AR052884A1 - Formulaciones peptidicas terapeuticas con estbilidad mejorada - Google Patents
Formulaciones peptidicas terapeuticas con estbilidad mejoradaInfo
- Publication number
- AR052884A1 AR052884A1 ARP060100220A ARP060100220A AR052884A1 AR 052884 A1 AR052884 A1 AR 052884A1 AR P060100220 A ARP060100220 A AR P060100220A AR P060100220 A ARP060100220 A AR P060100220A AR 052884 A1 AR052884 A1 AR 052884A1
- Authority
- AR
- Argentina
- Prior art keywords
- administration
- factor
- peptide
- therapeutic agents
- peptides
- Prior art date
Links
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
- 229960005202 streptokinase Drugs 0.000 abstract 1
- 229960004231 thymalfasin Drugs 0.000 abstract 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
- 229960003726 vasopressin Drugs 0.000 abstract 1
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Abstract
Composiciones y métodos para la formulacion y administracion de formulaciones de agentes terapéuticos de péptidos, polipéptidos y proteínas que tienen estabilidad física mejorada, y en donde la formacion de fibrillas se minimiza y/o controla, para dar una viscosidad de la composicion uniforme y predecible. Las composiciones y métodos para la formacion y administracion de agentes terapéuticos de péptidos, polipéptidos y proteínas de la presente además facilita su incorporacion en un recubrimiento biocompatible el cual puede emplearse para recubrir una microproyeccion de perforacion del estrato corneo, o una pluralidad de microproyecciones de perforacion del estrato corneo de un dispositivo de administracion, para la administracion de un recubrimiento biocompatible a través de la piel de un sujeto, suministrado de este modo un medio eficaz para la administracion de agentes terapéuticos peptídicos. Reivindicacion 4: Una composicion de la reivindicacion 1, en la cual dicho agente peptídico se selecciona del grupo integrado por la hormona de liberacion de la hormona del crecimiento (GHRH), factor de liberacion de la hormona del crecimiento (GHRF), insulina, insulinotropina, calcitonina, octreotida, endorfina, factores del crecimiento tal como el factor de liberacion del factor de crecimiento (GFRF), bMSH, factor de liberacion del factor de crecimiento derivado de plaquetas, hormonas pituitarias (hGH), ANF, ACTH, amilina angiotensina, angiogenina, péptidos anti-inflamatorios, BNP, endotelina, GLIP, hirudina, neuropéptido Y, PTH, VIP, somatostatina, gonadotropina, corionica humana, eritropoyetina, glucagon, hirulog, interferon alfa, interferon beta, interferon gamma, interleuquinas, factor de estimulacion de la colonina de macrofagos granulocíticos (GM-CSF), factor de estimulacion de la colonia granulocítica (G-CSF), menotropinas (urofolipropina (FSH) y (LH)), estreptoquinasa, activador del plasminogeno tisular, uroquinasa, ANF, ANP, inhibidores de depuracion de ANP agonistas de la hormona antidiurética, péptido relacionado con el gen de calcitonina (CGRP), IGF-1, pentigétido, proteína C, proteína S, timosin alfa-1, alfa-NSH, VEGF, PYY y análogos peptídicos y derivados de un agente peptídico en el grupo.
Applications Claiming Priority (1)
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| US64599605P | 2005-01-21 | 2005-01-21 |
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| EP (1) | EP1838290A2 (es) |
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| AR (1) | AR052884A1 (es) |
| AU (1) | AU2006206272A1 (es) |
| CA (1) | CA2593112A1 (es) |
| TW (1) | TW200637615A (es) |
| WO (1) | WO2006079019A2 (es) |
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| MXPA03003815A (es) * | 2000-10-26 | 2004-08-12 | Johnson & Johnson | Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos. |
| AU2002365162A1 (en) * | 2001-11-14 | 2003-07-09 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
| WO2003070749A2 (en) * | 2002-02-15 | 2003-08-28 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
| US7554021B2 (en) * | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
| US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
| JP5456234B2 (ja) * | 2003-06-30 | 2014-03-26 | アルザ・コーポレーシヨン | 非揮発性の対イオンを含有する被覆された微小突起のための製剤 |
| BRPI0413276B8 (pt) | 2003-08-05 | 2021-05-25 | Novo Nordisk As | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
| ES2377647T3 (es) | 2003-10-31 | 2012-03-29 | Alza Corporation | Aplicador auto-actuado para ordenamiento de microproyecciones |
| CN100548228C (zh) * | 2003-11-13 | 2009-10-14 | 阿尔扎公司 | 用于透皮递送的组合物和装置 |
| US7544661B2 (en) | 2003-12-05 | 2009-06-09 | Northwestern University | Self-assembling peptide amphiphiles and related methods for growth factor delivery |
| EP1838846A4 (en) * | 2005-01-21 | 2008-12-10 | Univ Northwestern | METHODS AND COMPOSITIONS FOR ENCAPSULATING CELLS |
| WO2006096614A2 (en) * | 2005-03-04 | 2006-09-14 | Northwestern University | Angiogenic heparin binding peptide amphiphiles |
| EP1924364A1 (en) * | 2005-09-12 | 2008-05-28 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
| US8632801B2 (en) * | 2005-12-28 | 2014-01-21 | Alza Corporation | Stable therapeutic formulations |
| ES2371361T3 (es) | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones. |
| US20080039775A1 (en) * | 2006-03-15 | 2008-02-14 | Alza Corporation | Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia |
| WO2007127811A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with grouped microprojections for high drug loading |
| WO2007127815A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
| EP2142207A4 (en) * | 2007-04-04 | 2013-01-16 | Theratechnologies Inc | PHARMACEUTICAL FORMULATIONS OF GHRH MOLECULES |
| US8076295B2 (en) * | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
| EP2167032B1 (en) | 2007-06-13 | 2019-08-07 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| BRPI0919946A2 (pt) | 2008-10-30 | 2016-02-16 | Novo Nordisk As | tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente |
| MX2011010780A (es) * | 2009-04-13 | 2011-10-28 | Univ Northwestern | Andamios novedosos basados en peptido para la regeneracion de cartilagos y metodos para su uso. |
| RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
| CA2843586A1 (fr) | 2011-08-10 | 2013-02-14 | Adocia | Solution injectable d'au moins une insuline basale |
| KR102143435B1 (ko) * | 2011-11-30 | 2020-08-11 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치 및 이의 제조 및 사용 방법 |
| US9198971B2 (en) * | 2012-01-09 | 2015-12-01 | Adocia | Injectable solution at pH 7 comprising at least one basal insulin the pI of which is between 5.8 and 8.5 and a substituted co-polyamino acid |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| KR101866005B1 (ko) | 2013-02-13 | 2018-06-08 | 히사미쓰 세이야꾸 가부시키가이샤 | 마이크로 니들 코팅용 조성물 및 마이크로 니들 디바이스 |
| CA2900920C (en) | 2013-02-13 | 2018-08-21 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle coating composition and microneedle device |
| WO2014151725A1 (en) * | 2013-03-14 | 2014-09-25 | Allergan, Inc. | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
| US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
| CN103932749A (zh) * | 2014-02-26 | 2014-07-23 | 李扬德 | 一种医用可降解镁合金多用吻合片 |
| US10537723B2 (en) | 2014-09-11 | 2020-01-21 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle device |
| WO2016067956A1 (ja) | 2014-10-27 | 2016-05-06 | 久光製薬株式会社 | 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス |
| MX2017013802A (es) | 2015-04-29 | 2018-08-15 | Radius Pharmaceuticals Inc | Métodos para tratar el cáncer. |
| LT3463280T (lt) * | 2016-05-31 | 2022-09-26 | Spexis Ag | Beta plaukų segtuko struktūros peptido mimetikas, pasižymintis elastazės slopiklio aktyvumu ir jo aerozolinės vaisto formos |
| MX2019007748A (es) | 2017-01-05 | 2019-09-09 | Radius Pharmaceuticals Inc | Formas polimorficas de rad1901-2hcl. |
| KR101927654B1 (ko) | 2018-03-09 | 2018-12-10 | 김정숙 | 마이크로 니들의 코팅 방법 및 코팅이 적용된 마이크로 니들 조립체 |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| CN111840660B (zh) * | 2020-07-30 | 2021-12-14 | 齐鲁工业大学 | 一种亲水性多肽单层膜及制备方法与应用 |
Family Cites Families (13)
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| US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
| US5571788A (en) * | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
| US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| CA2275890C (en) * | 1996-12-24 | 2011-11-01 | Biogen, Inc. | Stable liquid interferon formulations |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| HU227347B1 (en) * | 1999-10-04 | 2011-04-28 | Novartis Vaccines & Diagnostic | Stabilized liquid polypeptide-containing pharmaceutical compositions |
| AU2001220765A1 (en) * | 2000-01-24 | 2001-07-31 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
| ES2253375T3 (es) * | 2000-04-19 | 2006-06-01 | Genentech, Inc. | Formulaciones de liberacion sostenida. |
| MXPA03003815A (es) * | 2000-10-26 | 2004-08-12 | Johnson & Johnson | Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos. |
| EA008038B1 (ru) * | 2003-01-08 | 2007-02-27 | Чирон Корпорейшн | Стабилизированные водные композиции, содержащие ингибитор пути метаболизма, тканевого фактора (tfpi) или вариант ингибитора пути метаболизма тканевого фактора |
| JP5456234B2 (ja) * | 2003-06-30 | 2014-03-26 | アルザ・コーポレーシヨン | 非揮発性の対イオンを含有する被覆された微小突起のための製剤 |
| KR20060029162A (ko) * | 2003-06-30 | 2006-04-04 | 알자 코포레이션 | 피부 피어싱 미세돌출부를 코팅하는 방법 |
| US20060093658A1 (en) * | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
-
2006
- 2006-01-19 AU AU2006206272A patent/AU2006206272A1/en not_active Abandoned
- 2006-01-19 CN CNA2006800028458A patent/CN101106979A/zh active Pending
- 2006-01-19 JP JP2007552334A patent/JP2008528509A/ja active Pending
- 2006-01-19 CA CA002593112A patent/CA2593112A1/en not_active Abandoned
- 2006-01-19 US US11/336,134 patent/US20060188555A1/en not_active Abandoned
- 2006-01-19 EP EP06719212A patent/EP1838290A2/en not_active Withdrawn
- 2006-01-19 WO PCT/US2006/002262 patent/WO2006079019A2/en active Application Filing
- 2006-01-20 AR ARP060100220A patent/AR052884A1/es not_active Application Discontinuation
- 2006-01-20 TW TW095102136A patent/TW200637615A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200637615A (en) | 2006-11-01 |
| CA2593112A1 (en) | 2006-07-27 |
| EP1838290A2 (en) | 2007-10-03 |
| WO2006079019A2 (en) | 2006-07-27 |
| AU2006206272A1 (en) | 2006-07-27 |
| WO2006079019A3 (en) | 2006-12-21 |
| CN101106979A (zh) | 2008-01-16 |
| JP2008528509A (ja) | 2008-07-31 |
| US20060188555A1 (en) | 2006-08-24 |
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| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |