MX2022002938A - Compuestos inhibidores de la proteína arginina n-metil transferasa 5 (prmt5) cooperativos para metiltioadenosina (mta). - Google Patents

Compuestos inhibidores de la proteína arginina n-metil transferasa 5 (prmt5) cooperativos para metiltioadenosina (mta).

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Publication number
MX2022002938A
MX2022002938A MX2022002938A MX2022002938A MX2022002938A MX 2022002938 A MX2022002938 A MX 2022002938A MX 2022002938 A MX2022002938 A MX 2022002938A MX 2022002938 A MX2022002938 A MX 2022002938A MX 2022002938 A MX2022002938 A MX 2022002938A
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Mexico
Prior art keywords
mta
cooperative
prmt5 inhibitors
compounds
present
Prior art date
Application number
MX2022002938A
Other languages
English (en)
Inventor
John David Lawson
Jon Kuehler
Aaron Craig Burns
Matthew Arnold Marx
John Michael Ketcham
Christopher Ronald Smith
Thomas P Bobinski
Svitlana Kulyk
Anthony Ivetac
Original Assignee
Mirati Therapeutics Inc
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Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of MX2022002938A publication Critical patent/MX2022002938A/es

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    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

La presente invención se refiere a compuestos que inhiben la actividad de la proteína arginina N-metil transferasa 5 (PRMT5). En particular, la presente invención se refiere a compuestos, composiciones farmacéuticas y métodos de uso, tales como métodos para tratar el cáncer, usando los compuestos y las composiciones farmacéuticas de la presente invención.
MX2022002938A 2019-09-12 2020-09-11 Compuestos inhibidores de la proteína arginina n-metil transferasa 5 (prmt5) cooperativos para metiltioadenosina (mta). MX2022002938A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962899575P 2019-09-12 2019-09-12
US201962942833P 2019-12-03 2019-12-03
US202062961371P 2020-01-15 2020-01-15
US202062994927P 2020-03-26 2020-03-26
US202063060261P 2020-08-03 2020-08-03
PCT/US2020/050457 WO2021050915A1 (en) 2019-09-12 2020-09-11 Mta-cooperative prmt5 inhibitors

Publications (1)

Publication Number Publication Date
MX2022002938A true MX2022002938A (es) 2022-05-26

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MX2022002938A MX2022002938A (es) 2019-09-12 2020-09-11 Compuestos inhibidores de la proteína arginina n-metil transferasa 5 (prmt5) cooperativos para metiltioadenosina (mta).

Country Status (15)

Country Link
US (3) US11492351B2 (es)
EP (1) EP4028388A1 (es)
JP (1) JP2022548255A (es)
KR (1) KR20220083691A (es)
CN (1) CN114728912A (es)
AU (1) AU2020345899A1 (es)
BR (1) BR112022004248A2 (es)
CA (1) CA3150515A1 (es)
CL (1) CL2022000603A1 (es)
CO (1) CO2022004513A2 (es)
IL (1) IL290341A (es)
MX (1) MX2022002938A (es)
NO (1) NO20220309A1 (es)
TW (1) TW202122387A (es)
WO (1) WO2021050915A1 (es)

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WO2022192745A1 (en) * 2021-03-11 2022-09-15 Mirati Therapeutics, Inc. Mta-cooperative prmt5 inhibitors
IL307393A (en) * 2021-04-08 2023-12-01 Mirati Therapeutics Inc Combination therapies used in PRMT5 inhibitors to treat cancer
US20220331324A1 (en) * 2021-04-08 2022-10-20 Mirati Therapeutics, Inc. Combination Therapies Using PRMT5 Inhibitors for the Treatment of Cancer
WO2022256806A1 (en) * 2021-06-02 2022-12-08 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a type ii prmt inhibitor
IL311663A (en) 2021-10-06 2024-05-01 Mirati Therapeutics Inc Use of PRMT5 inhibitors to treat cancer
AU2022359896A1 (en) 2021-10-06 2024-05-02 Mirati Therapeutics, Inc. Methods for separation of enantiomers
WO2023081367A2 (en) 2021-11-05 2023-05-11 Mirati Therapeutics, Inc. 2-amino imidazole derivatives
WO2023098439A1 (zh) * 2021-11-30 2023-06-08 上海和誉生物医药科技有限公司 一种吡唑衍生物，其制备方法和在药学上的应用
WO2023125540A1 (zh) * 2021-12-27 2023-07-06 南京明德新药研发有限公司 吡唑-1(2h)-酞嗪酮类化合物及其应用
CN114315735B (zh) * 2021-12-29 2023-08-01 广州中医药大学(广州中医药研究院) 一种鲁米诺酯化衍生物及其制备方法与应用
CN116903611A (zh) * 2022-01-26 2023-10-20 上海优理惠生医药有限公司 一种酞嗪酮类化合物、其制备方法、包含其药物组合物及其应用
WO2023174250A1 (en) * 2022-03-15 2023-09-21 Beigene , Ltd. 4- (aminomethyl) -6- (1-methyl-1h-pyrazol-4-yl) isoquinolin-1 (2h) -one derivatives as mta-cooperative inhibitors of prmt5
WO2023202626A1 (zh) * 2022-04-22 2023-10-26 北京望实智慧科技有限公司 稠和哒嗪酮化合物作为prmt5抑制剂
WO2023226976A1 (zh) * 2022-05-24 2023-11-30 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
WO2024008176A1 (zh) * 2022-07-07 2024-01-11 西藏海思科制药有限公司 一种可抑制prmt5·mta的杂环化合物及其用途
CN117430596A (zh) * 2022-07-13 2024-01-23 上海海和药物研究开发股份有限公司 二并环类mat2a抑制剂及其用途
WO2024022186A1 (zh) * 2022-07-29 2024-02-01 四川科伦博泰生物医药股份有限公司 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途
WO2024027703A1 (zh) * 2022-08-02 2024-02-08 上海艾力斯医药科技股份有限公司 一种prmt5抑制剂、其制备方法及应用
WO2024038004A1 (en) 2022-08-15 2024-02-22 Astrazeneca Ab Mta-cooperative prmt5 inhibitors for use in the treatment of cancer
WO2024049948A1 (en) 2022-09-01 2024-03-07 Mirati Therapeutics, Inc. Combination therapies using prmt5 inhibitors and bcl-2 family inhibitors for the treatment of cancer

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WO2002030426A1 (en) * 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
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GB201604027D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds

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WO2021050915A1 (en) 2021-03-18
JP2022548255A (ja) 2022-11-17
IL290341A (en) 2022-04-01
TW202122387A (zh) 2021-06-16
US20210079003A1 (en) 2021-03-18
CA3150515A1 (en) 2021-03-18
BR112022004248A2 (pt) 2022-05-31
CN114728912A (zh) 2022-07-08
NO20220309A1 (en) 2022-03-11
AU2020345899A1 (en) 2022-03-03
US11479551B2 (en) 2022-10-25
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US20230054883A1 (en) 2023-02-23
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KR20220083691A (ko) 2022-06-20
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