SG11202013177WA - Polymorphic forms of rad 1901-2hcl - Google Patents

Polymorphic forms of rad 1901-2hcl

Info

Publication number
SG11202013177WA
SG11202013177WA SG11202013177WA SG11202013177WA SG11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA SG 11202013177W A SG11202013177W A SG 11202013177WA
Authority
SG
Singapore
Prior art keywords
2hcl
rad
polymorphic forms
polymorphic
forms
Prior art date
Application number
SG11202013177WA
Inventor
Michael Cruskie
Joshua Bolger
Jonathan Mckenzie
Pratik Sheth
Richard Edwards
Alex Eberlin
Michael Markey
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of SG11202013177WA publication Critical patent/SG11202013177WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
SG11202013177WA 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl SG11202013177WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862694003P 2018-07-04 2018-07-04
PCT/US2019/040527 WO2020010216A1 (en) 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl

Publications (1)

Publication Number Publication Date
SG11202013177WA true SG11202013177WA (en) 2021-01-28

Family

ID=67470668

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202013177WA SG11202013177WA (en) 2018-07-04 2019-07-03 Polymorphic forms of rad 1901-2hcl

Country Status (11)

Country Link
US (1) US11643385B2 (en)
EP (1) EP3817821A1 (en)
JP (1) JP7473486B2 (en)
KR (1) KR102792490B1 (en)
CN (1) CN112423844B (en)
AU (1) AU2019297421B2 (en)
CA (1) CA3104395A1 (en)
IL (1) IL279853B2 (en)
MX (1) MX2020013713A (en)
SG (1) SG11202013177WA (en)
WO (1) WO2020010216A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12021551319A1 (en) * 2018-12-06 2022-05-16 Radius Pharmaceuticals Inc Methods for treating cancer resistant to cdk4/6 inhibitors
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
CN119343330A (en) * 2022-05-25 2025-01-21 苏州科睿思制药有限公司 Crystal form of elastomeric dihydrochloride, preparation method and use thereof
WO2024104268A1 (en) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 Co-crystal of elacestrant dihydrochloride, preparation method therefor, and use thereof
EP4574811A1 (en) 2023-12-22 2025-06-25 Sandoz Ag Crystalline forms of elacestrant dihydrochloride

