, n은 50 미만이다.

마크로사이클 형성 링커 L의 예시적인 실시양태는 하기에 제시되어 있다.

다른 실시양태에서, 화학식 I의 화합물에서 D 및/또는 E는 세포 흡수가 용이하게 이루어지도록 하기 위해 추가로 변형될 수 있다. 일부 실시양태에서, 펩티드모방체 마크로사이클을 지질화시키거나, PEG화시키면, 세포 흡수는 용이하게 이루어질 수 있고/거나, 생체이용성은 증가되고/거나, 혈액 순환은 증가되고/거나, 약동학적 성질은 변경되고/거나, 필요한 투여 빈도는 감소된다.

다른 실시양태에서, 화학식 I의 화합물에서 [D] 및 [E] 중 적어도 하나는 펩티드모방체 마크로사이클이 2개 이상의 마크로사이클 형성 링커를 포함하도록 하는 추가의 마크로사이클 형성 링커를 포함하는 모이어티를 나타낸다. 구체적인 실시양태에서, 펩티드모방체 마크로사이클는 2개의 마크로사이클 형성 링커를 포함한다. 한 실시양태에서, u는 2이다.

일부 실시양태에서, 본원에 기술된 마크로사이클 형성 링커 중 임의의 것은 표 1, 표 1 a, 표 1b, 또는 표 1c에 제시된 서열 중 임의의 것, 및 또한 본원에서 언급된 R 치환기 중 임의의 것과 함께 임의 조합으로 사용될 수 있다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 하나 이상의 α 나선부 모티프를 포함한다. 예를 들어, 화학식 I의 화합물에서 A, B 및/또는 C는 하나 이상의 α 나선부를 포함한다. 일반적으로, α 나선부는 1개의 선회부당 3 내지 4개 아미노산 잔기를 포함한다. 일부 실시양태에서, 펩티드모방체 마크로사이클의 α 나선부는 1 내지 5개의 선회부를 포함하고, 따라서, 3 내지 20개의 아미노산 잔기를 포함한다. 구체적인 실시양태에서, α 나선부는 1개의 선회부, 2개의 선회부, 3개의 선회부, 4개의 선회부 또는 5개의 선회부를 포함한다. 일부 실시양태에서, 마크로사이클 형성 링커는 펩티드모방체 마크로사이클내 포함되어 있는 α 나선부 모티프를 안정화시킨다. 따라서, 일부 실시양태에서, 제1 Cα부터 제2 Cα까지의 마크로사이클 형성 링커의 길이는 α 나선부의 안정성을 증가시킬 수 있도록 선택된다. 일부 실시양태에서, 마크로사이클 형성 링커는 α 나선부의 1개의 선회부에서부터 5개의 선회부까지에 걸쳐 이어진다. 일부 실시양태에서, 마크로사이클 형성 링커는 α 나선부의 대략 1개의 선회부, 2개의 선회부, 3개의 선회부, 4개의 선회부, 또는 5개의 선회부에 걸쳐 이어진다. 일부 실시양태에서, 마크로사이클 형성 링커의 길이는 α 나선부의 1개의 선회부당 대략 5 Å 내지 9 Å이거나, α 나선부의 1개의 선회부당 대략 6 Å 내지 8 Å이다. 마크로사이클 형성 링커가 α 나선부의 대략 1개의 선회부에 걸쳐 이어질 경우, 길이는 대략 5개의 탄소-탄소 결합 내지 13개의 탄소-탄소 결합, 대략 7개의 탄소-탄소 결합 내지 11개의 탄소-탄소 결합, 또는 대략 9개의 탄소-탄소 결합과 같다. 마크로사이클 형성 링커가 α 나선부의 대략 2개의 선회부에 걸쳐 이어질 경우, 길이는 대략 8개의 탄소-탄소 결합 내지 16개의 탄소-탄소 결합, 대략 10개의 탄소-탄소 결합 내지 14개의 탄소-탄소 결합, 또는 대략 12개의 탄소-탄소 결합과 같다. 마크로사이클 형성 링커가 α 나선부의 대략 3개의 선회부에 걸쳐 이어질 경우, 길이는 대략 14개의 탄소-탄소 결합 내지 22개의 탄소-탄소 결합, 대략 16개의 탄소-탄소 결합 내지 20개의 탄소-탄소 결합, 또는 대략 18개의 탄소-탄소 결합과 같다. 마크로사이클 형성 링커가 α 나선부의 대략 4개의 선회부에 걸쳐 이어질 경우, 길이는 대략 20개의 탄소-탄소 결합 내지 28개의 탄소-탄소 결합, 대략 22개의 탄소-탄소 결합 내지 26개의 탄소-탄소 결합, 또는 대략 24개의 탄소-탄소 결합과 같다. 마크로사이클 형성 링커가 α 나선부의 대략 5개의 선회부에 걸쳐 이어질 경우, 길이는 대략 26개의 탄소-탄소 결합 내지 34개의 탄소-탄소 결합, 대략 28개의 탄소-탄소 결합 내지 32개의 탄소-탄소 결합, 또는 대략 30개의 탄소-탄소 결합과 같다. 마크로사이클 형성 링커가 α 나선부의 대략 1개의 선회부에 걸쳐 이어질 경우, 연결부는 대략 4개의 원자 내지 12개의 원자, 대략 6개의 원자 내지 10개의 원자, 또는 대략 8개의 원자를 포함한다. 마크로사이클 형성 링커가 α 나선부의 대략 2개의 선회부에 걸쳐 이어질 경우, 연결부는 대략 7개의 원자 내지 15개의 원자, 대략 9개의 원자 내지 13개의 원자, 또는 대략 11개의 원자를 포함한다. 마크로사이클 형성 링커가 α 나선부의 대략 3개의 선회부에 걸쳐 이어질 경우, 연결부는 대략 13개의 원자 내지 21개의 원자, 대략 15개의 원자 내지 19개의 원자, 또는 대략 17개의 원자를 포함한다. 마크로사이클 형성 링커가 α 나선부의 대략 4개의 선회부에 걸쳐 이어질 경우, 연결부는 대략 19개의 원자 내지 27개의 원자, 대략 21개의 원자 내지 25개의 원자, 또는 대략 23개의 원자를 포함한다. 마크로사이클 형성 링커가 α 나선부의 대략 5개의 선회부에 걸쳐 이어질 경우, 연결부는 대략 25개의 원자 내지 33개의 원자, 대략 27개의 원자 내지 31개의 원자, 또는 대략 29개의 원자를 포함한다. 마크로사이클 형성 링커가 α 나선부의 대략 1개의 선회부에 걸쳐 이어질 경우, 생성된 마크로사이클은 대략 17개의 구성원 내지 25개의 구성원, 대략 19개의 구성원 내지 23개의 구성원, 또는 대략 21개의 구성원을 함유하는 고리를 형성한다. 마크로사이클 형성 링커가 α 나선부의 대략 2개의 선회부에 걸쳐 이어질 경우, 생성된 마크로사이클은 대략 29개의 구성원 내지 37개의 구성원, 대략 31개의 구성원 내지 35개의 구성원, 또는 대략 33개의 구성원을 함유하는 고리를 형성한다. 마크로사이클 형성 링커가 α 나선부의 대략 3개의 선회부에 걸쳐 이어질 경우, 생성된 마크로사이클은 대략 44개의 구성원 내지 52개의 구성원, 대략 46개의 구성원 내지 50개의 구성원, 또는 대략 48개의 구성원을 함유하는 고리를 형성한다. 마크로사이클 형성 링커가 α 나선부의 대략 4개의 선회부에 걸쳐 이어질 경우, 생성된 마크로사이클은 대략 59개의 구성원 내지 67개의 구성원, 대략 61개의 구성원 내지 65개의 구성원, 또는 대략 63개의 구성원을 함유하는 고리를 형성한다. 마크로사이클 형성 링커가 α 나선부의 대략 5개의 선회부에 걸쳐 이어질 경우, 생성된 마크로사이클은 대략 74개의 구성원 내지 82개의 구성원, 대략 76개의 구성원 내지 80개의 구성원, 또는 대략 78개의 구성원을 함유하는 고리를 형성한다.

다른 실시양태에서, 하기 화학식 IV 또는 IVa의 펩티드모방체 마크로사이클을 제공한다:

<화학식 IV>

<화학식 IVa>

상기 식에서,

각각의 A, C, D, 및 E 독립적으로 천연 또는 비천연 아미노산이고, 말단 D 및 E는 독립적으로 임의적으로 캡핑 기를 포함하고;

B는 천연 또는 비천연 아미노산, 아미노산 유사체,

, [-NH-L₃-CO-], [-NH-L₃-SO₂-], 또는 [-NH-L₃-]이고;

R₃은 독립적으로 임의적으로 R₅로 치환된, 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 헤테로알킬, 사이클로알킬, 헤테로사이클로알킬, 사이클로알킬알킬, 사이클로아릴, 또는 헤테로사이클로아릴이고;

L은 식 -L₁-L₂-의 마크로사이클 형성 링커이고;

R₇은 임의적으로 R₅로 치환된, -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 사이클로아릴, 또는 헤테로사이클로아릴이고;

v 및 w는 독립적으로 정수 1-1,000이고;

u는 정수 1-10이고;

x, y 및 z는 독립적으로 정수 0-10이고;

n은 정수 1-5이다.

일례에서, L₁ 및 L₂는 단독으로 또는 조합하여 트리아졸 또는 티오에테르를 형성하지 않는다.

일례에서, R₁ 및 R₂ 중 하나 이상이 비치환되거나 또는 할로로 치환된 알킬이다. 또 다른 일례에서, R₁ 및 R₂, 둘 모두 독립적으로 비치환되거나 또는 할로로 치환된 알킬이다. 일부 실시양태에서, R₁ 및 R₂ 중 하나 이상은 메틸이다. 다른 실시양태에서, R₁ 및 R₂는 메틸이다.

일부 실시양태에서, x+y+z는 1 이상이다. 다른 실시양태에서, x+y+z는 2 이상이다. 다른 실시양태에서, x+y+z는 1, 2, 3, 4, 5, 6, 7, 8, 9 또는 10이다. 마크로사이클 또는 마크로사이클 전구체 중의 A, B, C, D 또는 E는 각각의 경우에 독립적으로 선택된다. 예를 들어, 화학식 [A]_x(x가 3일 때)로 나타낸 서열은 아미노산이 동일하지 않은, 예컨대, Gln-Asp-Ala인 실시양태 뿐만 아니라, 아미노산이 동일한, 예컨대, Gln-Gln-Gln인 실시양태를 포함한다. 이는 명시된 범위의 x, y, 또는 z의 임의 값에 적용된다.

이다.

마크로사이클 형성 링커 -L₁-L₂-의 예시적인 실시양태는 하기 제시되어 있다:

달리 언급되지 않는 한, 임의의 화합물(펩티드모방체 마크로사이클, 마크로사이클 전구체, 및 다른 조성물)은 또한 하나 이상의 동위원소 농축 원자가 존재한다는 점에서만 차이를 보이는 화합물을 포함하는 것으로 한다. 예를 들어, 기술된 구조를 가지되, 단, 예외적으로 수소가 중수소 또는 삼중 수소로 치환되거나, 또는 탄소가 ¹³C- 또는 ¹⁴C 농축 탄소로 치환된 화합물이 본 발명의 범주 내에 포함된다.

일부 실시양태에서, 본원에 개시된 화합물은 상기 화합물을 구성하는 원자 중 하나 이상에서 원자 동위원소를 비천연 비율로 포함할 수 있다. 예를 들어, 화합물은 방사성 동위원소, 예컨대, 삼중 수소(³H), 요오드 125(¹²⁵I) 또는 탄소 14(¹⁴C)로 방사성 표지될 수 있다. 다른 실시양태에서, 하나 이상의 탄소 원자는 실리콘 원자로 치환된다. 방사성 여부와는 상관없이, 본원에 개시된 화합물의 모든 동원원소 변형물도 본원에서 고려된다.

펩티드모방체 마크로사이클의 제조

당업계에 공지된 다양한 방법들 중 임의의 방법에 의해 펩티드모방체 마크로사이클을 제조할 수 있다. 예를 들어, 표 1, 표 1a, 표 1b, 또는 표 1c에서 "$" 또는 "$r8"로 표시된 잔기 중 임의의 것은 같은 분자내의 제2 잔기 또는 상기 잔기의 전구체와 가교제를 형성할 수 있는 잔기로 치환될 수 있다.

펩티드모방체 마크로사이클 형성에 영향을 미치는 다양한 방법이 당업계에 공지되어 있다. 예를 들어, 화학식 I의 펩티드모방체 마크로사이클의 제조법은 문헌 [Schafmeister et al., J. Am. Chem. Soc. 122:5891-5892 (2000)]; [Schafmeister & Verdine, J. Am. Chem. Soc. 122:5891 (2005)]; [Walensky et al., Science 305: 1466-1470 (2004)]; 미국 특허 번호 제7,192,713호 및 PCT 출원 WO 2008/121767에 기술되어 있다. 인용된 참고 문헌에 개시된 α,α-이치환된 아미노산 및 아미노산 전구체는 펩티드모방체 마크로사이클 전구체 폴리펩티드의 합성에 사용될 수 있다. 예를 들어, "S5-올레핀 아미노산"은 (S)-α-(2'-펜테닐) 알라닌이고, "R8 올레핀 아미노산"은 (R)-α-(2'-옥테닐) 알라닌이다. 상기 아미노산을 전구체 폴리펩티드 내로 도입한 후, 말단 올레핀을 복분해 촉매와 함께 반응시켜 펩티드모방체 마크로사이클을 형성한다. 다양한 실시양태에서, 하기 아미노산이 펩티드모방체 마크로사이클 합성에 사용될 수 있다:

다른 실시양태에서, 펩티드모방체 마크로사이클은 화학식 IV 또는 Iva의 것이다. 상기 마크로사이클을 제조하는 방법은 예를 들어, 미국 특허 번호 제7,202,332호에 기술되어 있다.

적합한 것으로 구상되는 펩티드모방체 마크로사이클을 형성하는 추가의 방법은 문헌 [Mustapa, M. Firouz Mohd et al., J. Org. Chem (2003), 68, pp. 8193-8198]; [Yang, Bin et al. Bioorg Med. Chem. Lett. (2004), 14, pp. 1403-1406]; 미국 특허 번호 제5,364,851호; 미국 특허 번호 제5,446,128호; 미국 특허 번호 제5,824,483호; 미국 특허 번호 제6,713,280호; 및 미국 특허 번호 제7,202,332호개시되어 있는 것을 포함한다. 상기 실시양태에서, 알파 위치에 추가의 치환기 R을 포함하는 아미노산 전구체가 사용된다. 상기 아미노산은 마크로사이클 전구체의 원하는 위치에 도입되고, 이는 가교제가 치환된 위치일 수 있거나, 또는 별법으로, 의 서열 어디에나 도입된다. 이어서, 전구체의 고리화는 언급된 방법에 따라 수행된다.

검정

예를 들어, 하기 기술되는 방법을 사용하여 펩티드모방체 마크로사이클의 특성을 검정한다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 본원에 기술된 치환기가 없는 상응하는 폴리펩티드에 비하여 개선된 생물학적 특성을 가진다.

α 나선도를 측정하는 검정

용액 중에서 α 나선 도메인을 포함하는 폴리펩티드의 2차 구조는, 대개 "나선도(%)"로 표현되는, 불규칙 코일 구조와 α 나선 구조 사이의 동적 평형에 도달하게 될 것이다. 따라서, 예를 들어, 알파 나선형 도메인은 대개 용액 중에서 불규칙 코일이며, α 나선 함량은 보통 25% 미만이다. 한편, 최적화된 링커를 포함하는 펩티드모방체 마크로사이클은 예를 들어, 상응하는 비가교 결합된 폴리펩티드의 것보다 2배 이상 더 큰 알파 나선도를 가진다. 일부 실시양태에서, 마크로사이클은 50% 초과의 알파 나선도를 가질 것이다. 펩티드모방체 마크로사이클의 나선도를 검정하기 위해, 화합물을 수용액에(예컨대, 50 mM 인산칼륨 용액(pH 7), 또는 증류된 H₂O에 25-50 μM의 농도로) 용해시킨다. 표준 측정 파라미터(예컨대, 온도, 20℃; 파장, 190-260 nm; 단계 해상도, 0.5 nm; 속도, 20 nm/sec; 축적, 10; 반응, 1 sec; 대역폭, 1 nm; 경로 길이, 0.1 cm)를 사용하여 분광편광계(예컨대, 자스코(Jasco) J-710)에서 원편광 이색성(CD: Circular Dichroism) 스펙트럼을 수득한다. 평균 잔기 타원율(예컨대, [φ]222obs)을 모델 나선 데카펩티드에 대해 보고된 값으로 나누어 각 펩티드의 α 나선 함량을 산출한다(문헌 [Yang et al. (1986), Methods Enzymol. 130:208)])

융점( Tm )을 측정하는 검정

2차 구조, 예컨대, α 나선부를 포함하는 펩티드모방체 마크로사이클은 예를 들어, 상응하는 비가교 결합된 폴리펩티드보다 더 높은 융점을 보인다. 전형적으로, 수용액 중 고도로 안정한 구조를 나타내는 펩티드모방체 마크로사이클은 > 60℃의 Tm을 보인다. 마크로사이클 형성이 융점에 미치는 효과를 검정하기 위해, 펩티드모방체 마크로사이클 또는 비변형된 펩티드를 증류된 H₂O에(예컨대, 50 μM의 최종 농도로) 용해시키고, 표준 파라미터(예컨대, 파장 222 nm; 단계 해상도, 0.5 nm; 속도, 20 nm/sec; 축적, 10; 반응, 1 sec; 대역폭, 1 nm; 온도 증가율: 1℃/min; 경로 길이, 0.1 cm)를 사용하여 분광편광계(예컨대, 자스코 J-710)에서 온도 범위(예컨대, 4 내지 95℃)에 걸쳐 타원율의 변화를 측정함으로써 Tm을 측정한다.

프로테아제 저항성 검정.

펩티드 골격의 아미드 결합은 프로테아제에 의한 가수분해에 감수성이고, 따라서, 펩티드성 화합물은 생체내에서 신속하게 분해되기 쉽다. 그러나, 펩티드 나선부 형성은 전형적으로 아미드 골격을 포매시키고, 따라서, 이를 단백질분해 절단으로부터 차폐시킬 수 있다. 펩티드모방체 마크로사이클은 시험관내 트립신 단백질분해에 감수성일 수 있고, 이로써, 상응하는 비가교 결합된 폴리펩티드와의 비교로 분해율상의 임의 변화를 평가할 수 있다. 예를 들어, 펩티드모방체 마크로사이클 및 상응하는 비가교 결합된 폴리펩티드를 트립신 아가로스와 함께 인큐베이션시키고, 원심분리하고, 이어서 HPLC 주입에 의해 다양한 시점에 반응을 퀀칭함으로써 280 nm에서의 자외선 흡수에 의해 잔류 기질을 정량화한다. 간략하면, 펩티드모방체 마크로사이클 및 펩티드모방체 전구체(5 meg)를 0, 10, 20, 90, 및 180분 동안 트립신 아가로스(피어스(Pierce))(S/E ~125)와 함께 인큐베이션시킨다. 고속으로 테이블탑 원심분리에 의해 반응을 퀀칭하고; 280 nm에서 HPLC 기반 피크 검출에 의해 단리된 상청액 중의 남은 기질을 정량화한다. 단백질분해 반응은 1차 동역학적 성질을 보이며, 및 속도 상수, k는 ln[S] 대 시간의 플롯으로부터 측정된다(k=-1 X 기울기).

생체외 안정성 검정 .

최적화된 링커를 포함하는 펩티드모방체 마크로사이클은 예를 들어, 상응하는 비가교 결합된 폴리펩티드보다 2배 이상 큰 생체외 반감기를 가지고, 12시간 이상의 생체외 반감기를 가진다. 생체외 혈청 안정성 연구를 위해, 다양한 검정법이 사용될 수 있다. 예를 들어, 펩티드모방체 마크로사이클 및 상응하는 비가교 결합된 폴리펩티드(2 meg)를 새 마우스, 래트 및/또는 인간 혈청(2 mL)과 함께 37℃에서 0, 1, 2, 4, 8, 및 24시간 동안 인큐베이션시켰다. 무손상 화합물의 수준을 측정하기 위해 하기 방법을 사용할 수 있다: 100 ㎕의 혈청을 2 ml 원심분리관으로 옮겨 놓은 후, 10 ㎕의 50% 포름산 및 500 ㎕ 아세토니트릴을 첨가하고, 4 ± 2℃에서 10 min 동안 14,000 RPM으로 원심분리하여 샘플을 추출한다. 이어서, 상청액을 새 2 ml 관으로 옮겨 놓고, N₂< 10 psi하에 37℃에서 터보뱁(Turbovap)에서 증발시킨다. 샘플을 100 ㎕의 50:50 아세토니트릴:물 중에서 재구성하고, LC-MS/MS 분석을 수행한다.

시험관내 결합 검정.

펩티드모방체 마크로사이클 및 펩티드모방체 전구체의 수용체 단백질에의 결합 및 친화도를 평가하기 위해, 예를 들어, 형광 편광 검정법(FPA: fluorescence 극성ization assay)을 사용한다. FPA 기법은 편광 및 형광 트레이서를 사용하여 분자 배향 및 이동도를 측정한다. 편광으로 여기되었을 때, 겉보기 분자량이 높은 분자에 부착된 형광 트레이서(예컨대, FITC)(예컨대, 거대 단백질에 결합된 FITC로 표지화된 펩티드)는 보다 소형인 분자에 부착된 형광 트레이서(예컨대, 용액 중 유리 상태인 FITC로 표지화된 펩티드)와 비교하여 그의 회전 속도가 더 느린 것에 기인하여 보다 높은 수준의 편광된 형광을 방출한다.

예를 들어, 플루오레세인화된 펩티드모방체 마크로사이클(25 nM)을 실온에서 30분 동안 결합 완충제(140 mM NaCl, 50 mM 트리스 HCl(pH 7.4)) 중에서 수용체 단백질(25-1,000 nM)과 함께 인큐베이션시켰다. 결합 활성은 예를 들어, 발광 분광광도계(예컨대, 퍼킨-엘머(Perkin-Elmer) LS50B)에서의 형광 편광에 의해 측정한다. Kd 값은 예를 들어, 그래프패드 프리즘(GraphPad PRISM) 소프트웨어(그래프패드 소프트웨어, 인크.(GraphPad Software, Inc.: 미국 캘리포니아주 샌디에고))를 이용하여 비선형 회귀 분석에 의해 측정될 수 있다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 상응하는 비가교 결합된 폴리펩티드와 유사하거나, 또는 그보다 낮은 Kd를 보인다.

펩티드-단백질 상호작용의 길항제의 특징을 규명하는 시험관내 치환 검정

펩티드와 수용체 단백질 사이의 상호작용을 길항시키는 화합물의 결합 및 친화도를 평가하기 위해, 예를 들어, 펩티드모방체 전구체 서열로부터 유도된 플루오레세인화된 펩티드모방체 마크로사이클을 사용하는 형광 편광 검정법(FPA)을 사용한다. FPA 기법은 편광 및 형광 트레이서를 사용하여 분자 배향 및 이동도를 측정한다. 편광으로 여기되었을 때, 겉보기 분자량이 높은 분자에 부착된 형광 트레이서(예컨대, FITC)(예컨대, 거대 단백질에 결합된 FITC로 표지화된 펩티드)는 보다 소형인 분자에 부착된 형광 트레이서(예컨대, 용액 중 유리 상태인 FITC로 표지화된 펩티드)와 비교하여 그의 회전 속도가 더 느린 것에 기인하여 보다 높은 수준의 편광된 형광을 방출한다. 플루오레세인화된 펩티드모방체 마크로사이클과 수용체 단백질 사이의 상호작용을 길항시키는 화합물은 경쟁 결합 FPA 실험에서 검출될 것이다.

예를 들어, 추정 길항제 화합물(1 nM 내지 1 mM) 및 플루오레세인화된 펩티드모방체 마크로사이클(25 nM)을 실온에서 30분 동안 결합 완충제(140 mM NaCl, 50 mM 트리스 HCl(pH 7.4)) 중에서 수용체 단백질(50 nM)과 함께 인큐베이션시킨다. 길항제 결합 활성은 예를 들어, 발광 분광광도계(예컨대 퍼킨-엘머 LS50B)에서 형광 편광에 의해 측정한다. Kd 값은 예를 들어, 그래프패드 프리즘 소프트웨어(그래프패드 소프트웨어, 인크.: 미국 캘리포니아주 샌디에고)를 이용하여 비선형 회귀 분석에 의해 측정될 수 있다.

본 검정에서는 임의 부류의 분자, 예컨대, 소형 유기 분자, 펩티드, 올리고뉴클레오티드 또는 단백질을 추정 길항제로서 조사할 수 있다.

친화도 선택 질량 분석법에 의한 단백질- 리간드 결합에 대한 검정

단백질에 대한 테스트 화합물의 결합 및 친화도를 평가하기 위해, 예를 들어, 친화도 선택 질량 분석 검정법을 사용한다. 1 μM 펩티드모방체 마크로사이클 + 5 μM hMDM2를 사용하는 시스템 전역에 걸친 대조군 실험에 대해 개요된 하기의 대표적인 방법에 따라 단백질-리간드 결합 실험을 수행한다. 1 ㎕ DMSO 분취량의 40 μM 펩티드모방체 마크로사이클 스톡 용액을 19 ㎕의 PBS(포스페이트 완충처리된 염수(Phosphate buffered saline): 150 mM NaCl을 함유하는 50 mM(pH 7.5) 포스페이트 완충제) 중에 용해시킨다. 피펫팅을 반복하여 생성된 용액을 혼합하고, 10 min 동안 10,OOO g으로 원심분리하여 정화시킨다. 4 ㎕ 분취량의 생성된 상청액에 PBS 중의 4 ㎕의 10 μM hMDM2를 첨가한다. 따라서, 각 8.0 ㎕씩의 실험 샘플은 PBS 중 5.0 μM 농도의 40 pmol (1.5 ㎍)의 단백질과 1 μM 펩티드모방체 마크로사이클 및 2.5% DMSO를 함유한다. 따라서, 각 농도점에 대하여 상기와 같이 제조된 이중의 샘플을 실온에서 60 min 동안 인큐베이션시킨 후, 5.0 ㎕ 주입량의 크기 배제 크로마토그래피-LC-MS 분석을 수행하기 전 4℃로 냉각시킨다. 표적 단백질, 단백질-리간드 복합체, 및 비결합 화합물을 함유하는 샘플을 SEC 칼럼 상에 주입하는데, 여기서, 복합체는 고속 SEC 단계에 의해 비결합 성분으로부터으로 분리된다. UV 검출기를 사용하여 SEC 칼럼 용리액을 모니터링하여 SEC 칼럼의 공극 부피로 용리되는 조기 용리 단백질 분획이 칼럼 상에 유지되는 비결합 성분으로부터 잘 분해된다는 것을 확인한다. 단백질 및 단백질-리간드 복합체를 함유하는 피크가 1차 UV 검출기로부터 용리된 후, 샘플 루프로 진입하는데, 여기서, 이는 SEC 단계의 유동 흐름으로부터 절개되어 밸브형 기전을 통해 LC-MS로 직접 전달된다. ESI-MS에 의해 펩티드모방체 마크로사이클의 (M + 3H)³⁺ 이온을 m/z 예측치로 관찰하고, 이를 통해 단백질-리간드 복합체의 검출을 확인한다.

단백질- 리간드 Kd 적정 검정 실험.

단백질에 대한 테스트 화합물의 결합 및 친화도를 평가하기 위해, 예를 들어, 단백질-리간드 Kd 적정 실험을 수행한다. 단백질-리간드 K_d 적정 실험을 하기와 같이 수행한다: 2 ㎕ DMSO 분취량의 일련으로 희석된 적정제 펩티드모방체 마크로사이클(5, 2.5, 0.098 mM) 스톡 용액을 제조한 후, 38 ㎕의 PBS 중에 용해시킨다. 피펫팅을 반복하여 생성된 용액을 혼합하고, 10 min 동안 10,OOO g으로 원심분리하여 정화시킨다. 4 ㎕ 분취량의 생성된 상청액에 PBS 중의 4 ㎕의 10 μM hMDM2를 첨가한다. 따라서, 각 8.0 ㎕씩의 실험 샘플은 PBS 중 5.0 μM 농도의 40 pmol (1.5 ㎍)의 단백질, 다양한 농도(125, 62.5, 0.24 μM)의 적정제 펩티드, 및 2.5% DMSO를 함유한다. 각 농도점에 대하여 상기와 같이 제조된 이중의 샘플을 실온에서 30 min 동안 인큐베이션시킨 후, 2.0 ㎕ 주입량의 SEC-LC-MS 분석을 수행하기 전 4℃로 냉각시킨다. (M + H)¹⁺, (M + 2H)²⁺, (M + 3H)³⁺, 및/또는 (M + Na)¹⁺ 이온을 ESI-MS에 의해 관찰하고; 추출된 이온 크로마토그램을 정량화한 후, 문헌 ["A General Technique to Rank Protein - Ligand Binding Affinities and Determine Allosteric vs . Direct Binding Site Competition in Compound Mixtures." Annis, D. A.; Nazef, N.; Chuang, C. C; Scott, M. P.; Nash, H. M. J. Am. Chem. Soc. 2004, 126, 15495-15503]; 및 또한 ["ALIS : An Affinity Selection - Mass Spectrometry System for the Discovery and Characterization of Protein - Ligand Interactions" D. A. Annis, C.-C. Chuang, and N. Nazef. In Mass Spectrometry in Medicinal Chemistry. Edited by Wanner K, Hofner G: Wiley-VCH; 2007:121-184. Mannhold R, Kubinyi H, Folkers G (Series Editors): Methods and Principles in Medicinal Chemistry]에 기술되어 있는 바와 같이, 등식에 피팅시켜 결합 친화도 K_d를 도출해 낸다.

