PT993439E
(pt)
|
1997-07-01 |
2004-12-31 |
Warner Lambert Co |
Derivados de acido 4-bromo ou 4-iodofenilaminobenzidroxamico e sua utilizacao como inibidores de mek
|
US5932580A
(en)
|
1997-12-01 |
1999-08-03 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
PDGF receptor kinase inhibitory compounds their preparation and compositions
|
ATE269295T1
(de)
|
1998-04-17 |
2004-07-15 |
Parker Hughes Inst |
Btk inhibitoren und verfahren zur identifizierung und verwendung
|
PL346840A1
(en)
|
1998-05-04 |
2002-02-25 |
Zentaris Ag |
Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation
|
BR9916894A
(pt)
|
1999-01-13 |
2001-11-20 |
Warner Lambert Co |
ácidos sulfohidroxâmicos e sulfohidroxamatos eseu uso como inibidores de mek
|
DE69928286T2
(de)
|
1999-01-13 |
2006-07-13 |
Warner-Lambert Co. Llc |
Benzenesulfonamid-derivative und ihre verwendung als mek-inhibitoren
|
GEP20032922B
(en)
|
1999-01-13 |
2003-03-25 |
Warner Lambert Co |
Benzoheterocycles and Their Use as MEK Inhibitors
|
CA2348236A1
(en)
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
CA2362380A1
(en)
|
1999-03-19 |
2000-09-28 |
Bristol-Meyers Squibb Pharma Company |
Amino-thio-acrylonitriles as mek inhibitors
|
GB9910577D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
WO2000075113A1
(fr)
|
1999-06-09 |
2000-12-14 |
Yamanouchi Pharmaceutical Co., Ltd. |
Nouveaux derives carboxamide heterocycliques
|
GB9918035D0
(en)
|
1999-07-30 |
1999-09-29 |
Novartis Ag |
Organic compounds
|
JP5036112B2
(ja)
|
1999-10-06 |
2012-09-26 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
チロシンキナーゼのインヒビターとして有益な複素環化合物
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
CN1615873A
(zh)
|
1999-12-24 |
2005-05-18 |
阿文蒂斯药物有限公司 |
氮杂吲哚类化合物
|
WO2001052892A2
(en)
|
2000-01-24 |
2001-07-26 |
Genzyme Corporation |
Jak/stat pathway inhibitors and the uses thereof
|
NZ520640A
(en)
|
2000-02-15 |
2005-04-29 |
Upjohn Co |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
US7087608B2
(en)
|
2000-03-03 |
2006-08-08 |
Robert Charles Atkins |
Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
|
AU2001247372A1
(en)
|
2000-03-15 |
2001-09-24 |
Warner Lambert Company |
5-amide substituted diarylamines as mex inhibitors
|
AR035851A1
(es)
|
2000-03-28 |
2004-07-21 |
Wyeth Corp |
3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
|
AR028261A1
(es)
|
2000-03-28 |
2003-04-30 |
Wyeth Corp |
Inhibidores triciclicos de la proteina quinasa
|
DE10017480A1
(de)
|
2000-04-07 |
2001-10-11 |
Transmit Technologietransfer |
Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren
|
JP2001302667A
(ja)
|
2000-04-28 |
2001-10-31 |
Bayer Ag |
イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
|
AU2002249261A1
(en)
|
2001-03-06 |
2002-09-19 |
Axxima Pharmaceuticals Ag |
Use of mek inhibitors for treating inflammation and virus induced hemorrhagic shock
|
EP1389209B1
(en)
|
2001-04-24 |
2009-04-08 |
Purdue Research Foundation |
Folate mimetics and folate-receptor binding conjugates thereof
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
US20050054617A1
(en)
|
2001-06-29 |
2005-03-10 |
Alain Moussy |
Use of potent, selective and non toxic c-kit inhibitors for treating mastocytosis
|
US20040266797A1
(en)
|
2001-06-29 |
2004-12-30 |
Alain Moussy |
Use of potent,selective and non toxic c-kit inhibitors for treating tumor angiogensis
|
US7727731B2
(en)
|
2001-06-29 |
2010-06-01 |
Ab Science |
Potent, selective and non toxic c-kit inhibitors
|
DE60225590T2
(de)
|
2001-09-20 |
2008-09-25 |
Ab Science |
C-kithemmer zur behandlung von bakteriellen infektionen
|
JP2005508337A
(ja)
|
2001-09-27 |
2005-03-31 |
スミスクライン ビーチャム コーポレーション |
化合物
|
US20030158195A1
(en)
|
2001-12-21 |
2003-08-21 |