Family Cites Families (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102671A (en) 1975-07-29 1978-07-25 Shell Oil Company Control of weeds with N-substituted alanine compounds
DE3939346A1 (en) 1989-11-29 1991-06-06 Behringwerke Ag MEDICINES FOR SUBCUTANEOUS OR INTRAMUSCULAR APPLICATION CONTAINING POLYPEPTIDES
US5411981A (en) 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5821225A (en) 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5977070A (en) 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
DE19517430A1 (en) 1995-05-12 1996-11-14 Boehringer Mannheim Gmbh Pharmaceutical dosage form of parathyroid hormone with a two to six hour drug release period
IT1285405B1 (en) 1995-06-06 1998-06-03 Alza Corp MODIFICATION OF POLYPEPTIDE DRUGS TO INCREASE FLOW BY ELECTROTRANSPORT.
UA51652C2 (en) 1995-06-08 2002-12-16 Новартіс Аг A method of hydrogenation of imines
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5723577A (en) 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US5955574A (en) 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
DE19538687A1 (en) 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stable pharmaceutical dosage forms containing parathyroid hormone
DE19539574A1 (en) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Preparations and processes for stabilizing biological materials by means of drying processes without freezing
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
US6017924A (en) 1996-06-27 2000-01-25 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
EP0951551B9 (en) 1996-12-23 2012-12-26 Immunex Corporation Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
JP2002509854A (en) 1997-09-09 2002-04-02 エフ．ホフマン−ラ ロシュ アーゲー Fracture healing using PTHrP analogs
FR2770842B1 (en) 1997-11-13 1999-12-17 Oreal NOVEL COMPOUNDS DERIVED FROM N-ARYL 2-HYDROXY ALKYLAMIDES
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
DE69806963T2 (en) 1997-12-11 2002-11-21 Alza Corp., Mountain View DEVICE FOR INCREASING THE TRANSDERMAL ACTIVE SUBSTANCE FLOW
CN1170603C (en) 1997-12-11 2004-10-13 阿尔扎有限公司 Device for enhancing transdermal agent flux
EP0922467A3 (en) 1997-12-12 2000-05-24 Takeda Chemical Industries, Ltd. Iontophoretic drug delivery
JP4154017B2 (en) 1997-12-30 2008-09-24 久光製薬株式会社 Iontophoresis device and drug unit
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
SE9801495D0 (en) 1998-04-28 1998-04-28 Astra Ab Protein formulation
US6316410B1 (en) 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU1280701A (en) 1999-11-17 2001-05-30 Novartis Ag Iontophoretic transdermal delivery of peptides
US6544553B1 (en) 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
GB9930882D0 (en) 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
WO2001051919A2 (en) * 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
US20010044431A1 (en) 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
NZ524423A (en) 2000-08-03 2004-04-30 Antares Pharma Ipl Ag A composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
KR20030027052A (en) 2000-08-23 2003-04-03 악조 노벨 엔.브이. 10-ARYL-11H-BENZO[b]FLUORENE DERIVATIVES AND ANALOGS FOR MEDICINAL USE
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
US7186683B2 (en) 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
CA2427381A1 (en) 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
WO2002085447A2 (en) 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
TR201809008T4 (en) 2001-06-26 2018-07-23 Amgen Fremont Inc Antibodies against opgl.
WO2003011824A1 (en) 2001-07-31 2003-02-13 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
EP1465535B1 (en) 2001-12-20 2007-11-28 ALZA Corporation Skin-piercing microprojections having piercing depth control
JP2005524630A (en) 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー／エス Inhibition of cartilage destruction via estrogen receptor
WO2003068805A2 (en) 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
CA2474171A1 (en) 2002-02-15 2003-08-21 Endorecherche, Inc. Biphenil derivatives and their use as antiandrogenic agents
DE60334202D1 (en) 2002-04-24 2010-10-28 Merck Sharp & Dohme MODULATORS OF THE ESTROGEN RECEPTOR
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
EP1513547A4 (en) 2002-05-23 2009-11-04 Michael F Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
TW200307553A (en) 2002-05-24 2003-12-16 Akzo Nobel Nv Treatment of post-menopausal complaints in breast cancer patients
AU2003251527A1 (en) 2002-06-13 2003-12-31 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
WO2004007520A2 (en) 2002-07-12 2004-01-22 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
AU2003251831B2 (en) 2002-07-19 2009-06-11 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
WO2004035624A2 (en) 2002-10-14 2004-04-29 Novo Nordisk A/S Glucagon - like peptide - 2 variants
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7622592B2 (en) 2002-11-01 2009-11-24 Merck & Co., Inc. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
EP1567178A4 (en) 2002-11-01 2009-07-15 Amgen Inc Modulators of receptors for parathyrois hormone and parathyroid hormone-related protein
US7795280B2 (en) 2002-11-07 2010-09-14 N.V. Organon Indoles useful in the treatment of androgen-receptor related diseases
WO2004045518A2 (en) 2002-11-15 2004-06-03 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
JP4500689B2 (en) 2002-12-26 2010-07-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 Selective estrogen receptor modulator
WO2004080377A2 (en) 2003-03-11 2004-09-23 Neurosearch A/S Kcnq channel modulating compounds and their pharmaceutical use
JP2007500245A (en) 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション Compound
JP2007505164A (en) 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション 1-aminonaphthalenes as modulators of androgens, glucocorticoids, mineralocorticoids and progesterone receptors
FI20030958A0 (en) 2003-06-27 2003-06-27 Orion Corp New compounds
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
