MX2022005216A - Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7). - Google Patents
Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7).Info
- Publication number
- MX2022005216A MX2022005216A MX2022005216A MX2022005216A MX2022005216A MX 2022005216 A MX2022005216 A MX 2022005216A MX 2022005216 A MX2022005216 A MX 2022005216A MX 2022005216 A MX2022005216 A MX 2022005216A MX 2022005216 A MX2022005216 A MX 2022005216A
- Authority
- MX
- Mexico
- Prior art keywords
- pyridazinones
- parp7
- inhibitors
- parp7 inhibitors
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
La presente invención se relaciona con piridazinonas y compuestos relacionados que son inhibidores de PARP7 y son útiles en el tratamiento de cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962927934P | 2019-10-30 | 2019-10-30 | |
PCT/US2020/057831 WO2021087025A1 (en) | 2019-10-30 | 2020-10-29 | Pyridazinones as parp7 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022005216A true MX2022005216A (es) | 2022-06-02 |
Family
ID=73699388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022005216A MX2022005216A (es) | 2019-10-30 | 2020-10-29 | Piridazinonas como inhibidores de poli(adp-ribosa) polimerasa 7 (parp7). |
Country Status (12)
Country | Link |
---|---|
US (2) | US11691969B2 (es) |
EP (1) | EP4051384A1 (es) |
JP (1) | JP2023501253A (es) |
KR (1) | KR20220109401A (es) |
CN (1) | CN114761086A (es) |
AR (1) | AR120338A1 (es) |
AU (1) | AU2020375821A1 (es) |
CA (1) | CA3159188A1 (es) |
IL (1) | IL292432A (es) |
MX (1) | MX2022005216A (es) |
TW (1) | TW202128653A (es) |
WO (1) | WO2021087025A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11293927B2 (en) | 2018-04-30 | 2022-04-05 | Ribon Therapeutics, Inc. | Screening methods for PARP modulators |
FI3788040T3 (fi) | 2018-04-30 | 2023-06-13 | Ribon Therapeutics Inc | Pyridatsinoneja parp7-inhibiittoreina |
KR20220109401A (ko) | 2019-10-30 | 2022-08-04 | 리본 테라퓨틱스 인코포레이티드 | Parp7 억제제로서의 피리다진온 |
CN116157396A (zh) * | 2020-11-27 | 2023-05-23 | 成都百裕制药股份有限公司 | 哒嗪酮衍生物及其在医药上的应用 |
CN116724044A (zh) * | 2021-02-03 | 2023-09-08 | 上海湃隆生物科技有限公司 | 三并杂环类化合物、其制备方法及其应用 |
EP4291560A1 (en) * | 2021-02-09 | 2023-12-20 | Jacobio Pharmaceuticals Co., Ltd. | Tricyclic derivatives useful as parp7 inhibitors |
CN117425648A (zh) * | 2021-03-12 | 2024-01-19 | 杭州英创医药科技有限公司 | 作为parp7抑制剂的化合物 |
BR112023023866A2 (pt) * | 2021-05-21 | 2024-02-06 | Chengdu Baiyu Pharmaceutical Co Ltd | Derivado de piperazina e seu uso na medicina |
CN117396485A (zh) * | 2021-05-25 | 2024-01-12 | 轩竹生物科技股份有限公司 | Parp7抑制剂 |
CN115477640A (zh) * | 2021-05-31 | 2022-12-16 | 由理生物医药(上海)有限公司 | 作为parp7抑制剂的哒嗪酮类化合物 |
WO2023001247A1 (zh) * | 2021-07-21 | 2023-01-26 | 南京明德新药研发有限公司 | 哒嗪酮类化合物 |
CN115677664A (zh) * | 2021-07-23 | 2023-02-03 | 武汉人福创新药物研发中心有限公司 | 作为parp7抑制剂的哒嗪酮类化合物 |
WO2023011629A1 (zh) * | 2021-08-06 | 2023-02-09 | 成都百裕制药股份有限公司 | 吡咯烷酮衍生物及其在医药上的应用 |
CN117377665A (zh) * | 2021-08-16 | 2024-01-09 | 北京华森英诺生物科技有限公司 | Parp7抑制剂及其应用 |
TW202330504A (zh) | 2021-10-28 | 2023-08-01 | 美商基利科學股份有限公司 | 嗒𠯤—3(2h)—酮衍生物 |
CN115745971A (zh) * | 2021-12-20 | 2023-03-07 | 重庆华森制药股份有限公司 | Parp7抑制剂及其应用 |
WO2023185073A1 (zh) * | 2022-04-01 | 2023-10-05 | 诺沃斯达药业(上海)有限公司 | Parp7抑制剂及其用途 |
WO2024037558A1 (en) * | 2022-08-17 | 2024-02-22 | Jacobio Pharmaceuticals Co., Ltd. | Solid forms of compound i or salts thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE317122T1 (de) | 1997-09-05 | 2006-02-15 | Matsushita Electric Ind Co Ltd | Fluoreszierende polarisation |
