ES2194437T3 - Procedimiento para producir microparticulas absorbibles. - Google Patents
Procedimiento para producir microparticulas absorbibles.Info
- Publication number
- ES2194437T3 ES2194437T3 ES99902793T ES99902793T ES2194437T3 ES 2194437 T3 ES2194437 T3 ES 2194437T3 ES 99902793 T ES99902793 T ES 99902793T ES 99902793 T ES99902793 T ES 99902793T ES 2194437 T3 ES2194437 T3 ES 2194437T3
- Authority
- ES
- Spain
- Prior art keywords
- peptide
- absorbable
- hormone
- polymer
- microparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un procedimiento para preparar una micropartícula o micropartículas unida(s) y confinada(s), en el que la micropartícula o las micropartículas unidas y confinadas comprenden micropartícula o micropartículas unidas y un polímero de confinamiento absorbible en el que: la micropartícula o micropartículas unidas comprenden un núcleo polímero heterocatenario absorbible y uno o más péptidos, una o más proteínas o una de sus combinaciones, inmovilizados sobre dicho núcleo polímero heterocatenario absorbible en el que cada péptido se selecciona independientemente del péptido liberador de la hormona del crecimiento (GHRP), hormona liberadora de la hormona luteinizante (LHRH), somatostatina, bombesina, péptido liberador de gastrina (GRP), calcitonina, bradiquinina, galamina, hormona estimuladora de melanocitos (MSH), factor de liberación de la hormona del crecimiento (GRF), amilina, taquiquininas, secretina, hormona de paratiroides (PTH), encefalina, endotelina, péptido liberador del gen de calcitonina (CGRP), neuromedinas, proteína relacionada con la hormona de paratiroides (PTHrP), glucagón, neurotensina, hormona adrenocorticotrófica (ACTH), péptido YY (PYY), péptido liberador de glucagón (GLP), péptido intestinal vasoactivo (VIP), péptido activador de adenilato-ciclasa de la glándula pituitaria (PACAP), motilina, sustancia P, neuropéptido Y (NPY), TSH y sus análogos y fragmentos o una de sus sales farmacéuticamente aceptables; y en el que cada proteína se selecciona independientemente de hormona del crecimiento, eritropoyetina, factor estimulador de colonias de granulocitos, factor estimulador de colonias de macrógafos-granulocitos e interferones; dicho procedimiento que comprende las etapas de: obtener una dispersión, en el que la dispersión comprende micropartículas unidas sólidas en una solución del polímero de confinamiento absorbible, por homogeneización y simultáneamente por dispersión de dichas micropartículas unidas sólidas en la solución de un polímero de confinamiento absorbible; y nebulizar dicha dispersión a través de una sonda de nebulización, en el que dicha sonda tiene un intervalo operativo de frecuencia ultrasónica de 12 kHz a 36 kHz, en un medio, en el que el medio es un no disolvente de dicho polímero de confinamiento absorbible, a un caudal de aproximadamente 1 ml/minuto a 15 ml/min.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE980054 | 1998-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194437T3 true ES2194437T3 (es) | 2003-11-16 |
Family
ID=11041696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99902793T Expired - Lifetime ES2194437T3 (es) | 1998-01-29 | 1999-01-25 | Procedimiento para producir microparticulas absorbibles. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6555156B1 (es) |
EP (1) | EP1051194B9 (es) |
JP (1) | JP2002501907A (es) |
CN (1) | CN1289255A (es) |
AR (1) | AR014069A1 (es) |
AT (1) | ATE240121T1 (es) |
AU (1) | AU740493B2 (es) |
CA (1) | CA2318513A1 (es) |
DE (1) | DE69907870T2 (es) |
DK (1) | DK1051194T3 (es) |
ES (1) | ES2194437T3 (es) |
HU (1) | HUP0102373A2 (es) |
IL (1) | IL137349A0 (es) |
NO (1) | NO20003804L (es) |
PL (1) | PL342135A1 (es) |
PT (1) | PT1051194E (es) |
WO (1) | WO1999038535A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413539B1 (en) * | 1996-10-31 | 2002-07-02 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
IES990700A2 (en) | 1999-08-18 | 2001-08-22 | Kinerton Ltd | Process to make a sustained release formulation |
US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US7186692B2 (en) | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
EP1581245A2 (en) | 2002-12-17 | 2005-10-05 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity |
US7229966B2 (en) | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
JP2007517911A (ja) * | 2004-01-13 | 2007-07-05 | バソジェニックス ファーマシューティカルズ, インコーポレイテッド | 心臓血管の適応症および腎臓の適応症に対してcgrpを使用する方法 |
US7976847B2 (en) * | 2004-01-13 | 2011-07-12 | Vasogenix Pharmaceuticals, Inc. | Controlled release CGRP delivery composition for cardiovascular and renal indications |
TW200538148A (en) * | 2004-01-13 | 2005-12-01 | Vasogenix Pharmaceuticals Inc | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