친화도 선택 질량 분석법에 의한 경쟁 결합에 대한 검정 실험

테스트 화합물이 단백질에 경쟁적으로 결합할 수 있는 능력을 측정하기 위해, 예를 들어, 친화도 선택 질량 분석 검정법을 수행한다. 2 ㎕ 분취량의, 3가지 화합물 각각의 400 μM 스톡을 14 ㎕의 DMSO와 배합하여 성분당 40 μM의 리간드 혼합물을 제조한다. 이어서, 1 ㎕ 분취량의, 성분당 40 μM의 상기 혼합물을 1 ㎕ DMSO 분취량의 1 ㎕ DMSO 분취량의 일련으로 희석된 적정제 펩티드모방체 마크로사이클 스톡 용액(10, 5, 2.5, 0.078 mM)과 배합한다. 상기 2 ㎕의 샘플을 38 ㎕의 PBS 중에 용해시킨다. 피펫팅을 반복하여 생성된 용액을 혼합하고, 10 min 동안 10,OOO g으로 원심분리하여 정화시켰다. 4 ㎕ 분취량의 생성된 상청액에 PBS 중의 4 ㎕의 10 μM hMDM2 단백질을 첨가한다. 따라서, 각 8.0 ㎕씩의 실험 샘플은 PBS 중 5.0 μM 농도의 40 pmol(1.5 ㎍)의 단백질과 0.5 μM 리간드, 2.5% DMSO, 및 다양한 농도 125, 62.5, 0.98 μM)의 적정제 펩티드모방체 마크로사이클을 함유한다. 각 농도점에 대하여 상기와 같이 제조된 이중의 샘플을 실온에서 60 min 동안 인큐베이션시킨 후, 2.0 ㎕ 주입량의 SEC-LC-MS 분석을 수행하기 전 4℃로 냉각시킨다. 상기 및 다른 방법에 대한 추가의 상세한 설명은 문헌 ["A General Technique to Rank Protein - Ligand Binding Affinities and Determine Allosteric vs . Direct Binding Site Competition in Compound Mixtures." Annis, D. A.; Nazef, N.; Chuang, C. C.; Scott, M. P.; Nash, H. M. J. Am . Chem . Soc. 2004, 126, 15495-15503]; 및 또한 ["ALIS : An Affinity Selection - Mass Spectrometry System for the Discovery and Characterization of Protein - Ligand Interactions " D. A. Annis, C.-C. Chuang, and N. Nazef. In Mass Spectrometry in Medicinal Chemistry. Edited by Wanner K, Hoefner G: Wiley-VCH; 2007:121-184. Mannhold R, Kubinyi H, Folkers G (Series Editors): Methods and Principles in Medicinal Chemistry]에 제공되어 있다.

무손상(intact) 세포에서의 결합 검정

면역침강 실험에 의해 무손상 세포에서 펩티드 또는 펩티드모방체 마크로사이클의 그의 천연 수용체에의 결합을 측정할 수 있다. 예를 들어, 무손상 세포를 혈청 부재하에 4 hrs 동안 플루오레세인화된(FITC로 표지화된) 화합물과 함께 인큐베이션시킨 후, 혈청 교체하고, 4-18 hrs 범위의 시간 동안 추가로 인큐베이션시킨다. 이어서, 세포를 펠릿화하고, 4℃에서 10분 동안 용해 완충제(50 mM 트리스[pH 7.6], 150 mM NaCl, 1% CHAPS 및 프로테아제 억제제 칵테일) 중에서 인큐베이션시킨다. 추출물을 15분 동안 14,000 rpm으로 원심분리하고, 상청액을 수집하고, 4℃에서 회전시키면서, 2 hrs 동안 10 ㎕ 염소 항FITC 항체와 함께 인큐베이션시킨 후, 4℃에서 추가로 2 hrs 동안 단백질 A/G 세파로스(50 ㎕의 50% 비스 슬러리)와 함께 인큐베이션시킨다. 고속 원심분리 후, 농도를 증가시키면서(예컨대, 150, 300, 500 mM) 염을 함유하는 용해 완충제로 펠릿을 세척한다. 이어서, SDS 함유 샘플 완충제를 첨가하고, 비등시키기 이전에 비드를 150 mM NaCl로 재평형화시킨다. 원심분리 후, 4%-12% 구배 비스-트리스 겔을 사용하여 상청액을 임의적으로 전기영동시킨 후, 임모빌론-P(Immobilon-P) 막으로 전달한다. 차단시킨 후, 임의적으로 블롯을, FITC를 검출하는 항체와 함께, 및 또한 펩티드모방체 마크로사이클에 결합하는 단백질을 검출하는 하나 이상의 항체와 함께 인큐베이션시킨다.

세포 투과성 검정.

펩티드모방체 마크로사이클은 예를 들어, 상응하는 비가교 결합된 마크로사이클에 비하여 더욱 큰 세포 투과성을 가진다. 최적화된 링커를 포함하는 펩티드모방체 마크로사이클은 예를 들어, 상응하는 비가교 결합된 폴리펩티드보다 2배 이상 큰 세포 투과성을 가지고, 대개 적용된 펩티드모방체 마크로사이클 중 20% 이상이 4시간 이후에 세포를 투과한 것을 관찰하게 될 것이다. 펩티드모방체 마크로사이클 및 상응하는 비가교 결합된 마크로사이클의 세포 투과성을 측정하기 위해, 무손상 세포를 무혈청 배지 중에 37℃에서 4 hrs 동안 형광 표지화된(예컨대, 플루오레세인화된) 펩티드모방체 마크로사이클 또는 상응하는 비가교 결합된 마크로사이클(10 μM)가 함께 인큐베이션시키고, 배지로 2회에 걸쳐 세척하고, 37℃에서 10 min 동안 트립신(0.25%)과 함께 인큐베이션시킨다. 세포를 다시 세척하고, PBS 중에 재현탁시킨다. 예를 들어, FACSCalibur 유세포 측정기 또는 셀로믹스 키네틱스캔(Cellomics KineticScan)® HCS 판독기를 사용하여 세포 형광을 분석한다.

세포 효능 검정.

예를 들어, 인간 또는 마우스 세포 집단으로부터 유래된 다양한 종양 형성성 및 비종양 형성성 세포주 및 1차 세포를 사용하여 세포 기반 사멸 검정법으로 특정 펩티드모방체 마크로사이클의 효능을 측정한다. 예를 들어, 펩티드모방체 마크로사이클(0.5 내지 50 μM)과 함께 24-96 hrs에 걸쳐 인큐베이션시키면서 세포 생존능을 모니터링함으로써 EC₅₀ <10 μM에서 사멸되는 것을 확인한다. 세포 생존능을 측정하는 수개의 표준 검정법은 상업적으로 이용가능하고, 임의적으로 이를 사용하여 펩티드모방체 마크로사이클의 효능을 평가한다. 추가로, 임의적으로 아넥신(Annexin) V 및 카스파제 활성화를 측정하는 검정법을 사용하여 펩티드모방체 마크로사이클이 아폽토시스성 기구를 활성화시킴으로써 세포를 사멸시키는지 여부를 평가한다. 예를 들어, 세포내 ATP 농도의 함수로서 세포 생존능을 측정하는 셀 타이터-글로(Cell Titer-glo) 검정법을 사용한다.

생체내 안정성 검정.

펩티드모방체 마크로사이클의 생체내 안정성을 조사하기 위해, 화합물을 0.1 내지 50 mg/kg 범위의 농도로 IV, IP, PO 또는 흡입 경로에 의해 마우스 및/또는 래트에 투여하고, 주사 후 0', 5', 15', 30', 1 hr, 4 hrs, 8 hrs 및 24시간째에 혈액 표본을 채취한다. 이어서, 25 ㎕의 새 혈청 중의 무손상 화합물의 수준을 상기와 같이 LC -MS/MS에 의해 측정한다.

동물 모델에서의 생체내 효능

생체내에서 펩티드모방체 마크로사이클의 항종양원성 활성을 측정하기 위해, 화합물을 예를 들어, 단독으로(IP, IV, PO, 흡입 또는 비내 경로에 의해) 또는 차선 용량의 관련 화학요법(예컨대, 사이클로포스파미드, 독소루비신, 에토포시드)과 조합하여 투여한다. 일례에서, 전신 방사선 조사를 받은 후 3 hrs가 경과하였을 때, (급성 림프아구성 백혈병 환자의 골수로부터 확립된) 안전하게 루시퍼라제를 발현하는 5 x 10⁶개의RS4;11 세포를 NOD-SCID 마우스 꼬리 정맥에 주사한다. 비처리된 상태로 남겨진 경우, 상기 모델에서 상기 형태의 백혈병은 3주 경과 후에는 치명적이다. 예를 들어, 마우스에 D-루시페린(60 mg/kg)을 주사하고, 마취시킨 동물을 영상화하여[예컨대, 제노겐 인 비트로 이미징 시스템(Xenogen In vitro Imaging System), 캘리퍼 라이프 사이언시즈(Caliper Life Sciences: 미국 매사추세츠주 홉킨턴)) 백혈병을 쉽게 모니터링한다. 라이빙 이미지 소프트웨어(Living Image Software)(캘리퍼 라이프 사이언시즈: 미국 매사추세츠주 홉킨턴)에 의해 광자 유속 (광자/sec) 적분에 의해 전신 생체발광을 정량한다. 펩티드모방체 마크로사이클을 O.1 mg/kg 내지 50 mg/kg 범위의 용량으로 단독으로, 또는 차선 용량의 관련 화학요법제와 함께 조합하여 예를 들어, 7 내지 21일 동안 꼬리 정맥에 의해 또는 IP 경로에 의해 백혈병 마우스에 투여한다(주사 후 10일일째/실험 1일째, 생체발광 범위 14-16). 임의적으로, 실험 전 기간 동안 격일로 마우스를 영상화하고, 실험 기간 동안 매일 생존을 모니터링한다. 임의적으로, 수명이 다한 마우스는 실험 종료시 부검한다. 인간 여포성 림프종으로부터 유래된 세포주인, 안정하게 루시퍼라제를 발현하는, DoHH2를 이식받은 NOD-SCID 마우스이다. 상기 생체내 테스트를 통해 임의적으로 예비 약동학적, 약역학적, 및 독성 데이터를 작성한다.

임상 시험

펩티드모방체 마크로사이클의 인간 치료용으로서의 적합성을 측정하기 위해, 임상 시험을 수행한다. 예를 들어, 암 진단을 받고, 치료를 필요로 하는 환자를 선택하고, 처리군 및 하나 이상의 대조군으로 분리하는데, 여기서, 처리군에는 펩티드모방체 마크로사이클을 투여한 반면, 대조군에는 위약 또는 공지된 항암 약물을 투여한다. 따라서, 펩티드모방체 마크로사이클의 치료 안전성 및 효능은 인자, 예컨대, 생존율 및 삶의 질과 관련하여 환자군을 비교함으로써 평가될 수 있다. 상기 예에서, 펩티드모방체 마크로사이클로 처리된 환자군은 위약으로 처리된 환자 대조군과 비교하여 개선된 장기간의 생존율을 보일 수 있다.

약학 조성물 및 투여 경로

본원에 개시된 약학 조성물은 펩티드모방체 마크로사이클 및 그의 약학적으로 허용가능한 유도체 또는 프로드럭을 포함한다. "약학적으로 허용가능한 유도체"란 수혜자에게 투여되었을 때, 본원에 개시된 화합물을 (직접 또는 간접적으로) 제공할 수 있는, 본원에 개시된 화합물의 임의의 약학적으로 허용가능한 염, 에스테르, 에스테르의 염, 프로드럭 또는 유도체를 의미한다. 특히 바람직한 약학적으로 허용가능한 유도체는 포유동물에게 투여되었을 때 (예컨대, 경구적으로 투여된 화합물의 혈액 내로의 흡수를 증가시킴으로써) 화합물의 생체이용성을 증가시키거나, 또는 활성 화합물의 생물학적 구획(예컨대, 뇌, 또는 림프계)으로의 전달을 모체 종에 비하여 증가시키는 것이다. 일부 약학적으로 허용가능한 유도체는 위장관 점막을 가로지르는 수 용해도 또는 능동 수송을 증가시키는 화학 기를 포함한다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 선택적 생물학적 특성을 증진시키기 위해 적절한 작용기를 공유적으로 또는 비공유적으로 결합시킴으로써 변형된다. 상기 변형으로는 주어진 생물학적 구획(예컨대, 혈액, 림프계, 중추 신경계)으로의 생물학적 투과를 증가시키는 것, 경구 이용가능성을 증가시키는 것, 주사에 의해 투여될 수 있도록 하는 용해도를 증가시키는 것, 대사를 변경시키는 것, 및 배설률을 증가시키는 것을 포함한다.

본원에 개시된 화합물의 약학적으로 허용가능한 염으로는 약학적으로 허용가능한 무기산 및 유기산 및 염기로부터 유도된 것을 포함한다. 적합한 산 염의 예로는 아세테이트, 아디페이트, 벤조에이트, 벤젠술포네이트, 부티레이트, 시트레이트, 디글루코네이트, 도데실술페이트, 포르메이트, 푸마레이트, 글리콜레이트, 헤미술페이트, 헵타노에이트, 헥사노에이트, 하이드로클로라이드, 하이드로브로마이드, 하이드로요오다이드, 락테이트, 말레이트, 말로네이트, 메탄술포네이트, 2-나프탈렌술포네이트, 니코티네이트, 니트레이트, 팔모에이트, 포스페이트, 피크레이트, 피발레이트, 프로피오네이트, 살리실레이트, 숙시네이트, 술페이트, 타르트레이트, 토실레이트, 및 운데카노에이트를 포함한다. 적절한 염으로부터 유도된 염으로는 알칼리 금속(예컨대, 나트륨), 알칼리토 금속(예컨대, 마그네슘), 암모늄 및 N-(알킬)₄ ⁺ 염을 포함한다.

본원에 개시된 화합물로부터 약학 조성물을 제조하기 위힌 약학적으로 허용가능한 담체로는 고체 또는 액체 담체를 포함한다. 고체 형태 제제로는 분제, 정제, 환제, 캡슐제, 카세제, 좌제, 및 분산성 과립제를 포함한다. 고체 담체는 희석제, 향미제, 결합제, 보존제, 정제 붕해제, 또는 캡슐화 물질로도 작용할 수 있는, 하나 이상의 물질일 수 있다. 제제화 및 투여 기법에 관한 상세한 설명은 과학 문헌 및 특허 문헌에 잘 기술되어 있고, 예컨대, 문헌 [Remington's Pharmaceutical Sciences, Maack Publishing Co, Easton PA]의 최신판을 참조할 수 있다.

분제에서 담체는 미분된 활성 성분과의 혼합물 형태인, 미분된 고체이다. 정제에서, 활성 성분은 필요한 결합 특성을 가지는 담체와 적절한 비율로 혼합되고, 원하는 형상 및 크기로 압축된다.

적합한 고체 부형제는 탄수화물 또는 단백질 충전제이며, 이는 당(락토스, 수크로스, 만닛톨, 또는 소르비톨 포함); 옥수수, 소맥, 벼, 감자, 또는 다른 식물로부터의 전분; 셀룰로스, 예컨대, 메틸 셀룰로스, 하이드록시프로필메틸-셀룰로스, 또는 나트륨 카복시메틸셀룰로스; 및 검(아라비아 검 및 트라가칸트 검 포함); 뿐만 아니라, 단백질, 예컨대, 젤라틴 및 콜라겐을 포함하나, 이에 한정되지 않는다. 원하는 경우, 붕해제 또는 가용화제, 예컨대, 가교 결합된 폴리비닐 피롤리돈, 아가, 알긴산, 또는 그의 염, 예컨대, 알긴산 나트륨이 첨가된다.

액체 형태의 제제로는 액제, 현탁제, 및 에멀젼, 예를 들어, 물 또는 물/프로필렌 글리콜 용액을 포함한다. 비경구적 주사를 위해, 액체 제제는 폴리에틸렌 글리콜 수용액 중의 액제로 제제화될 수 있다.

약학 제제는 단위 투여 형태일 수 있다. 상기 형태에서, 제제는 적절한 양의 활성 성분을 함유하는 단위 용량으로 세분된다. 단위 투여 형태는 패키지가 별개의 양으로 제제를 함유하는 것인 패키징된 제제, 예컨대, 바이알 또는 앰플 중 패킷된 정제, 캡슐제, 및 분제일 수 있다. 또한, 단위 투여 형태는 캡슐제, 정제, 카세제, 또는 로젠지 그 자체일 수 있거나, 또한 적절한 개수의, 패키징된 형태의 상기 중 임의 것일 수 있다.

본원에 개시된 하나 이상의 조성물이 펩티드모방체 마크로사이클, 및 추가의 치료제 또는 예방제의 조합물을 포함할 경우, 상기 화합물 및 추가 작용제, 둘 모두 단일요법 방식에서 보통 투여되는 투여량의 약 1 내지 100%, 및 더욱 바람직하게, 약 5 내지 95%인 투여량 수준으로 존재할 수 있다. 일부 실시양태에서, 추가 작용제는 다중 투약 요법의 일부로서 본원에 개시된 하나 이상의 화합물과 별개로 투여된다. 별법으로, 상기 작용제는 단일 투여 형태의 일부이며, 이를 본원에 개시된 화합물과 함께 단일 조성물로 혼합된다.

사용 방법

한 측면에서, 펩티드모방체 마크로사이클을 모델링하였을 때 단백질 또는 펩티드의 천연 리간드(들)에 결합하는 작용제를 확인하기 위한 경쟁 결합 검정에서 유용한 신규한 펩티드모방체 마크로사이클을 제공한다. 예를 들어, p53/MDMX 시스템에서, p53에 기반한 표지화된 펩티드모방체 마크로사이클은 MDMX에 경쟁적으로 결합하는 소형 분자에 따라 MDMX 결합 검정에서 사용될 수 있다. 경쟁 결합 연구를 통해 p53/MDMX 시스템에 특이적인 약물 후보물질을 신속하게 시험관내 평가하고, 측정할 수 있다. 상기 결합 연구는 본원에 개시된 펩티드모방체 마크로사이클 중 임의의 것과 그의 결합 파트너로 수행될 수 있다.

펩티드모방체 마크로사이클에 대한 항체를 생성하는 방법을 추가로 제공한다. 일부 실시양태에서, 상기 항체는 펩티드모방체 마크로사이클, 및 펩티드모방체 마크로사이클과 관련된, 전구체 펩티드, 예컨대, p53, 둘 모두에 특이적으로 결합한다. 예를 들어, 상기 항체는 천연 단백질-단백질 상호작용, 예를 들어, p53과 MDMX 사이의 결합을 파괴시킨다.

다른 측면에서, p53, MDM2 또는 MDMX를 비롯한 분자의 비정상적인(예컨대, 불충분, 또는 과도한) 발현과 관련된 장애를 앓을 위험이 있거나(그에 걸릴 위험이 있거나), 그러한 장애를 앓고 있는 피험체를 치료하는 예방학적 및 치료학적 방법, 둘 모두를 제공한다.

또 다른 실시양태에서, 장애는 적어도 부분적으로는 비정상적인 수준의 p53 또는 MDM2 또는 MDMX에 의해(예컨대, 과다발현 또는 과소발현), 또는 비정상적인 활성을 보이는 p53 또는 MDM2 또는 MDMX의 존재에 의해 유발된다. 따라서, 예를 들어, 장애를 호전시키거나, 장애의 유해 증상을 감소시키기 위해, p53으로부터 유도된 펩티드모방체 마크로사이클에 의해 p53 또는 MDM2 또는 MDMX의 수준 및/또는 활성을 감소시키거나, p53 또는 MDM2 또는 MDMX의 수준 및/또는 활성을 증가시키는 것인 사용된다.

또 다른 측면에서, 본원에서는 예를 들어, p53과 MDM2, 또는 p53과 MDMX와 같은 결합 파트너 사이의 상호작용 또는 결합을 방해함으로써 과증식성 질환 및 염증성 장애를 비롯한 질환을 치료 또는 예방하는 방법을 제공한다. 상기 방법은 인간을 비롯한 온혈 동물에게 유효량의 화합물을 투여하는 단계를 포함한다. 일부 실시양태에서, 본원에 개시된 하나 이상의 화합물을 투여하면, 세포 성장 정지 또는 아폽토시스가 유도된다.

본원에서 사용되는 바, "치료"라는 용어는 질환, 질환의 증상, 질환에 대한 소인을 고치거나, 치유하거나, 완화시키거나, 경감시키거나, 변경시키거나, 제거하거나, 호전시키거나, 개선시키거나, 또는 영향을 주는 것을 목적으로 하여 질환, 질환의 증상, 질환에 대한 소인을 가지는 환자에게 치료제를 적용 또는 투여하거나, 또는 상기와 같은 환자로부터 단리된 조직 또는 세포주에게 치료제를 적용 또는 투여하는 것으로 정의된다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 암 및 신생물성 병증을 치료, 예방, 및/또는 진단하는 데 사용될 수 있다. 본원에서 사용되는 바, "암", "과증식성" 및 "신생물성"이라는 용어는 세포가 자율 성장하는 능력, 즉, 세포 성장을 신속하게 증식시키는 것을 특징으로 하는 비정상적인 상태 또는 병증을 가진다는 것을 의미한다. 과증식성 및 신생물성 질환 상태는 병적인 것으로, 즉, 질환 상태를 특징으로 하거나, 그러한 것을 구성하는 것으로 분류될 수 있거나, 또는 비병적인 것으로, 즉, 정상에서 벗어나기는 하였지만, 질환 상태와는 관련이 없는 것으로 분류될 수 있다. 상기 용어는 조직병리학적 유형 또는 침윤 단계와 상관없이, 모든 유형의 암성 성장 또는 종양원성 과정, 전이성 조직 또는 악성 형질전환된 세포, 조직, 또는 기관을 포함하는 것으로 한다. 전이성 종양은 유방, 폐, 간, 결장, 및 난소 기원의 종양을 포함하나, 이에 한정되지 않는, 다수의 원발성 종양 유형으로부터 발생될 수 있다. "병적 과증식성" 세포는 악성 종양 성장을 특징으로 하는 지환 상태에 존재한다. 비병적 과증식성 세포의 예로는 상처 수복과 관련된 세포의 증식을 포함한다. 세포 증식성 및/또는 분화성 장애의 예로는 암, 예컨대, 암종, 육종, 또는 전이성 장애를 포함한다. 일부 실시양태에서, 펩티드모방체 마크로사이클은 유방암, 난소암, 결장암, 폐암, 상기 암의 전이 등을 제어하기 위한 신규한 치료제이다.

암 또는 신생물성 병증의 예로는 섬유육종, 근육종, 지방육종, 연골육종, 골 육종, 척삭종, 혈관육종, 내피종, 림프관육종, 림프관내피육종, 활막종, 중피종, 유잉(Ewing's) 종양, 평활근육종, 횡문근육종, 위암, 식도암, 직장암, 췌장암, 난소암, 전립샘암, 자궁암, 두경부암, 피부암, 뇌암, 편평 세포 암종, 피지샘 암종, 유두상 암종, 유두상 샘암종, 낭샘암종, 수질 암종, 기관지원성 암종, 신세포 암종, 간암, 담관 암종, 육모암종, 정상피종, 배아암종 암종, 윌름즈(Wilm's) 종양, 자궁경부암, 고환 암, 소세포 폐암종, 비소세포 폐암종, 방광 암종, 상피 암종, 신경교종, 성상세포종, 수모세포종, 두개인두종, 뇌실막세포종, 송과체종, 혈관아세포종, 청신경종, 희소돌기신경교종, 수막종, 흑색종, 신경아세포종, 망막아세포, 백혈병, 림프종, 또는 카포시(Kaposi) 육종을 포함하나, 이에 한정되지 않는다.

일부 실시양태에서, 암은 두경부암, 두경부암, 흑색종, 폐암, 유방암, 또는 신경교종이다.

증식성 장애의 예로는 조혈 신생물성 장애를 포함한다. 본원에서 사용되는 바, "조혈 신생물성 장애"라는 용어는 조혈 기원의, 예컨대, 골수성, 림프성 또는 적혈구 계통으로부터 발생된 과형성성/신생물성 세포, 또는 그의 전구체 세포를 포함하는 질환을 의미한다. 질환은 저분화 급성 백혈병, 예컨대, 적아구성 백혈병 및 급성 거핵아구성 백혈병으로부터 유발될 수 있다. 추가의 예시적인 골수성 장애로는 급성 전골수성 백혈병(APML: acute promyeloid leukemia), 급성 골수 백혈병(AML: acute myelogenous leukemia) 및 만성 골수 백혈병(CML: chronic myelogenous leukemia)(문헌 [Vaickus (1991), Crit Rev . Oncol ./ Hemotol. 11:267-97]에서 리뷰)을 포함하나, 이에 한정되지 않고; 림프성 악성 종양으로는 급성 림프아구성 백혈병(ALL: acute lymphoblastic leukemia)(B 계통 ALL 및 T 계통 ALL 포함), 만성 림프구성 백혈병(CLL: chronic lymphocytic leukemia), 전림프구성 백혈병(PLL: prolymphocytic leukemia), 유모세포 백혈병(HLL: hairy cell leukemia) 및 발덴스트롬 마크로글로불린혈증(WM: Waldenstrom's macroglobulinemia)을 포함하나, 이에 한정되지 않는다. 악성 림프종의 추가 형태로는 비호지킨 림프종 및 그의 변이체, 말초 T 세포 림프종, 성인 T 세포 백혈병/림프종(ATL: adult T cell leukemia/lymphoma), 피부 T 세포 림프종(CTCL: cutaneous T-cell lymphoma), 대 과립 림프구성 백혈병(LGF: large granular lymphocytic leukemia), 호지킨 질환 및 리드-슈테른베르크(Reed-Stemberg) 질환을 포함하나, 이에 한정되지 않는다.

유방의 세포 증식성 및/또는 분화성 장애의 예로는 증식성 유방 질환(예컨대, 상피 과형성, 경화샘증, 및 소관 유두종 포함); 종양, 예컨대, 간질 종양, 예컨대, 섬유샘종, 엽상 종양, 및 육종, 및 상피 종양, 예컨대, 대관 유두종; 유방 암종(유관 상피내 암종(파제트병(Paget's disease) 포함) 및 상피내 소엽성 암종을 포함하는 상피내 (비침습성) 암종, 및 침습성 유관 암종, 침습성 소엽성 암종, 수질 암종, 콜로이드성(점액) 암종, 관암종, 및 침습성 유두상 암종을 포함하나, 이에 한정되지 않는 침습성(침윤성) 암종 포함), 및 기타 악성 신생물을 포함하나, 이에 한정되지 않는다. 남성 유방에서의 장애로는 여성유방증 및 암종을 포함하나, 이에 한정되지 않는다.

피부의 세포 증식성 및/또는 분화성 장애의 예로는 증식성 피부 질환 예컨대, 흑색종(점막 흑색종, 표재 확산성 흑색종, 결절 흑색종, 흑색점(예컨대 악성 흑색점, 악성 흑색점 흑색종, 또는 말단 흑자 흑색종), 멜라닌 결핍 흑색종, 섬유 조직 형성 흑색종, 스피츠(Spitz) 모반 형상을 가지는 흑색종, 소형 모반 유사 세포를 포함하는 흑색종, 폴립모양 흑색종, 및 연조직 흑색종 포함); 기저 세포 암종(미세결절 기저 세포 암종, 표재 기저 세포 암종, 결절 기저 세포 암종(잠식 궤양), 낭종성 기저 세포 암종, 반흔성 기저 세포 암종, 색소 기저 세포 암종, 이소성 기저 세포 암종, 침윤성 기저 세포 암종, 모반 모양 기저 세포 암종 증후군, 폴립모양 기저 세포 암종, 구멍 유사 기저 세포 암종, 및 핑커스(Pinkus)의 섬유상피종 포함); 편평 세포 암종(극세포종(대세포 극세포종), 샘모양 편평 세포 암종, 기저양 편평 세포 암종, 투명 세포 편평 세포 암종, 반지 세포 편평 세포 암종, 방추 세포 편평 세포 암종, 마졸린 궤양(Marjolin's ulcer), 퀘이라 홍색 비후증(erythroplasia of Queyrat), 및 보엔병(Bowen's disease) 포함); 또는 다른 피부 또는 피하 종양을 포함하나, 이에 한정되지 않는다.