Cywin Charles L. |
1,6 naphthyridines useful as inhibitors of SYK kinase
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
TWI343377B
(en)
|
2002-03-13 |
2011-06-11 |
Array Biopharma Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
WO2003077855A2
(en)
|
2002-03-13 |
2003-09-25 |
Array Biopharma, Inc |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
DE60308337T2
(de)
|
2002-03-15 |
2007-09-20 |
Novartis Ag |
4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen
|
CN1665808A
(zh)
|
2002-05-06 |
2005-09-07 |
沃泰克斯药物股份有限公司 |
噻二唑或噁二唑及其作为jak蛋白激酶抑制剂的用途
|
WO2003101989A1
(en)
|
2002-05-30 |
2003-12-11 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of jak and cdk2 protein kinases
|
GB0215823D0
(en)
|
2002-07-09 |
2002-08-14 |
Astrazeneca Ab |
Quinazoline derivatives
|
WO2004011461A1
(en)
|
2002-07-25 |
2004-02-05 |
Pfizer Products Inc. |
Isothiazole derivatives useful as anticancer agents
|
BRPI0313165B8
(pt)
|
2002-08-02 |
2021-05-25 |
Ab Science |
2-(3-aminoaril)amino-4-aril-tiazóis e sua utilização como inibidores de c-kit
|
US7312227B2
(en)
|
2002-11-01 |
2007-12-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of JAK and other protein kinases
|
JP4688498B2
(ja)
|
2002-11-04 |
2011-05-25 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Jakインヒビターとしてのヘテロアリール−ピリミジン誘導体
|
EP1560824A1
(en)
|
2002-11-05 |
2005-08-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of jak and other protein kinases
|
US7098332B2
(en)
|
2002-12-20 |
2006-08-29 |
Hoffmann-La Roche Inc. |
5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
|
JPWO2004080462A1
(ja)
|
2003-03-10 |
2006-06-08 |
エーザイ株式会社 |
c−Kitキナーゼ阻害剤
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
AU2004259012C1
(en)
|
2003-07-23 |
2012-08-02 |
Exelixis, Inc. |
Anaplastic lymphoma kinase modulators and methods of use
|
US20050026933A1
(en)
|
2003-08-01 |
2005-02-03 |
Wyeth Holdings Corporation |
Use of a combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer
|
SG145749A1
(en)
|
2003-08-15 |
2008-09-29 |
Novartis Ag |
2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
|
US7521448B2
(en)
|
2003-08-21 |
2009-04-21 |
Osi Pharmaceuticals, Inc. |
N-substituted benzimidazolyl c-Kit inhibitors
|
CA2536174A1
(en)
|
2003-08-21 |
2005-03-10 |
Osi Pharmaceuticals, Inc. |
N3-substituted imidazopyridine-derivatives as c-kit inhibitors
|
MXPA06002017A
(es)
|
2003-08-21 |
2006-05-31 |
Osi Pharm Inc |
Pirazolil-amidil-bencimidazolilo n-sustituidos, ibnhibidores de c-kit.
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
US7538120B2
(en)
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
DE10342794A1
(de)
|
2003-09-16 |
2005-04-21 |
Basf Ag |
Sekretion von Proteinen aus Hefen
|
GB0321710D0
(en)
|
2003-09-16 |
2003-10-15 |
Novartis Ag |
Organic compounds
|
TW200520745A
(en)
|
2003-09-19 |
2005-07-01 |
Chugai Pharmaceutical Co Ltd |
Novel 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors
|
CN1856327A
(zh)
|
2003-09-23 |
2006-11-01 |
诺瓦提斯公司 |
Vegf受体抑制剂与化疗剂的组合
|
SG132683A1
(en)
|
2003-10-15 |
2007-06-28 |
Osi Pharm Inc |
Imidazopyrazine tyrosine kinase inhibitors
|
EP1526177A1
(en)
|
2003-10-24 |
2005-04-27 |
Institut Curie |
Nucleic acids useful for triggering tumor cell lethality
|
US7476729B2
(en)
|
2003-10-24 |
2009-01-13 |
Institut Curie |
Dbait and uses thereof
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
CA2546486A1
(en)
|
2003-11-19 |
2005-06-09 |
Array Biopharma Inc. |
Heterocyclic inhibitors of mek and methods of use thereof
|
DE102004001607A1
(de)
|
2004-01-09 |
2005-08-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern
|
WO2005073225A1
(en)
|
2004-01-30 |
2005-08-11 |
Ab Science |
2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors
|
TW200538097A
(en)
|
2004-02-27 |
2005-12-01 |
Eisai Co Ltd |
Novel pyridine derivative and pyrimidine derivative
|
CN101676285A
(zh)
|
2004-03-30 |
2010-03-24 |
沃泰克斯药物股份有限公司 |
用作jak和其它蛋白激酶抑制剂的氮杂吲哚
|
FR2868422B1
(fr)
|
2004-03-31 |
2006-07-14 |
Aventis Pharma Sa |
Nouveaux derives pyrrolo(2,3-b) pyridine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
|
DK1740591T3
(da)
|
2004-04-02 |
2009-10-26 |
Osi Pharm Inc |
Heterobicykliske proteinkinaseinhibitorer substitueret med en 6,6-biocyclisk ring
|
JP2008502666A
(ja)
|
2004-06-15 |
2008-01-31 |
アストラゼネカ アクチボラグ |
抗癌剤としての置換キナゾロン類
|
TW200616974A
(en)
|
2004-07-01 |
2006-06-01 |
Astrazeneca Ab |
Chemical compounds
|
AU2005274852B2
(en)
|
2004-07-19 |
2011-12-08 |
The Johns Hopkins University |
FLT3 inhibitors for immune suppression
|
TWI361066B
(en)
|
2004-07-26 |
2012-04-01 |
Chugai Pharmaceutical Co Ltd |
5-substituted-2-phenylamino benzamides as mek inhibitors
|
WO2007040469A2
(en)
|
2005-09-15 |
2007-04-12 |
Kosak Ken M |
Chloroquine coupled compositions and methods for their synthesis
|
NZ553087A
(en)
|
2004-08-31 |
2010-12-24 |
Astrazeneca Ab |
Quinazolinone derivatives and their use as B-raf inhibitors
|
KR20070055575A
(ko)
|
2004-09-01 |
2007-05-30 |
아스트라제네카 아베 |
퀴나졸리논 유도체 및 이의 b―raf 억제제로서의 용도
|
PT1791830E
(pt)
|
2004-09-17 |
2011-04-04 |
Vertex Pharma |
Compostos de diaminotriazole úteis como inibidores de proteína-quinase
|
US20080207616A1
(en)
|
2004-10-15 |
2008-08-28 |
Astrazeneca Ab |
Quinoxalines as B Baf Inhhibitors
|
JP2008520615A
(ja)
|
2004-11-24 |
2008-06-19 |
ラボラトワール セローノ ソシエテ アノニム |
過増殖性障害を処置するためのmek阻害剤としての新規4−アリールアミノピリドン誘導体
|
JP2008520612A
(ja)
|
2004-11-24 |
2008-06-19 |
ノバルティス アクチエンゲゼルシャフト |
JAK阻害剤およびBcr−Abl、Flt−3、FAKまたはRAFキナーゼ阻害剤のうち少なくとも1個の組合せ
|
US20070299103A1
(en)
|
2004-12-01 |
2007-12-27 |
Ulrich Abel |
[1,2,4]Triazolo[4,3-A]Pyridine Derivatives for the Treatment of Hyperproliferative Diseases
|
BRPI0518794A2
(pt)
|
2004-12-01 |
2008-12-09 |
Osi Pharm Inc |
composto, composiÇço, mÉtodo de tratamento de distérbio hiperproliferativo, e, biblioteca combinatorial
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
AU2005317870A1
(en)
|
2004-12-22 |
2006-06-29 |
Astrazeneca Ab |
Pyridine carboxamide derivatives for use as anticancer agents
|
MX2007008924A
(es)
|
2005-01-25 |
2007-08-21 |
Astrazeneca Ab |
Compuestos quimicos.
|
US7605272B2
(en)
|
2005-01-27 |
2009-10-20 |
Kyowa Hakko Kirin Co., Ltd. |
IGF-1R inhibitor
|
PT1846394E
(pt)
|
2005-02-04 |
2012-01-05 |
Astrazeneca Ab |
Derivados de pirazolilaminopiridina úteis como inibidores da quinase
|
AU2006215386B2
(en)
|
2005-02-16 |
2009-06-11 |
Astrazeneca Ab |
Chemical compounds
|
DE602006015431D1
(de)
|
2005-02-16 |
2010-08-26 |
Astrazeneca Ab |
Chemische verbindungen
|
WO2006093247A1
(ja)
|
2005-02-28 |
2006-09-08 |
Japan Tobacco Inc. |
Syk阻害活性を有する新規なアミノピリジン化合物
|
AU2006229343A1
(en)
|
2005-03-28 |
2006-10-05 |
Kirin Pharma Kabushiki Kaisha |
Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency
|
CA2603826C
(en)
|
2005-04-04 |
2013-03-12 |
Ab Science |
Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
|
KR20080011199A
(ko)
|
2005-04-19 |
2008-01-31 |
교와 핫꼬 고교 가부시끼가이샤 |
질소 함유 복소환 화합물
|
JP2008540622A
(ja)
|
2005-05-16 |
2008-11-20 |
アストラゼネカ アクチボラグ |
化合物
|
UA93678C2
(ru)
|
2005-05-18 |
2011-03-10 |
Астразенека Аб |
Гетероциклические ингибиторы mek и их применение
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
WO2006133417A1
(en)
|
2005-06-07 |
2006-12-14 |
Valeant Pharmaceuticals International |
Phenylamino isothiazole carboxamidines as mek inhibitors
|
US20070021435A1
(en)
|
2005-06-10 |
2007-01-25 |
Gaul Michael D |