WO2002082082A2 (en) | 2001-04-09 | 2002-10-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Fluorescence polarization assay |
GB0301628D0 (en) | 2002-09-19 | 2003-02-26 | Aventis Pharma Inc | Method for assaying compounds that decrease the activity of poly (ADP-ribose) - polymerase (PARP) |
GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
RS52626B (en) | 2006-07-25 | 2013-06-28 | Cephalon Inc. | PYRIDIZINONA DERIVATIVES |
RU2490265C2 (ru) | 2007-11-15 | 2013-08-20 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти С.П.А. | Пиридазиноновые производные в качестве ингибиторов parp |
MX2010010406A (es) | 2008-03-27 | 2010-10-25 | Janssen Pharmaceutica Nv | Tetrahidrofenantridinonas y tetrahidrociclopentaquinolinonas como inhibidores de la polimerizacion de poli(adp-ribosa)polimerasa-1 y tubulina. |
EP2467142B1 (en) | 2009-08-17 | 2016-09-21 | Memorial Sloan-Kettering Cancer Center | 2-(Pyrimidin-5-yl)-thiopyrimidine derivatives as Hsp70 and Hsc70 modulators for the treatment of proliferative disorders |
CN103570725B (zh) | 2012-08-01 | 2017-03-22 | 中国科学院上海药物研究所 | 哌嗪并三唑类化合物及其制备方法和用途 |
JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
EP2970289A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
WO2016116602A1 (en) | 2015-01-23 | 2016-07-28 | Astrazeneca Ab | Treatment of cancer |
CN106749261A (zh) | 2015-11-23 | 2017-05-31 | 中国科学院上海药物研究所 | 一类取代三唑并哌嗪类parp抑制剂及其制备方法和用途 |
TWI785022B (zh) | 2017-03-28 | 2022-12-01 | 美商富曼西公司 | 新穎噠嗪酮類除草劑 |
CA3075727A1 (en) * | 2017-09-18 | 2019-03-21 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
GB201717080D0 (en) | 2017-10-18 | 2017-11-29 | Syngenta Participations Ag | Chemical process |
FI3788040T3 (fi) | 2018-04-30 | 2023-06-13 | Ribon Therapeutics Inc | Pyridatsinoneja parp7-inhibiittoreina |
US11293927B2 (en) | 2018-04-30 | 2022-04-05 | Ribon Therapeutics, Inc. | Screening methods for PARP modulators |
WO2020223229A1 (en) | 2019-04-29 | 2020-11-05 | Ribon Therapeutics, Inc. | Solid forms of a parp7 inhibitor |
WO2021087018A1 (en) | 2019-10-30 | 2021-05-06 | Ribon Therapeutics, Inc. | Pyridazinones as parp7 inhibitors |
KR20220109401A (ko) | 2019-10-30 | 2022-08-04 | 리본 테라퓨틱스 인코포레이티드 | Parp7 억제제로서의 피리다진온 |
-
2020
- 2020-10-29 KR KR1020227018075A patent/KR20220109401A/ko unknown
- 2020-10-29 US US17/083,442 patent/US11691969B2/en active Active
- 2020-10-29 IL IL292432A patent/IL292432A/en unknown
- 2020-10-29 CA CA3159188A patent/CA3159188A1/en active Pending
- 2020-10-29 AR ARP200102992A patent/AR120338A1/es unknown
- 2020-10-29 MX MX2022005216A patent/MX2022005216A/es unknown
- 2020-10-29 AU AU2020375821A patent/AU2020375821A1/en active Pending
- 2020-10-29 TW TW109137556A patent/TW202128653A/zh unknown
- 2020-10-29 CN CN202080083214.3A patent/CN114761086A/zh active Pending
- 2020-10-29 EP EP20819919.0A patent/EP4051384A1/en active Pending
- 2020-10-29 WO PCT/US2020/057831 patent/WO2021087025A1/en unknown
- 2020-10-29 JP JP2022525496A patent/JP2023501253A/ja active Pending
-
2023
- 2023-05-12 US US18/196,601 patent/US20240034728A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TW202128653A (zh) | 2021-08-01 |
KR20220109401A (ko) | 2022-08-04 |
IL292432A (en) | 2022-06-01 |
AR120338A1 (es) | 2022-02-09 |
US20210130342A1 (en) | 2021-05-06 |
US20240034728A1 (en) | 2024-02-01 |
US11691969B2 (en) | 2023-07-04 |
EP4051384A1 (en) | 2022-09-07 |
CA3159188A1 (en) | 2021-05-06 |
JP2023501253A (ja) | 2023-01-18 |
CN114761086A (zh) | 2022-07-15 |
WO2021087025A1 (en) | 2021-05-06 |
AU2020375821A1 (en) | 2022-06-02 |
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