폐의 세포 증식성 및/또는 분화성 장애의 예로는 기관지원성 암종(부신생물성 증후군, 세기관지폐포 암종, 신경내분비 종양, 예컨대, 기관지 카르시노이드, 기타 종양, 및 전이성 종양 포함); 흉막 병리(염증성 흉막 삼출, 비염증성 흉막 삼출, 기흉, 및 고립 섬유 종양(흉막 섬유종)을 비롯한 흉막 종양 포함) 및 악성 중피종을 포함하나, 이에 한정되지 않는다.

결장의 세포 증식성 및/또는 분화성 장애의 예로는 비신생물성 폴립, 샘종, 가족성 증후군, 결장직장 발암, 결장직장암종, 및 카르시노이드 종양을 포함하나, 이에 한정되지 않는다.

간의 세포 증식성 및/또는 분화성 장애의 예로는 결절 과형성, 샘종, 및 악성 종양(간의 원발성 암종 및 전이성 종양 포함)을 포함하나, 이에 한정되지 않는다.

난소의 세포 증식성 및/또는 분화성 장애의 예로는 난소 종양, 예컨대, 체강 상피 종양, 장액성 종양, 점액 종양, 자궁 내막양 종양, 투명 세포 샘암종, 낭샘섬유종, 브렌너(Brenner) 종양, 표면 상피 종양; 생식 세포 종양, 예컨대, 성숙(양성) 기형종, 단배엽성 기형종, 미성숙 악성 기형종, 난소생식세포종, 내배엽동 종양, 융모막암종; 성삭-기질 종양, 예컨대, 과립 난포막 세포 종양, 난포막종 섬유종, 남성모세포종, 힐(hill) 세포 종양, 및 생식아세포종; 및 전이성 종양 예컨대, 크루켄버그(Krukenberg) 종양을 포함하나, 이에 한정되지 않는다.

본원에서는 본 발명의 바람직한 실시양태가 제시되고, 기술되었지만, 상기 실시양태는 단지 일례에서 제공되었다는 것은 당업자에게 자명할 것이다. 이에 당업자는 본 발명으로부터 벗어남 없이 다수의 수정, 변형 및 치환을 수행할 수 있을 것이다. 본 발명을 실시하는 데 본원에 기술된 실시양태에 대한 다수의 대안이 사용될 수 있다는 점을 이해하여야 한다. 하기의 특허청구범위가 범주를 정의하며, 이러한 특허청구범위의 범주 내에 포함된 방법 및 구조 및 그의 등가물이 그에 의해 포함되는 것으로 한다.

실시예

실시예 1:

6- 클로로트립토판 Fmoc 아미노산의 합성

Tert-부틸 6-클로로-3-포르밀-1H-인돌-1-카복실레이트 (1). 아르곤하에 0℃에서 건식 DMF의 교반된 용액(12 mL)에 POCl₃(3.92 mL, 43 mmol, 1.3 equiv)을 적가하였다. 건식 DMF(30 mL) 중의 6-클로로인돌(5.0 g, 33 mmol, 1 eq.)의 용액을 적가하기 전에 20 min 동안 동일 온도에서 용액을 교반하였다. 생성된 혼합물을 실온으로 가온시키고, 추가의 2.5 h 동안 교반하였다. 물(50 mL)을 첨가하고, 용액을 4 M 수성 NaOH(pH ~8)로 중화시켰다. 생성된 고체를 여과하고, 물로 세척하고, 진공하에서 건조시켰다. 상기 물질을 추가로 정제하지 않고 다음 단계에서 직접 사용하였다. N₂하에 실온에서 THF(150 mL) 중의 조 포르밀 인돌(33 mmol, 1 eq.)의 교반된 용액에 Boc₂O(7.91 g, 36.3 mmol, 1.1 equiv) 및 DMAP(0.4 g, 3.3 mmol, 0.1 equiv)를 연속하여 첨가하였다. 생성된 혼합물을 실온에서 1.5 h 동안 교반하고, 용매를 감압하에 증발시켰다. 잔류물을 EtOAc 중에 용해시키고, 1 N HCl로 세척하고, 건조시키고, 농축시켜 백색 고체로서 포르밀 인돌 (1)(9 g, 2단계를 거쳐 98%)을 수득하였다. ¹H NMR (CDCl₃)δ: 1.70 (s, Boc, 9H); 7.35 (dd, 1H); 8.21 (m, 3H); 10.07 (s, 1H).

Tert-부틸 6-클로로-3-(하이드록시메틸)-1H-인돌-1-카복실레이트 (2). 에탄올(150 mL) 중의 화합물 (1)(8.86g, 32 mmol, 1 eq.)의 용액에 NaBH₄(2.4g, 63 mmol, 2 eq.)를 첨가하였다. 반응물을 실온에서 3 h 동안 교반시켰다. 반응 혼합물을 농축시키고, 잔류물을 디에틸 에테르 및 물에 부었다. 유기층을 분리시키고, 황산마그네슘 상에서 건조시키고, 농축시켜 백색 고체(8.7 g, 98%)를 수드하였다. 상기 물질을 추가로 정제하지 않고 다음 단계에서 직접 사용하였다. ¹H NMR (CDCl₃)δ: 1.65 (s, Boc, 9H); 4.80 (s, 2H, CH₂); 7.21 (dd, 1H); 7.53 (m, 2H); 8.16 (bs, 1H).

Tert-부틸 3-(브로모메틸)-6-클로로-1H-인돌-1-카복실레이트 (3). 아르곤하에 -40℃에서 디클로로메탄(50 mL) 중의 화합물 (2)(4.1 g, 14.6 mmol, 1 eq.)의 용액에 디클로로메탄(50 mL) 중의 트리페닐포스핀(4.59 g, 17.5 mmol, 1.2 eq.)의 용액을 첨가하였다. 반응 용액을 40℃에서 추가의 30 min 동안 교반하였다. 이어서, NBS (3.38 g, 19 mmol, 1.3 eq.)를 첨가하였다. 생성된 혼합물을 실온으로 가온시키고, 밤새도록 교반하였다. 디클로로메탄을 증발시키고, 사염화탄소(100 mL)을 첨가하고, 혼합물을 1 h 동안 교반하고, 여과하였다. 여액을 농축시키고, 실리카 플러그에 로딩하고, 헥산 중 25% EtOAc로 신속하게 용리시켰다. 용액을 농축시켜 백색 기포(3.84g, 77%)를 수득하였다. ¹H NMR (CDCl₃)δ: 1.66 (s, Boc, 9H); 4.63 (s, 2H, CH₂); 7.28 (dd, 1H); 7.57 (d, 1H); 7.64 (bs, 1H); 8.18 (bs, 1H).

αMe-6Cl-Trp(Boc)-Ni-S-BPB (4). 아르곤하에서 S- Ala - Ni -S-BPB(2.66g, 5.2 mmol, 1 eq.) 및 KO-tBu(0.87g, 7.8 mmol, 1.5 eq.)에 50 mL의 DMF를 첨가하였다. DMF(5.0 mL) 용액 중의 브로마이드 유도체인 화합물 (3)(2.68g, 7.8 mmol, 1.5 eq.)을 시린지를 통해 첨가하였다. 반응 혼합물을 주변 온도에서 1 h 동안 교반하였다. 이어서, 용액을 5% 수성 아세트산으로 퀀칭시키고, 물로 희석시켰다. 원하는 생성물을 디클로로메탄 중에서 추출하고, 건조시키고, 농축시켰다. 용리제로서 EtOAc 및 헥산을 사용하여 정상 상에서 플래쉬 크로마토그래피(고체 로딩)에 의해 오일성 생성물 (4)을 정제하여 적색 고체(1.78g, 수율 45%)를 수득하였다. αMe-6Cl-Trp(Boc)-Ni-S-BPB (4):

Fmoc-ocMe-6Cl-Trp(Boc)-OH (6). 50℃에서 3 N HCl/MeOH(1/3, 15 mL)의 용액에 MeOH(5 ml) 중의 화합물 (4)(1.75g, 2.3 mmol, 1 eq.)의 용액을 적가하였다. 출발 물질이 3-4 h 이내에 소멸되었다. 이어서, 산성 용액을 얼음 배쓰를 이용하여 0℃로 냉각시키고, Na₂CO₃(1.21g, 11.5 mmol, 5 eq.)의 수용액으로 퀀칭시켰다. 메탄올을 제거하고, 8 초과 당량의 Na₂CO₃(1.95g, 18.4 mmol)을 상기 현탁액에 첨가하였다. 이어서, 니켈 제거 EDTA 이나트륨 염 2수화물(1.68 g, 4.5 mmol, 2 eq.)을 첨가하고, 현탁액을 2 h 동안 교반하였다. 아세톤(50 mL) 중의 Fmoc-OSu(0.84g, 2.5 mmol, 1.1 eq.)의 용액을 첨가하고, 반응물을 밤새도록 교반하였다. 이어서, 반응물을 디에틸 에테르 및 1 N HCl로 희석시켰다. 이어서, 유기층을 황산마그네슘 상에서 건조시키고, 진공에서 농축시켰다. 용리제로서 아세톤 및 디클로로메탄을 사용하여 정상 상에서 원하는 생성물 (6)을 정제하여 백색 기포(0.9g, 수율 70%)를 수득하였다. Fmoc-αMe-6Cl-Trp(Boc)-OH (6):

6Cl-Trp(Boc)-Ni-S-BPB (5). 아르곤하에 Gly - Ni -S-BPB(4.6g, 9.2 mmol, 1 eq.) 및 KO-tBu(1.14g, 10.1 mmol, 1.1 eq.)에 95 mL의 DMF를 첨가하였다. DMF (10 mL) 용액 중 브로마이드 유도체 화합물 (3)(3.5g, 4.6 mmol, 1.1 eq.)을 시린지를 통해 첨가하였다. 반응 혼합물을 주변 온도에서 1 h 동안 교반하였다. 이어서, 용액을 5% 수성 아세트산으로 퀀칭시키고, 물로 희석시켰다. 원하는 생성물을 디클로로메탄 중에서 추출하고, 건조시키고, 농축시켰다. 용리제로서 EtOAc 및 헥산을 사용하여 정상 상에서 플래쉬 크로마토그래피(고체 로딩)에 의해 오일성 생성물 (5)을 정제하여 적색 고체를 수득하였다(5 g, 수율 71%). 6Cl-Trp(Boc)-Ni-S-BPB (5):

Fmoc-6Cl-Trp(Boc)-OH (7). 50℃에서 3 N HCl/MeOH(1/3, 44 mL)의 용액에 MeOH(10 ml) 중의 화합물 (5)(5 g, 6.6 mmol, 1 eq.)의 용액을 적가하였다. 출발 물질이 3-4 h 이내에 소멸되었다. 이어서, 산성 용액을 얼음 배쓰를 이용하여 0℃로 냉각시키고, Na₂CO₃(3.48 g, 33 mmol, 5 eq.) 수용액으로 퀀칭시켰다. 메탄올을 제거하고, 8 초과 당량의 Na₂CO₃(5.57 g, 52 mmol)을 현탁액에 첨가하였다. 니켈 제거 EDTA 이나트륨 염 2수화물(4.89 g, 13.1 mmol, 2 eq.) 및 현탁액을 2 h 동안 교반하였다. 아세톤(100 mL) 중의 Fmoc-OSu(2.21 g, 6.55 mmol, 1.1 eq.)의 용액을 첨가하고, 반응물을 밤새도록 교반하였다. 이어서, 반응물을 디에틸 에테르 및 1 N HCl로 희석시켰다. 이어서, 유기층을 황산마그네슘 상에서 건조시키고, 진공에서 농축시켰다. 용리제로서 아세톤 및 디클로로메탄을 사용하여 정상 상에서 원하는 생성물 (7)을 정제하여 백색 기포(2.6g, 수율 69%)를 수득하였다.

실시예 2: 펩티드모방체 마크로사이클

앞서 기술된 바와 같이, 및 하기 기술되는 바와 같이 펩티드모방체 마크로사이클을 합성하고, 정제하고, 분석하였다(문헌 [Schafmeister et al., J. Am. Chem. Soc. 122:5891-5892 (2000)]; [Schafmeister & Verdine, J. Am. Chem. Soc. 122:5891 (2005)]; [Walensky et al., Science 305: 1466-1470 (2004)]; 및 미국 특허 번호 제7,192,713호). 2개 이상의 자연적으로 발생된 아미노산을 상응하는 합성 아미노산으로 치환시킴으로써 펩티드모방체 마크로사이클을 디자인하였다. 치환은 i과 i+4, 및 i과 i+7번 위치에서 이루어졌다. 고체상 조건, 링크 아미드 AM 수지(노바바이오켐(Novabiochem)), 및 Fmoc 주쇄 보호기 화학법을 사용하여 수동으로 또는 자동 펩티드 합성 장치(어플라이드 바이오시스템즈(Applied Biosystems), 모델 433A) 상에서 펩티드 합성을 수행하였다. 천연 Fmoc-보호된 아미노산(노바바이오켐)을 커플링시키기 위해, 10 등가량의 아미노산 및 1:1:2 몰비의 커플링 시약 HBTU/HOBt(노바바이오켐)/DIEA를 사용하였다. 비천연 아미노산(4 equiv)을 1:1:2 몰비의 HATU (어플라이드 바이오시스템즈)/HOBt DIEA와 커플링시켰다. 합성 펩티드의 N 말단은 아세틸화시킨 반면, C 말단은 아미드화시켰다.

가교 결합된 화합물을 역상 C18 칼럼(베리안(Varian)) 상에서 고성능 액체 크로마토그래피(HPLC: high performance liquid chromatography)(베리안 프로스타(Varian ProStar))에 의해 정제함으로써 순수한 화합물을 수득하였다. LC/MS 질량 분석법(애질런트(Agilent) 1100 HPLC 시스템과 인터페이스로 접속하고 있는 마이크로매스 LCT(Micromass LCT)) 및 아미노산 분석(어플라이드 바이오시스템즈, 모델 420A)에 의해 순수한 생성물의 화학 조성물을 확인하였다.

SP662, SP663 및 SP664를 비롯한, 디알킨-가교 결합된 펩티드모방체 마크로사이클을 합성하는 데 하기 프로토콜을 사용하였다. 완전하게 보호된 수지 결합된 펩티드를 0.2 mmol 규모로 PEG-PS 수지(로딩 0.45 mmol/g) 상에서 합성하였다. DMF 중의 20% (v/v) 피페리딘으로 수지 결합된 펩티드를 3 x 10 min 처리함으로써 일시적 Fmoc 기의 탈보호화를 달성하였다. NMP(3x), 디클로로메탄(3x) 및 NMP(3x)로 세척한 후, 적절한 예비활성화된 Fmoc-아미노산 유도체와 함께 1 x 60 min 인큐베이션시킴으로써 각각의 연속 아미노산의 커플링을 달성하였다. 모든 보호된 아미노산(0.4 mmol)을 NMP에 용해시키고, 커플링 용액을 탈보호화된 수지 결합된 펩티드로 옮기기 전에 HCTU(0.4 mmol) 및 DIEA(0.8 mmol)로 활성화시켰다. 커플링을 완료한 후, 다음 탈보호화/커플링 사이클을 위한 제제 중에서 수지를 세척하였다. NMP 중 아세트산 무수물/DIEA의 존재하에서 아미노 말단의 아세틸화를 수행하였다. 각각의 커플링이 완료되었음을 확인하기 위해 분취량의, 완전하게 조립된 수지 결합된 펩티드로부터 수득된 절단된 및 탈보호화된 샘플의 LC-MS 분석을 수행하였다. 전형적인 예에서, 테트라하이드로푸란(4 ml) 및 트리에틸아민(2 ml)을 40 ml 유리 바이알 중의 펩티드 수지(0.2 mmol) 중에 첨가하고, 10분 동안 진탕시켰다. 이어서,Pd(PPh₃)₂Cl₂(0.014 g, 0.02 mmol) 및 요오드화 구리(0.008g, 0.04 mmol)를 첨가하고, 생성된 반응 혼합물을 대기 개방 중에서 16시간 동안 기계식으로 진탕시켰다. 디인-고리화된 수지 결합된 펩티드를 탈보호화시키고, 실온에서 2.5 h 동안 TFA/H₂O/TIS(95/5/5 v/v)로 처리함으로써 고체 지지체로부터 절단시켰다. 수지를 여과한 후, TFA 용액을 냉 디에틸 에테르 중에서 침강시키고, 원심분리하여 고체로서 원하는 생성물을 수득하였다. 조 생성물을 분취용 HPLC에 의해 정제하였다.

SP665를 비롯한, 단일 알킨-가교 결합된 펩티드모방체 마크로사이클을 합성하는 데 하기 프로토콜을 사용하였다. 완전하게 보호된 수지 결합된 펩티드를 0.1 mmol 규모로 링크 아미드 MBHA 수지(로딩 0.62 mmol/g) 상에서 합성하였다. NMP 중의 25% (v/v) 피페리딘으로 수지 결합된 펩티드를 2 x 20 min 처리함으로써 일시적 Fmoc 기의 탈보호화를 달성하였다. NMP 및 디클로로메탄을 이용하는 광범위한 유동 세척을 수행한 후, 적절한 예비활성화된 Fmoc-아미노산 유도체와 함께 1 x 60 min 인큐베이션시킴으로써 각각의 연속 아미노산의 커플링을 달성하였다. 모든 보호된 아미노산(1 mmol)을 NMP에 용해시키고, 커플링 용액을 탈보호화된 수지 결합된 펩티드로 옮기기 전에 HCTU(1 mmol) 및 DIEA(1 mmol)로 활성화시켰다. 커플링을 완료한 후, 다음 탈보호화/커플링 사이클을 위한 제제 중에서 수지를 광범위하게 유동 세척하였다. NMP/NMM 중 아세트산 무수물/DIEA의 존재하에서 아미노 말단의 아세틸화를 수행하였다. 각각의 커플링이 완료되었음을 확인하기 위해 분취량의, 완전하게 조립된 수지 결합된 펩티드로부터 수득된 절단된 및 탈보호화된 샘플의 LC-MS 분석을 수행하였다. 전형적인 예에서, 펩티드 수지(0.1 mmol)를 DCM으로 세척하였다. 수지를 마이크로웨이브 바이알에 로딩하였다. 베쓸을 진공처리하고, 질소로 퍼징시켰다. 몰리브덴헥사카보닐(0.01 eq, 시그마 알드리치(Sigma Aldrich) 199959)을 첨가하였다. 무수 클로로벤젠을 반응 베쓸에 첨가하였다. 이어서, 2-플루오로페놀 (1 eq, 시그마 알드리치 F 12804)을 첨가하였다. 이어서, 반응물을 마이크로웨이브 내로 로딩하고, 130℃에서 10분 동안 보관하였다. 완료되도록 하기 위해 반응은 후속 시간을 늦출 수 있다. 알킨 복분해된 수지 결합된 펩티드를 탈보호화시키고, 실온에서 3 h 동안 TFA/H₂O/TIS(94/3/3 v/v)로 처리함으로써 고체 지지체로부터 절단시켰다. 수지를 여과한 후, TFA 용액을 냉 디에틸 에테르 중에서 침강시키고, 원심분리하여 고체로서 원하는 생성물을 수득하였다. 조 생성물을 분취용 HPLC에 의해 정제하였다.

하기 표 1에는 제조된 펩티드모방체 마크로사이클의 목록이 제시되어 있다.

<표 1>

하기 표 1a에는 선별된 펩티드모방체 마크로사이클이 제시되어 있다.

<표 1a>

표 1b에는 추가로 선별된 펩티드모방체 마크로사이클이 제시되어 있다.

<표 1b>

상기 및 다른 곳에서 제시된 서열에서 하기 약어가 사용된다: "Nle"는 노르류신을 나타내고, "Aib"는 2-아미노이소부티르산을 나타내고, "Ac"는 아세틸을 나타내고, "Pr"은 프로피오닐을 나타낸다. "$"로 표시된 아미노산은 하나의 이중 결합을 포함하는 모든 탄소 가교제에 의해 연결된 알파-Me S5-펜테닐-알라닌 올레핀 아미노산이다. "$r5"로 표시된 아미노산은 하나의 이중 결합을 포함하는 모든 탄소에 의해 연결된 알파-Me R5-펜테닐-알라닌 올레핀 아미노산이다. "$s8"로 표시된 아미노산은 하나의 이중 결합을 포함하는 모든 탄소 가교제에 의해 연결된 알파-Me S8-옥테닐-알라닌 올레핀 아미노산이다. "$r8"로 표시된 아미노산은 하나의 이중 결합을 포함하는 모든 탄소 가교제에 의해 연결된 알파-Me R8-옥테닐-알라닌 올레핀 아미노산이다. "Ahx"는 아미노사이클로헥실 링커를 나타낸다. 가교제는 각 아미노산의 알파 탄소 사이의 8 또는 11개의 탄소 원자를 포함하는 선형의 모든 탄소 가교제이다. "$/"로 표시된 아미노산은 어느 가교제로도 연결되지 않은 알파-Me S5-펜테닐-알라닌 올레핀 아미노산이다. "$/r5"로 표시된 아미노산은 어느 가교제로도 연결되지 않은 알파-Me R5-펜테닐-알라닌 올레핀 아미노산이다. "$/s8"로 표시된 아미노산은 어느 가교제로도 연결되지 않은 알파-Me S8-옥테닐-알라닌 올레핀 아미노산이다. "$/r8"로 표시된 아미노산은 어느 가교제로도 연결되지 않은 알파-Me R8-옥테닐-알라닌 올레핀 아미노산이다. "Amw"로 표시된 아미노산은 알파-Me 트립토판 아미노산이다. "Ami"로 표시된 아미노산은 알파-Me 류신 아미노산이다. "Amf"로 표시된 아미노산은 알파-Me 페닐알라닌 아미노산이다. "2ff"로 표시된 아미노산은 2-플루오로- 페닐알라닌 아미노산이다. "3ff"로 표시된 아미노산은 3-플루오로-페닐알라닌 아미노산이다. "St"로 표시된 아미노산은 각각이 명시된 또 다른 아미노산에 가교 결합되어 있는 것인, 2개의 펜테닐-알라닌 올레핀 측쇄를 포함하는 아미노산이다. "St//"로 표시된 아미노산은 가교 결합되지 않은 2개의 펜테닐-알라닌 올레핀 측쇄를 포함하는 아미노산이다. "%St"로 표시된 아미노산은 각각이 완전하게 포화된 탄화수소 가교결합을 통해 명시된 바와 같이 또 다른 아미노산에 가교 결합되어 있는 것인, 2개의 펜테닐-알라닌 올레핀 측쇄를 포함하는 아미노산이다. "Ba"로 표시된 아미노산은 베타 알라닌이다. 가교 결합된 아미노산(예컨대 "$er8" 또는 "$zr8") 명칭 내의 소문자 "e" 또는 "z"는 이중 결합(각각 E 또는 Z)의 배위를 나타낸다. 다른 문맥에서, 소문자, 예컨대, "a" 또는 "f"는 D 아미노산(각각 예컨대 D-알라닌, 또는 D-페닐알라닌)을 나타낸다. "NmW"로 표시된 아미노산은 N-메틸트립토판을 나타낸다. "NmY"로 표시된 아미노산은 N-메틸티로신을 나타낸다. "NmA"로 표시된 아미노산은 N-메틸알라닌을 나타낸다. "Kbio"는 리신 잔기의 측쇄 아미노 기에 부착된 비오틴 기를 나타낸다. "Sar"로 표시된 아미노산은 사르코신을 나타낸다. "Cha"로 표시된 아미노산은 사이클로헥실 알라닌을 나타낸다. "Cpg"로 표시된 아미노산은 사이클로펜틸 글리신을 나타낸다. "Chg"로 표시된 아미노산은 사이클로헥실 글리신을 나타낸다. "Cba"로 표시된 아미노산은 사이클로부틸 알라닌을 나타낸다. "F4I"로 표시된 아미노산은 4-요오도 페닐알라닌을 나타낸다. "7L"은 N15 동위원소 류신을 나타낸다. "F3Cl"은 3-클로로 페닐알라닌을 나타낸다. "F4cooh"로 표시된 아미노산은 4-카복시 페닐알라닌을 나타낸다. "F34F2"로 표시된 아미노산은 3,4-디플루오로 페닐알라닌을 나타낸다. "6clW"로 표시된 아미노산은 6-클로로 트립토판을 나타낸다. "$rda6"으로 표시된 아미노산은 디알킨 결합을 통해 제2 알키닐 아미노산에 가교 결합된, 알파-Me R6-헥시닐-알라닌 알키닐 아미노산을 나타낸다, "$da5"으로 표시된 아미노산은, 알킨이 제2 알키닐 아미노산과 함께 디알킨의 절반부를 형성하는 것인, 알파-Me S5-펜티닐-알라닌 알키닐 아미노산을 나타낸다, "$ra9"로 표시된 아미노산은 알킨 복분해 반응을 통해 제2 알키닐 아미노산에 가교 결합된, 알파-Me R9-노니닐-알라닌 알키닐 아미노산을 나타낸다. "$a6"으로 표시된 아미노산은 알킨 복분해 반응을 통해 제2 알키닐 아미노산에 가교 결합된, 알파-Me S6-헥시닐-알라닌 알키닐 아미노산을 나타낸다. "iso1" 또는 "iso2"로 명시된 것은 펩티드모방체 마크로사이클이 단일 이성체라는 것을 나타낸다.

"Cit"로 표시된 아미노산은 시트룰린을 나타낸다. "Cou4," "Cou6," "Cou7" 및 "Cou8"로 표시된 아미노산은 각각 하기 구조를 나타낸다:

일부 실시양태에서, 펩티드모방체 마크로사이클은 예를 들어, 가교제의 구조내 이중 결합의 배위 (E 또는 Z)에 기인하여 1 초과의 이성체로 수득된다. 상기 이성체는 종래 크로마토그래피 방법에 의해 분리될 수 있거나, 분리될 수 있다. 일부 실시양태에서, 한 이성체는 다른 이성체에 비하여 개선된 생물학적 특성을 가진다. 한 실시양태에서, 펩티드모방체 마크로사이클의 E 가교제 올레핀 이성체는 그의 Z 대응물에 비하여 우수한 용해도, 우수한 표적 친화성, 우수한 생체내 또는 시험관내 효능, 더 높은 나선도, 또는 개선된 세포 투과성을 가진다. 또 다른 실시양태에서, 펩티드모방체 마크로사이클의 Z 가교제 올레핀 이성체는 그의 E Z 대응물에 비하여 우수한 가용성, 우수한 표적 친화성, 우수한 생체내 또는 시험관내 효능, 더 높은 나선도, 또는 개선된 세포 투과성을 가진다.

하기 표 1c에는 예시적인 펩티드모방체 마크로사이클이 제시되어 있다:

<표 1c>

일부 실시양태에서, 펩티드모방체 마크로사이클은 하기 표 2a에 제시되어 있는 펩티드모방체 마크로사이클은 배제한다:

<표 2a>

표 2a에서, X는 S 또는 임의의 아미노산을 나타낸다. 제시된 펩티드는 N 말단 캡핑 기, 예컨대, 아세틸 또는 추가의 링커, 예컨대, 캡핑 기와 펩티드 서열의 출발점 사이의 베타 알라닌을 포함할 수 있다.

일부 실시양태에서, 펩티드모방체 마크로사이클은 표 2a에 제시된 펩티드모방체 마크로사이클 구조를 포함하지 않는다.

다른 실시양태에서, 펩티드모방체 마크로사이클은 하기 표 2b에 제시되어 있는 펩티드모방체 마크로사이클은 배제한다:

<표 2b>

일부 실시양태에서, 본원에 개시된 펩티드모방체 마크로사이클은 표 2b에 제시된 펩티드모방체 마크로사이클 구조를 포함하지 않는다.

하기 표 2c에는 D 아미노산을 포함하는 비가교 결합된 폴리펩티드의 예가 제시되어 있다.

<표 2C>

실시예 3: MDMX 와의 복합체 중의 펩티드모방체 마크로사이클의 X선 동시 결정학

펩티드 46(표 2b)과의 동시 결정화를 위해, DMSO 중 100 mM 스톡 용액으로부터의 화학량론적 양의 화합물을 제브라피쉬 MDMX 단백질 용액에 첨가하고, 결정화 실험을 시작하기 전에 4℃ 밤새도록 방치하였다. 본 방법은 (Popowicz) 등에 의해 기술된 것과 유사하였고, 일부는 하기 언급되는 바와 같이 변형된 방법이었다. pET15b 벡터를 사용하여 E. 콜라이(E. coli) BL21(DE3) 발현 시스템으로부터 단백질(잔기 15-129, L46V/V95L)을 수득하였다. 세포를 37℃에서 성장시키고, OD₆₀₀ = 0.7일 때, 1 mM IPTG로 유도하였다. 세포를 23℃에서 추가로 18 hr 동안 성장시켰다. 단백질을 Ni-NT 아가로스, 이어서, 50 mM NaPO₄(pH 8.0), 150 mM NaCl, 2 mM TCEP로 완충처리된 수퍼덱스 75(Superdex 75)를 사용하여 정제한 후, 24 mg/ml로 농축시켰다. 결정화 실험을 위해 완충제를 20 mM 트리스(pH 8.0), 50 mM NaCl, 2 mM DTT로 교환하였다. 넥스탈(Nextal)(퀴아젠(Qiagen)) AMS 스크린 #94를 사용하여 초기 결정을 수득하고, 최종 최적화된 저장소는 2.6 M AMS, 75 mM Hepes(pH 7.5)이다. 결정은 4℃에서 얇은 플레이트와 같이 통상적으로 성장하였고, 진한(3.4 M) 말로네이트를 함유하는 용액을 통과시킨 후, 급 냉각, 보관, 및 액체 질소 중에서 수송하여 냉동 보호하였다.

