TW200637615A - Therapeutic peptide formulations with improved stability - Google Patents
Therapeutic peptide formulations with improved stabilityInfo
- Publication number
- TW200637615A TW200637615A TW095102136A TW95102136A TW200637615A TW 200637615 A TW200637615 A TW 200637615A TW 095102136 A TW095102136 A TW 095102136A TW 95102136 A TW95102136 A TW 95102136A TW 200637615 A TW200637615 A TW 200637615A
- Authority
- TW
- Taiwan
- Prior art keywords
- delivering
- peptide
- improved stability
- formulating
- stratum
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000000434 stratum corneum Anatomy 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64599605P | 2005-01-21 | 2005-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200637615A true TW200637615A (en) | 2006-11-01 |
Family
ID=36692983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095102136A TW200637615A (en) | 2005-01-21 | 2006-01-20 | Therapeutic peptide formulations with improved stability |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060188555A1 (zh) |
EP (1) | EP1838290A2 (zh) |
JP (1) | JP2008528509A (zh) |
CN (1) | CN101106979A (zh) |
AR (1) | AR052884A1 (zh) |
AU (1) | AU2006206272A1 (zh) |
CA (1) | CA2593112A1 (zh) |
TW (1) | TW200637615A (zh) |
WO (1) | WO2006079019A2 (zh) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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AR008242A1 (es) * | 1996-06-18 | 1999-12-29 | Alza Corp | Dispositivo para atravesar el estrato corneo de una superficie corporal |
EP2085109A3 (en) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
US7491690B2 (en) * | 2001-11-14 | 2009-02-17 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
US7371719B2 (en) * | 2002-02-15 | 2008-05-13 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
US7554021B2 (en) * | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
EP1638523B8 (en) * | 2003-06-30 | 2013-12-25 | ALZA Corporation | Formulations for coated microprojections containing non-volatile counterions |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
EP2264065B1 (en) | 2003-08-05 | 2017-03-08 | Novo Nordisk A/S | Novel insulin derivatives |
CN100571643C (zh) | 2003-10-31 | 2009-12-23 | 阿尔扎公司 | 用于微凸起阵列的自驱动施加器 |
AU2004292954A1 (en) * | 2003-11-13 | 2005-06-09 | Alza Corporation | Composition and apparatus for transdermal delivery |
ATE541580T1 (de) | 2003-12-05 | 2012-02-15 | Univ Northwestern | Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor |
KR20070100948A (ko) * | 2005-01-21 | 2007-10-15 | 노오쓰웨스턴 유니버시티 | 세포의 캡슐화 방법 및 조성물 |
CA2598251A1 (en) * | 2005-03-04 | 2006-09-14 | Northwestern University | Angiogenic heparin binding peptide amphiphiles |
WO2007033015A1 (en) * | 2005-09-12 | 2007-03-22 | Alza Corporation | Coatable transdermal delivery microprojection assembly |
CN101389650B (zh) | 2005-12-28 | 2012-10-10 | 诺沃-诺迪斯克有限公司 | 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法 |
JP2009522288A (ja) * | 2005-12-28 | 2009-06-11 | アルザ コーポレイション | 安定な治療剤形 |
CA2680690A1 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
WO2007127815A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
WO2008122118A1 (en) * | 2007-04-04 | 2008-10-16 | Theratechnologies Inc. | Pharmaceutical formulations of ghrh molecules |
US8076295B2 (en) * | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
JP2012523463A (ja) * | 2009-04-13 | 2012-10-04 | ノースウエスタン ユニバーシティ | 軟骨再生のための新規なペプチドベースの足場およびその使用方法 |
RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
JP5950477B2 (ja) | 2011-08-10 | 2016-07-13 | アドシア | 少なくとも1種の基礎インスリンの注射溶液 |
CA2857502C (en) * | 2011-11-30 | 2019-08-13 | 3M Innovative Properties Company | Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same |