Aminopyrimidines as kinase modulators
|
TW200738638A
(en)
|
2005-06-23 |
2007-10-16 |
Merck & Co Inc |
Tyrosine kinase inhibitors
|
DK1896421T3
(da)
|
2005-06-23 |
2012-01-09 |
Merck Sharp & Dohme |
Benzocyclohetapyridiner som hæmmere af receptoren tyrosinkinase MET
|
TW200740820A
(en)
|
2005-07-05 |
2007-11-01 |
Takeda Pharmaceuticals Co |
Fused heterocyclic derivatives and use thereof
|
EP1904065A2
(en)
|
2005-07-14 |
2008-04-02 |
AB Science |
Use of dual c-kit/fgfr3 inhibitors for treating multiple myeloma
|
JP5071374B2
(ja)
|
2005-07-14 |
2012-11-14 |
アステラス製薬株式会社 |
ヘテロ環ヤヌスキナーゼ3阻害剤
|
WO2007028445A1
(en)
|
2005-07-15 |
2007-03-15 |
Glaxo Group Limited |
6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
|
TW200740805A
(en)
|
2005-07-15 |
2007-11-01 |
Glaxo Group Ltd |
Novel compounds
|
CA2618218C
(en)
|
2005-07-21 |
2015-06-30 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
ES2424651T3
(es)
|
2005-08-24 |
2013-10-07 |
Eisai R&D Management Co., Ltd. |
Nuevo derivado de piridina y derivado de pirimidina (3)
|
WO2007030680A2
(en)
|
2005-09-07 |
2007-03-15 |
Rigel Pharmaceuticals, Inc. |
Triazole derivatives useful as axl inhibitors
|
NZ566862A
(en)
|
2005-09-27 |
2010-12-24 |
Irm Llc |
Diarylamine-containing compounds and compositions, and their use as modulators of C-kit receptors
|
FR2891273B1
(fr)
|
2005-09-27 |
2007-11-23 |
Aventis Pharma Sa |
NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
|
AU2006302415B2
(en)
|
2005-10-07 |
2012-09-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
AU2006301435A1
(en)
|
2005-10-13 |
2007-04-19 |
Glaxo Group Limited |
Pyrrolopyrimidine derivatives as Syk inhibitors
|
CA2632283C
(en)
|
2005-12-05 |
2011-06-21 |
Pfizer Products Inc. |
Polymorphs of a c-met/hgfr inhibitor
|
DK2455382T3
(da)
|
2005-12-13 |
2017-01-02 |
Incyte Holdings Corp |
Heteroaryl substituerede pyrrolo[2,3-b]pyridiner og pyrrolo[2,3-b]pyrimidiner som Janus kinase-inhibitorer
|
US20080299113A1
(en)
|
2005-12-19 |
2008-12-04 |
Arnold Lee D |
Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents
|
EP1966155A1
(en)
|
2005-12-21 |
2008-09-10 |
AstraZeneca AB |
Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer
|
AU2006328194A1
(en)
|
2005-12-22 |
2007-06-28 |
Astrazeneca Ab |
Quinazoline derivatives, process for their preparation and their use as anti-cancer agents
|
EP2537849A3
(en)
|
2006-01-17 |
2013-04-03 |
Vertex Pharmaceuticals, Inc. |
Azaindoles useful as inhibitors of janus kinases
|
FR2896504B1
(fr)
|
2006-01-23 |
2012-07-13 |
Aventis Pharma Sa |
Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
|
FR2896503B1
(fr)
|
2006-01-23 |
2012-07-13 |
Aventis Pharma Sa |
Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
|
WO2007085540A1
(en)
|
2006-01-27 |
2007-08-02 |
Glaxo Group Limited |
1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
TW200740776A
(en)
|
2006-02-06 |
2007-11-01 |
Osi Pharm Inc |
N-phenylbenzotriazolyl c-kit inhibitors
|
WO2007111904A2
(en)
|
2006-03-22 |
2007-10-04 |
Vertex Pharmaceuticals Incorporated |
C-met protein kinase inhibitors for the treatment of proliferative disorders
|
US20090163525A1
(en)
|
2006-04-05 |
2009-06-25 |
Astrazeneca Ab |
Substituted quinazolines with anti-cancer activity
|
US8741912B2
(en)
|
2006-04-05 |
2014-06-03 |
Vertex Pharmaceuticals Incorporated |
Deazapurines useful as inhibitors of Janus kinases
|
JP2009532450A
(ja)
|
2006-04-05 |
2009-09-10 |
アストラゼネカ アクチボラグ |
化合物
|
US20090203718A1
(en)
|
2006-04-13 |
2009-08-13 |
Smithkline Beecham (Cork) Ltd. |
Cancer treatment method
|
MX2008013097A
(es)
|
2006-04-18 |
2008-10-27 |
Ardea Biosciences Inc |
Piridona sulfonamidas y piridona sulfamidas como inhibidores de metiletilcetona.