100°K 및 파장 0.97929 Å에서 빔라인 31-ID(SGX-CAT)하에 APS에서 데이터를 수집하였다. 빔라인에 레이닉스(Rayonix)-HE 검출기를 장착하였다. 데이터 수집을 위해, 0.8초의 노출 시간을 사용하여 1°씩의 증가분으로 180°까지 결정을 회전시켰다. 데이터를 프로세싱하고, 공간군 C2(단위 격자: a = 109.2786, b = 81.0836, c = 30.9058 Å, α = 90, β = 89.8577, γ = 90°)에서 Mosflm/스칼라(CCP4; 문헌 [The CCP4 Suite: Programs for Protein Crystallography. Acta Crystallogr. D50, 760-763 (1994)]; [P.R. Evans. Joint CCP4 and ESF-EACBM Newsletter 33, 22-24 (1997)] 참조)를 사용하여 축소시켰다. (Popowicz) 등에 의해 결정된 구조의 MDMX 성분(2Z5S; 문헌 [G.M. Popowicz, A. Czarna, U. Rothweiler, A. Szwagierczak, M. Krajewski, L. Weber & T.A. Holak. Cell Cycle 6, 2386-2392 (2007)] 참조) 및 비대칭 단위 중의 확인된 두 분자를 이용하여 프로그램 Molrep(CCP4; [A.Vagin & A. Teplyakov. J. Appl. Cryst. 30, 1022-1025 (1997)] 참조)를 이용하는 분자 치환을 수행하였다. 제브라피쉬 MDMX with 프로그램 Refmac(CCP4; 문헌 [G.N. Murshudov, A.A. Vagin & E.J. Dodson. Acta Crystallogr. D53, 240-255 (1997)] 참조)을 이용하여 제브라피쉬 MDMX의 두 분자에 대해서만 초기 정련화를 수행하여 R 계수 0.3424(R_자유=0.3712) 및 결합(0.018 Å) 및 각(1.698°)에 대한 rmsd 값을 얻었다. Gln¹⁹로 시작되고, 지방족 스테이플 모두를 포함하는 스테이플형 펩티드 성분에 대한 전자 밀도는 매우 명확하였다. 2.3 Å 해상도로 데이터를 사용하여 CNX(Accelrys)로 추가 정련화를 수행하여 잘 정련된(R_자유=0.2601, R_자유=0.3162, rmsd 결합 = 0.007 Å 및 rmsd 각 = 0.916°) (MDMX로부터 1,448개의 원자, 스테이플형 펩티드로부터 272개의 원자, 및 물 분자로부터 46개의 원자로 이루어진) 모델을 얻었다.

상기 실시예로부터 얻은 결과는 도 1 및 2에 제시되어 있다.

실시예 4: 알파 나선도에 대한 원편광 이색성 ( CD ) 분석

자스코 스펙트라 매니저 Ver.2(Jasco Spectra Manager Ver.2) 시스템 소프트웨어와 함께 자스코 J-815 분광편광계(자스코 인크.(Jasco Inc.: 미국 메릴랜주 이스턴))를 이용하여 CD 분광법에 의해 펩티드 용액을 분석하였다. 펠티에 온도 조절 장치를 사용하여 광학 격자의 온도 조절을 유지시켰다. 결과는 방정식 [θ]=θobs·MRW/lO*l*c(여기서, θobs는 타원율 관측치(밀리도)이고, MRW는 펩티드의 평균 잔기 중량(펩티드 분자량/잔기의 개수)이고, l은 격장의 광로 길이(cm)이고, c는 펩티드 농도(mg/ml)이다)로 산출된, 평균 몰 타원율 [θ](deg ㎠ dmol^-1)로 표시하였다. 아미노산 분석에 의해 펩티드 농도를 측정하였다. 온화한 CD 완충제(20 mM 인산(pH 2)) 중에서 펩티드의 스톡 용액을 제조하였다. 10 mm 경로 길이의 격자에서 분석하기 위해 스톡을 사용하여 온화한 CD 완충제 또는 50% 트리플루오로에탄올 (TFE)을 포함하는 CD 완충제 중 0.05 mg/ml의 펩티드 용액을 제조하였다. 4℃에서 0.2 nm의 증가분으로 195 nm에서부터 250 nm까지, 및 분당 스캔 속도 50 nm로 하여 펩티드 용액의 다양한 파장 측정을 스캐닝하였다. 6개의 스캔의 평균값을 기록하였다.

하기 표 3에는 선별된 펩티드모방체 마크로사이클에 대한 원편광 이색성 데이터가 제시되어 있다.

<표 3>

실시예 5: 형광 편광( FP : Fluorescence polarization )을 이용한 MDM2 의 직접 결합 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

1. FP 완충제(고염 완충제-200 mM Nacl, 5 mM CHAPS(pH 7.5)) 중에 MDM2(사내, 41 kD)를 희석시켜 10 μM 작업 스톡 용액을 제조하였다.

2. 30 ㎕의 10 μM 단백질 스톡 용액을 96 웰 블랙 HE 마이크로플레이트 (몰레큘러 디바이시즈(Molecular Devices))의 A1 및 B1 웰에 첨가하였다.

3. A2열 내지 A12열, B2열 내지 B12열, C1열 내지 C12열, 및 D1열 내지 D12열로 30 ㎕의 FP 완충제 중에 충전시켰다.

4. 최종 희석점의 농도가 한 자릿수 농도(nM)에 도달할 때까지 단백질 스톡을 A1, B1로부터 A2, B2; A2, B2로, A3, B3;...으로 2 또는 3배씩 일련으로 희석시켰다.

5. DMSO를 이용하여 (100% DMSO 중) 1 mM의 FAM 표지화된 선형 펩티드를 100 μM(희석률 1:10)로 희석시켰다. 이어서, 물을 이용하여 100 μM에서 10 μM로 희석시킨 후(희석률 1:10), FP 완충제를 이용하여 10 μM에서 40 nM로 희석시켰다(희석률 1:250). 이는 웰 중 농도가 10 nM이 되는 작업 용액(희석률 1:4)이 되었다. 희석된 FAM 표지화된 펩티드를 사용시까지 암실에서 보관하였다.

6. 10 ㎕의 10 nM FAM 표지화된 펩티드를 각 웰에 첨가하고, 인큐베이션시키고, 상이한 시점에 판독하였다. 5-FAM-BaLTFEHYWAQLTS-NH₂(서열 번호 943)와의 Kd는 ~13.38 nM이었다.

실시예 6: MDM2 에 대한 경쟁 형광 편광 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

1. FP 완충제(고염 완충제-200 mM Nacl, 5 mM CHAPS(pH 7.5)) 중에 MDM2(사내, 41 kD)를 희석시켜 84 nM(2X) 작업 스톡 용액을 제조하였다.

2. 20 ㎕의 84 nM (2X) 단백질 스톡 용액을 96 웰 블랙 HE 마이크로플레이트 (몰레큘러 디바이시즈)의 각 웰에 첨가하였다.

3. DMSO를 이용하여 (100% DMSO 중) 1 mM의 FAM 표지화된 선형 펩티드를 100 μM(희석률 1:10)로 희석시켰다. 이어서, 물을 이용하여 100 μM에서 10 μM로 희석시킨 후(희석률 1:10), FP 완충제를 이용하여 10 μM에서 40 nM로 희석시켰다(희석률 1:250). 이는 웰 중 농도가 10 nM이 되는 작업 용액(희석률 1:4)이 되었다. 희석된 FAM 표지화된 펩티드를 사용시까지 암실에서 보관하였다.

4. 하기 희석 방식을 사용하여 1 μM (최종) 펩티드를 출발로 하여 6개 지점에 대해 5배 일련의 희석액을 제조하면서 FP 완충제를 이용하여 비표지화된 펩티드 용량 플레이트를 제조하였다.

DMSO를 이용하여 (100% DMSO 중) 10 mM을 5 mM(희석률 1:2)로 희석시켰다. 이어서, H₂O를 이용하여 5 mM에서 500 μM로 희석시킨 후(희석률 1:10), FP 완충제를 이용하여 500 μM에서 20 μM로 희석시켰다(희석률 1:25). 6개 지점에 대하여 4 μM(4X)로부터 5배 일련의 희석액을 제조하였다.

5. 10 ㎕의 일련의 희석된 비표지화된 펩티드를, 20 ㎕의 84 nM 단백질로 충전되어 있는 각 웰로 옮겨 놓았다.

6. 10 ㎕의 10 nM(4X) FAM 표지화된 펩티드를 각 웰에 첨가하고, 3 hr 동안 인큐베이션시키고, 판독하였다.

실시예 7: 형광 편광 ( FP )을 이용한 MDMX의 직접 결합 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

1 . FP 완충제(고염 완충제-200 mM Nacl, 5 mM CHAPS(pH 7.5)) 중에 MDMX(사내, 40 kD)를 희석시켜 10 μM 작업 스톡 용액을 제조하였다.

2. 30 ㎕의 10 μM 단백질 스톡 용액을 96 웰 블랙 HE 마이크로플레이트 (몰레큘러 디바이시즈)의 A1 및 B1 웰에 첨가하였다.

4. 최종 희석점의 농도가 한 자릿수 농도(nM)에 도달할 때까지 단백질 스톡을 A1, B1 로부터 A2, B2; A2, B2로, A3, B3;...으로 2 또는 3배씩 일련으로 희석시켰다.

6. 10 ㎕의 10 nM FAM 표지화된 펩티드를 각 웰에 첨가하고, 인큐베이션시키고, 상이한 시점에 판독하였다. 5-FAM-BaLTFEHYWAQLTS-NH₂(서열 번호 943)와의 Kd는 ~51 nM이었다.

실시예 8: MDMX 에 대한 경쟁 형광 편광 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

1. FP 완충제(고염 완충제-200 mM Nacl, 5 mM CHAPS(pH 7.5)) 중에 MDMX(사내, 41 kD)를 희석시켜 300 nM(2X) 작업 스톡 용액을 제조하였다.

2. 20 ㎕의 300 nM(2X) 단백질 스톡 용액을 96 웰 블랙 HE 마이크로플레이트 (몰레큘러 디바이시즈)의 각 웰에 첨가하였다.

5. DMSO를 이용하여 (100% DMSO 중) 10 mM을 5 mM(희석률 1:2)로 희석시켰다. 이어서, H₂O를 이용하여 5 mM에서 500 μM로 희석시킨 후(희석률 1:10), FP 완충제를 이용하여 500 μM에서 20 μM로 희석시켰다(희석률 1:25). 6개 지점에 대하여 20 μM(4X)로부터 5배 일련의 희석액을 제조하였다.

6. 10 ㎕의 일련의 희석된 비표지화된 펩티드를, 20 ㎕의 300 nM 단백질로 충전되어 있는 각 웰로 옮겨 놓았다.

7. 10 ㎕의 10 nM(4X) FAM 표지화된 펩티드를 각 웰에 첨가하고, 3 hr 동안 인큐베이션시키고, 판독하였다.

실시예 5-8로부터의 결과는 하기 표 4에 제시되어 있다.

하기 척도를 사용하였다: "+"는 값이 1,000 nM 초과인 것을 나타내고, "++"는 값이 100 nM 초과 내지 1,000 nM 이하인 것을 나타내고, "+++"는 값이 10 nM 초과 내지 100 nM 이하인 것을 나타내고, "++++"는 값이 10 nM 이하인 것을 나타낸다.

<표 4>

실시예 9: 경쟁 결합 ELISA( MDM2 & MDMX )

p53-His6 단백질(서열 번호 1501로 개시된 "His6")(30 nM/웰)을 실온에서 밤새도록 96 웰 임뮤론(Immulon) 플레이트 중의 웰에서 코팅시켰다. 실험 당일, 자동 ELISA 플레이트 세척기를 사용하여 1X PBS-트윈 20(0.05%)으로 플레이트를 세척하고, 실온에서 30분 동안 ELISA 마이크로 웰 블로킹(ELISA Micro well Blocking)으로 차단시키고; 1X PBS-트윈 20(0.05%)으로 플레이트를 세척하여 과량의 차단제를 세척해 내었다. 펩티드를 멸균수 중에서 10 mM DMSO 스톡에서 500 μM 작업 스톡으로 희석시키고, 샘플 간에 걸쳐 DMSO 농도를 일정하게 유지시키기 위해 0.5% DMSO 중에서 추가의 희석액을 제조하였다. 펩티드를 50 ㎕ 부피 중 2X 원하는 농도로 웰에 첨가한 후, 희석된 GST-MDM2 또는 GST-HMDX 단백질(최종 농도: 10 nM)을 첨가하였다. 샘플을 실온에서 2 h 동안 인큐베이션시키고, HRP 안정화 완충제 중에 0.5 ㎍/ml로 희석된 100 ㎕의 HRP 컨쥬게이트된 항GST 항체[하이프로매트릭스, 인크.(Hypromatrix, INC)]에 첨가하기 이전에, PBS-트윈 20(0.05%)으로 플레이트를 세척하였다. 검출용 항체와 함께 30 min 동안 인큐베이션시킨 후, 플레이트를 세척하고, TMB-E 기질 용액의 웰당 100 ㎕씩 최대 30분까지의 시간 동안 인큐베이션시켰다; 1 M HCl을 사용하여 반응 종결시키고, 마이크로 플레이트 판독기 상에서 450 nm에서 흡광도를 측정하였다. 그래프 패드 프리즘 소프트웨어를 이용하여 데이터를 분석하였다.

실시예 10: 세포 생존능 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

세포 플레이팅: 검정을 수행하기 전날, 세포를 트립신으로 처리하고, 계수하고, 96 웰 플레이트 중에 사전 결정된 밀도로 시딩하였다. 사용시 각 세포주에 대하여 하기 세포 밀도를 사용하였다:

· SJSA-1: 7,500개의 세포/웰

· RKO: 5,000개의 세포/웰

· RKO-E6: 5,000개의 세포/웰

· HCT-116: 5,000개의 세포/웰

· SW-480: 2,000개의 세포/웰

· CF-7: 5,000개의 세포/웰

연구 당일, 실온에서 배지를 11% FBS를 포함하는 새 배지(검정용 배지)로 대체하였다. 웰당 180 ㎕의 검정용 배지를 첨가하였다. 대조군 웰에는 세포 없이, 200 ㎕ 배지를 제공하였다.

펩티드 희석: 모든 희석액을 실온에서 제조하고, 실온에서 세포에 첨가하였다.

· DMSO 중에서 10 mM 펩티드 스톡을 제조하였다. 1:3 희석 방식을 사용하여 희석제로서 DMSO를 이용하여 스톡을 일련으로 희석함으로써 10, 3.3, 1.1, 0.33, 0.11, 0.03, O.01 mM 용액을 수득하였다. DMSO로 희석된 펩티드를 멸균수를 이용하여 33.3배로 일련으로 희석하였다. 이를 통해 다양한 범위의 10X 작업 스톡을 얻었다. 대조군 웰을 위해 DMSO/멸균수(3% DMSO) 믹스를 제조하였다.

· 따라서, 작업 스톡 농도 범위(μM)는 300, 100, 30, 10, 3, 1, 0.3 및 0 μM이 되었다. 다중채널을 이용하여 각 희석 단계에서 웰을 혼합하였다.

· H행은 대조군을 포함하였다. H1-H3에는 20 ㎕의 검정용 배지를 제공하였다. H4-H9에는 20 ㎕의 3% DMSO-물 비히클을 제공하였다. H10-H12는 세포 없이 오직 대조군만을 포함하는 배지를 가졌다.

· 양성 대조군: MDM2 소형 분자 억제제인 뉴트린(Nutlin)-3a(10 mM)를 양성 대조군으로서 사용하였다.

뉴트린을 펩티드와 동일한 희석 방식을 사용하여 희석하였다.

작업 스톡의 세포에의 첨가:

· 20 ㎕의 10X 원하는 농도를 적절한 웰에 첨가하여 웰 중 총 200 ㎕ 부피 중의 최종 농도를 달성하였다(20 ㎕의 300 μM 펩티드 + 배지 중 180 ㎕의 세포 = 웰 중 총 200 ㎕ 부피 중의 30 μM 최종 농도). 피펫을 사용하여 수회에 걸쳐 완만하게 혼합하였다. 따라서, 사용된 최종 농도 범위는 30, 10, 3, 1, 0.3, 0.1, 0.03 & 0 μM이 되었다(효능이 강력한 펩티드의 경우, 추가 희석을 포함하였다).

· 대조군은 펩티드는 포함하지 않지만, 펩티드를 함유하는 웰과 동일한 농도의 DMSO를 함유하는 웰, 및 세포를 함유하지 않는 웰을 포함하였다.

· 습윤화된 5% CO₂ 대기하에 37℃에서 72시간 동안 인큐베이션시켰다.

· 프로메가(Promega)로부터 입수한 MTT 시약을 사용하여 세포의 세존능을 측정하였다. SJSA-1, RKO, RKO-E6, HCT-116 세포의 생존능을 3일째에, MCF-7 세포의 생존능을 5일째에, 및 SW-480 세포의 생존능을 6일째에 측정하였다. 지정된 인큐베이션 시간 종료시, 플레이트를 실온에 오도록 하였다. 각 웰로부터 80 ㎕의 검정용 배지를 제거하였다. 15 ㎕의 해동된 MTT 시약을 각 웰에 첨가하였다.

· 습윤화된 5% CO₂ 대기하에 37℃에서 2 h 동안 플레이트를 인큐베이션시키고, 제조사의 프로토콜에 따라 100 ㎕ 가용화 시약을 첨가하였다. 실온에서 1 h 동안 교반하면서 인큐베이션시키고, 시너지 바이오테크(Synergy Biotek) 다중플레이트 판독기 상에서 570 nM에서의 흡광도를 판독하였다.

· 그래프패드 프리즘 분석 도구를 이용하여 DMSO에 대한 세포 생존능을 분석하였다.

시약:

· 인비트로겐(인비트로겐) 세포 배양 배지

i. 팔콘(Falcon) 96 웰 투명 세포 배양물 처리된 플레이트(눈크(Nunc) 353072)

· DMSO(시그마 D 2650)

· RPMI 1640(인비트로겐 72400)

· MTT(프로메가 G4000)

장치: 흡광도 판독용 다중플레이트 판독기(시너지 2(Synergy 2)).

세포 생존능 검정으로부터 얻은 결과는 하기 표 5 및 6에 제시되어 있다. 하기 척도를 사용하였다: "+"는 값이 30 μM인 초과인 것을 나타내고, "++"는 값이 15 μM 초과 내지 30 μM 이하인 것을 나타내고, "+++"는 값이 5 μM 초과 내지 15 μM 이하인 것을 나타내고, "++++"는 값이 5 μM 이하인 것을 나타낸다. "IC50 비"는 p53-/- 세포에서의 평균 IC50에 대해 상대적인 p53+/+ 세포에서의 평균 IC50의 비를 나타낸다.

<표 5>

<표 6>

실시예 11: P21 ELISA 검정

하기의 일반 프로토콜에 따라 검정을 수행하였다:

세포 플레이팅 :

· 검정을 수행하기 전날, SJSA1 세포를 트립신으로 처리하고, 계수하고, 96 웰 플레이트 중에 7,500개의 세포/100 ㎕/웰인 밀도로 시딩하였다.

· 연구 당일, 배지를 새 RPMI-11% FBS(검정용 배지)로 대체하였다. 웰당 90 ㎕의 검정용 배지를 첨가하였다. 대조군 웰에는 세포 없이, 100 ㎕ 배지를 제공하였다.

펩티드 희석:

· DMSO 중에서 10 mM 펩티드 스톡을 제조하였다. 1:3 희석 방식을 사용하여 희석제로서 DMSO를 이용하여 스톡을 일련으로 희석함으로써 10, 3.3, 1.1, 0.33, 0.11, 0.03, 0.01 mM 용액을 수득하였다. DMSO로 희석된 펩티드를 멸균수를 이용하여 33.3배로 일련으로 희석하였다. 이를 통해 다양한 범위의 10X 작업 스톡을 얻었다. 또한 대조군 웰을 위해 DMSO/멸균수(3% DMSO) 믹스를 제조하였다.

· H행은 대조군을 포함하였다. H1-H3에는 10 ㎕의 검정용 배지를 제공하였다. H4-H9에는 10 ㎕의 3% DMSO-물 비히클을 제공하였다. H10-H12는 세포 없이 오직 대조군만을 포함하는 배지를 가졌다.

· 양성 대조군: MDM2 소형 분자 억제제인 뉴트린-3a(10 mM)를 양성 대조군으로서 사용하였다. 뉴트린을 펩티드와 동일한 희석 방식을 사용하여 희석하였다.

작업 스톡의 세포에의 첨가:

· 10 ㎕의 10X 원하는 농도를 적절한 웰에 첨가하여 웰 중 총 100 ㎕ 부피 중의 최종 농도를 달성하였다(10 ㎕의 300 μM 펩티드 + 배지 중 90 ㎕의 세포 = 웰 중 총 100 ㎕ 부피 중의 30 μM 최종 농도). 따라서, 사용된 최종 농도 범위는 30, 10, 3, 1, 0.3 & 0 μM이 되었다.

· 인큐베이션시킨 후 20 h째에 배지를 흡인시켰다; 세포를 ( Ca⁺⁺/Mg⁺⁺를 함유하지 않는) 1X PBS로 세척하고, 30 min 동안 얼음 상에서 (1X로 희석되고, 프로테아제 억제제 및 포스파타제 억제제로 보충된 셀 시그날링 테크놀러지즈(Cell Signaling technologies) 10X 완충제) 60 ㎕의 1X 세포 용해 완충제 중에서 용해시켰다.

· 4℃에서 8 min 동안 5,000 rpm 속도로 플레이트를 원심분리하였다; 투명한 상청액을 수집하고, 추가 사용시까지 -80℃에서 냉동시켰다.

단백질 추정:

· 써모피셔(Thermofisher)로부터 BCA 단백질 검출 키트 및 BSA 표준을 사용하여 용해물의 단백질 총 함량을 측정하였다. 전형적으로, 웰당 약 6-7 g의 단백질이 예상되었다.

· 웰당 50 ㎕의 용해물을 사용하여 p21 ELISA를 설정하였다.

인간 총 p21 ELISA : 제조사의 설명서에 따라 ELISA 검정 프로토콜을 진행하였다. 각 웰당 50 ㎕ 용해물을 사용하고, 각 웰을 3부로 설정하였다.

시약:

· -셀 베이스드 어세이(-)-뉴트린-3(-Cell-Based 검정(-)-Nutlin-3)(10 mM): 케이만 케미칼즈(Cayman Chemicals), 카탈로그 번호 600034

· -옵티MEM(OptiMEM), 인비트로겐 카탈로그 번호 51985

· -셀 시그날링 라이시스 버퍼(Cell Signaling Lysis Buffer)(10X), 셀 시그날링 테크놀러지즈, 카탈로그 번호 9803

- -프로테아제 억제제 칵테일 정제(미니), 로슈 케미칼즈(Roche Chemicals), 카탈로그 번호 04693124001

- -포스파타제 억제제 칵테일 정제, 로슈 케미칼즈, 카탈로그 번호 04906837001

- -인간 전체 p21 ELISA 키트, R&D 시스템즈(R&D Systems), DYC 1047-5

- -스톱(STOP) 용액(1 M HCl), 셀 시그날링 테크놀러지즈, 카탈로그 번호 7002

장치: 마이크로 센트리퓨즈-에펜도르프 5415D(Micro centrifuge-Eppendorf 5415D) 및 멀티플레이트 리더 포 업저번스 레드아웃(Multiplate Reader for Absorbance readout)(시너지 2).

실시예 12: 카스파제 3 검출 검정:

하기의 일반 프로토콜에 따라 검정을 수행하였다:

세포 플레이팅 : · 검정을 수행하기 전날, SJSA1 세포를 트립신으로 처리하고, 계수하고, 96 웰 플레이트 중에 7,500개의 세포/100 ㎕/웰인 밀도로 시딩하였다. 연구 당일, 배지를 새 RPMI-11% FBS(검정용 배지)로 대체하였다. 웰당 180 ㎕의 검정용 배지를 첨가하였다. 대조군 웰에는 세포 없이, 200 ㎕ 배지를 제공하였다.

펩티드 희석:

· 따라서, 작업 스톡 농도 범위(μM)는 300, 100, 30, 10, 3, 1, 0.3 및 0 μM이 되었다. 다중채널을 이용하여 각 희석 단계에서 웰을 혼합하였다. 20 ㎕의 10X 작업 스톡을 적절한 웰에 첨가하였다.

작업 스톡의 세포에의 첨가:

· 10 ㎕의 10X 원하는 농도를 적절한 웰에 첨가하여 웰 중 총 100 ㎕ 부피 중의 최종 농도를 달성하였다(10 ㎕의 300 μM 펩티드 + 배지 중 90 ㎕의 세포 = 웰 중 총 100 ㎕ 부피 중의 30 μM 최종 농도). 따라서, 사용된 최종 농도 범위는 30, 10, 3, 1, 0.3 & 0 μM이 되었다.

· 인큐베이션시킨 후 48 h째에 각 웰로부터 80 ㎕ 배지를 흡인시켰다; 웰당 100 ㎕의 카스파제3/7글로 검정용 시약(프로메가 카스파제 3/7 글로 어세이 시스템(Promega Caspase 3/7 glo 검정 system), G8092)을 시약에서 1 h 동안 완만하게 진탕시키면서 인큐베이션시켰다.

· 시너지 바이오테크 다중플레이트 판독기 상에서 발광을 판독하였다.

· DMSO로 처리된 세포에 대한 카스파제 3 활성화로서 데이터를 분석하였다.

실시예 11 및 12로부터 얻은 결과는 하기 표 7에 제시되어 있다:

<표 7>

실시예 13: 펩티드모방체 마크로사이클에 의한 세포 용해

하루 전날 미리, H행 10-12열은 배지만을 단독으로 제공하기 위해 빈 상태로 남겨둔 채, 100 ul/웰의 성장 배지와 함께 SJSA-1 세포를 바닥이 평평한 투명 플레이트(코스타(Costar), 카탈로그 번호 353072) 중에 7,500개의 세포/웰로 플레이팅 아웃시켰다. 검정하는 날 당일, 배지를 90 uL의 배지/웰로 RPMI 1% FBS 배지로 교체하였다.

10 mM 펩티드모방체 마크로사이클 스톡 용액을 100% DMSO 중에서 제조하였다. 이어서, 펩티드모방체 마크로사이클을 100% DMSO 중에서 일련으로 희석시킨 후, 멸균수 중에서 20배로 추가로 희석시켜 농도 범위가 500 uM 내지 62.5 uM인, 5% DMSO/물 중의 각 펩티드모방체 마크로사이클의 작업 스톡 용액을 제조하였다.

10 uL의 각 화합물을 90 uL의 SJSA-1 세포에 첨가하여 0.5% DMSO를 함유하는 배지 중 50 uM 내지 6.25 uM인 최종 농도를 얻었다. 음성 대조군(비용해) 샘플은 0.5% DMSO 단독이었고, 양성 대조군(용해) 샘플은 10 uM 멜리틴(Melittin) 및 1% 트리톤 X-100을 포함한다.

세포 플레이트를 37℃에서 1시간 동안 인큐베이션시켰다. 1시간 동안 인큐베이션시킨 후, 현미경으로 세포의 형태를 조사한 후, 플레이트를 실온에서 5분 동안 1,200 rpm으로 원심분리하였다. 각 펩티드모방체 마크로사이클 및 대조군 샘플에 대한 상청액 40 uL씩을 투명 검정용 플레이트로 옮겨 놓았다. LDH 세포독성 검정용 키트(케이멘(Caymen)으로부터 입수, 카탈로그 번호 1000882)를 사용하여 LDH 방출을 측정하였다.

결과는 하기 표 8에 제시되어 있다.

<표 8>

실시예 14: p53 GRIP 검정

약물 화합물 또는 다른 자극에 대한 반응으로 이루어지는 GFP 태깅된 p53의 MDM2와의 단백질 상호작용 및 세포 전위를 써모 사이언티픽* 바이오이미지 p53-MDM2 리디스트리뷰션 어세이(Thermo Scientific* BioImage p53-MDM2 Redistribution Assay)를 통해 모니터링하였다. 재조합 CHO-hIR 세포는 증강된 녹색형광성 단백질(EGFP: enhanced green fluorescent protein)의 C 말단에 융합된 인간 p53(1-312), 및 PDE4A4와 MDM2(1-124) 사이의 융합 단백질인 PDE4A4-MDM2(1-124)를 안정하게 발현하였다. 이는 실험 조건이 p53과 MDM2의 상호작용에 대해 미치는 효과를 측정하기 위한 즉석 검정 시스템을 제공한다. HCS 플랫폼을 이용하여 영상화 및 분석을 수행하였다.