US7578951B2 (en) * | 2004-01-27 | 2009-08-25 | Hewlett-Packard Development Company, L.P. | Method of making microcapsules utilizing a fluid ejector |
US20060084628A1 (en) | 2004-10-19 | 2006-04-20 | Achillion Pharmaceuticals | Combination therapy for treating viral infections |
FR2880272A1 (fr) * | 2005-01-04 | 2006-07-07 | Jean Marc Ruiz | Preparation contenant des microparticules d'un sel de polymere insoluble portant un principe actif, ainsi que son procede de fabrication |
JP5649825B2 (ja) | 2007-01-31 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 安定化させたp53ペプチドおよびその使用法 |
KR101525754B1 (ko) | 2007-03-28 | 2015-06-09 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
WO2010009291A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
US8968787B2 (en) * | 2010-05-24 | 2015-03-03 | Micro Powders, Inc. | Composition comprising biodegradable polymers for use in a cosmetic composition |
CN108570097A (zh) | 2010-08-13 | 2018-09-25 | 爱勒让治疗公司 | 拟肽大环化合物 |
DE102011114864A1 (de) | 2011-10-05 | 2013-04-11 | Acino Ag | Verfahren zur Herstellung einer homogenen Pulvermischung und Verfahren zur Herstellung eines Implantats sowie Implantat |
MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
EP2914256B1 (en) | 2012-11-01 | 2019-07-31 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
JP2017533889A (ja) | 2014-09-24 | 2017-11-16 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
EP3294318A4 (en) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF |
JP2018532785A (ja) | 2015-11-06 | 2018-11-08 | フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー.ファオ. | 生体適合性かつ生分解性のポリマー、ナノ担体および薬物を含む組成物ならびにその作製および使用方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US5385738A (en) | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
JPH0778017B2 (ja) | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | パルス的かつ持続放出性製剤 |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5077049A (en) | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
EP0565618A4 (en) * | 1991-01-03 | 1994-06-29 | Alkermes Inc | Stabilization of proteins by cationic biopolymers |
US5366756A (en) | 1992-06-15 | 1994-11-22 | United States Surgical Corporation | Method for treating bioabsorbable implant material |
US5672659A (en) | 1993-01-06 | 1997-09-30 | Kinerton Limited | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
EP0712421A1 (en) * | 1993-07-23 | 1996-05-22 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
US5612052A (en) | 1995-04-13 | 1997-03-18 | Poly-Med, Inc. | Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof |
US5665702A (en) | 1995-06-06 | 1997-09-09 | Biomeasure Incorporated | Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
US6270700B1 (en) * | 1998-07-23 | 2001-08-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Encapsulation of water soluble peptides |
-
1999
- 1999-01-25 HU HU0102373A patent/HUP0102373A2/hu unknown
- 1999-01-25 WO PCT/IE1999/000007 patent/WO1999038535A1/en active IP Right Grant
- 1999-01-25 AR ARP990100287A patent/AR014069A1/es unknown
- 1999-01-25 EP EP99902793A patent/EP1051194B9/en not_active Expired - Lifetime
- 1999-01-25 JP JP2000529267A patent/JP2002501907A/ja active Pending
- 1999-01-25 AU AU22966/99A patent/AU740493B2/en not_active Ceased
- 1999-01-25 PL PL99342135A patent/PL342135A1/xx unknown
- 1999-01-25 AT AT99902793T patent/ATE240121T1/de not_active IP Right Cessation
- 1999-01-25 CN CN99802448A patent/CN1289255A/zh active Pending
- 1999-01-25 ES ES99902793T patent/ES2194437T3/es not_active Expired - Lifetime
- 1999-01-25 DE DE69907870T patent/DE69907870T2/de not_active Expired - Lifetime
- 1999-01-25 IL IL13734999A patent/IL137349A0/xx unknown
- 1999-01-25 CA CA002318513A patent/CA2318513A1/en not_active Abandoned
- 1999-01-25 DK DK99902793T patent/DK1051194T3/da active
- 1999-01-25 PT PT99902793T patent/PT1051194E/pt unknown
- 1999-01-25 US US09/601,074 patent/US6555156B1/en not_active Expired - Fee Related
-
2000
- 2000-07-25 NO NO20003804A patent/NO20003804L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL342135A1 (en) | 2001-05-21 |
DE69907870T2 (de) | 2004-03-04 |
HUP0102373A2 (hu) | 2001-10-28 |
PT1051194E (pt) | 2003-09-30 |
NO20003804D0 (no) | 2000-07-25 |
EP1051194A1 (en) | 2000-11-15 |
EP1051194B1 (en) | 2003-05-14 |
AU740493B2 (en) | 2001-11-08 |
JP2002501907A (ja) | 2002-01-22 |
EP1051194B9 (en) | 2003-11-05 |
WO1999038535A1 (en) | 1999-08-05 |
AU2296699A (en) | 1999-08-16 |
CA2318513A1 (en) | 1999-08-05 |
IL137349A0 (en) | 2001-07-24 |
NO20003804L (no) | 2000-09-20 |
DE69907870D1 (de) | 2003-06-18 |
AR014069A1 (es) | 2001-01-31 |
US6555156B1 (en) | 2003-04-29 |
CN1289255A (zh) | 2001-03-28 |
ATE240121T1 (de) | 2003-05-15 |
DK1051194T3 (da) | 2003-09-01 |
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