|
EP2010504A1
(en)
|
2006-04-18 |
2009-01-07 |
AstraZeneca AB |
Quinazolin-4-one derivatives, process for their preparation and pharmaceutical compositions containing them
|
BRPI0711625A2
(pt)
|
2006-04-19 |
2011-12-06 |
Serono Lab |
derivados de arilaminopiridina substituìda por heteroarila como inibidores de mek
|
US8163746B2
(en)
|
2006-04-19 |
2012-04-24 |
Astellas Pharma Inc. |
Azolecarboxamide derivative
|
WO2007124369A2
(en)
|
2006-04-20 |
2007-11-01 |
Janssen Pharmaceutica N.V. |
Method of inhibiting c kit kinase
|
ES2542344T3
(es)
|
2006-05-09 |
2015-08-04 |
Novaremed Ltd. |
Uso de inhibidores de tirosina cinasa Syk para el tratamiento de trastornos proliferativos celulares
|
CN104706637A
(zh)
|
2006-05-18 |
2015-06-17 |
卫材R&D管理有限公司 |
针对甲状腺癌的抗肿瘤剂
|
US20090281115A1
(en)
|
2006-06-30 |
2009-11-12 |
Board of Regents, The University of Texas System, a Texas University |
Inhibitors of c-kit and uses thereof
|
TW200813021A
(en)
|
2006-07-10 |
2008-03-16 |
Merck & Co Inc |
Tyrosine kinase inhibitors
|
ATE456392T1
(de)
|
2006-07-20 |
2010-02-15 |
Amgen Inc |
Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin
|
BRPI0714665A2
(pt)
|
2006-08-04 |
2012-03-13 |
Takeda Pharmaceutical Company Limited |
Composto, pró-droga, agente farmacêutico, e, método para a profilaxia ou tratamento do câncer
|
WO2008020203A1
(en)
|
2006-08-17 |
2008-02-21 |
Astrazeneca Ab |
Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors
|
AU2007285782B2
(en)
|
2006-08-18 |
2010-06-24 |
Arrowhead Research Corporation |
Polyconjugates for in vivo delivery of polynucleotides
|
AU2007288793B2
(en)
|
2006-08-23 |
2012-04-19 |
Eisai R & D Management Co., Ltd. |
Salt of phenoxypyridine derivative or crystal thereof and process for producing the same
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
KR101315610B1
(ko)
|
2006-09-22 |
2013-10-10 |
파마시클릭스, 인코포레이티드 |
브루톤 티로신 키나제 억제제
|
US8097630B2
(en)
|
2006-10-10 |
2012-01-17 |
Rigel Pharmaceuticals, Inc. |
Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors
|
CN101558068A
(zh)
|
2006-10-16 |
2009-10-14 |
诺瓦提斯公司 |
用作蛋白激酶抑制剂的苯乙酰胺类
|
EP2108642A1
(en)
|
2006-10-17 |
2009-10-14 |
Kyowa Hakko Kirin Co., Ltd. |
Jak inhibitor
|
TW200829566A
(en)
|
2006-12-08 |
2008-07-16 |
Astrazeneca Ab |
Chemical compounds
|
EP2101759B1
(en)
|
2006-12-14 |
2018-10-10 |
Exelixis, Inc. |
Methods of using mek inhibitors
|
WO2008076143A1
(en)
|
2006-12-18 |
2008-06-26 |
Osi Pharmaceuticals, Inc. |
Combination of igfr inhibitor and anti-cancer agent
|
US7737149B2
(en)
|
2006-12-21 |
2010-06-15 |
Astrazeneca Ab |
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
|
MX2009006706A
(es)
|
2006-12-22 |
2009-07-02 |
Astex Therapeutics Ltd |
Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
|
US7879856B2
(en)
|
2006-12-22 |
2011-02-01 |
Rigel Pharmaceuticals, Inc. |
Diaminothiazoles useful as Axl inhibitors
|
PT2114955E
(pt)
|
2006-12-29 |
2013-04-18 |
Rigel Pharmaceuticals Inc |
Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl
|
US7872000B2
(en)
|
2006-12-29 |
2011-01-18 |
Rigel Pharmaceuticals, Inc. |
Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as Axl inhibitors
|
AU2007342007A1
(en)
|
2006-12-29 |
2008-07-10 |
Rigel Pharmaceuticals, Inc. |
Substituted triazoles useful as Axl inhibitors
|
DK2078010T3
(da)
|
2006-12-29 |
2014-04-28 |
Rigel Pharmaceuticals Inc |
Polycyklisk heteroaryl-substituerede triazoler, der er anvendelige som axl-hæmmere
|
US9650391B2
(en)
|
2006-12-29 |
2017-05-16 |
Rigel Pharmaceuticals Inc. |
N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors
|
EP1944369A1
(en)
|
2007-01-12 |
2008-07-16 |
The Centre National de la Recherche Scientifique |
Dbait and its standalone uses thereof
|
WO2008089459A1
(en)
|
2007-01-19 |
2008-07-24 |
Ardea Biosciences, Inc. |
Inhibitors of mek
|
EP2114983B8
(en)
|
2007-02-07 |
2015-02-18 |
The Regents of the University of Colorado, A Body Corporate |
Axl tyrosine kinase inhibitors and methods of making and using the same
|
KR20090090365A
(ko)
|
2007-02-23 |
2009-08-25 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Hgfr 유전자 증폭 세포주에 대하여 우수한 세포 증식 억제 효과 및 항종양 효과를 나타내는 피리딘 유도체 또는 피리미딘 유도체
|
EP2133095A4
(en)
|
2007-03-05 |
2012-09-26 |
Kyowa Hakko Kirin Co Ltd |
PHARMACEUTICAL COMPOSITION
|
KR101737753B1
(ko)
|
2007-03-12 |
2017-05-18 |
와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 |
페닐 아미노 피리미딘 화합물 및 이의 용도
|
KR20090129488A
(ko)
|
2007-03-22 |
2009-12-16 |
버텍스 파마슈티칼스 인코포레이티드 |
야누스 키나아제의 억제제로서 유용한 n-헤테로사이클릭 화합물
|
CA2874756C
(en)
|
2007-03-28 |
2018-05-29 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
CA2682733A1
(en)
|
2007-04-13 |
2008-10-23 |
Supergen, Inc. |
Axl kinase inhibitors
|
UA99459C2
(en)
|
2007-05-04 |
2012-08-27 |
Астразенека Аб |
9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
GB0714384D0
(en)
|
2007-07-23 |
2007-09-05 |
Ucb Pharma Sa |
theraputic agents
|
CA2924436A1
(en)
|
2007-07-30 |
2009-02-05 |
Ardea Biosciences, Inc. |
Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use
|
MX2010001244A
(es)
|
2007-07-30 |
2010-08-31 |
Ardea Biosciences Inc |
Derivados de n-(arilamino) sulfonamidas que incluyen polimorfos como inhibidores de mek asi como composiciones, metodos de uso y de preparacion de los mismos.