1% 페니실린 스트렙토마이신, 0.5 mg/ml 게네티신(Geneticin), 1 mg/ml ㅈ오신(Zeocin), 및 10% FBS로 보충된 햄(Ham's) F12 배지 중에서 CHO-hIR 세포를 주기적으로 유지시켰다. 배양 배지를 사용하여 검정을 수행하기 18-24시간 전에 세포를 96 웰 플레이트 중에 7,000개의 세포/100 ㎕/웰인 밀도로 시딩하였다. 다음날, 배지를 새로 공급하고, PD177을 세포에 첨가함으로써 최종 농도가 3 μM이 되도록 히야 병소 형성을 활성화시켰다. 대조군 웰은 PD177 용액을 함유하지 않는 상태 그대로 유지시켰다. PD177로 자극시킨 후, 24 h째에 세포를 옵티MEM 배지로 1회 세척하고, PD-177(6 μM)로 보충된 50 ㎕의 옵티MEM 배지를 세포에 첨가하였다. 펩티드를 멸균수 중에서 10 mM DMSO 스톡에서부터 500 μM 작업 스톡으로 희석시키고, 샘플 간에 걸쳐 DMSO 농도를 일정하게 유지시키기 위해 0.5% DMSO 중에서 추가의 희석액을 제조하였다. 최종의 최고 DMSO 농도는 0.5%였고, 이를 음성 대조군으로서 사용하였다. 케이만 케미칼즈 셀 베이스드 어세이(-)-뉴트린-3(10 mM)을 양성 대조군으로서 사용하였다. 뉴트린을 펩티드와 동일한 희석 방식을 사용하여 희석하였다. 50 ㎕의 2X 원하는 농도를 적절한 웰에 첨가하여 최종의 원하는 농도를 얻었다. 이어서, 세포를 습윤화된 5% CO₂ 대기하에 37℃에서 6 h 동안 펩티드와 함께 인큐베이션시켰다. 인큐베이션 기간이 경과한 후, 배지를 완만하게 흡인시키고, 실온에서 20분 동안 웰당 150 ㎕의 고정액을 첨가함으로써 세포를 고정시켰다. 고정된 세포를 매회 웰당 200 ㎕씩의 PBS를 사용하여 4회에 걸쳐 세척하였다. 최종 세척 종료시, 100 ㎕의 1 μM 훽스트(Hoechst) 염색 용액을 첨가하였다. 실링된 플레이트를 암실에서 30 min 이상 동안 인큐베이션시키고, PBS로 세척하여 과량의 염료를 제거하고, PBS를 각 웰에 첨가하였다. 플레이트를 4℃ 암실에서 최대 3일까지 보관하였다. 10x 대물렌즈, 훽스트용 XF-100 필터 세트 및 GFP를 이용하여 셀로믹스 어레이스캔(Cellomics Arrayscan) 장치에서 분자 전위 모듈을 이용하여 p53/MDM2의 전위를 영상화하였다. 결과 파라미터는 Mean-CircRINGAveIntenRatio(핵 및 세포질의 평균 형광 강도의 비(웰 평균))였다. 영상 분석에 사용되는, 웰당 세포의 최소 허용 개수는 500개의 세포로 설정하였다.

실시예 15: SP315 . SP249 및 SP154 를 이용한 MCF -7 유방암 연구

MCF-7 유방암 이종이식편 모델인 무흉선 마우스에서 종양 성장을 억제시키는 데 있어서 SP315, SP249 및 SP154의 효능을 테스트하기 위해 이종이식편 연구를 수행하였다. 음성 대조군 스테이플형 펩티드. SP154의 점 돌연변이(19번 위치에서 F→A)인 SP252 또한 군에서 테스트하였다; 상기 펩티드는 SJSA-1 시험관내 생존능 검정에서 어떤 활성도 보이지 않았다. 서방형 90일 0.72 mg 17β 에스트라디올 펠릿(이노배이티브 리서치(Innovative Research: 미국 플로리다주 사라소타))을 종양 세포 이식 하루 전(-1일째) 목 뒷쪽에 피하로(sc)이식하였다. 0일째, MCF-7 종양 세포를 암컷 누드(Crl:NU-Foxnlnu) 마우스의 옆구리에 sc로 이식하였다. 18일째, 생성된 sc 종양의 길이 및 폭을 캘리퍼를 사용하여 측정하고, 마우스의 체중을 측정하였다. 식 (길이 x 폭²)/2를 사용하여 종양 크기를 산출하고, 세제곱밀리미터(㎣)로 표시하였다. 85.3 ㎣보다 작거나, 417.4 ㎣보다 큰 종양을 가진 마우스는 후속되는 군 형성에서 배제시켰다. 군의 평균 종양 크기가 본질적으로 등가인 값이 되도록(군의 평균 ± 군의 표준 편차 = 180.7 ± 17.5 ㎣) 무작위하여 군당 10마리의 마우스로 이루어진 13개의 마우스 군을 형성하였다.

10 mM 히스티딘 완충처리된 염수(pH 7) 중 MPEG(2K)-DSPE를 함유하는 비히클 중에서 50 mg/mL 농도로 제제화된 펩티드로부터 SP315, SP249, SP154 및 SP252 투약 용액을 제조하였다. 상기 제제는 연구 기간 동안 1회 제조하였다. 상기 비히클은 후속 연구에서 비히클 대조군으로서 사용하였다.

각 군을 상이한 처리군으로 지정하였다. 비히클 음성 대조군으로서의 1군은 18일째부터 39일째까지 주당 3회에 걸쳐 비히클을 8 mL/kg(체중)으로 정맥내로 투여받았다. 2군 및 3군은 SP154를 각각 주당 3회에 걸쳐 30 mg/kg, 또는 주당 2회에 걸쳐 40 mg/kg으로 iv 주사받았다. 4군은 6.7 mg/kg SP249를 주당 3회에 걸쳐 iv 주사받았다. 5, 6, 7 및 8군은 SP315를 각각 주당 3회에 걸쳐 26.7 mg/kg, 주당 2회에 걸쳐 20 mg/kg, 주당 2회에 걸쳐 30 mg/kg, 또는 주당 2회에 걸쳐 40 mg/kg으로 iv 주사받았다. 9군은 30 mg/kg SP252를 주당 3회에 걸쳐 iv 주사받았다.

투약 기간 동안 마우스의 체중을 측정하고 주당 1-2회에 걸쳐 종양을 측정하였다. 결과를 도 3-6에 종양 부피로 제시하고, 비히클 기와의 비교로 제시된 종양 성장 억제율, 체중 변화 및 체중 손실이 ≥20%이거나, 사망한 마우스의 마리수는 하기 표 9에 제시되어 있다. 종양 성장 억제율(TGI: Tumor growth inhibition)는 TGI(%)=100-[(TuVol^{처리군-x일째}-TuVol^{처리군-18일째})/(TuVol^비히클 ^{음성 대조군-x일째}-TuVol^비히클 ^{음성 대조군군-18일째})*100(여기서, x=처리 효과가 평가되는 날의 일수)로서 산출되었다. 비히클 음성 대조군인 1군은 상기 종양 모델에 대하여 우수한 종양 성장률을 보였다.

SP154의 경우, 주당 2회에 걸쳐 40 mg/kg으로 투약받은 군에서 2마리의 마우스가 처리 기간 동안 사망하였으며, 이는 상기 투약 요법이 내약성을 가지지 않는다는 것을 시사하는 것이다. 주당 3회에 걸쳐 30 mg/kg의 SP154를 투여하는 투약 요법은 내약성이 우수하였고, 84%의 TGI를 얻었다.

SP249의 경우, 주당 3회에 걸쳐 6.7 mg/kg으로 투약받은 군에서는 4마리의 마우스가 처리 기간 동안 사망하였으며, 이는 상기 투약 요법이 내약성을 가지지 않는다는 것을 시사하는 것이다.

SP315에 사용된 모든 투약 요법은 어떤 체중 손실도 사망도 관찰되지 않았으며, 우수한 내약성을 보였다. 주당 2회에 걸쳐 40 mg/kg의 SP315를 투여하는 투약을 통해 최고 TGI(92%)를 얻었다. 주당 3회에 걸쳐 26.7 mg/kg, 주당 2회에 걸쳐 20 mg/kg, 주당 2회에 걸쳐 30 mg/kg의 SP315를 투여하는 투약 요법을 통해 각각 86, 82, 및 85%의 TGI를 얻었다.

시험관내 검정에서 어떤 인식될 수 있는 활성도 보이지 않은 SP154의 점 돌연변이인 SP252의 경우, 주당 3회에 걸쳐 30 mg/kg을 투여하는 투약은 어떤 체중 손실도 사망도 관찰되지 않았으며, 우수한 내약성을 보였다. 32일째까지 TGI는 88%인 것으로 관찰된 반면, 39일째에 TGI는 41%로 감소되었다.

상기 실시예로부터 얻은 결과는 도 3-6에 제시되어 있고, 하기 표 9에 요약되어 있다.

<표 9>

실시예 21: 펩티드모방체 마크로사이클에 대한 가용성 측정

펩티드모방체 마크로사이클을 먼저 순수한(neat) N,N-디메틸아세트아미드(DMA, 시그마 알드리치, 38840-1L-F) 중에 용해시켜 20-140 mg/mL 범위에 걸친 농도의 20X 스톡 용액을 제조하였다. DMA 스톡 용액을 2% 솔루톨(Solutol)-HS-15, 25 mM 히스티딘, 45 mg/mL 만닛톨을 함유하는 수성 비히클 중에 20배로 희석시켜 5% DMA, 2% 솔루톨-HS-15, 25 mM 히스티딘, 45 mg/mL 만닛톨 중에 최종 농도 1-7 mg/ml의 펩티드모방체 마크로사이클을 수득하였다. 반복하여 피펫팅하거나, 가볍게 와동시켜 최종 용액을 완만하게 혼합한 후, 최종 용액을 초음파 수조에서 실온하에 10 min 동안 처리하였다. 이어서, 7x 시각적 확대경을 사용하여 후드 광하에서 시각적 관찰을 주의 깊게 수행하여 침전물을 바닥에 존재하는지 또는 현탁액으로서 존재하는지를 측정하였다. 필요에 따라 추가 농도 범위를 테스트하여 각 펩티드모방체 마크로사이클에 대한 최고 용해 한도를 측정하였다.

상기 실시예로부터 얻은 결과는 도 7에 제시되어 있다.

실시예 22: Boc 보호된 아미노산를 사용한 펩티드모방체 마크로사이클 제조

"i" 위치에 R8 아미노산, 및 "i+7" 위치에 S5 아미노산을 포함하는 펩티드모방체 마크로사이클 전구체를 실시예 2에 기술되어 있는 바와 같이 제조하였다. "i+3" 위치의 아미노산은 고체상 합성 동안 도입된 Boc 보호된 트립토판이었다. 구체적으로, 하기 제시된 Boc 보호된 트립토판 아미노산(및 예를 들어, 노바바이오켐으로부터 상업적으로 이용가능)을 고체상 합성 동안 사용하였다:

절단 및 탈보호 단계 이전에 루테늄 촉매를 사용하여 복분해를 수행하였다. 고리화한 후 수득된 조성물을 HPLC 분석에 의해 측정함으로써 트랜스 올레핀("iso2", E 배위로 이중 결합을 포함)을 포함하는 가교제를 가지는 펩티드모방체 마크로사이클을 주로 포함하는 것을 확인하였다. 예상 밖으로, 트랜스 및 시스 생성물이 각각 90:10의 비로 관찰되었다.