PL1638468T3 (en) 2003-06-30 2008-01-31 Alza Corp Method for coating skin piercing microprojections
CN1842320B (en) 2003-06-30 2013-06-19 阿尔扎公司 Formulations for coated microprojections containing non-volatile counterions
CN1816324A (en) 2003-07-04 2006-08-09 尼克麦德丹麦公司 Parathyroid hormone (pth) containing pharmaceutical compositions for oral use
US20050032698A1 (en) 2003-07-14 2005-02-10 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
US7141544B2 (en) 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
GB0324551D0 (en) 2003-10-21 2003-11-26 Karobio Ab Novel compounds
WO2005044985A2 (en) 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
CA2543641A1 (en) 2003-10-31 2005-05-19 Alza Corporation Self-actuating applicator for microprojection array
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
BRPI0416042A (en) 2003-11-13 2007-01-02 Alza Corp composition and apparatus for transdermal delivery
WO2005049574A1 (en) 2003-11-20 2005-06-02 Warner-Lambert Company Llc Androgen receptor modulators
WO2005051455A2 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
IL159273A0 (en) 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
WO2005060956A1 (en) 2003-12-12 2005-07-07 University Of Maryland, Baltimore IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
CN1930181A (en) 2004-01-07 2007-03-14 恩多研究公司 Helix 12 directed pharmaceutical products
SG149867A1 (en) 2004-01-22 2009-02-27 Lilly Co Eli Selective estrogen receptor modulators for the treatment of vasomotor symptoms
IL160033A0 (en) 2004-01-25 2004-06-20 Transpharma Medical Ltd Transdermal delivery system for polynucleotides
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
TWI359026B (en) 2004-02-12 2012-03-01 Sankyo Co Pharmaceutical composition for the osteoclast rela
US7514470B2 (en) 2004-03-03 2009-04-07 Smithkline Beecham Corporation Aniline derivatives as selective androgen receptor modulators
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7388027B2 (en) 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
GB0405033D0 (en) 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
JP4402992B2 (en) 2004-03-18 2010-01-20 株式会社日立製作所 Backup system, method and program
CA2562132A1 (en) 2004-04-08 2005-10-27 Merck & Co., Inc. 17 beta-acetamide-4-azasteroids as androgen receptor modulators
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
EP1753749B1 (en) 2004-05-03 2014-07-30 Janssen Pharmaceutica NV Novel indole derivatives as selective androgen receptor modulators (sarms)
MXPA06012980A (en) 2004-05-10 2007-06-12 Nastech Pharm Co Compositions and methods for enhanced mucosal delivery of parathyroid hormone.
MXPA06013115A (en) 2004-05-11 2007-02-28 Pfizer Prod Inc Benzonitrile derivatives to treat musculoskeletal frailty.
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7906137B2 (en) 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
US20090069226A1 (en) 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
ATE514700T1 (en) 2004-09-20 2011-07-15 Janssen Pharmaceutica Nv NEW TETRACYCLIC HETEROATOME WITH DERIVATIVES SUITABLE AS SEXUAL STEROID HORMONE RECEPTOR MODULATORS
WO2006039243A1 (en) 2004-09-30 2006-04-13 Janssen Pharmaceutica N.V. Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
US8143425B2 (en) 2004-10-12 2012-03-27 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
EP1809275A1 (en) 2004-10-13 2007-07-25 Smithkline Beecham Corporation Chemical compounds
CA2585276A1 (en) 2004-10-29 2006-06-08 Merck & Co., Inc. N-(pyridin-3-yl)-2-phenylbutanamides as androgen receptor modulators
WO2006055184A2 (en) 2004-11-16 2006-05-26 Janssen Pharmaceutica N.V. Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms)
JP4927751B2 (en) 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー Microneedle array coating method
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP2008520331A (en) 2004-11-18 2008-06-19 トランスファーマ メディカル リミテッド Combined microchannel formation and iontophoresis for transdermal delivery of drugs
ZA200705458B (en) 2005-01-10 2008-12-31 Acadia Pharm Inc Aminophenyl derivatives as selective androgen receptor modulators
JP2008528509A (en) 2005-01-21 2008-07-31 アルザ コーポレイション Therapeutic peptide formulation for coating microneedles with improved stability comprising at least one counter ion
EP1871379A4 (en) 2005-04-15 2010-06-02 Glaxosmithkline Llc Cyanoarylamines
CN101175747B (en) 2005-05-13 2011-06-22 伊莱利利公司 Substituted N-arylpyrrolidines as selective androgen receptor modulators
KR100700869B1 (en) 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Stable PTH Compositions Including PTH, Buffers, and Stabilizers
WO2006133216A2 (en) 2005-06-06 2006-12-14 Smithkline Beecham Corporation 4-substituted arylamine derivatives and their use in pharmaceutical compositions
US7829589B2 (en) 2005-06-10 2010-11-09 Elixir Pharmaceuticals, Inc. Sulfonamide compounds and uses thereof
CN101203491A (en) 2005-06-24 2008-06-18 伊莱利利公司 Tetrahydrocarbazole derivatives used as androgen receptor modifier
WO2007005887A2 (en) 2005-07-01 2007-01-11 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds, compositions and uses thereof
US20070021216A1 (en) 2005-07-19 2007-01-25 Sony Ericsson Mobile Communications Ab Seamless gaming method and apparatus
WO2007015567A1 (en) 2005-08-01 2007-02-08 Takeda Pharmaceutical Company Limited Cyclic amine compound
JP2008303145A (en) 2005-09-22 2008-12-18 Takeda Chem Ind Ltd Cardiotonic comprising grk inhibitor
TW200730505A (en) 2005-12-07 2007-08-16 Merck & Co Inc Polymorphs of an androgen receptor modulator
AU2006336187A1 (en) 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
RS52756B (en) 2006-01-24 2013-08-30 Janssen Pharmaceutica N.V. 2-substituierte benzimidazole als selektive androgenrezeptomodulatoren (sarms)
RU2435756C2 (en) 2006-03-03 2011-12-10 Орион Корпорейшн Selective androgen receptor modulators
AU2007225056A1 (en) 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
WO2007124409A2 (en) 2006-04-20 2007-11-01 Velocys, Inc. Process for treating and/or forming a non-newtonian fluid using microchannel process technology