|
PA8792501A1
(es)
|
2007-08-09 |
2009-04-23 |
Sanofi Aventis |
Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.
|
AU2008294473B2
(en)
|
2007-09-05 |
2013-12-05 |
Rigel Pharmaceuticals, Inc. |
Xinafoate salt of N4-(2,2-difluoro-4H-benzo[1,4]oxazin-3-one) -6-yl]-5-fluoro-N2-[3-methylaminocar-bonylmethyleneoxy)phenyl]-2,4-pyrimidinediamine
|
EP2205564B1
(en)
|
2007-10-23 |
2014-07-30 |
F. Hoffmann-La Roche AG |
Novel kinase inhibitors
|
CA2703106C
(en)
|
2007-10-24 |
2015-12-01 |
Astellas Pharma Inc. |
Azolecarboxamide derivatives as trka inhibitors
|
US7935693B2
(en)
|
2007-10-26 |
2011-05-03 |
Rigel Pharmaceuticals, Inc. |
Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
|
EP3109249A1
(en)
|
2007-11-15 |
2016-12-28 |
YM BioSciences Australia Pty Ltd |
N-containing heterocyclic compounds
|
US20110039856A1
(en)
|
2007-11-29 |
2011-02-17 |
Pfizer Inc. |
Polymorphs of a c-met/hgfr inhibitor
|
EP2240494B1
(en)
|
2008-01-21 |
2016-03-30 |
UCB Biopharma SPRL |
Thieno-pyridine derivatives as mek inhibitors
|
GB0801416D0
(en)
|
2008-01-25 |
2008-03-05 |
Piramed Ltd |
Pharmaceutical compounds
|
PL2252597T3
(pl)
|
2008-02-01 |
2014-09-30 |
Akinion Pharmaceuticals Ab |
Pochodne pirazyny i ich zastosowanie jako inhibitorów kinaz białkowych
|
SI2242749T1
(sl)
|
2008-02-05 |
2013-07-31 |
F.Hoffmann-La Roche Ag |
Novi piridinoni in piridazinoni
|
EP2252612B1
(en)
|
2008-02-22 |
2012-03-28 |
Irm Llc |
Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors
|
CA2716947A1
(en)
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
|
JP2011513330A
(ja)
|
2008-02-29 |
2011-04-28 |
アレイ バイオファーマ、インコーポレイテッド |
Raf阻害化合物およびその使用方法
|
CA2716949A1
(en)
|
2008-02-29 |
2009-09-11 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
AR072657A1
(es)
|
2008-02-29 |
2010-09-15 |
Genentech Inc |
Compuestos inhibidores de raf y metodos para su uso
|
EA017218B1
(ru)
|
2008-03-11 |
2012-10-30 |
Инсайт Корпорейшн |
Производные азетидина и циклобутана как ингибиторы jak-киназ
|
WO2009117097A1
(en)
|
2008-03-19 |
2009-09-24 |
Chembridge Corporation |
Novel tyrosine kinase inhibitors
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
CA2720671A1
(en)
|
2008-04-14 |
2009-10-22 |
Ardea Biosciences, Inc. |
Compositions and methods for preparing and using same
|
WO2009136995A2
(en)
|
2008-04-16 |
2009-11-12 |
Portola Pharmaceuticals, Inc. |
Inhibitors of syk protein kinase
|
WO2009127417A1
(en)
|
2008-04-16 |
2009-10-22 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Quinoline derivatives as axl kinase inhibitors
|
JP5705720B2
(ja)
|
2008-04-16 |
2015-04-22 |
ポートラ ファーマシューティカルズ, インコーポレイテッド |
Sykまたはjakキナーゼ阻害剤としての2,6−ジアミノ−ピリミジン−5−イル−カルボキサミド
|
CA2723185A1
(en)
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
US8871753B2
(en)
|
2008-04-24 |
2014-10-28 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
DK2300013T3
(en)
|
2008-05-21 |
2017-12-04 |
Ariad Pharma Inc |
PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS
|
HUE034716T2
(hu)
|
2008-05-21 |
2018-02-28 |
Incyte Holdings Corp |
2-Fluor-N-metil-4-[7-(kinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamid sói és eljárások ezek elõállítására
|
GB0811304D0
(en)
|
2008-06-19 |
2008-07-30 |
Ucb Pharma Sa |
Therapeutic agents
|
AU2009261683A1
(en)
|
2008-06-19 |
2009-12-23 |
Astrazeneca Ab |
Pyrazole compounds 436
|
PE20110063A1
(es)
|
2008-06-20 |
2011-02-16 |
Genentech Inc |
DERIVADOS DE [1, 2, 4]TRIAZOLO[1, 5-a]PIRIDINA COMO INHIBIDORES DE JAK
|
CA2727036C
(en)
|
2008-06-20 |
2017-03-21 |
Genentech, Inc. |
Triazolopyridine jak inhibitor compounds and methods
|
EP2297142B1
(en)
|
2008-06-24 |
2015-10-14 |
F. Hoffmann-La Roche AG |
Novel substituted pyridin-2-ones and pyridazin-3-ones
|
PL2328888T3
(pl)
|
2008-07-09 |
2013-04-30 |
Rigel Pharmaceuticals Inc |
Triazole podstawione mostkowanym bicyklicznym heteroarylem użyteczne jako inhibitory AXL