SEQUENCE LISTING <110> GUERLAVAIS, VINCENT ELKIN, CARL NASH, HUW M. SAWYER, TOMI K. GRAVES, BRADFORD J. FEYFANT, ERIC <120> PEPTIDOMIMETIC MACROCYCLES <130> 35224-766.201 <140> US 13/767,852 <141> 2013-02-14 <150> 61/723,770 <151> 2012-11-07 <150> 61/656,962 <151> 2012-06-07 <150> 61/599,328 <151> 2012-02-15 <160> 1501 <170> PatentIn version 3.5 <210> 1 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 1 Arg Thr Gln Ala Thr Phe Ala Asn Gln Trp Xaa Ala Leu Ala Thr Asn 1 5 10 15 Xaa Thr Arg <210> 2 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 2 Arg Thr Gln Ala Thr Phe Ala Asn Gln Trp Xaa Ala Leu Ala Thr Asn 1 5 10 15 Xaa Thr Arg <210> 3 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (1)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 3 Ala Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 4 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon i to i+7 crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 4 Gln Ser Gln Ala Thr Phe Ser Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 5 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 5 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 6 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 6 Gln Ser Gln Gln Ala Phe Ser Asn Leu Trp Arg Ala Leu Xaa Gln Asn 1 5 10 15 <210> 7 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 7 Gln Ala Gln Gln Thr Phe Ser Asn Ala Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 8 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Any amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Any amino acid <220> <223> see specification as filed for detailed description of substitutions and preferred embodiments <400> 8 Phe Xaa His Tyr Trp Ala Gln Leu Xaa Ser 1 5 10 <210> 9 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Any amino acid <220> <221> MOD_RES <222> (8)..(8) <223> Leu or Cba <220> <221> MOD_RES <222> (9)..(9) <223> Any amino acid <220> <223> see specification as filed for detailed description of substitutions and preferred embodiments <400> 9 Phe Xaa Glu Tyr Trp Ala Gln Xaa Xaa Ala 1 5 10 <210> 10 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 10 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Ala 1 5 10 <210> 11 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 11 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Xaa Ala 1 5 10 <210> 12 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 12 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Leu 1 5 10 <210> 13 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 13 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Leu 1 5 10 <210> 14 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 14 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Met 1 5 10 <210> 15 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> hLeu <220> <223> C-term NH2 <400> 15 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Leu 1 5 10 <210> 16 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 16 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Phe 1 5 10 <210> 17 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 17 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ile 1 5 10 <210> 18 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Cyclohexyl-Gly <220> <223> C-term NH2 <400> 18 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Gly 1 5 10 <210> 19 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 19 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Xaa 1 5 10 <210> 20 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 20 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 21 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (11)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 21 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ser Ala Leu 1 5 10 <210> 22 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (11)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 22 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 23 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <223> C-term NH2 <400> 23 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Leu 1 5 10 <210> 24 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 24 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Leu 1 5 10 <210> 25 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 25 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Met 1 5 10 <210> 26 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> hLeu <220> <223> C-term NH2 <400> 26 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Leu 1 5 10 <210> 27 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 27 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Phe 1 5 10 <210> 28 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 28 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Ile 1 5 10 <210> 29 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Cyclohexyl-Gly <220> <223> C-term NH2 <400> 29 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Gly 1 5 10 <210> 30 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Cyclohexyl-Ala <220> <223> C-term NH2 <400> 30 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Ala 1 5 10 <210> 31 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 31 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala Xaa 1 5 10 <210> 32 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 32 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Val 1 5 10 15 <210> 33 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 33 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Val 1 5 10 15 <210> 34 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 34 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Xaa Ala Ala 1 5 10 15 <210> 35 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 35 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Xaa Ala Ala 1 5 10 15 <210> 36 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(16) <223> Norleucine <220> <223> C-term NH2 <400> 36 His Leu Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Leu Leu 1 5 10 15 <210> 37 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 37 Asp Leu Thr Phe Ala His His Trp His Gln Leu Ala Arg Arg Leu Val 1 5 10 15 <210> 38 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 38 His His Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Met Leu 1 5 10 15 <210> 39 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Cyclohexyl-Ala <220> <223> C-term NH2 <400> 39 Phe Ala His His Trp His Gln Leu Ala Arg Arg Asp Ala 1 5 10 <210> 40 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 40 Phe Ala His His Trp His Gln Leu Ala His Arg Phe Val 1 5 10 <210> 41 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> hLeu <220> <223> C-term NH2 <400> 41 His Leu Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 42 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 42 Asp Leu Thr Phe Ala His His Trp His Gln Leu Ala Arg Arg Gly Leu 1 5 10 15 <210> 43 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 43 Asp Leu Thr Phe Ala His His Trp His Gln Leu Ala Arg Arg Gly Leu 1 5 10 15 <210> 44 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 44 His His Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Ala Val 1 5 10 15 <210> 45 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 45 Phe Ala His His Trp His Gln Leu Ala Arg Arg Asp Ala 1 5 10 <210> 46 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 46 Phe Ala His His Trp His Gln Leu Ala His Arg Xaa Gly 1 5 10 <210> 47 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <223> C-term NH2 <400> 47 Phe Ala Ala Tyr Trp Ala Gln Leu Ala His His Leu Leu 1 5 10 <210> 48 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <223> C-term NH2 <400> 48 Phe Ala Ala Tyr Trp Ser Ala Leu Ala His Gln Ala Leu 1 5 10 <210> 49 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 49 Phe Ala Ala Tyr Trp Val Gln Leu Ala Gln His Gly Leu 1 5 10 <210> 50 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 50 Phe Ala Ala Tyr Trp Thr Ala Leu Ala Gln Gln Leu Val 1 5 10 <210> 51 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 51 Phe Ala Ala Tyr Trp Tyr Gln Leu Ala His Xaa Ala Ala 1 5 10 <210> 52 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 52 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His His Leu Ala 1 5 10 15 <210> 53 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 53 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His His Leu Ala 1 5 10 15 <210> 54 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 54 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His Gln Leu Val 1 5 10 15 <210> 55 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 55 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His Gln Leu Val 1 5 10 15 <210> 56 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 56 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Gln Gln Met Leu 1 5 10 15 <210> 57 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 57 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Gln Gln Met Leu 1 5 10 15 <210> 58 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> hLeu <220> <223> C-term NH2 <400> 58 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His Xaa Leu Val 1 5 10 15 <210> 59 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 59 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 60 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 60 His Leu Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Leu Leu 1 5 10 15 <210> 61 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 61 Asp Leu Thr Phe Ala His His Trp His Gln Leu Ala Arg Arg Leu Ala 1 5 10 15 <210> 62 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 62 His His Thr Phe Ala His His Trp His Gln Leu Ala Ala Ala Met Val 1 5 10 15 <210> 63 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 63 Phe Ala His His Trp His Gln Leu Ala Arg Arg Asp Ala 1 5 10 <210> 64 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Cyclohexyl-Ala <220> <223> C-term NH2 <400> 64 Phe Ala His His Trp His Gln Leu Ala His Arg Phe Ala 1 5 10 <210> 65 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHAm <400> 65 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 66 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHiAm <400> 66 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 67 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr3Ph <400> 67 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 68 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnBu33Me <400> 68 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 69 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr <400> 69 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 70 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnEt2Ch <400> 70 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 71 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnEt2Cp <400> 71 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 72 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHHex <400> 72 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 73 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 73 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 74 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 74 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 75 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 75 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Met Ala 1 5 10 15 <210> 76 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 76 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Met Ala 1 5 10 15 <210> 77 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 77 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 78 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 78 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 79 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 79 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 80 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 80 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 81 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 81 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Met Ala 1 5 10 15 <210> 82 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 82 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Met Ala 1 5 10 15 <210> 83 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 83 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 84 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 84 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 85 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 85 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ile Val 1 5 10 15 <210> 86 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 86 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ile Val 1 5 10 15 <210> 87 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 87 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Met Val 1 5 10 15 <210> 88 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 88 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Leu Val 1 5 10 15 <210> 89 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 89 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Leu Val 1 5 10 15 <210> 90 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 90 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Leu 1 5 10 15 <210> 91 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 91 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Leu 1 5 10 15 <210> 92 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 92 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Met Leu 1 5 10 15 <210> 93 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 93 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Leu 1 5 10 15 <210> 94 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 94 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Leu 1 5 10 15 <210> 95 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 95 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Met Ala 1 5 10 <210> 96 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <223> C-term NH2 <400> 96 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Leu Ala 1 5 10 <210> 97 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 97 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Ile Ala 1 5 10 <210> 98 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 98 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Met Ala 1 5 10 <210> 99 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 99 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Leu Ala 1 5 10 <210> 100 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 100 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Ile Val 1 5 10 <210> 101 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 101 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Met Val 1 5 10 <210> 102 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 102 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Leu Val 1 5 10 <210> 103 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 103 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Ile Leu 1 5 10 <210> 104 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 104 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Met Leu 1 5 10 <210> 105 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 105 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Leu Leu 1 5 10 <210> 106 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 106 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Leu Leu 1 5 10 <210> 107 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 107 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 108 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 108 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 109 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 109 Trp Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ala Val Ala Ala 1 5 10 15 <210> 110 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 110 Trp Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ala Val Ala Ala 1 5 10 15 <210> 111 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 111 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ala Val Ala 1 5 10 <210> 112 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 112 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ala Val Ala 1 5 10 <210> 113 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 113 Trp Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ser Ala Ala Ala 1 5 10 15 <210> 114 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 114 Trp Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ser Ala Ala Ala 1 5 10 15 <210> 115 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 115 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ala Val Ala Ala Ala 1 5 10 15 <210> 116 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 116 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ala Val Ala Ala Ala 1 5 10 15 <210> 117 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 117 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Val Gly 1 5 10 <210> 118 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 118 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Val Gly 1 5 10 <210> 119 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 119 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Val Gln 1 5 10 <210> 120 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 120 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Val Gln 1 5 10 <210> 121 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 121 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 122 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 122 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 123 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 123 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 124 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 124 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 125 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 125 Leu Thr Phe Ala Ala Tyr Trp Glu Gln Leu Ala Ser Ala Ala 1 5 10 <210> 126 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 126 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Leu Ala 1 5 10 <210> 127 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 127 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Leu Ala 1 5 10 <210> 128 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 128 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Trp Ala 1 5 10 <210> 129 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 129 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Trp Ala 1 5 10 <210> 130 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 130 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Val Ser 1 5 10 <210> 131 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 131 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ser 1 5 10 <210> 132 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 132 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Val Gly 1 5 10 <210> 133 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 133 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 134 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 134 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 135 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 135 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ala 1 5 10 <210> 136 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 136 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Leu Ala 1 5 10 <210> 137 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 137 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Trp Ala 1 5 10 <210> 138 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 138 Glu Thr Phe Ala Lys Tyr Trp Ala Gln Leu Ala Ser Trp Ala 1 5 10 <210> 139 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 139 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ser 1 5 10 <210> 140 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 140 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ser 1 5 10 <210> 141 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 141 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Gly 1 5 10 <210> 142 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 142 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ser Ala 1 5 10 <210> 143 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 143 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ser Ala 1 5 10 <210> 144 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 144 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Asn Ala 1 5 10 <210> 145 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 145 Glu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Asn Ala 1 5 10 <210> 146 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 146 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 147 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 147 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ala 1 5 10 <210> 148 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 148 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ala 1 5 10 <210> 149 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 149 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Trp Ala 1 5 10 <210> 150 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 150 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ser 1 5 10 <210> 151 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 151 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Ser 1 5 10 <210> 152 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 152 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ser 1 5 10 <210> 153 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 153 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Ala Ser 1 5 10 <210> 154 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 154 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Gly 1 5 10 <210> 155 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 155 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser Val Gly 1 5 10 <210> 156 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 156 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 157 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 157 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 158 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclopentyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 158 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Gly Ala Ser Ala Ala 1 5 10 <210> 159 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclopentyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 159 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Gly Ala Ser Ala Ala 1 5 10 <210> 160 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 160 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Phe Ala Ser Ala Ala 1 5 10 <210> 161 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 161 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Phe Ala Ser Ala Ala 1 5 10 <210> 162 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 162 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 163 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 163 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 164 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 164 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 165 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 165 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 166 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 166 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 167 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 167 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 168 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 168 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 169 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 169 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 170 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 170 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 171 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 171 Leu Thr Phe Ala Ala Tyr Trp Val Gln Leu Ala Ser Ala Ala 1 5 10 <210> 172 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 172 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 173 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 173 Leu Thr Phe Ala Ala Glu Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 174 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 174 Leu Thr Phe Ala Ala Ser Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 175 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 175 Leu Thr Phe Ala Ala Glu Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 176 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 176 Leu Thr Phe Ala Ala Ser Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 177 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 177 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 178 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 178 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 179 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 179 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 180 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 180 Ile Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 181 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 181 Ile Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 182 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 182 Ile Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 183 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 183 Glu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 184 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 184 Glu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 185 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 185 Leu Thr Phe Ala Ala His Trp Val Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 186 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 186 Ile Thr Phe Ala Phe Tyr Trp Val Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 187 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 187 Ile Thr Phe Ala Glu Tyr Trp Val Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 188 Ile Thr Phe Ala Glu His Trp Val Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 189 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 189 Leu Thr Phe Ala Ala Glu Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 190 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 190 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 191 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 191 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 192 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 192 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 193 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 193 Ile Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 194 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 194 Ile Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 195 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 195 Ile Thr Phe Ala Phe His Trp Ala Gln Leu Ala Ala Glu Phe Ala 1 5 10 15 <210> 196 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 196 Ile Thr Phe Ala Phe His Trp Ala Gln Leu Ala Ala Glu Phe Ala 1 5 10 15 <210> 197 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 197 Ile Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 198 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 198 Ile Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 199 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 199 Leu Thr Phe Ala Ala His Trp Val Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 200 Ile Thr Phe Ala Phe Tyr Trp Val Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 201 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 201 Ile Thr Phe Ala Glu Tyr Trp Val Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 202 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 202 Ile Thr Phe Ala Glu His Trp Val Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 203 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 203 Ile Thr Phe Ala Glu His Trp Val Gln Leu Ala Ala His Phe Ala 1 5 10 15 <210> 204 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 204 Glu Thr Phe Ala Glu Tyr Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 205 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 205 Leu Thr Phe Ala Ala Tyr Trp Val Ala Leu Ala Ser Ala Ala 1 5 10 <210> 206 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 206 Leu Thr Phe Ala Ala His Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 207 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 207 Leu Thr Phe Ala Ala Glu Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 208 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 208 Leu Thr Phe Ala Ala Glu Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 209 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 209 Leu Thr Phe Ala Ala Ser Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 210 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 210 Leu Thr Phe Ala Ala Ser Trp Ala Ala Leu Ala Ser Ala Ala 1 5 10 <210> 211 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 211 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 212 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 212 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 213 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 213 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala His Phe Ala 1 5 10 15 <210> 214 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 214 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala His Ile Ala 1 5 10 15 <210> 215 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 215 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala His Ile Ala 1 5 10 15 <210> 216 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 216 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ala His Ile Ala 1 5 10 15 <210> 217 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 217 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala His Ile Ala 1 5 10 15 <210> 218 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 218 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Phe Ala 1 5 10 15 <210> 219 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 219 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Phe Ala 1 5 10 15 <210> 220 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 220 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Trp Ala 1 5 10 15 <210> 221 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 221 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Val Ala 1 5 10 15 <210> 222 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 222 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Val Ala 1 5 10 15 <210> 223 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 223 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 224 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 224 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 225 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 225 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 226 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 226 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 227 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 227 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Phe Ala 1 5 10 15 <210> 228 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 228 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Phe Ala 1 5 10 15 <210> 229 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 229 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Val Ala 1 5 10 15 <210> 230 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 230 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Val Ala 1 5 10 15 <210> 231 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 231 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 232 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 232 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 233 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 233 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Trp Ala 1 5 10 15 <210> 234 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 234 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Trp Ala 1 5 10 15 <210> 235 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 235 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 236 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 236 Leu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 237 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 237 Glu Thr Phe Ala Glu His Trp Val Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 238 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 238 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 239 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 239 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 240 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 240 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Ala 1 5 10 15 <210> 241 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 241 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Ala 1 5 10 15 <210> 242 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 242 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 243 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 243 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ile Ala 1 5 10 15 <210> 244 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 244 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 245 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 245 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala 1 5 10 15 <210> 246 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 246 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala 1 5 10 15 <210> 247 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 247 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala 1 5 10 15 <210> 248 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 248 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 249 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 249 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 250 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 250 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 251 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 251 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Phe Ala 1 5 10 15 <210> 252 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 252 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 253 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 253 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 254 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 254 Leu Thr Phe Ala Glu Tyr Trp Ser Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 255 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 255 Leu Thr Phe Ala Glu Tyr Trp Trp Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 256 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 256 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 257 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 257 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 258 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 258 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 259 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pam <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 259 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 260 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> homo-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 260 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 261 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 261 Leu Thr Ala Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 262 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 262 Leu Thr Phe Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 263 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 263 Leu Thr Phe Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 264 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 264 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 265 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 265 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Phe 1 5 10 <210> 266 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 266 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Phe Ala 1 5 10 15 <210> 267 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 267 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser Ala Phe 1 5 10 <210> 268 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 268 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser Ala Phe 1 5 10 <210> 269 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 269 Leu Thr Phe Ala Ala Phe Trp Ala Gln Ala Ala Ser Ala Phe 1 5 10 <210> 270 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 270 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Phe 1 5 10 <210> 271 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 271 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Ala Ala Ser Ala Phe 1 5 10 <210> 272 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 272 Leu Thr Phe Ala Ala Tyr Trp Trp Gln Ala Ala Ser Ala Phe 1 5 10 <210> 273 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 273 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 274 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 274 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 275 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 275 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 276 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 276 Leu Thr Phe Ala Ala Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 277 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 277 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Phe Ala 1 5 10 15 <210> 278 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 278 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Phe Ala 1 5 10 15 <210> 279 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 279 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 280 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 280 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 281 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 281 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 282 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 282 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Trp Leu Ala 1 5 10 15 <210> 283 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 283 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser Ala Phe Ala 1 5 10 15 <210> 284 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 284 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser Ala Phe Ala 1 5 10 15 <210> 285 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 285 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Trp Leu Ala 1 5 10 15 <210> 286 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 286 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Trp Leu Ala 1 5 10 15 <210> 287 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 287 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Trp Leu Ala 1 5 10 15 <210> 288 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 288 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 289 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Hexac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 289 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 290 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Napac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 290 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 291 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Decac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 291 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 292 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Admac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 292 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 293 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Tmac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 293 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 294 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pam <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 294 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 295 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 295 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala 1 5 10 15 <210> 296 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 296 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 297 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 297 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 298 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 298 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 299 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 299 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 300 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 300 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 301 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 301 Leu Thr Phe Ala Glu Tyr Trp Ser Gln Ala Ala Ser Ala Ala 1 5 10 <210> 302 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 302 Leu Thr Phe Ala Glu Tyr Trp Ser Gln Ala Ala Ser Ala Ala 1 5 10 <210> 303 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 303 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 304 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 304 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Phe 1 5 10 <210> 305 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 305 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Phe 1 5 10 <210> 306 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 306 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 307 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 307 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 308 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 308 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 309 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 309 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 310 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 310 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser Ala Ala 1 5 10 <210> 311 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 311 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser Ala Ala 1 5 10 <210> 312 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 312 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 313 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 313 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 314 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 314 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 315 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 315 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 316 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 316 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 317 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 317 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 318 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 318 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 319 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 319 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 320 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 320 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 321 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 321 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 322 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 322 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 323 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 323 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 324 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 324 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 325 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 325 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 326 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 326 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 327 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 327 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 328 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 328 Ala Ala Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 329 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 329 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 330 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 330 Ala Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 Ala <210> 331 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 331 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 332 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 332 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 333 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 333 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 334 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 334 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 335 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala Ala 1 5 10 15 <210> 336 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 336 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala Ala 1 5 10 15 <210> 337 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 337 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 338 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 338 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 339 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 339 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 340 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 340 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 341 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 341 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 342 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 342 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 343 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 343 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 344 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 344 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 345 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 345 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 346 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 346 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 347 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 347 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 348 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(4) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 348 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 349 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 350 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 350 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 351 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 351 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 352 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 352 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 353 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 353 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 Ala <210> 354 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 354 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 Ala <210> 355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 355 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 356 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 356 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 357 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 357 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 358 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 358 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 359 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 359 Leu Thr Phe Ala Glu Tyr Trp Ser Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 360 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 360 Leu Thr Phe Ala Glu Tyr Trp Ser Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 361 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 361 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 362 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 362 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 363 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 363 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 364 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 364 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 <210> 365 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 365 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 Ala <210> 366 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 366 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala 1 5 10 15 Ala <210> 367 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 367 Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 Ala Ala <210> 368 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 368 Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 Ala Ala <210> 369 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 369 Arg Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 370 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 370 Leu Arg Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 371 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 371 Leu Thr Phe Ala Glu Tyr Trp Arg Gln Ala Ala Ser Ala Ala 1 5 10 <210> 372 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 372 Leu Thr Phe Ala Glu Tyr Trp Ala Arg Ala Ala Ser Ala Ala 1 5 10 <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 373 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Arg Ala Ala 1 5 10 <210> 374 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 374 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Arg Ala 1 5 10 <210> 375 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 375 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Arg 1 5 10 <210> 376 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 376 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 377 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 377 Ala Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 378 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 378 Leu Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 379 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 379 Ala Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 380 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 380 Ala Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 381 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 381 Ala Ala Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 382 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> Norleucine <220> <223> C-term NH2 <400> 382 Ala Ala Ala Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu 1 5 10 15 Ala <210> 383 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 383 Ala Ala Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 384 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> Norleucine <220> <223> C-term NH2 <400> 384 Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu 1 5 10 15 Ala <210> 385 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> Norleucine <220> <223> C-term NH2 <400> 385 Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 15 Leu Ala <210> 386 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 386 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 387 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 387 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 Ala <210> 388 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> Norleucine <220> <223> C-term NH2 <400> 388 Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu 1 5 10 15 Ala Ala <210> 389 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 389 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 390 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 390 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> hLeu <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Norleucine <220> <223> C-term NH2 <400> 391 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 Ala <210> 392 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> N-methyl-Tyr <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 392 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 393 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> N-methyl-Tyr <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 393 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 394 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> N-methyl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 394 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 395 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> N-methyl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 395 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 396 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 396 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 397 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 397 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 398 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 398 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 399 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 399 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 400 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 400 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 401 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 401 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 402 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 402 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 403 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 403 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 404 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Sarcosine <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 404 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 405 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Sarcosine <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 405 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 406 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 406 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Xaa 1 5 10 15 <210> 407 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 407 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Xaa 1 5 10 15 <210> 408 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> N-methyl-Ala <220> <223> C-term NH2 <400> 408 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 409 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> N-methyl-Ala <220> <223> C-term NH2 <400> 409 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 410 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> Sarcosine <220> <223> C-term NH2 <400> 410 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Xaa 1 5 10 15 <210> 411 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> Sarcosine <220> <223> C-term NH2 <400> 411 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Xaa 1 5 10 15 <210> 412 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 412 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Xaa 1 5 10 15 <210> 413 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 413 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Xaa 1 5 10 15 <210> 414 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> N-methyl-Ala <220> <223> C-term NH2 <400> 414 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 415 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> N-methyl-Ala <220> <223> C-term NH2 <400> 415 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 416 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 416 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 417 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 417 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 <210> 418 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> Sarcosine <220> <223> C-term NH2 <400> 418 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Xaa 1 5 10 15 <210> 419 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> Sarcosine <220> <223> C-term NH2 <400> 419 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Xaa 1 5 10 15 <210> 420 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 420 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 421 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 421 Leu Thr Phe Xaa Ala Tyr Trp Ala Gln Leu Xaa Ala Ala Leu Ala 1 5 10 15 <210> 422 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Cou4 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 422 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 423 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Cou4 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 423 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 424 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou4 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 424 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 425 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Cou4 <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 425 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Xaa Ala Leu Ala 1 5 10 15 <210> 426 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Cou4 <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 426 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Xaa Ala Leu Ala 1 5 10 15 <210> 427 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Cou4 <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 427 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 428 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Cou4 <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 428 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Xaa Leu Ala 1 5 10 15 <210> 429 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term OH <400> 429 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 430 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term OH <400> 430 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 431 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHnPr <400> 431 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 432 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHnPr <400> 432 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 433 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHnBu33Me <400> 433 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 434 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHnBu33Me <400> 434 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 435 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHHex <400> 435 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 436 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NHHex <400> 436 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 437 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 437 Leu Thr Ala Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 438 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> hLeu <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 438 Leu Thr Leu Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 439 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 439 Leu Thr Phe Ala Ala Tyr Ala Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 440 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 440 Leu Thr Phe Ala Ala Tyr Ala Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 441 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou4 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 441 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 442 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 442 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 443 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon saturated crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 443 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 444 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 444 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 445 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 445 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 446 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 446 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 447 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 447 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 448 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 448 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 449 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 449 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 450 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 450 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ile Ala 1 5 10 15 <210> 451 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 451 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 452 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 452 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 453 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 453 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala 1 5 10 15 <210> 454 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 454 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 455 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Cou6 <220> <221> MOD_RES <222> (2)..(2) <223> Beta-Ala <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> hLeu <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 455 Xaa Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 15 <210> 456 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Cou8 <220> <221> MOD_RES <222> (2)..(2) <223> Beta-Ala <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> hLeu <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 456 Xaa Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 15 <210> 457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 4-iodo-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 457 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 458 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 458 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 459 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term OH <400> 459 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 460 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term OH <400> 460 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 461 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 461 Leu Thr Phe Ala Glu Tyr Trp Ala Glu Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 462 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 462 Leu Thr Phe Ala Glu Tyr Trp Ala Glu Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term OH <400> 463 Leu Thr Phe Ala Glu Tyr Trp Ala Glu Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 464 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 464 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 465 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4bOH2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 465 Leu Thr Phe Ala Glu Phe Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 466 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (20)..(20) <223> D-amino acid <220> <223> C-term NH2 <400> 466 Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala 20 <210> 467 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 467 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 468 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 468 Arg Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 469 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 469 Leu Thr Ala Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 470 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 470 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 471 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 471 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Xaa Ala Ala Ala 1 5 10 15 Ala <210> 472 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 472 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Ala Ala 1 5 10 15 Ala <210> 473 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 473 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Xaa Ala 1 5 10 15 Ala <210> 474 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 474 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Xaa 1 5 10 15 Ala <210> 475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 475 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Xaa 1 5 10 15 Ala <210> 476 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 476 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Xaa <210> 477 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 477 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 478 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 478 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 479 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 479 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 480 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 480 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 481 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 482 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 482 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 483 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Sarcosine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 483 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Xaa Ala Ala Ala 1 5 10 15 Ala <210> 484 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Sarcosine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 484 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Xaa Ala Ala 1 5 10 15 Ala <210> 485 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Sarcosine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 485 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Xaa Ala 1 5 10 15 Ala <210> 486 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> Sarcosine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 486 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Xaa 1 5 10 15 Ala <210> 487 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> Sarcosine <220> <223> C-term NH2 <400> 487 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Xaa <210> 488 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> N15 isotopic-Leu <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 488 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 489 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 489 Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 490 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 490 Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 491 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 491 Leu Val Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 492 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 492 Ala Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 493 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 493 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 494 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 494 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 495 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 495 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala 1 5 10 <210> 496 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 496 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 497 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 497 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 498 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 498 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala 1 5 10 <210> 499 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 499 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 500 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 500 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala 1 5 10 <210> 501 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 501 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 502 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 502 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 503 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 503 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 504 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 4FBzl <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 504 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 505 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 4FBzl <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 505 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 506 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 506 Leu Thr Phe Ala Arg Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 507 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 507 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 508 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 508 Leu Thr Phe Ala Gln Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 509 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Cit <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 509 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 510 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(7) <223> D-amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (19)..(19) <223> D-amino acid <220> <223> C-term NH2 <400> 510 Leu Thr Phe Ala Glu Leu Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala <210> 511 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Phe-4 <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(121) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 511 Leu Thr Phe Ala Phe Gly Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 512 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 2m-Arg <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 512 Leu Thr Phe Ala Arg Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 513 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> ip-Lys <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 513 Leu Thr Phe Ala Lys Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 514 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Phe-4NH2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 514 Leu Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 515 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 515 Leu Thr Phe Ala Glu Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 516 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 516 Leu Thr Phe Ala Glu Tyr Trp Ala Leu Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 517 Leu Thr Phe Ala Glu Tyr Trp Ala Xaa Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 518 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 518 Leu Thr Phe Ala Glu Tyr Trp Ala Ser Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 519 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 519 Leu Thr Phe Ala Glu Tyr Trp Ala Asn Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 520 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Cit <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 520 Leu Thr Phe Ala Glu Tyr Trp Ala Xaa Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 521 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 521 Leu Thr Phe Ala Glu Tyr Trp Ala His Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 522 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 522 Leu Thr Phe Ala Glu Tyr Trp Ala Arg Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (6)..(6) <223> pTyr <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 523 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 524 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Cbm <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 524 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 525 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Cbm <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 525 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 526 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 526 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala Ala Ala 1 5 10 15 Ala <210> 527 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 527 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ser 1 5 10 15 Ala <210> 528 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 528 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala Ala Ser 1 5 10 15 Ala <210> 529 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Beta-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 529 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Thr Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 530 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Adamantyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 530 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Gly Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 531 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 531 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 532 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> homo-cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 532 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 533 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 533 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Phe Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 534 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> homo-Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 534 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Phe Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 535 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 535 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 Ala <210> 536 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Adamantyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 536 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Gly Ala Ala Ala Leu Ala Ala 1 5 10 15 Ala <210> 537 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 4FBz <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 537 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 538 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 4FBz <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 538 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 539 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 539 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 540 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 540 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> hhLeu <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 541 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Leu Ala Ala 1 5 10 15 Ala <210> 542 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (19)..(19) <223> D-amino acid <220> <223> C-term NH2 <400> 542 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala <210> 543 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (20)..(20) <223> D-amino acid <220> <223> C-term NH2 <400> 543 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala 20 <210> 544 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (21)..(21) <223> D-amino acid <220> <223> C-term NH2 <400> 544 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala Ala 20 <210> 545 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 545 Leu Thr Ala Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 546 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 546 Leu Thr Ala Ala Glu Tyr Ala Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Pmp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 547 Leu Thr Phe Ala Glu Xaa Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 548 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Pmp <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 548 Leu Thr Phe Ala Glu Xaa Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 549 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 549 Ala Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 550 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 550 Leu Thr Phe Ala His Ala Trp Ala Gln Leu Ala Ser 1 5 10 <210> 551 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 551 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 552 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 552 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala 1 5 10 <210> 553 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 553 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser Ala Ala 1 5 10 <210> 554 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 554 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 555 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 555 Leu Thr Phe Ala Ser Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 556 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 556 Leu Thr Phe Ala Arg Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 557 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 557 Leu Thr Phe Ala Lys Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 558 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 558 Leu Thr Phe Ala Gln Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 559 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 559 Leu Thr Phe Ala Glu Tyr Trp Ala Ala Ala Ala Ser Ala Ala 1 5 10 <210> 560 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 560 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala 1 5 10 <210> 561 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 561 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 562 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 562 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 563 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 563 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 564 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4bOH2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 564 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 565 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4bOH2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 565 Leu Thr Phe Ala Ala Phe Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 566 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4bOH2 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 566 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 567 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> pY <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 567 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 568 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> pY <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 568 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 569 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> pY <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 569 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 570 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentynyl-alanine alkynyl amino acids, wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 570 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 571 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentynyl-alanine alkynyl amino acids, wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <223> C-term NH2 <400> 571 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 572 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentynyl-alanine alkynyl amino acids, wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 572 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 573 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R9-nonynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 573 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 574 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R9-nonynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 574 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 575 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R9-nonynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <223> C-term NH2 <400> 575 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 576 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R9-nonynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <223> C-term NH2 <400> 576 Leu Thr Ala Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 577 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R9-nonynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid crosslinked via an alkyne metathesis reaction with a second alkynyl amino acid <220> <223> C-term NH2 <400> 577 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 578 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 578 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 579 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 579 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 580 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 580 Ala Leu Thr Ala Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 581 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 581 Ala Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 582 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 582 Ala Ala Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 583 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 583 Ala Leu Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 584 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 584 Ala Leu Thr Phe Ala Glu Ala Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 585 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 585 Ala Leu Thr Phe Ala Glu Tyr Ala Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 586 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 586 Ala Leu Thr Ala Ala Glu Tyr Ala Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 587 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 587 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 588 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 588 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 589 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 589 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 590 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 590 Ala Leu Thr Ala Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 591 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 591 Ala Leu Thr Phe Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 592 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 592 Ala Leu Thr Ala Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 593 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 593 Ala Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 15 Asn <210> 594 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 594 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 595 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 595 Ala Leu Thr Ala Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 596 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 596 Ala Leu Thr Phe Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 597 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 597 Ala Leu Thr Ala Ala Glu Tyr Ala Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 598 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 598 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 599 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 599 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 600 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 600 Ala Leu Thr Ala Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 601 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-TAMRA <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 601 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 602 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 602 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 603 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 603 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Ala Ala Ser 1 5 10 <210> 604 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 604 Leu Thr Ala Ala Glu Tyr Trp Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 605 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 605 Leu Thr Phe Ala Glu Tyr Ala Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 606 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 606 Leu Thr Ala Ala Glu Tyr Ala Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 607 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 607 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Ala Ala Ser Ala Ala 1 5 10 <210> 608 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 608 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 609 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 609 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 610 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 610 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 611 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 611 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 612 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 612 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala Ala 1 5 10 <210> 613 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 613 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala Ala 1 5 10 <210> 614 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou7 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 614 Leu Thr Phe Ala Glu Tyr Trp Xaa Gln Leu Ala Ala 1 5 10 <210> 615 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 615 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ser 1 5 10 15 Ala <210> 616 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 616 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 617 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Biotin <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 617 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 618 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 618 Leu Thr Phe Ala His Ala Trp Ala Gln Leu Ala Ser 1 5 10 <210> 619 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 619 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala 1 5 10 <210> 620 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 620 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 621 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 621 Leu Thr Phe Ala Ser Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 622 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 622 Leu Thr Phe Ala Arg Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 623 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 623 Leu Thr Phe Ala Lys Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 624 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 624 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala 1 5 10 <210> 625 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <221> MOD_RES <222> (18)..(18) <223> Beta-Ala <220> <223> C-term NH2 <400> 625 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Cys <210> 626 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(18) <223> D-amino acid <220> <221> MOD_RES <222> (19)..(19) <223> Peg4C <220> <223> C-term NH2 <400> 626 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Asp Cys <210> 627 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 627 Leu Thr Ala Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 628 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 628 Leu Thr Phe Ala Ala Tyr Ala Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 629 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 629 Ala Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 630 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 630 Leu Thr Ala Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 631 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 631 Leu Thr Phe Ala Ala Tyr Ala Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 632 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentynyl-alanine alkynyl amino acids, wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 632 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 633 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term FITC <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (18)..(18) <223> D-amino acid <220> <223> C-term NH2 <400> 633 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 634 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term FITC <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 634 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 635 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 635 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Glu Ala Ala Ala Ala 1 5 10 15 Ala <210> 636 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 636 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Glu Ala Ala Ala Ala 1 5 10 15 Ala <210> 637 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <221> MOD_RES <222> (18)..(18) <223> Beta-Ala <220> <221> MOD_RES <222> (19)..(19) <223> Lys-bio <220> <223> C-term NH2 <400> 637 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Lys <210> 638 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 638 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 639 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 639 Leu Thr Phe Ala Ala Tyr Ala Ala Ala Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 640 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 640 Leu Thr Phe Ala Ala Tyr Ala Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 641 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 641 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Glu Ala Ala Ala Ala 1 5 10 15 Ala <210> 642 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 642 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Glu Ala Ala Ala Ala 1 5 10 15 Ala <210> 643 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 643 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala Ala Ala 1 5 10 15 Ala <210> 644 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 644 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 645 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (13)..(17) <223> Crosslink between residues <220> <221> MOD_RES <222> (17)..(17) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 645 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala <210> 646 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (14)..(18) <223> Crosslink between residues <220> <221> MOD_RES <222> (18)..(18) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 646 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala <210> 647 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (15)..(19) <223> Crosslink between residues <220> <221> MOD_RES <222> (19)..(19) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 647 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala 20 <210> 648 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term OH <400> 648 Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 15 Ala <210> 649 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 649 Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 15 Ala <210> 650 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 650 Ala Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 15 Ala Ala <210> 651 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (9)..(16) <223> Crosslink between residues <220> <221> MOD_RES <222> (16)..(16) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 651 Ala Ala Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala 1 5 10 15 Ala Ala Ala <210> 652 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (10)..(17) <223> Crosslink between residues <220> <221> MOD_RES <222> (17)..(17) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 652 Ala Ala Ala Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu 1 5 10 15 Ala Ala Ala Ala 20 <210> 653 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acid wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <223> C-term NH2 <400> 653 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 <210> 654 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(6) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(5) <223> D-amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 654 Thr Ala Trp Tyr Ala Ala Phe Glu Lys Leu Leu Arg 1 5 10 <210> 655 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(8) <223> D-amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 655 Thr Ala Trp Tyr Ala Asn Phe Glu Ala Leu Leu Arg 1 5 10 <210> 656 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(5) <223> D-amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(9) <223> D-amino acid <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 656 Thr Ala Trp Tyr Ala Ala Phe Glu Lys Ala Leu Arg 1 5 10 <210> 657 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(8) <223> D-amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (9)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(12) <223> D-amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 657 Thr Ala Trp Tyr Ala Asn Phe Glu Ala Leu Leu Arg Ala Ala 1 5 10 <210> 658 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(8) <223> D-amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 658 Thr Ala Trp Tyr Ala Asn Phe Glu Ala Leu Leu Arg 1 5 10 <210> 659 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(11) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 659 Thr Ala Trp Tyr Ala Asn Phe Glu Lys Leu Leu Ala Ala 1 5 10 <210> 660 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(5) <223> D-amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(12) <223> D-amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 660 Thr Ala Trp Tyr Ala Ala Phe Glu Lys Leu Leu Arg Ala Ala 1 5 10 <210> 661 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(11) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 661 Thr Ala Trp Tyr Ala Asn Ala Glu Lys Leu Leu Ala Ala 1 5 10 <210> 662 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (2)..(5) <223> D-amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> D-amino acid <220> <221> MOD_RES <222> (8)..(8) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (9)..(12) <223> D-amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 662 Ala Thr Ala Trp Tyr Ala Asn Phe Glu Lys Leu Leu Ala Ala 1 5 10 <210> 663 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (2)..(5) <223> D-amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(12) <223> D-amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 663 Ala Thr Ala Trp Tyr Ala Asn Ala Glu Lys Leu Leu Ala Ala 1 5 10 <210> 664 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(11) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 664 Thr Ala Trp Tyr Ala Asn Phe Glu Ala Leu Leu Ala Ala 1 5 10 <210> 665 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(11) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 665 Thr Ala Trp Tyr Ala Asn Phe Glu Lys Leu Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 666 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(4) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(11) <223> D-amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 666 Thr Ala Trp Tyr Ala Asn Phe Glu Ala Leu Leu Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 667 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 667 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ser Ala Leu Ala 1 5 10 15 <210> 668 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 668 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 669 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 669 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 670 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (20)..(20) <223> D-amino acid <220> <223> C-term NH2 <400> 670 Ala Ala Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 15 Ala Ala Ala Ala 20 <210> 671 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 671 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 672 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 672 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Xaa Ala Ala Ala 1 5 10 15 Ala <210> 673 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 673 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Xaa Ala 1 5 10 15 Ala <210> 674 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 674 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Xaa 1 5 10 15 Ala <210> 675 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 675 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Xaa <210> 676 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 676 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 677 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 677 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 678 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> Sarcosine <220> <223> C-term NH2 <400> 678 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Xaa <210> 679 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term OH <400> 679 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 680 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentynyl-alanine alkynyl amino acids, wherein the alkyne forms one half of a dialkyne bond with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 680 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 681 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 681 Ala Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ser Ala Ala 1 5 10 15 <210> 682 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 4-carboxy Phe <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 682 Leu Thr Phe Ala Glu Phe Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 683 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 683 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 684 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 684 Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 685 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 685 Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 686 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 686 Leu Val Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 687 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <400> 687 Ala Ala Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 688 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (16)..(16) <223> D-amino acid <220> <223> C-term NH2 <400> 688 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 <210> 689 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (15)..(15) <223> D-amino acid <220> <223> C-term NH2 <400> 689 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala 1 5 10 15 <210> 690 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> D-amino acid <220> <223> C-term NH2 <400> 690 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala 1 5 10 <210> 691 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (13)..(13) <223> D-amino acid <220> <223> C-term NH2 <400> 691 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 692 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 692 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 693 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 693 Leu Ala Gln Glu Thr Phe Ser Asp Ala Trp Lys Leu Leu Pro Glu Asn 1 5 10 15 <210> 694 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 694 Leu Ser Gln Ala Thr Phe Ser Asp Leu Trp Ala Leu Leu Pro Glu Asn 1 5 10 15 <210> 695 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 695 Leu Ser Gln Glu Ala Phe Ser Asp Leu Trp Lys Ala Leu Pro Glu Asn 1 5 10 15 <210> 696 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 696 Leu Ser Gln Glu Thr Ala Ser Asp Leu Trp Lys Leu Ala Pro Glu Asn 1 5 10 15 <210> 697 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 697 Leu Ser Gln Glu Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Glu Asn 1 5 10 15 <210> 698 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Any amino acid <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 698 Leu Xaa Gln Glu Thr Phe Ser Ala Leu Trp Lys Leu Leu Pro Ala Asn 1 5 10 15 <210> 699 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (9)..(16) <223> Crosslink between residues <220> <221> MOD_RES <222> (16)..(16) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 699 Leu Ser Gln Glu Thr Phe Ser Asp Ala Trp Lys Leu Leu Pro Glu Ala 1 5 10 15 <210> 700 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 700 Leu Ser Gln Gln Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Glu Asn 1 5 10 15 <210> 701 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 701 Leu Ser Gln Glu Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 702 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 702 Leu Ser Gln Gln Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 703 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 703 Leu Ser Gln Glu Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 704 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 704 Leu Ser Gln Gln Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 705 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 705 Leu Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 706 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 706 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 707 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 707 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 708 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 708 Gln Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 709 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 709 Leu Ala Gln Glu Thr Phe Ser Asp Ala Trp Lys Leu Leu Pro Glu Asn 1 5 10 15 <210> 710 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 710 Leu Ser Gln Ala Thr Phe Ser Asp Leu Trp Ala Leu Leu Pro Glu Asn 1 5 10 15 <210> 711 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 711 Leu Ser Gln Glu Ala Phe Ser Asp Leu Trp Lys Ala Leu Pro Glu Asn 1 5 10 15 <210> 712 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 712 Leu Ser Gln Glu Thr Ala Ser Asp Leu Trp Lys Leu Ala Pro Glu Asn 1 5 10 15 <210> 713 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 713 Leu Ser Gln Glu Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Glu Asn 1 5 10 15 <210> 714 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Any amino acid <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 714 Leu Xaa Gln Glu Thr Phe Ser Ala Leu Trp Lys Leu Leu Pro Ala Asn 1 5 10 15 <210> 715 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (9)..(16) <223> Crosslink between residues <220> <221> MOD_RES <222> (16)..(16) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 715 Leu Ser Gln Glu Thr Phe Ser Asp Ala Trp Lys Leu Leu Pro Glu Ala 1 5 10 15 <210> 716 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 716 Leu Ser Gln Gln Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Glu Asn 1 5 10 15 <210> 717 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 717 Leu Ser Gln Glu Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 718 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 718 Leu Ser Gln Gln Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 719 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 719 Leu Ser Gln Glu Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 720 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 720 Leu Ser Gln Gln Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 721 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 721 Leu Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 722 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 722 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 723 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 723 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 724 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 724 Gln Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 725 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 725 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Lys Lys Ala Gln Asn 1 5 10 15 <210> 726 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 726 Gln Gln Thr Phe Ala Asp Leu Trp Arg Leu Leu Ala Glu Asn 1 5 10 <210> 727 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 727 Gln Gln Thr Phe Ala Asp Leu Trp Arg Leu Leu Ala 1 5 10 <210> 728 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 728 Leu Ser Gln Gln Thr Phe Ala Asp Leu Trp Ala Leu Leu 1 5 10 <210> 729 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 729 Gln Gln Thr Phe Ala Asp Leu Trp Ala Leu Leu 1 5 10 <210> 730 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 730 Gln Gln Thr Ala Ala Asp Leu Trp Arg Leu Leu Ala Glu Asn 1 5 10 <210> 731 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 731 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 732 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 732 Gln Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 733 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 733 Gln Ser Gln Gln Thr Phe Ala Asp Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 734 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 734 Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala 1 5 10 <210> 735 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 735 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Pro Gln Asn 1 5 10 15 <210> 736 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 736 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 737 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (1)..(5) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 737 Ala Thr Phe Ser Ala Leu Trp Lys Leu Leu 1 5 10 <210> 738 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 738 Glu Thr Phe Ala Asp Leu Trp Ala Leu Leu 1 5 10 <210> 739 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 739 Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu 1 5 10 <210> 740 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (1)..(5) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <400> 740 Ala Ser Gln Glu Ala Phe Ser Asn Leu Trp Lys Leu Leu 1 5 10 <210> 741 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 741 Leu Ser Gln Glu Thr Phe Ala Asp Leu Trp Lys Leu Leu Ala Glu Asn 1 5 10 15 <210> 742 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 742 Leu Ser Gln Glu Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 743 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 743 Leu Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 744 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 744 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Lys Leu Leu Ala Gln Asn 1 5 10 15 <210> 745 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 745 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 746 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 746 Gln Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 747 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 747 Gln Xaa Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 748 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 748 Gln Ser Gln Gln Thr Phe Ser Asn Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 749 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 749 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 750 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 750 Gln Ser Gln Xaa Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 751 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 751 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Ala Asn 1 5 10 15 <210> 752 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 752 Ala Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 753 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 753 Gln Ser Gln Gln Thr Phe Ala Ala Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 754 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 754 Gln Ser Gln Glu Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 755 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 755 Arg Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 756 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 756 Arg Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Glu Asn 1 5 10 15 <210> 757 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 757 Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 1 5 10 15 <210> 758 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 758 Gln Ser Gln Ala Thr Phe Ser Ala Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 759 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 759 Gln Ser Gln Gln Ala Phe Ser Asn Ala Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 760 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 760 Gln Ser Gln Gln Thr Ala Ser Asn Leu Ala Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 761 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 761 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Pro Gln Asn 1 5 10 15 <210> 762 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (17)..