MX2018014631A - Formulacion de neurotoxina. - Google Patents
Formulacion de neurotoxina.Info
- Publication number
- MX2018014631A MX2018014631A MX2018014631A MX2018014631A MX2018014631A MX 2018014631 A MX2018014631 A MX 2018014631A MX 2018014631 A MX2018014631 A MX 2018014631A MX 2018014631 A MX2018014631 A MX 2018014631A MX 2018014631 A MX2018014631 A MX 2018014631A
- Authority
- MX
- Mexico
- Prior art keywords
- tryptophan
- tyrosine
- liquid
- amino acid
- formulation stabilized
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title abstract 3
- 101710138657 Neurotoxin Proteins 0.000 title abstract 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title abstract 3
- 239000002581 neurotoxin Substances 0.000 title abstract 3
- 231100000618 neurotoxin Toxicity 0.000 title abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Diabetes (AREA)
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- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
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- Medicinal Preparation (AREA)
Abstract
La invención se refiere a formulaciones de neurotoxinas líquidas estables que están libres de proteínas de origen animal, que comprenden un agente surfactante, un aminoácido seleccionado a partir de triptófano y tirosina, un amortiguador que comprende iones sodio, cloruro y fosfato, que tienen un pH entre 5.5 y 8, los cuales son estables durante 2 meses. Estas composiciones son adecuadas para su uso en terapia y en particular para su administración a un paciente para lograr así un efecto estético o terapéutico deseado. La invención también se relaciona al uso de un aminoácido seleccionado a partir de triptófano y tirosina para proteger una neurotoxina proteica de la degradación en una composición líquida que esté libre de proteínas derivadas de animales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2016062085 | 2016-05-27 | ||
| PCT/EP2017/062785 WO2017203038A1 (en) | 2016-05-27 | 2017-05-26 | Liquid neurotoxin formulation stabilized with tryptophan or tyrosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014631A true MX2018014631A (es) | 2019-06-12 |
Family
ID=56289455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014631A MX2018014631A (es) | 2016-05-27 | 2017-05-26 | Formulacion de neurotoxina. |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US20190183988A1 (es) |
| EP (3) | EP3463432B1 (es) |
| JP (1) | JP7053498B2 (es) |
| KR (2) | KR102423739B1 (es) |
| CN (2) | CN111701010B (es) |
| AR (1) | AR108631A1 (es) |
| AU (1) | AU2017270359B2 (es) |
| BR (1) | BR112018074311A2 (es) |
| CA (1) | CA3025437A1 (es) |
| CY (2) | CY1124237T1 (es) |
| DK (2) | DK3679946T3 (es) |
| EA (1) | EA038124B1 (es) |
| ES (2) | ES2911124T3 (es) |
| GE (1) | GEP20207139B (es) |
| HR (2) | HRP20220024T1 (es) |
| HU (2) | HUE057640T2 (es) |
| IL (2) | IL285190B (es) |
| LT (2) | LT3679946T (es) |
| MX (1) | MX2018014631A (es) |
| PL (2) | PL3679946T3 (es) |
| PT (2) | PT3463432T (es) |
| RS (2) | RS61340B1 (es) |
| RU (1) | RU2741497C9 (es) |
| SA (1) | SA518400513B1 (es) |
| SG (1) | SG11201810561YA (es) |
| SI (2) | SI3463432T1 (es) |
| TW (1) | TWI777955B (es) |
| UA (1) | UA123679C2 (es) |
| WO (1) | WO2017203038A1 (es) |
| ZA (1) | ZA201807904B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168206B1 (en) | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
| SG172812A1 (en) | 2008-12-31 | 2011-08-29 | Revance Therapeutics Inc | Injectable botulinum toxin formulations |
| KR102328155B1 (ko) | 2009-06-25 | 2021-11-17 | 레반스 테라퓨틱스, 아이엔씨. | 알부민불포함 보툴리눔 독소 제제 |
| US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
| CN112351992A (zh) * | 2017-12-20 | 2021-02-09 | 阿勒根公司 | 肉毒杆菌毒素细胞结合结构域多肽及其用于皮肤再生的方法 |
| UY38744A (es) * | 2019-06-07 | 2020-12-31 | Nestle Skin Health S A | Tratamiento de líneas glabelares y líneas cantales laterales de moderadas a muy graves |
| WO2023135428A1 (en) * | 2022-01-14 | 2023-07-20 | Galderma Holding SA | Treatment of moderate to very severe glabellar lines and lateral canthal lines |
| WO2023156389A1 (en) | 2022-02-15 | 2023-08-24 | Merz Pharma Gmbh & Co. Kgaa | Liquid botulinum toxin formulation and use thereof |
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| TWI240627B (en) * | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
| US20030118598A1 (en) * | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| PT1253932E (pt) * | 2000-02-08 | 2005-07-29 | Allergan Inc | Composicoes farmaceuticas de toxina botulinica |
| EP1260230A4 (en) * | 2000-02-29 | 2008-08-06 | Chugai Pharmaceutical Co Ltd | LONG-TERM STABILIZED PREPARATIONS |
| US6627602B2 (en) * | 2001-11-13 | 2003-09-30 | Duke University | Preventing desensitization of receptors |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| CA2799413A1 (en) * | 2004-07-26 | 2006-02-23 | Merz Pharma Gmbh & Co. Kgaa | Therapeutic composition with a botulinum neurotoxin |
| WO2006013370A1 (en) * | 2004-08-04 | 2006-02-09 | Ipsen Limited | Pharmaceutical composition containing botulinum neurotoxin a2 |
| US20080220021A1 (en) * | 2005-02-14 | 2008-09-11 | Pankaj Modi | Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis |
| FR2902341B1 (fr) | 2006-06-16 | 2011-02-25 | Scras | Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace |
| CA2690773C (en) * | 2007-07-10 | 2013-09-17 | Medy-Tox, Inc. | Pharmaceutical liquid composition of botulinum toxin with improved stability |
| US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| LT2715355T (lt) | 2011-06-01 | 2017-06-12 | Biomadison, Inc. | Ne fret (fluorescencijos rezonansinės energijos perdavimas) būdu atliekamas botulino tyrimas |
| MX348188B (es) | 2011-09-29 | 2017-06-01 | Cellsnap Llc | Composiciones y metodos para pruebas de toxigenicidad. |
| KR101357999B1 (ko) * | 2012-03-20 | 2014-02-03 | 함종욱 | 보툴리눔 에이형 독소의 액상제품 |
| EP3052120A1 (en) | 2013-09-30 | 2016-08-10 | Galderma S.A. | Prostate cancer treatment |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
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