|
US8349838B2
(en)
|
2008-07-09 |
2013-01-08 |
Rigel Pharmaceuticals, Inc. |
Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
|
ES2660418T3
(es)
|
2008-07-16 |
2018-03-22 |
Pharmacyclics Llc |
Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos
|
AU2009272516A1
(en)
|
2008-07-18 |
2010-01-21 |
Sanofi-Aventis |
Novel triazolo(4,3-a)pyridine derivatives, process for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use, in particular as MET inhibitors
|
WO2010007317A1
(fr)
|
2008-07-18 |
2010-01-21 |
Sanofi-Aventis |
NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
|
FR2933982A1
(fr)
|
2008-07-18 |
2010-01-22 |
Sanofi Aventis |
Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
|
US8404725B2
(en)
|
2008-08-04 |
2013-03-26 |
Merck Patent Gmbh |
Phenylamino isonicotinamide compounds
|
UY32049A
(es)
|
2008-08-14 |
2010-03-26 |
Takeda Pharmaceutical |
Inhibidores de cmet
|
CA2952692C
(en)
|
2008-09-22 |
2020-04-28 |
Array Biopharma Inc. |
Substituted imidazo[1,2b]pyridazine compounds
|
TWI458729B
(zh)
|
2008-10-22 |
2014-11-01 |
Array Biopharma Inc |
作為TRK激酶抑制劑之經取代吡唑并〔1,5-a〕嘧啶化合物
|
EP2962566A1
(en)
|
2008-10-31 |
2016-01-06 |
Genentech, Inc. |
Pyrazolopyrimidine jak inhibitor compounds and methods
|
US8598174B2
(en)
|
2008-11-12 |
2013-12-03 |
Genetech, Inc. |
Pyridazinones, method of making, and method of use thereof
|
JP5596047B2
(ja)
|
2008-11-19 |
2014-09-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
c−Metタンパク質キナーゼのトリアゾロチアジアゾール阻害剤
|
CA2745871C
(en)
|
2008-12-08 |
2018-02-20 |
Gilead Connecticut, Inc. |
Imidazopyrazine syk inhibitors
|
KR20170013414A
(ko)
|
2008-12-08 |
2017-02-06 |
질레드 코네티컷 인코포레이티드 |
이미다조피라진 syk 억제제
|
ITMI20082336A1
(it)
|
2008-12-29 |
2010-06-30 |
Univ Parma |
Composti inibitori irreversibili di egfr con attivita' antiproliferativa
|
AU2010219097A1
(en)
|
2009-01-13 |
2011-08-04 |
Glaxo Group Limited |
Pyrimidinecarboxamide derivatives as inhibitors of SYK kinase
|
JOP20190231A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
PT2387395E
(pt)
|
2009-01-16 |
2015-02-04 |
Rigel Pharmaceuticals Inc |
Inibidores de axl para utilização em terapia de combinação para prevenir, tratar ou gerir cancro metastático
|
US8765727B2
(en)
|
2009-01-23 |
2014-07-01 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
FR2941952B1
(fr)
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
FR2941951B1
(fr)
|
2009-02-06 |
2011-04-01 |
Sanofi Aventis |
Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
|
WO2010090764A1
(en)
|
2009-02-09 |
2010-08-12 |
Supergen, Inc. |
Pyrrolopyrimidinyl axl kinase inhibitors
|
JP5844727B2
(ja)
|
2009-03-27 |
2016-01-20 |
アルデア バイオサイエンシズ,インコーポレイティド |
Mek阻害剤としてのジヒドロピリジンスルホンアミド及びジヒドロピリジンスルファミド
|
CA2761108A1
(en)
|
2009-04-21 |
2010-10-28 |
Novartis Ag |
Heterocyclic compounds as mek inhibitors
|
WO2010126960A1
(en)
|
2009-04-29 |
2010-11-04 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
WO2010129053A2
(en)
|
2009-05-05 |
2010-11-11 |
Dana Farber Cancer Institute |
Egfr inhibitors and methods of treating disorders
|
CA2761954C
(en)
|
2009-05-22 |
2018-07-31 |
Incyte Corporation |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
DK2975024T3
(en)
|
2009-06-10 |
2018-04-23 |
Chugai Pharmaceutical Co Ltd |
Tetracyclic compounds
|
AR077033A1
(es)
|
2009-06-11 |
2011-07-27 |
Hoffmann La Roche |
Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas
|
CN102134218A
(zh)
|
2009-06-15 |
2011-07-27 |
凯美隆(北京)药业技术有限公司 |
6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂
|
CA2765534C
(en)
|
2009-06-15 |
2018-09-18 |
Rigel Pharmaceuticals, Inc. |
Small molecule inhibitors of spleen tyrosine kinase (syk)
|
TWI462920B
(zh)
|
2009-06-26 |
2014-12-01 |
葛萊伯格有限公司 |
用於治療退化性及發炎疾病之新穎化合物
|
UA110324C2
(en)
|
2009-07-02 |
2015-12-25 |
Genentech Inc |