(17) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 762 Arg Thr Gln Ala Thr Phe Ala Asn Gln Trp Xaa Ala Leu Ala Thr Asn 1 5 10 15 Xaa Thr Arg <210> 763 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 763 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Arg Asn 1 5 10 15 <210> 764 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 764 Gln Ser Gln Arg Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 765 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 765 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 766 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 766 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 767 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 767 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 768 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 768 Gln Ser Gln Gln Thr Tyr Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 769 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 769 Arg Xaa Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 770 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 770 Met Pro Arg Phe Met Asp Tyr Trp Glu Gly Leu Asn 1 5 10 <210> 771 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 771 Arg Ser Gln Gln Arg Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 772 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 772 Gln Ser Gln Gln Arg Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 773 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 773 Arg Xaa Gln Gln Arg Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 774 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 774 Arg Ser Gln Gln Arg Phe Ala Asn Phe Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 775 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 775 Arg Ser Gln Gln Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 776 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 776 Arg Ser Gln Gln Thr Phe Ala Asn Leu Trp Gln Leu Leu Ala Gln Asn 1 5 10 15 <210> 777 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me-Leu <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 777 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Gln Leu Leu Ala Gln Asn 1 5 10 15 <210> 778 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me-Leu <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 778 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 779 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 779 Leu Pro Arg Phe Ala Asp Tyr Trp Glu Gly Leu Ala Gln Asn 1 5 10 <210> 780 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 780 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 781 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 781 Arg Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 <210> 782 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> 2-fluoro-Phe <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 782 Gln Ser Gln Gln Thr Phe Ala Asn Phe Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 783 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> 3-fluoro-Phe <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 783 Gln Ser Gln Gln Thr Phe Ala Asn Phe Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 784 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-hydrogen R8-octenyl-alanine olefin amino acid connected by an all-carbon saturated crosslinker with no double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-hydrogen S5-pentenyl-alanine olefin amino acid connected by an all-carbon saturated crosslinker with no double bond <220> <223> C-term NH2 <400> 784 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 785 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 785 Arg Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 786 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 786 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 787 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term acetylated with heptanoic acid and connected to internal olefin amino acid by an all-carbon crosslinker to position 4 comprising one double bond <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker to the N-term comprising one double bond <220> <223> C-term NH2 <400> 787 Gln Ser Gln Ala Thr Phe Ser Asn Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 788 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term acetylated with heptanoic acid and connected to internal olefin amino acid by an all-carbon crosslinker to position 4 comprising one double bond <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker to the N-term comprising one double bond <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 788 Gln Ser Gln Ala Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 789 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> 6cl-Trp <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 789 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 790 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Me6cl-Trp <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 790 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 791 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 791 Leu Thr Phe Glu His Tyr Trp Ala Gln Leu Thr Ser 1 5 10 <210> 792 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 792 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Thr Ser 1 5 10 <210> 793 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 793 Leu Thr Phe Glu Ala Tyr Trp Ala Ala Leu Thr Ser 1 5 10 <210> 794 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one Z configured double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one Z configured double bond <220> <223> C-term NH2 <400> 794 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 795 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 795 Leu Thr Phe Ala His Tyr Trp Arg Gln Leu Ala Ser 1 5 10 <210> 796 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 796 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 797 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 797 Gln Ser Gln Gln Thr Ala Ser Asn Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 798 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 798 Gln Ser Gln Gln Thr Ala Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 799 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 799 Ala Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 800 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (1)..(5) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 800 Ala Ser Gln Gln Ala Phe Ser Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 801 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 801 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 802 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 802 Gln Ser Gln Gln Ala Phe Ser Asn Ala Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 803 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 803 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 804 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 804 Gln Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Ala Leu Xaa Gln Asn 1 5 10 15 <210> 805 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (11)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 805 Gln Ser Gln Gln Thr Phe Ser Asn Leu Trp Ala Leu Leu Ala Ala Asn 1 5 10 15 <210> 806 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 806 Ala Ser Gln Gln Ala Phe Ser Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 807 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 807 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 808 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 808 Gln Ser Gln Gln Ala Phe Ser Asn Ala Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 809 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 809 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 810 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 810 Gln Ser Gln Ala Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 811 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 811 Gln Ser Gln Ala Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 812 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid not connected by any crosslinker <220> <221> MOD_RES <222> (7)..(7) <223> Amino acid comprising two pentenyl-alanine olefin side chains that are not crosslinked <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S8-octenyl-alanine olefin amino acid not connected by any crosslinker <220> <223> C-term NH2 <400> 812 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 813 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (1)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 813 Ala Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 814 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 814 Gln Ser Gln Ala Thr Phe Ser Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 815 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (8)..(15) <223> Crosslink between residues <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 815 Gln Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Ala Ala Asn 1 5 10 15 <210> 816 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 816 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 817 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 817 Ala Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 818 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 818 Gln Ser Gln Ala Thr Phe Ser Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 819 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (15)..(15) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 819 Gln Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Ala Ala Asn 1 5 10 15 <210> 820 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (7)..(7) <223> Amino acid comprising two pentenyl-alanine olefin side chains that are not crosslinked <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 820 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 821 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 821 Gln Ser Gln Gln Thr Phe Ser Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 822 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term acetylated with heptanoic acid <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 822 Gln Ser Gln Ala Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 823 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 823 Ala Ser Gln Gln Thr Phe Ala Asn Leu Arg Trp Leu Leu Ala Gln Asn 1 5 10 15 <210> 824 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 824 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 15 <210> 825 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 825 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 15 <210> 826 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 826 Ala Ala Ala Arg Ala Ala Ala Ala Ala Ala Arg Ala Ala Ala Ala Ala 1 5 10 15 <210> 827 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 827 Leu Thr Phe Glu His Tyr Trp Ala Gln Leu Thr Ser Ala 1 5 10 <210> 828 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 828 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser Ala 1 5 10 <210> 829 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 829 Ala Ser Gln Gln Thr Phe Ser Asn Leu Trp Arg Leu Leu Pro Gln Asn 1 5 10 15 <210> 830 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated <220> <221> misc_feature <222> (7)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 830 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Xaa Gln Asn 1 5 10 15 <210> 831 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 831 Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 832 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 832 Gln Ser Gln Gln Thr Phe Leu Asn Leu Trp Arg Leu Leu Leu Gln Asn 1 5 10 15 <210> 833 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 833 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 834 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (14)..(14) <223> Norleucine <220> <223> C-term NH2 <400> 834 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Leu Gln Asn 1 5 10 15 <210> 835 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 835 Gln Ser Gln Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 836 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 836 Gln Ser Gln Gln Thr Phe Leu Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 837 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> 6cl-Trp <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 837 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 838 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (7)..(3) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Me6clW <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 838 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 839 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Norleucine <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 839 Phe Leu Ala Tyr Trp Glu Ala Leu 1 5 <210> 840 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 840 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala 1 5 10 <210> 841 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 841 Phe Ala Ala Tyr Trp Gln Leu Leu Ala Ala 1 5 10 <210> 842 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 842 Leu Pro Arg Phe Ala Asn Tyr Trp Glu Leu Leu Ala Gln Asn 1 5 10 <210> 843 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 843 Leu Pro Arg Phe Ala Asp Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 844 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 844 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln 1 5 10 <210> 845 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 845 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala 1 5 10 <210> 846 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 846 Gln Ser Gln Gln Thr Phe Ala Asp Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 847 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 847 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Glu Asn 1 5 10 15 <210> 848 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 848 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asp 1 5 10 15 <210> 849 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 849 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Ser 1 5 10 15 <210> 850 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 850 Glu Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 851 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 851 Leu Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 <210> 852 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 852 Leu Arg Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 <210> 853 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 853 Gln Ser Gln Gln Thr Phe Ala Asn Trp Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 854 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 854 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln 1 5 10 15 <210> 855 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 855 Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 856 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 856 Leu Pro Arg Phe Ala Asn Trp Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 857 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 857 Leu Pro Arg Phe Ala Asn Trp Trp Arg Leu Leu Ala Ala 1 5 10 <210> 858 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 858 Thr Ser Phe Ala Glu Tyr Trp Asn Leu Leu 1 5 10 <210> 859 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 859 Gln Thr Phe Ala His Trp Trp Ser Gln Leu Ala Ser 1 5 10 <210> 860 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 860 Phe Met Ala Tyr Trp Glu Ala Leu 1 5 <210> 861 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 861 Gln Thr Phe Glu His Trp Trp Ser Gln Leu Leu Ser 1 5 10 <210> 862 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me-Trp <220> <221> MOD_RES <222> (13)..(13) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 862 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 863 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <223> C-term NH2 <400> 863 Phe Met Xaa Tyr Trp Glu Xaa Leu 1 5 <210> 864 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Norleucine <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 864 Phe Leu Ala Tyr Trp Glu Ala Leu 1 5 <210> 865 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one Z configured double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one Z configured double bond <220> <223> C-term NH2 <400> 865 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala 1 5 <210> 866 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 866 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 867 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> 6cl-Trp <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 867 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 868 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 868 Ala Phe Ala Ala Ala Trp Ala Leu Ala Ala Ala 1 5 10 <210> 869 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 869 Thr Phe Ala Ala Ala Trp Arg Leu Ala Ala Gln 1 5 10 <210> 870 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pr <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 870 Thr Phe Ala Ala Ala Trp Arg Leu Ala Ala Gln 1 5 10 <210> 871 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 871 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 872 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 872 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser Ala 1 5 10 <210> 873 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 873 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 874 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> 6cl-Trp <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 874 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 875 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 875 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 876 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (3)..(7) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Amino acid comprising two pentenyl-alanine olefin side chains, each of which is crosslinked to another amino acid as indicated via fully saturated hydrocarbon crosslinks <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 876 Gln Ser Ala Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 877 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 877 Leu Thr Phe Ala His Tyr Trp Arg Gln Leu Ala Ser 1 5 10 <210> 878 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> 6cl-Trp <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 878 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Arg Leu Leu Ala Gln Asn 1 5 10 15 <210> 879 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (1)..(8) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 879 Ala Ser Gln Gln Thr Phe Ser Ala Leu Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 880 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 880 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 881 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 881 Thr Ser Phe Ala Gln Tyr Trp Asn Leu Leu Ala Pro 1 5 10 <210> 882 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <223> C-term NH2 <400> 882 Leu Thr Phe Glu His Tyr Trp Ala Gln Leu Thr Ser 1 5 10 <210> 883 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <223> C-term NH2 <400> 883 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala 1 5 <210> 884 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 884 Ala Phe Ala Ala Ala Trp Ala Leu Ala Ala Ala 1 5 10 <210> 885 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 885 Thr Phe Ala Ala Ala Trp Arg Leu Ala Ala Gln 1 5 10 <210> 886 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pr <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 886 Thr Phe Ala Ala Ala Trp Arg Leu Ala Ala Gln 1 5 10 <210> 887 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <223> C-term NH2 <400> 887 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 888 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Beta-Ala <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (14)..(21) <223> Crosslink between residues <220> <221> MOD_RES <222> (21)..(21) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 888 Cys Cys Pro Gly Cys Cys Ala Gln Ser Gln Gln Thr Phe Ala Asn Leu 1 5 10 15 Trp Arg Leu Leu Ala Gln Asn 20 <210> 889 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Beta-Ala <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (14)..(21) <223> Crosslink between residues <220> <221> MOD_RES <222> (21)..(21) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 889 Cys Cys Pro Gly Cys Cys Ala Gln Ser Gln Gln Thr Ala Ala Asn Leu 1 5 10 15 Trp Arg Leu Leu Ala Gln Asn 20 <210> 890 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Beta-Ala <220> <221> MOD_RES <222> (8)..(8) <223> Norleucine <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (12)..(19) <223> Crosslink between residues <220> <221> MOD_RES <222> (19)..(19) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 890 Cys Cys Pro Gly Cys Cys Ala Leu Pro Arg Phe Ala Asn Tyr Trp Arg 1 5 10 15 Leu Leu Ala Gln Asn 20 <210> 891 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 891 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 892 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 892 Phe Ala His Tyr Trp Arg Xaa Leu Ala 1 5 <210> 893 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 893 Gln Thr Phe Ala His Trp Trp Ser Gln Leu Ala Ser 1 5 10 <210> 894 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 894 Leu Thr Ala Ala His Tyr Trp Arg Gln Leu Ala Ser 1 5 10 <210> 895 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 895 Gln Ala Gln Gln Thr Phe Ser Asn Ala Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 896 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 896 Gln Ser Gln Gln Ala Phe Ser Asn Leu Trp Arg Ala Leu Xaa Gln Asn 1 5 10 15 <210> 897 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 897 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 898 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 898 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ser 1 5 10 <210> 899 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 899 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Gln 1 5 10 <210> 900 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 900 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ser 1 5 10 <210> 901 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 901 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ser 1 5 10 <210> 902 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 902 Phe Ala Ala Tyr Trp Glu Gln Leu Ala Ser 1 5 10 <210> 903 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 903 Phe Ala His Tyr Trp Glu Gln Leu Ala Ser 1 5 10 <210> 904 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 904 Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 905 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 905 Phe Ala His Tyr Trp Ala Xaa Leu Ala Ser 1 5 10 <210> 906 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 906 Phe Ala His Tyr Trp Arg Xaa Leu Ala Ser 1 5 10 <210> 907 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-hydrogen S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 907 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 908 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (5)..(3) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 908 Leu Pro Thr Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 909 Thr Phe Ala Ala Ala Trp Arg Ala Leu Ala Gln 1 5 10 <210> 910 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 910 Thr Ser Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 911 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 911 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 912 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 912 Leu Thr Phe Ala His Tyr Trp Ala Gln Ile Ala Ser 1 5 10 <210> 913 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 913 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 914 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 914 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 915 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Abu <220> <223> C-term NH2 <400> 915 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Xaa 1 5 10 <210> 916 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Abu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 916 Leu Thr Phe Ala His Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 917 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <223> C-term NH2 <400> 917 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 918 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 918 Leu Ala Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 919 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 919 Leu Ala Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 920 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <223> C-term NH2 <400> 920 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 921 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 921 Leu Ala Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 922 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 922 Leu Thr Phe Ala Asn Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 923 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 923 Leu Thr Phe Ala Asn Leu Trp Ala Leu Leu Ala Ala 1 5 10 <210> 924 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 924 Leu Thr Phe Ala Ala Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 925 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 925 Leu Ala Phe Ala Asn Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 926 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 926 Leu Ala Phe Ala Ala Leu Trp Ala Leu Leu Ala Ala 1 5 10 <210> 927 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 927 Ala Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 928 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 928 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ala 1 5 10 <210> 929 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 929 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Xaa 1 5 10 <210> 930 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 930 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Leu 1 5 10 <210> 931 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 931 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 932 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 932 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 933 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 933 Phe Ala Ala Tyr Trp Glu Xaa Ile Ala Ala 1 5 10 <210> 934 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 934 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 935 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me-Leu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 935 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala 1 5 10 <210> 936 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 936 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala 1 5 10 <210> 937 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 937 Phe Ala Ala Tyr Trp Gln Xaa Leu Ala Ala 1 5 10 <210> 938 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 938 Phe Ala Ala Tyr Trp Ala Xaa Leu Ala Ala 1 5 10 <210> 939 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Abu <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 939 Phe Ala Ala Tyr Trp Xaa Xaa Leu Ala Ala 1 5 10 <210> 940 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Norleucine <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 940 Phe Ala Ala Tyr Trp Leu Xaa Leu Ala Ala 1 5 10 <210> 941 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(3) <223> Abu <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 941 Phe Ala Xaa Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 942 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(3) <223> Norleucine <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 942 Phe Ala Leu Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 943 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <223> C-term NH2 <400> 943 Ala Leu Thr Phe Glu His Tyr Trp Ala Gln Leu Thr Ser 1 5 10 <210> 944 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term 5-FAM <220> <221> MOD_RES <222> (1)..(1) <223> Beta-Ala <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 944 Ala Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 945 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 945 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 946 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Tert-butyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 946 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 947 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Adamantyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 947 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 948 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> homo-cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 948 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 949 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 949 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 950 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Ac6c <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 950 Leu Thr Phe Ala His Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 951 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Ac5c <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 951 Leu Thr Phe Ala His Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 952 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> homo-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 952 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 953 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Indanyl-Gly <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 953 Leu Thr Gly Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 954 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 954 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 955 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 955 Leu Thr Phe Ala His Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 956 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Indanyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 956 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 957 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 957 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 958 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclopentyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 958 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 959 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> hY <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 959 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 960 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> hLeu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 960 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 961 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Tert-butyl-Gly <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 961 Phe Ala Ala Tyr Trp Glu Xaa Gly Ala Ala 1 5 10 <210> 962 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Adamantyl-Gly <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 962 Phe Ala Ala Tyr Trp Glu Xaa Gly Ala Ala 1 5 10 <210> 963 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> homo-cyclohexyl-Ala <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 963 Phe Ala Ala Tyr Trp Glu Xaa Ala Ala Ala 1 5 10 <210> 964 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 964 Phe Ala Ala Tyr Trp Glu Xaa Ala Ala Ala 1 5 10 <210> 965 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac6c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 965 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 966 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac5c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 966 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 967 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> homo-Phe <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 967 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 968 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Indanyl-Gly <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 968 Gly Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 969 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 969 Phe Ala Ala Tyr Trp Glu Xaa Phe Ala Ala 1 5 10 <210> 970 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Indanyl-Gly <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 970 Phe Ala Ala Tyr Trp Glu Xaa Gly Ala Ala 1 5 10 <210> 971 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 971 Phe Ala Ala Tyr Trp Glu Xaa Ala Ala Ala 1 5 10 <210> 972 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (8)..(8) <223> Cyclopentyl-Gly <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 972 Phe Ala Ala Tyr Trp Glu Xaa Gly Ala Ala 1 5 10 <210> 973 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (4)..(4) <223> hY <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 973 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 974 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 974 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Gln 1 5 10 <210> 975 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 975 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 976 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 976 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 977 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 977 Leu Ala Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala 1 5 10 <210> 978 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Ac3c <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 978 Leu Thr Phe Ala His Tyr Trp Ala Xaa Leu Ala Ser 1 5 10 <210> 979 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 979 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 980 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 980 Val Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 981 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 981 Phe Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 982 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 982 Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 983 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 983 Arg Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 984 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 984 Lys Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 985 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Norleucine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 985 Leu Leu Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 986 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 986 Leu Val Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 987 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 987 Leu Phe Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 988 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 988 Leu Trp Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 989 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 989 Leu Arg Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 990 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 990 Leu Lys Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 991 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 991 Leu Thr Phe Ala Leu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 992 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 992 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 993 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 993 Leu Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 994 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 994 Leu Thr Phe Ala Trp Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 995 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 995 Leu Thr Phe Ala Arg Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 996 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 996 Leu Thr Phe Ala Lys Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 997 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 997 Leu Thr Phe Ala His Leu Trp Ala Gln Leu Ala Ser 1 5 10 <210> 998 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 998 Leu Thr Phe Ala His Val Trp Ala Gln Leu Ala Ser 1 5 10 <210> 999 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 999 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1000 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1000 Leu Thr Phe Ala His Trp Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1001 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1001 Leu Thr Phe Ala His Arg Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1002 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1002 Leu Thr Phe Ala His Lys Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1003 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1003 Leu Thr Phe Ala His Tyr Trp Leu Gln Leu Ala Ser 1 5 10 <210> 1004 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1004 Leu Thr Phe Ala His Tyr Trp Val Gln Leu Ala Ser 1 5 10 <210> 1005 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1005 Leu Thr Phe Ala His Tyr Trp Phe Gln Leu Ala Ser 1 5 10 <210> 1006 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1006 Leu Thr Phe Ala His Tyr Trp Trp Gln Leu Ala Ser 1 5 10 <210> 1007 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1007 Leu Thr Phe Ala His Tyr Trp Lys Gln Leu Ala Ser 1 5 10 <210> 1008 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1008 Leu Thr Phe Ala His Tyr Trp Ala Leu Leu Ala Ser 1 5 10 <210> 1009 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1009 Leu Thr Phe Ala His Tyr Trp Ala Val Leu Ala Ser 1 5 10 <210> 1010 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1010 Leu Thr Phe Ala His Tyr Trp Ala Phe Leu Ala Ser 1 5 10 <210> 1011 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1011 Leu Thr Phe Ala His Tyr Trp Ala Trp Leu Ala Ser 1 5 10 <210> 1012 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1012 Leu Thr Phe Ala His Tyr Trp Ala Arg Leu Ala Ser 1 5 10 <210> 1013 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Norleucine <220> <223> C-term NH2 <400> 1013 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Leu 1 5 10 <210> 1014 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1014 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Val 1 5 10 <210> 1015 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1015 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Phe 1 5 10 <210> 1016 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1016 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Trp 1 5 10 <210> 1017 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1017 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Arg 1 5 10 <210> 1018 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1018 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Lys 1 5 10 <210> 1019 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 1019 Gln Ala Gln Gln Thr Phe Ser Asn Ala Trp Arg Leu Leu Xaa Gln Asn 1 5 10 15 <210> 1020 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (14)..(14) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 1020 Gln Ser Gln Gln Ala Phe Ser Asn Leu Trp Arg Ala Leu Xaa Gln Asn 1 5 10 15 <210> 1021 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2Pal <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1021 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1022 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3Pal <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1022 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1023 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 4Pal <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1023 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1024 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2CF3 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1024 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1025 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2CN <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1025 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1026 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2Me <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1026 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1027 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1027 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1028 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1028 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1029 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4tBu <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1029 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1030 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-5F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1030 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1031 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 3Bth <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1031 Leu Thr Phe Ala His Tyr Xaa Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1032 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2Br <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1032 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1033 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4Br <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1033 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1034 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2Cl <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1034 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1035 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4Cl <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1035 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1036 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-3CN <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1036 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1037 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4CN <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1037 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1038 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-34Cl2 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1038 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1039 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1039 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1040 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,5-difluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1040 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1041 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,3-di-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1041 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1042 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Fluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1042 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1043 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-fluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1043 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1044 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1044 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1045 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 4-iodo-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1045 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1046 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-3Me <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1046 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1047 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4Me <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1047 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1048 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1048 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1049 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1049 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1050 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-3CF3 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1050 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1051 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4NO2 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1051 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1052 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-3NO2 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1052 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1053 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 2Thi <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1053 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1054 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Bi-Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1054 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1055 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4tBu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1055 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1056 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1056 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1057 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4Cl <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1057 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1058 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4Me <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1058 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1059 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4Br <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1059 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1060 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4CN <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1060 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1061 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Phe-4NO2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1061 Leu Thr Phe Ala His Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1062 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1062 Leu Thr Phe Ala His Ala Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1063 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1063 Leu Thr Phe Ala His Ala Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1064 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1064 Leu Thr Phe Ala His Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1065 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1065 Leu Thr Phe Ala His Tyr Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1066 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1066 Leu Thr Phe Ala His Tyr Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1067 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1067 Leu Thr Phe Ala His Tyr Trp Ala Gln Ile Ala Ser 1 5 10 <210> 1068 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1068 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1069 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one E configured double bond <220> <223> C-term NH2 <400> 1069 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1070 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> Abu <220> <223> C-term NH2 <400> 1070 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Xaa 1 5 10 <210> 1071 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Abu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1071 Leu Thr Phe Ala His Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1072 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1072 Leu Ala Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1073 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1073 Leu Thr Phe Ala Asn Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1074 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1074 Leu Thr Phe Ala Ala Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1075 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1075 Leu Ala Phe Ala Asn Leu Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1076 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1076 Phe Ala Ala Tyr Trp Ala Xaa Leu Ala Ala 1 5 10 <210> 1077 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1077 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1078 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1078 Leu Val Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1079 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Abu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1079 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1080 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1080 Leu Thr Phe Ala Ala Tyr Trp Leu Gln Leu Ala Ser 1 5 10 <210> 1081 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Abu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1081 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1082 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1082 Leu Thr Phe Ala Ala Tyr Trp His Gln Leu Ala Ser 1 5 10 <210> 1083 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1083 Leu Thr Phe Ala Ala Tyr Trp Lys Gln Leu Ala Ser 1 5 10 <210> 1084 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Ornithine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1084 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1085 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1085 Leu Thr Phe Ala Ala Tyr Trp Arg Gln Leu Ala Ser 1 5 10 <210> 1086 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1086 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1087 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1087 Leu Thr Phe Ala Ala Tyr Trp Arg Ala Leu Ala Ser 1 5 10 <210> 1088 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1088 Leu Thr Phe Ala Ala Tyr Trp Arg Gln Leu Ala Ala 1 5 10 <210> 1089 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1089 Leu Thr Phe Ala Ala Tyr Trp Arg Ala Leu Ala Ala 1 5 10 <210> 1090 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1090 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1091 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1091 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1092 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1092 Leu Thr Phe Ala His Tyr Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1093 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Abu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1093 Leu Thr Phe Ala His Tyr Trp Ala Xaa Leu Ala Ser 1 5 10 <210> 1094 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1094 Leu Thr Phe Ala His Tyr Trp Ala Leu Leu Ala Ser 1 5 10 <210> 1095 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1095 Phe Ala Ala Tyr Trp His Ala Leu Ala Ala 1 5 10 <210> 1096 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1096 Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1097 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1097 Phe Ala Ala Tyr Trp Ser Ala Leu Ala Ala 1 5 10 <210> 1098 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1098 Phe Ala Ala Tyr Trp Arg Ala Leu Ala Ala 1 5 10 <210> 1099 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1099 Phe Ala Ala Tyr Trp Lys Ala Leu Ala Ala 1 5 10 <210> 1100 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Ornithine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1100 Phe Ala Ala Tyr Trp Xaa Ala Leu Ala Ala 1 5 10 <210> 1101 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1101 Phe Ala Val Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1102 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1102 Phe Ala Phe Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1103 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1103 Phe Ala Trp Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1104 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1104 Phe Ala Arg Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1105 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1105 Phe Ala Lys Tyr Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1106 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (4)..(4) <223> Norleucine <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1106 Phe Ala Ala Leu Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1107 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1107 Phe Ala Ala Val Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1108 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1108 Phe Ala Ala Phe Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1109 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1109 Phe Ala Ala Trp Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1110 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1110 Phe Ala Ala Arg Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1111 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1111 Phe Ala Ala Lys Trp Glu Xaa Leu Ala Ala 1 5 10 <210> 1112 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1112 Phe Ala Ala Tyr Trp Val Xaa Leu Ala Ala 1 5 10 <210> 1113 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1113 Phe Ala Ala Tyr Trp Phe Xaa Leu Ala Ala 1 5 10 <210> 1114 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1114 Phe Ala Ala Tyr Trp Trp Xaa Leu Ala Ala 1 5 10 <210> 1115 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1115 Phe Ala Ala Tyr Trp Arg Xaa Leu Ala Ala 1 5 10 <210> 1116 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1116 Phe Ala Ala Tyr Trp Lys Xaa Leu Ala Ala 1 5 10 <210> 1117 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1117 Phe Ala Ala Tyr Trp Glu Val Leu Ala Ala 1 5 10 <210> 1118 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1118 Phe Ala Ala Tyr Trp Glu Phe Leu Ala Ala 1 5 10 <210> 1119 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1119 Phe Ala Ala Tyr Trp Glu Trp Leu Ala Ala 1 5 10 <210> 1120 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1120 Phe Ala Ala Tyr Trp Glu Arg Leu Ala Ala 1 5 10 <210> 1121 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1121 Phe Ala Ala Tyr Trp Glu Lys Leu Ala Ala 1 5 10 <210> 1122 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1122 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Val 1 5 10 <210> 1123 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1123 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Phe 1 5 10 <210> 1124 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1124 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Trp 1 5 10 <210> 1125 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1125 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Arg 1 5 10 <210> 1126 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1126 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Lys 1 5 10 <210> 1127 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1127 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Val 1 5 10 <210> 1128 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1128 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Phe 1 5 10 <210> 1129 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1129 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Trp 1 5 10 <210> 1130 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1130 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Arg 1 5 10 <210> 1131 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1131 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Lys 1 5 10 <210> 1132 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1132 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala His 1 5 10 <210> 1133 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2NO2 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1133 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1134 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1134 Leu Thr Ala Ala His Tyr Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1135 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1135 Leu Thr Phe Ala His Tyr Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1136 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1136 Gln Ser Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Ala Ala Asn 1 5 10 15 <210> 1137 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1137 Gln Xaa Gln Gln Thr Phe Ala Asn Leu Trp Ala Leu Leu Ala Ala Asn 1 5 10 15 <210> 1138 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1138 Gln Xaa Gln Gln Thr Phe Ala Ala Leu Trp Ala Leu Leu Ala Ala Asn 1 5 10 15 <210> 1139 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (7)..(14) <223> Crosslink between residues <220> <221> MOD_RES <222> (14)..(14) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1139 Ala Ala Ala Ala Thr Phe Ala Ala Ala Trp Ala Ala Leu Ala Ala Ala 1 5 10 15 <210> 1140 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1140 Phe Ala Ala Ala Trp Arg Ala Leu Ala Gln 1 5 10 <210> 1141 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1141 Thr Phe Ala Ala Ala Trp Ala Ala Leu Ala Gln 1 5 10 <210> 1142 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1142 Thr Phe Ala Ala Ala Trp Arg Ala Leu Ala Ala 1 5 10 <210> 1143 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1143 Val Phe Ala Ala Ala Trp Arg Ala Leu Ala Gln 1 5 10 <210> 1144 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1144 Ala Phe Ala Ala Ala Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1145 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1145 Thr Phe Ala Ala Ala Trp Lys Ala Leu Ala Gln 1 5 10 <210> 1146 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ornithine <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1146 Thr Phe Ala Ala Ala Trp Xaa Ala Leu Ala Gln 1 5 10 <210> 1147 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1147 Thr Phe Ala Ala Ala Trp Ser Ala Leu Ala Gln 1 5 10 <210> 1148 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1148 Leu Thr Phe Ala Ala Ala Trp Arg Ala Leu Ala Gln 1 5 10 <210> 1149 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1149 Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1150 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1150 Phe Ala Ala Trp Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1151 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1151 Phe Ala Ala Trp Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1152 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1152 Phe Ala Ala Tyr Trp Glu Ala Leu Ala 1 5 <210> 1153 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1153 Phe Ala Ala Tyr Trp Ala Ala Leu Ala 1 5 <210> 1154 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1154 Phe Ala Ala Tyr Trp Lys Ala Leu Ala 1 5 <210> 1155 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Ornithine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1155 Phe Ala Ala Tyr Trp Xaa Ala Leu Ala 1 5 <210> 1156 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1156 Phe Ala Ala Tyr Trp Gln Ala Leu Ala 1 5 <210> 1157 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1157 Phe Ala Ala Tyr Trp Ala Gln Leu Ala 1 5 <210> 1158 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1158 Phe Ala His Tyr Trp Asp Gln Leu Ala Ser 1 5 10 <210> 1159 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1159 Phe Ala His Phe Trp Glu Gln Leu Ala Ser 1 5 10 <210> 1160 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1160 Phe Ala Ala Tyr Trp His Gln Leu Ala Ser 1 5 10 <210> 1161 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1161 Phe Ala Ala Tyr Trp Lys Gln Leu Ala Ser 1 5 10 <210> 1162 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Ornithine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1162 Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1163 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1163 Phe Ala His Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1164 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1164 Phe Ala His Trp Trp Glu Gln Leu Ala Ser 1 5 10 <210> 1165 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1165 Phe Ala His Trp Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1166 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1166 Phe Ala Ala Trp Trp His Gln Leu Ala Ser 1 5 10 <210> 1167 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1167 Phe Ala Ala Trp Trp Lys Gln Leu Ala Ser 1 5 10 <210> 1168 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Ornithine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1168 Phe Ala Ala Trp Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1169 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1169 Phe Ala His Trp Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1170 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1170 Leu Thr Phe Ala Asn Tyr Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1171 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1171 Leu Thr Phe Ala Asn Leu Trp Ala Gln Leu Ala Gln 1 5 10 <210> 1172 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1172 Leu Thr Phe Ala Asn Tyr Trp Ala Leu Leu Ala Ala 1 5 10 <210> 1173 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1173 Leu Thr Phe Ala Asn Leu Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1174 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1174 Leu Thr Phe Ala Ala Tyr Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1175 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1175 Leu Thr Phe Ala Ala Leu Trp Ala Gln Leu Ala Gln 1 5 10 <210> 1176 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1176 Leu Ala Phe Ala Asn Tyr Trp Ala Leu Leu Ala Gln 1 5 10 <210> 1177 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1177 Leu Ala Phe Ala Asn Leu Trp Ala Gln Leu Ala Gln 1 5 10 <210> 1178 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1178 Leu Ala Phe Ala Ala Tyr Trp Ala Leu Leu Ala Ala 1 5 10 <210> 1179 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1179 Leu Ala Phe Ala Ala Leu Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1180 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1180 Leu Ala Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1181 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> 2-aminoisobutyric acid <220> <223> C-term NH2 <400> 1181 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Xaa 1 5 10 <210> 1182 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1182 Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 1183 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1183 Phe Ala Ala Tyr Trp Ala Xaa Leu Ala Ala Ala 1 5 10 <210> 1184 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1184 Phe Ala Ala Tyr Trp Ser Xaa Leu Ala Ala Ala 1 5 10 <210> 1185 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1185 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Ser 1 5 10 <210> 1186 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1186 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Thr 1 5 10 <210> 1187 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1187 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Leu 1 5 10 <210> 1188 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1188 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ala Gln 1 5 10 <210> 1189 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1189 Phe Ala Ala Phe Trp Glu Xaa Leu Ala Ala Ala 1 5 10 <210> 1190 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1190 Phe Ala Ala Trp Trp Glu Xaa Leu Ala Ala Ala 1 5 10 <210> 1191 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1191 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Ser Ala 1 5 10 <210> 1192 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1192 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1193 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1193 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala Ala 1 5 10 <210> 1194 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1194 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Xaa Ala 1 5 10 <210> 1195 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 1195 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Leu Ala 1 5 10 <210> 1196 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 1196 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Leu Ala 1 5 10 <210> 1197 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 1197 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Leu Ala 1 5 10 <210> 1198 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 1198 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Leu Ala 1 5 10 <210> 1199 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1199 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Xaa 1 5 10 <210> 1200 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1200 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Xaa 1 5 10 <210> 1201 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1201 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Xaa 1 5 10 <210> 1202 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1202 Leu Thr Phe Ala Ala Phe Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1203 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1203 Leu Thr Phe Ala Ala Trp Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1204 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1204 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ile Ala Ser 1 5 10 <210> 1205 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1205 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1206 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1206 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser Ala 1 5 10 <210> 1207 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1207 Leu Thr Phe Ala Ala Trp Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1208 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1208 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ile Ala Ala 1 5 10 <210> 1209 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1209 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1210 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1210 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 1211 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1211 Leu Thr Phe Ala His Trp Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1212 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1212 Leu Thr Phe Ala His Arg Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1213 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1213 Leu Thr Phe Ala His Lys Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1214 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1214 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Trp 1 5 10 <210> 1215 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Abu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1215 Phe Ala Ala Tyr Trp Xaa Ala Leu Ala Ala 1 5 10 <210> 1216 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(3) <223> Abu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1216 Phe Ala Xaa Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1217 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Norleucine <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 1217 Leu Pro Arg Phe Ala Asn Tyr Trp Arg Leu Leu Ala Gln Asn 1 5 10 <210> 1218 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 1218 Thr Ser Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1219 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 1219 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1220 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1220 His Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1221 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1221 Leu His Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1222 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1222 Leu Thr Phe Ala His His Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1223 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1223 Leu Thr Phe Ala His Tyr Trp His Gln Leu Ala Ser 1 5 10 <210> 1224 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1224 Leu Thr Phe Ala His Tyr Trp Ala His Leu Ala Ser 1 5 10 <210> 1225 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1225 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala His 1 5 10 <210> 1226 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHPr <400> 1226 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1227 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHsBu <400> 1227 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1228 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHiBu <400> 1228 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1229 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHBn <400> 1229 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1230 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHPe <400> 1230 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1231 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHChx <400> 1231 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1232 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1232 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1233 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1233 Ser Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1234 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1234 Leu Glu Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1235 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1235 Leu Ser Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1236 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1236 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1237 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1237 Leu Thr Phe Ala Ser Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1238 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1238 Leu Thr Phe Ala Ala Tyr Trp Glu Gln Leu Ala Ser 1 5 10 <210> 1239 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1239 Leu Thr Phe Ala Ala Tyr Trp Ala Glu Leu Ala Ser 1 5 10 <210> 1240 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1240 Leu Thr Phe Ala Ala Tyr Trp Ala Ser Leu Ala Ser 1 5 10 <210> 1241 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1241 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Glu 1 5 10 <210> 1242 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-2CN <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1242 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1243 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1243 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1244 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,3-di-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1244 Leu Thr Xaa Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1245 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Tert-butyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1245 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1246 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1246 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1247 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl6br-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1247 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1248 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl6f-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1248 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1249 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl4m-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1249 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1250 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl5cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1250 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1251 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl7m-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1251 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1252 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising no double bonds <220> <223> C-term NH2 <400> 1252 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1253 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Cou <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1253 Leu Thr Phe Ala His Xaa Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1254 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (6)..(6) <223> Cou <220> <223> C-term NH2 <400> 1254 Leu Thr Phe Glu His Xaa Trp Ala Gln Leu Thr Ser 1 5 10 <210> 1255 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Cou <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1255 Leu Thr Ala Ala His Xaa Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1256 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1256 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Xaa Ala 1 5 10 <210> 1257 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1257 Phe Ala Ala Tyr Trp Glu Ala Ile Ala Ala Ala 1 5 10 <210> 1258 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1258 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1259 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Alpha-Me-Leu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1259 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala Ala 1 5 10 <210> 1260 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1260 Phe Ala Ala Tyr Trp Gln Ala Leu Ala Ala Ala 1 5 10 <210> 1261 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1261 Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ala Ala 1 5 10 <210> 1262 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Abu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1262 Phe Ala Ala Tyr Trp Xaa Ala Leu Ala Ala Ala 1 5 10 <210> 1263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1263 Phe Ala Ala Tyr Trp Leu Ala Leu Ala Ala Ala 1 5 10 <210> 1264 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(3) <223> Abu <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1264 Phe Ala Xaa Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1265 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (3)..(3) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1265 Phe Ala Leu Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1266 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1266 Phe Ala Phe Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1267 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1267 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1268 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Adamantyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1268 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1269 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Indanyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1269 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1270 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1270 Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala Ala 1 5 10 <210> 1271 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1271 Leu Thr Phe Ala Ala Leu Trp Ala Gln Leu Ala Gln 1 5 10 <210> 1272 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1272 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1273 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1273 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Ala Ala 1 5 10 <210> 1274 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1274 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Xaa 1 5 10 <210> 1275 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1275 Phe Ala Ala Tyr Trp Glu Leu Leu Ala Xaa 1 5 10 <210> 1276 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1276 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Xaa 1 5 10 <210> 1277 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Abu <220> <223> C-term NH2 <400> 1277 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Xaa Ala 1 5 10 <210> 1278 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> Ac3c <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (10)..(10) <223> Norleucine <220> <223> C-term NH2 <400> 1278 Phe Ala Ala Tyr Trp Glu Xaa Leu Ala Leu Ala 1 5 10 <210> 1279 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term H <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1279 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1280 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term mdPEG3 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1280 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1281 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term mdPEG7 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1281 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1282 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (4)..(4) <223> Pmp <220> <221> MOD_RES <222> (5)..(5) <223> Et6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1282 Phe Ala Ala Xaa Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1283 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1283 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1284 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1284 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1285 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1285 Leu Thr Phe Ala His Tyr Trp Trp Gln Leu Ala Ser 1 5 10 <210> 1286 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1286 Leu Thr Phe Ala Ala Tyr Trp Trp Gln Leu Ala Ser 1 5 10 <210> 1287 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1287 Leu Thr Phe Ala Ala Tyr Trp Trp Gln Leu Ala Ser 1 5 10 <210> 1288 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1288 Leu Thr Phe Ala His Tyr Trp Trp Gln Leu Ala Ala 1 5 10 <210> 1289 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1289 Leu Thr Phe Ala Ala Tyr Trp Trp Gln Leu Ala Ala 1 5 10 <210> 1290 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1290 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1291 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Fluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1291 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1292 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-fluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1292 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1293 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,4-difluoro Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1293 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1294 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3,5-difluoro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1294 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1295 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1295 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1296 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1296 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1297 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1297 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala Ala 1 5 10 <210> 1298 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1298 Phe Ala Ala Tyr Trp Glu Ala Leu Ala 1 5 <210> 1299 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (11)..(11) <223> Amino acid comprising two pentenyl-alanine olefin side chains that are not crosslinked <220> <223> C-term NH2 <400> 1299 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1300 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHsBu <400> 1300 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1301 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1301 Ser Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1302 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1302 Leu Thr Phe Ala Ala Tyr Trp Ala Glu Leu Ala Ser 1 5 10 <210> 1303 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1303 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Glu 1 5 10 <210> 1304 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term mdPEG3 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1304 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1305 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1305 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1306 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1306 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1307 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1307 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1308 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1308 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1309 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1309 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1310 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1310 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1311 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1311 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1312 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1312 Leu Thr Phe Ala His Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1313 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1313 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1314 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1314 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1315 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1315 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1316 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1316 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1317 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1317 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1318 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1318 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1319 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1319 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1320 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1320 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1321 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1321 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1322 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> homo-Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1322 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1323 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Phe-3CF3 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1323 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1324 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Phe-3Me <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1324 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1325 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1325 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1326 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Bi-Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1326 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1327 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1327 Leu Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1328 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHAm <400> 1328 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1329 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHiAm <400> 1329 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1330 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr3Ph <400> 1330 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1331 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnBu3,3Me <400> 1331 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1332 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr <400> 1332 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1333 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnEt2Ch <400> 1333 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1334 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHHex <400> 1334 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1335 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHmdPeg2 <400> 1335 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1336 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHmdPeg2 <400> 1336 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1337 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHmdPeg4 <400> 1337 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1338 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl4m-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1338 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1339 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> dl5cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1339 Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1340 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> homo-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1340 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1341 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1341 Leu Thr Ala Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1342 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1342 Leu Thr Ala Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1343 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1343 Leu Thr Phe Ala Ala Tyr Trp Val Gln Leu Ala Ser 1 5 10 <210> 1344 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1344 Leu Thr Phe Ala His Tyr Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1345 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1345 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1346 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1346 Leu Thr Phe Ala Ile Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1347 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1347 Phe Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1348 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1348 Ile Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1349 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1349 Ala Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1350 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1350 Ile Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1351 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1351 Phe Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1352 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1352 Trp Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1353 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1353 Trp Thr Phe Ala Trp Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1354 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1354 Val Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1355 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1355 Trp Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1356 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1356 Phe Thr Phe Ala Ile Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1357 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1357 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1358 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1358 Phe Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1359 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1359 Tyr Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1360 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1360 Leu Thr Phe Ala Ala Tyr Trp Glu Ala Leu Ala Ala 1 5 10 <210> 1361 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1361 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1362 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1362 Phe Ala Ala Tyr Trp Ser Ala Leu Ala Ala 1 5 10 <210> 1363 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1363 Phe Ala Ala Tyr Trp Gln Ala Leu Ala Ala Ala 1 5 10 <210> 1364 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1364 Leu His Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1365 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1365 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1366 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1366 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1367 Leu Thr Phe Ala Ala Tyr Trp Ala His Leu Ala Ser 1 5 10 <210> 1368 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1368 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His 1 5 10 <210> 1369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1369 His Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1370 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1370 His His Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1371 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1371 Ala Xaa Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1372 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1372 Xaa Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1373 Xaa Ala Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1374 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1374 Phe Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1375 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1375 Xaa Trp Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1376 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1376 Trp Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1377 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1377 Trp Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1378 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 1378 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ala 1 5 10 <210> 1379 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1379 Leu Thr Phe Ala Glu Tyr Trp Ala Arg Leu Ala Ala 1 5 10 <210> 1380 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1380 Leu Thr Phe Ala Glu Tyr Trp Ala His Leu Ala Ala 1 5 10 <210> 1381 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1381 Ala Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1382 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1382 Xaa Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1383 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1383 Phe Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1384 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me-Trp <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1384 Trp Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1385 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> N-methyl-Leu <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1385 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1386 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> N-methyl-Thr <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1386 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1387 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Sarcosine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1387 Leu Xaa Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1388 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1388 Leu Gly Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1389 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> N-methyl-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1389 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1390 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1390 Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1391 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1391 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1392 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1392 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1393 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1393 Leu Thr Ala Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1394 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1394 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1395 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> homo-cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1395 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1396 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1396 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1397 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1397 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1398 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Phe-3CF3 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1398 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1399 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1399 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1400 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Bi-Phe <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1400 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Phe Ala Ser 1 5 10 <210> 1401 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1401 Leu Thr Ala Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1402 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1402 Leu Thr Phe Ala Ala Tyr Trp Val Gln Leu Ala Ser 1 5 10 <210> 1403 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1403 Leu Thr Phe Ala Ala Trp Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1404 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1404 Phe Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1405 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1405 Ile Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1406 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1406 Ile Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1407 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1407 Phe Thr Phe Ala Phe Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1408 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1408 Val Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1409 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1409 Leu Thr Phe Ala Ala His Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1410 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1410 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala His 1 5 10 <210> 1411 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1411 Leu Thr Phe Ala Ala Tyr Trp Ala His Leu Ala Ser 1 5 10 <210> 1412 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (2)..(2) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1412 Ala Xaa Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1413 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1413 Xaa Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1414 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1414 Xaa Ala Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1415 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (5)..(12) <223> Crosslink between residues <220> <221> MOD_RES <222> (12)..(12) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1415 Phe Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1416 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (6)..(6) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (6)..(13) <223> Crosslink between residues <220> <221> MOD_RES <222> (13)..(13) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1416 Xaa Trp Trp Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1417 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1417 Trp Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1418 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Norleucine <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1418 Trp Thr Phe Ala Leu Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1419 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> MOD_RES <222> (12)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 1419 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ala 1 5 10 <210> 1420 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1420 Leu Thr Phe Ala Glu Tyr Trp Ala Arg Leu Ala Ala 1 5 10 <210> 1421 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1421 Leu Thr Phe Ala Glu Tyr Trp Ala His Leu Ala Ala 1 5 10 <210> 1422 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> D-amino acid <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1422 Ala Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1423 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> 2-aminoisobutyric acid <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1423 Xaa Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1424 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1424 Phe Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1425 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Alpha-Me-Trp <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1425 Trp Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1426 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> N-methyl-Leu <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1426 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1427 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> N-methyl-Thr <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1427 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1428 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Sarcosine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1428 Leu Xaa Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1429 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (3)..(10) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1429 Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1430 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1430 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1431 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1431 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1432 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1432 Trp Thr Phe Ala Val Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1433 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1433 Tyr Thr Phe Ala Phe Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1434 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (2)..(2) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (2)..(9) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> 6cl-Trp <220> <221> MOD_RES <222> (9)..(9) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1434 Phe Ala Ala Tyr Trp Ser Ala Leu Ala Ala 1 5 10 <210> 1435 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1435 Glu Thr Phe Ala Glu Tyr Trp Val Gln Leu Ala Ser 1 5 10 <210> 1436 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1436 Glu Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1437 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1437 Ile Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1438 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1438 Ile Thr Phe Ala Glu His Trp Val Gln Leu Ala Ala 1 5 10 <210> 1439 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1439 Ile Thr Phe Ala Glu His Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1440 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1440 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1441 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1441 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1442 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1442 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1443 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1443 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1444 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 3-Chloro-Phe <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1444 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1445 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (7)..(7) <223> 6cl-Trp <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1445 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1446 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1446 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1447 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclobutyl-Ala <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1447 Leu Thr Phe Ala His Tyr Trp Ala Gln Ala Ala Ser 1 5 10 <210> 1448 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> hLeu <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1448 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1449 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> Phe-4F <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (10)..(10) <223> Cyclohexyl-Gly <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1449 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Gly Ala Ser 1 5 10 <210> 1450 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1450 Glu Thr Phe Ala Glu Tyr Trp Val Ala Leu Ala Ser 1 5 10 <210> 1451 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1451 Glu Thr Phe Ala Glu His Trp Ala Ala Leu Ala Ala 1 5 10 <210> 1452 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1452 Ile Thr Phe Ala Glu Tyr Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1453 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1453 Ile Thr Phe Ala Glu His Trp Val Ala Leu Ala Ala 1 5 10 <210> 1454 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1454 Ile Thr Phe Ala Glu His Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1455 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pam <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1455 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1456 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pam <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1456 Glu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1457 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1457 Leu Thr Phe Ala Ala Tyr Trp Leu Gln Leu Ala Ser 1 5 10 <210> 1458 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1458 Leu Thr Phe Ala Glu Tyr Trp Leu Gln Leu Ala Ser 1 5 10 <210> 1459 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1459 Leu Thr Phe Ala Glu His Trp Leu Gln Leu Ala Ser 1 5 10 <210> 1460 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1460 Leu Thr Phe Ala Val Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1461 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1461 Leu Thr Phe Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1462 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1462 Glu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1463 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1463 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1464 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHAm <400> 1464 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1465 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHiAm <400> 1465 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1466 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr3Ph <400> 1466 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1467 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnBu3,3Me <400> 1467 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1468 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnBu <400> 1468 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1469 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnPr <400> 1469 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1470 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHnEt2Ch <400> 1470 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1471 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHHex <400> 1471 Leu Thr Phe Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1472 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHmdPeg2 <400> 1472 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1473 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NHmdPeg2 <400> 1473 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1474 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1474 Leu Thr Phe Ala Ala Tyr Trp Ala Ala Leu Ala Ser 1 5 10 <210> 1475 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1475 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1476 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Cou <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1476 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1477 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Cou <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1477 Xaa Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1478 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term H <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1478 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ala 1 5 10 <210> 1479 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1479 His His Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1480 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1480 Leu Thr Ala Ala Ala Tyr Trp Ser Gln Leu Ala Ser 1 5 10 <210> 1481 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Cou <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1481 Leu Thr Phe Ala His Xaa Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1482 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (8)..(8) <223> Cou2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1482 Leu Thr Phe Ala Ala Tyr Trp Xaa Gln Leu Ala Ser 1 5 10 <210> 1483 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (5)..(5) <223> Cou2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1483 Leu Thr Phe Ala Xaa Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1484 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(1) <223> Cou2 <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1484 Xaa Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1485 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (6)..(6) <223> Cou2 <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1485 Leu Thr Phe Ala Ala Xaa Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1486 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Dmaac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1486 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1487 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Hexac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1487 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1488 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Napac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1488 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1489 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Pam <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1489 Leu Thr Phe Ala Ala Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1490 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1490 Leu Thr Ala Ala His Tyr Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1491 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid that is not connected by a crosslinker <220> <223> C-term NH2 <400> 1491 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1492 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1492 Leu Thr Ala Ala His Tyr Phe Ala Gln Leu Ala Ser 1 5 10 <210> 1493 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1493 Leu Thr Ala Ala His Trp Ala Ala Gln Leu Ala Ser 1 5 10 <210> 1494 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1494 Leu Thr Ala Ala His Tyr Ala Trp Gln Leu Ala Ser 1 5 10 <210> 1495 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 2-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1495 Leu Thr Ala Ala His Tyr Ala Ala Gln Trp Ala Ser 1 5 10 <210> 1496 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1496 Leu Thr Trp Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1497 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (3)..(3) <223> 1-Naphthalanine <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R8-octenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S5-pentenyl-alanine olefin amino acid connected by an all-carbon crosslinker comprising one double bond <220> <223> C-term NH2 <400> 1497 Leu Thr Ala Ala His Tyr Trp Ala Gln Leu Ala Ser 1 5 10 <210> 1498 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 1498 Thr Ala Trp Tyr Ala Asn Phe Glu Lys Leu Leu Arg 1 5 10 <210> 1499 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (1)..(6) <223> D-amino acid <220> <221> MOD_RES <222> (7)..(7) <223> D-Phe-4CF3 <220> <221> MOD_RES <222> (8)..(12) <223> D-amino acid <220> <223> C-term NH2 <400> 1499 Thr Ala Trp Tyr Ala Asn Phe Glu Lys Leu Leu Arg 1 5 10 <210> 1500 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <223> N-term Ac <220> <221> MOD_RES <222> (4)..(4) <223> Alpha-Me R6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> misc_feature <222> (4)..(11) <223> Crosslink between residues <220> <221> MOD_RES <222> (11)..(11) <223> Alpha-Me S6-hexynyl-alanine alkynyl amino acids, crosslink via a dialkyne bond with a second alkynyl amino acid <220> <221> MOD_RES <222> (17)..(17) <223> D-amino acid <220> <223> C-term NH2 <220> <223> see specification as filed for detailed description of substitutions and preferred embodiments <400> 1500 Leu Thr Phe Ala Glu Tyr Trp Ala Gln Leu Ala Ala Ala Ala Ala Ala 1 5 10 15 Ala <210> 1501 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic 6xHis tag <400> 1501 His His His His His His 1 5