BRPI0710814A2 (en) 2006-04-20 2011-08-16 Amgen Inc stable emulsion formulations
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
ES2436028T3 (en) 2006-06-23 2013-12-26 Radius Health, Inc. Treatment of vasomotor symptoms with selective estrogen receptor modulators
PT2038252T (en) 2006-07-12 2016-12-16 Univ Tennessee Res Found Substituted acylanilides and methods of use thereof
EP2040709A2 (en) 2006-07-19 2009-04-01 Osurf Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
KR101202240B1 (en) 2006-08-24 2012-11-16 유니버시티 오브 테네시 리서치 파운데이션 Substituted acylanilides and methods of use thereof
KR101419961B1 (en) 2006-08-25 2014-07-30 아레스 트레이딩 에스.에이. Treatment of Cartilage Disease with FGF-18
EP2079466B1 (en) 2006-09-29 2014-01-15 GlaxoSmithKline LLC Substituted indole compounds
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
ES2637283T3 (en) 2006-10-03 2017-10-11 Radius Health, Inc. A stable composition comprising PTHrP and uses thereof
WO2008044033A1 (en) 2006-10-11 2008-04-17 Astrazeneca Ab Amide derivatives
UA98777C2 (en) 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
EP2119469B1 (en) 2007-02-06 2014-05-14 Hisamitsu Pharmaceutical Co., Inc. Microneedle device for diagnosis of allergy
WO2008121602A1 (en) 2007-03-29 2008-10-09 Smithkline Beecham Corporation Chemical compounds
WO2008124000A2 (en) 2007-04-02 2008-10-16 Ligand Pharmaceuticals Incorporated Thiazole derivatives as androgen receptor modulator compounds
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
US7696227B2 (en) 2007-04-13 2010-04-13 Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
ES2817249T3 (en) 2007-04-16 2021-04-06 Corium Inc Microneedle matrices obtained by dissolution and casting containing an active principle
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
EP2171447A1 (en) 2007-06-12 2010-04-07 Schering Corporation Histone h2ax (hh2ax) biomarker for fti sensitivity
US8450481B2 (en) 2007-06-14 2013-05-28 The Regents Of The University Of California Compounds for inhibiting protein aggregation, and methods for making and using them
US20120150023A1 (en) 2007-08-06 2012-06-14 Kaspar Roger L Microneedle arrays for active agent delivery
EA017429B1 (en) 2007-08-07 2012-12-28 Такеда Фармасьютикал Компани Лимитед Cyclic amine compounds
EP2205169B1 (en) 2007-09-28 2016-11-16 The Queen's University of Belfast Delivery device and method
WO2009054988A1 (en) 2007-10-23 2009-04-30 Alza Corporation Transdermal sustained release drug delivery
EP2052736A1 (en) 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
WO2009065126A2 (en) 2007-11-16 2009-05-22 Boston Protein Solutions Excipients for protein stabilization
EP2222636B1 (en) 2007-12-21 2013-04-10 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (sarms) and uses thereof
US8067448B2 (en) 2008-02-22 2011-11-29 Radius Health, Inc. Selective androgen receptor modulators
WO2009133861A1 (en) 2008-04-28 2009-11-05 武田薬品工業株式会社 Cyclic amine compound
WO2009137104A1 (en) 2008-05-09 2009-11-12 Radius Health, Inc. Combination therapy for breastcancer comprising an antiestrogenic agent
WO2009140448A1 (en) 2008-05-16 2009-11-19 Eli Lilly And Company Tetrahydrocyclopenta[b]indole androgen receptor modulators
WO2010022176A1 (en) 2008-08-19 2010-02-25 Ferring International Center S.A. Methods of treatment for skeletal conditons
CA2738715C (en) 2008-10-15 2013-07-16 Intarcia Therapeutics, Inc. Highly concentrated drug particles, formulations, suspensions and uses thereof
WO2010052879A1 (en) 2008-11-04 2010-05-14 あすか製薬株式会社 Aqueous composition containing follicle-stimulating hormone
AU2009316789B2 (en) 2008-11-18 2013-09-19 Kindeva Drug Delivery L.P. Hollow microneedle array and method
KR101634836B1 (en) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 Microneedle device
US20100203014A1 (en) 2009-02-04 2010-08-12 Aegis Therapeutics Llc Zwitterionic buffered acidic peptide and protein formulations
US20100226966A1 (en) 2009-03-03 2010-09-09 Daddona Peter E Method for transdermal controlled release drug delivery
WO2010118287A1 (en) 2009-04-10 2010-10-14 Radius Health, Inc. Selective androgen receptor modulators
CA2759850C (en) 2009-04-24 2019-10-22 Corium International, Inc. Methods for manufacturing microprojection arrays
KR101712226B1 (en) 2009-07-31 2017-03-03 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Hollow microneedle arrays
WO2011051916A2 (en) 2009-11-02 2011-05-05 Universite De Geneve Stabilized protein formulations and use thereof
US20110172609A1 (en) 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
CN101912600B (en) 2010-01-11 2014-01-29 杨国汉 Method for improving stability of insulin in solution
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
IE20100174A1 (en) 2010-03-25 2012-02-29 Trinity College Dublin Transdermal administration of peptides
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
LT2568806T (en) 2010-05-12 2016-09-26 Radius Health, Inc. Therapeutic regimens
CA2800253C (en) 2010-05-28 2022-07-12 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
CA2800673A1 (en) 2010-06-10 2011-12-15 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
WO2012075375A1 (en) 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of parathyroid hormones by microinjection systems
AU2012223279A1 (en) 2011-03-01 2013-09-26 Sloan-Kettering Institute For Cancer Research Parathyroid hormone analogs, compositions and uses thereof
SG194570A1 (en) 2011-04-22 2013-12-30 Radius Health Inc Method of drug delivery for pth, pthrp and related peptides
EP2785406A4 (en) 2011-11-30 2015-10-21 3M Innovative Properties Co Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
GB201217439D0 (en) 2012-09-28 2012-11-14 Topotarget As Combination therapy
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
RU2745678C2 (en) * 2015-04-29 2021-03-30 Радиус Фармасьютикалз, Инк. Methods for treating cancer
HRP20240923T1 (en) 2017-01-05 2024-10-11 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl

Also Published As

Publication number Publication date
EP3817821A1 (en) 2021-05-12
CA3104395A1 (en) 2020-01-09
CN112423844A (en) 2021-02-26
IL279853A (en) 2021-03-01
AU2019297421A1 (en) 2021-01-28
US11643385B2 (en) 2023-05-09
CN112423844B (en) 2024-08-13
WO2020010216A1 (en) 2020-01-09
JP7473486B2 (en) 2024-04-23
US20210269389A1 (en) 2021-09-02
IL279853B2 (en) 2025-01-01
JP2021529783A (en) 2021-11-04
KR20210030393A (en) 2021-03-17
MX2020013713A (en) 2021-03-02
KR102792490B1 (en) 2025-04-04
IL279853B1 (en) 2024-09-01
AU2019297421B2 (en) 2024-08-29

Similar Documents

Publication Publication Date Title
IL282984A (en) Bicyclic compounds
IL279853A (en) Polymorphic forms of rad 1901-2hcl
IL267772B (en) Polymorphic forms of rad1901-2hcl
IL286218A (en) Solid state forms of ripretinib
IL272697A (en) Polymorphic form of tg02
GB201806072D0 (en) Methods of manufacture
IL281718A (en) Polymorphic compounds and uses thereof
IL276592A (en) Derivatives of sobetirome
IL269792B (en) Crystalline forms of (s)-afoxolaner
PL3532457T3 (en) Crystalline forms of hydroxynorketamine
GB201805904D0 (en) Methods of Manufacture
SG11202100267TA (en) Solid forms of an azolopyrimidine compound
IL276107A (en) Solid forms of fasoracetam
GB201703041D0 (en) Installation of mono-pile
SG11202105136WA (en) Application of chidamide
GB201912411D0 (en) Crystalline forms of ivosidenib
HK40050183A (en) Polymorphic forms of rad 1901-2hcl
EP3649126A4 (en) Polymorphic forms of dasatinib
IL263363A (en) Polymorph of nintedanib
HK40106713A (en) Polymorphic form of tg02
IL283421A (en) Solid state forms of reproxalap
HK40030306B (en) Polymorphic form of tg02
IL270937A (en) Crystalline forms of seletalisib
GB201915908D0 (en) Crystalline forms of entrectinib
ZA202101758B (en) Methods for sythesis of oxypicolinamides