CN113730555A (zh) * | 2012-01-09 | 2021-12-03 | 阿道恰公司 | Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液 |
US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
JP6246784B2 (ja) | 2013-02-13 | 2017-12-13 | 久光製薬株式会社 | マイクロニードルコーティング用組成物及びマイクロニードルデバイス |
JP6175485B2 (ja) | 2013-02-13 | 2017-08-02 | 久光製薬株式会社 | マイクロニードルコーティング用組成物及びマイクロニードルデバイス |
JP6649246B2 (ja) * | 2013-03-14 | 2020-02-19 | アラーガン、インコーポレイテッドAllergan,Incorporated | タンパク質の徐放性送達の組成物及び製造プロセス中のタンパク質の安定化方法 |
EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
CN103932749A (zh) * | 2014-02-26 | 2014-07-23 | 李扬德 | 一种医用可降解镁合金多用吻合片 |
CN106687172B (zh) | 2014-09-11 | 2020-06-23 | 久光制药株式会社 | 微针装置 |
JP6621754B2 (ja) | 2014-10-27 | 2019-12-18 | 久光製薬株式会社 | 遺伝子組換型卵胞刺激ホルモンを含有するマイクロニードルデバイス |
IL310069A (en) | 2015-04-29 | 2024-03-01 | Radius Pharmaceuticals Inc | Cancer treatment methods |
HUE060119T2 (hu) * | 2016-05-31 | 2023-02-28 | Spexis Ag | Béta-hairpin peptidomimetikum elasztáz gátló hatással és annak aeroszolos adagolási formái |
WO2018129419A1 (en) | 2017-01-05 | 2018-07-12 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
KR101927654B1 (ko) | 2018-03-09 | 2018-12-10 | 김정숙 | 마이크로 니들의 코팅 방법 및 코팅이 적용된 마이크로 니들 조립체 |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
CN111840660B (zh) * | 2020-07-30 | 2021-12-14 | 齐鲁工业大学 | 一种亲水性多肽单层膜及制备方法与应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
US5571788A (en) * | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
KR20000069664A (ko) * | 1996-12-24 | 2000-11-25 | 아스트루 마이클 제이 | 안정한 액체 인터페론 제제 |
US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
PT1491208E (pt) * | 1999-10-04 | 2010-05-12 | Novartis Vaccines & Diagnostic | Composições farmacêuticas contendo polipéptido líquidas estabilizadas |
US6734162B2 (en) * | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
DK1274459T3 (da) * | 2000-04-19 | 2006-02-06 | Genentech Inc | Præparater med vedholdende frigivelse indeholdende væksthormon |
EP2085109A3 (en) * | 2000-10-26 | 2009-09-02 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
SI1599222T1 (sl) * | 2003-01-08 | 2009-08-31 | Novartis Vaccines & Diagnostic | Stabilizirani vodni sestavki, ki obsegajo inhibitor poti tkivnega faktorja (TFPI) ali varianto inhibitorja poti tkivnega faktorja |
EP1638523B8 (en) * | 2003-06-30 | 2013-12-25 | ALZA Corporation | Formulations for coated microprojections containing non-volatile counterions |
AU2004255228A1 (en) * | 2003-06-30 | 2005-01-20 | Alza Corporation | Method for coating skin piercing microprojections |
US20060093658A1 (en) * | 2004-10-26 | 2006-05-04 | Gayatri Sathyan | Apparatus and method for transdermal delivery of desmopressin |
-
2006
- 2006-01-19 JP JP2007552334A patent/JP2008528509A/ja active Pending
- 2006-01-19 CN CNA2006800028458A patent/CN101106979A/zh active Pending
- 2006-01-19 CA CA002593112A patent/CA2593112A1/en not_active Abandoned
- 2006-01-19 US US11/336,134 patent/US20060188555A1/en not_active Abandoned
- 2006-01-19 EP EP06719212A patent/EP1838290A2/en not_active Withdrawn
- 2006-01-19 AU AU2006206272A patent/AU2006206272A1/en not_active Abandoned
- 2006-01-19 WO PCT/US2006/002262 patent/WO2006079019A2/en active Application Filing
- 2006-01-20 TW TW095102136A patent/TW200637615A/zh unknown
- 2006-01-20 AR ARP060100220A patent/AR052884A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20060188555A1 (en) | 2006-08-24 |
JP2008528509A (ja) | 2008-07-31 |
AR052884A1 (es) | 2007-04-11 |
EP1838290A2 (en) | 2007-10-03 |
AU2006206272A1 (en) | 2006-07-27 |
CA2593112A1 (en) | 2006-07-27 |
CN101106979A (zh) | 2008-01-16 |
WO2006079019A2 (en) | 2006-07-27 |
WO2006079019A3 (en) | 2006-12-21 |
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