Claims

하기 화학식의 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

상기 식에서,
Xaa₃은 Phe(F), 또는 3,4-디플루오로 페닐알라닌이고,
Xaa₅는 Ala(A), 또는 Glu(E)이고,
Xaa₆은 Tyr(Y)이고,
Xaa₇은 Trp(W)이고,
Xaa₈은 Ala(A)이고,
Xaa₉은 Gln(Q)이고,
Xaa₁₀은 Leu(L) 또는 호모류신이고,
[D]v는 -Leu₁-Thr₂이고,
각각의 E는 독립적으로 Ala(알라닌), D-Ala(D-알라닌), Aib(α-아미노이소부티르산), Sar(N-메틸 글리신), 및 Ser(세린)로 이루어진 군으로부터 선택된 아미노산이고;
R₁ 및 R₂는 독립적으로 -H 또는 메틸이고;
L은 식 L₁-L₂- 의 C₁₀ - C₁₄ 마크로사이클 형성 링커이고;
각 L₁및 L₂는 독립적으로 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 시클로알킬렌, 헤테로시클로알킬렌, 아릴렌, 헤테로아릴렌, 또는 [-R₄-K-R₄-]n이고 각각은 R₅로 치환되거나 비치환되며;
각 R₄는 독립적으로 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 시클로알킬렌, 헤테로시클로알킬렌, 아릴렌, 또는 헤테로아릴렌이며;
각 K는 독립적으로 O, S, SO, SO₂, CO, CO₂, 또는 CONR₃이며;
각 R₃은 독립적으로 수소, 알킬, 알케닐, 알키닐, 아릴알킬, 헤테로알킬, 사이클로알킬, 헤테로사이클로알킬, 사이클로알킬알킬, 아릴, 또는 헤테로아릴이고, R₅로 치환되거나 비치환되며;
각 R₅는 독립적으로 할로겐, 알킬, -OR₆, -N(R₆)₂, -SR₆, -SOR₆, -SO₂R₆, -CO₂R₆, 형광성 모이어티, 방사성 동위원소 또는 치료제이고;
각 R₆는 독립적으로 -H, 알킬, 알케닐, 알키닐, 아릴알킬, 시클로알킬알킬, 헤테로시클로알킬, 형광성 모이어티, 방사성 동위원소 또는 치료제이고;
R₇은 -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 아릴, 또는 헤테로아릴이고, R₅로 치환되거나 비치환되며; 또는 D 잔기를 갖는 사이클릭 구조의 일부이고;
R₈은 -H, 알킬, 알케닐, 알키닐, 아릴알킬, 사이클로알킬, 헤테로알킬, 사이클로알킬알킬, 헤테로사이클로알킬, 아릴, 또는 헤테로아릴이고, R₅로 치환되거나 비치환되며; 또는 E 잔기를 갖는 사이클릭 구조의 일부이고;
n은 1 내지 5의 정수이고;
w는 3 내지 10의 정수이다.
제1항에 있어서, 각 L₁및 L₂는 독립적으로 알킬렌, 알케닐렌, 알키닐렌, 헤테로알킬렌, 시클로알킬렌, 헤테로시클로알킬렌, 아릴렌, 또는 헤테로아릴렌이고, 각각은 R₅로 치환되거나 비치환되는 것인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제2항에 있어서, L₁및 L₂가 독립적으로 알킬렌 또는 알케닐렌인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, L이 알킬렌, 알케닐렌, 또는 알키닐렌인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제4항에 있어서, L이 알케닐렌인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, 각 E가 독립적으로 Ala(알라닌), D-Ala(D-알라닌), 및 Ser(세린)로부터 선택된 아미노산인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, w가 6-10의 정수인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, w가 3-6의 정수인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

.
하기 화학식을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염:

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제1항에 있어서, 서열 번호 570의 아미노산 서열을 갖는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, w가 6인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, R₁ 및 R₂ 둘 모두가 H인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, R₁ 및 R₂ 둘 모두가 메틸인 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, 서열 번호 10-457로 이루어진 군으로부터 선택된 아미노산 서열과 80% 이상 동일한 아미노산 서열을 포함하고 MDM2 또는 MDMX에 결합하는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, 서열 번호 10-457로 이루어진 군으로부터 선택된 아미노산 서열과 90% 이상 동일한 아미노산 서열을 포함하고 MDM2 또는 MDMX에 결합하는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항에 있어서, 서열 번호 10-457로 이루어진 군으로부터 선택된 아미노산 서열과 95% 이상 동일한 아미노산 서열을 포함하고 MDM2 또는 MDMX에 결합하는 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염.
제1항의 펩티드모방체 마크로사이클 화합물 또는 그의 약학적으로 허용가능한 염, 및 약학적으로 허용가능한 담체를 포함하는, 피험체에서 암 치료를 위한 약학 조성물.
제40항에 있어서, 약학적으로 허용가능한 담체가 액체 담체인 약학 조성물.
제40항에 있어서, 암 치료가 피험체에서 p53 및/또는 MDM2 및/또는 MDMX의 활성을 조절하는 것을 포함하는 약학 조성물.
제40항에 있어서, 암 치료가 피험체에서 p53과 MDM2 단백질 사이 및/또는 p53과 MDMX 단백질 사이의 상호작용을 길항시키는 것을 포함하는 약학 조성물.
복분해 반응을 겪을 수 있는 2 이상의 모이어티를 포함하는 펩티드모방체 전구체를 복분해 촉매와 접촉시켜 제1항의 펩티드모방체 마크로사이클 화합물을 형성하는 단계를 포함하는, 제1항의 펩티드모방체 마크로사이클 화합물의 제조 방법.
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