Jak inhibitory compounds based on pyrazolo pyrimidine
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
TW201105669A
(en)
|
2009-07-30 |
2011-02-16 |
Irm Llc |
Compounds and compositions as Syk kinase inhibitors
|
US8722692B2
(en)
|
2009-07-30 |
2014-05-13 |
Jianwei Che |
Compounds and compositions as Syk kinase inhibitors
|
WO2011025951A1
(en)
|
2009-08-28 |
2011-03-03 |
Array Biopharma Inc. |
Raf inhibitor compounds and methods of use thereof
|
CA2772316A1
(en)
|
2009-08-28 |
2011-03-03 |
Array Biopharma Inc. |
1h-pyrazolo [3,4-b] pyridine compounds for inhibiting raf kinase
|
WO2011025938A2
(en)
|
2009-08-28 |
2011-03-03 |
Array Biopharma Inc. |
Raf inhibitor compounds and methods of use thereof
|
US20120214811A1
(en)
|
2009-08-28 |
2012-08-23 |
Ignacio Aliagas |
Raf inhibitor compounds and methods of use thereof
|
DK2473049T3
(en)
|
2009-09-04 |
2019-04-01 |
Biogen Ma Inc |
INHIBITORS OF BRUTON'S TYROSINKINASE
|
WO2011029043A1
(en)
|
2009-09-04 |
2011-03-10 |
Biogen Idec Ma Inc. |
Heteroaryl btk inhibitors
|
US9238571B2
(en)
|
2009-09-30 |
2016-01-19 |
Merck Sharp & Dohme Limited |
Formulations for c-Met kinase inhibitors
|
US9034861B2
(en)
|
2009-10-13 |
2015-05-19 |
Allomek Therapeutics Llc |
MEK inhibitors useful in the treatment of diseases
|
PL2488033T3
(pl)
|
2009-10-16 |
2019-12-31 |
Novartis Ag |
Kombinacja zawierająca inhibitor MEK i inhibitor B-raf
|
AU2010317167B2
(en)
|
2009-11-04 |
2012-11-29 |
Novartis Ag |
Heterocyclic sulfonamide derivatives useful as MEK inhibitors
|
EP2512246B1
(en)
|
2009-12-17 |
2015-09-30 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
MA33926B1
(fr)
|
2009-12-17 |
2013-01-02 |
Merck Sharp & Dohme |
Aminopyrimidines en tant qu'inhibiteurs de la syk
|
SI2516434T1
(sl)
|
2009-12-23 |
2015-10-30 |
Takeda Pharmaceutical Company Limited |
Zliti heteroaromatski pirolidinoni kot inhibitorji SYK
|
EP3081567A3
(en)
|
2009-12-23 |
2016-11-16 |
ArQule, Inc. |
Methods for preparing of (-)trans-3-(5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1h-indol-3-yl)pyrrolidine-2,5-dione
|
EP2338888A1
(en)
|
2009-12-24 |
2011-06-29 |
Almirall, S.A. |
Imidazopyridine derivatives as JAK inhibitors
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
WO2011086085A1
(en)
|
2010-01-12 |
2011-07-21 |
Ab Science |
Thiazole and oxazole kinase inhibitors
|
EP2528915B1
(en)
|
2010-01-29 |
2015-10-28 |
Boehringer Ingelheim International GmbH |
Substituted naphthyridines and their use as syk kinase inhibitors
|
US9562056B2
(en)
|
2010-03-11 |
2017-02-07 |
Gilead Connecticut, Inc. |
Imidazopyridines Syk inhibitors
|
US8481541B2
(en)
|
2010-03-22 |
2013-07-09 |
Hoffmann-La Roche Inc. |
Pyrrolopyrazine kinase inhibitors
|
KR101844088B1
(ko)
|
2010-03-24 |
2018-03-30 |
아미텍 테러퓨틱 솔루션즈 인크 |
인산화효소 억제에 유용한 헤테로환 화합물
|
TW201202242A
(en)
|
2010-03-30 |
2012-01-16 |
Sanofi Aventis |
6-(alkyl-or cycloalkyl-triazolopyridazine-sulfanyl)benzo-thiazole derivatives: preparation, and use as medicaments and as MET inhibitors
|
GB201007203D0
(en)
|
2010-04-29 |
2010-06-16 |
Glaxo Group Ltd |
Novel compounds
|
EP2566858A2
(en)
|
2010-05-04 |
2013-03-13 |
Pfizer Inc. |
Heterocyclic derivatives as alk inhibitors
|
WO2011143646A1
(en)
|
2010-05-14 |
2011-11-17 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
WO2011144585A1
(en)
|
2010-05-20 |
2011-11-24 |
F. Hoffmann-La Roche Ag |
Pyrrolo [2, 3 - b] pyrazine - 7 - carboxamide derivatives and their use as jak and syk inhibitors
|
WO2011144584A1
(en)
|
2010-05-20 |
2011-11-24 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrazine derivatives as syk and jak inhibitors
|
JP2013527195A
(ja)
|
2010-05-27 |
2013-06-27 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
c−Metプロテインキナーゼのアミノピラゾールトリアゾロチアジアゾールインヒビター
|
WO2011147764A1
(en)
|
2010-05-28 |
2011-12-01 |
N.V. Organon |
Thieno (2, 3b) pyrazine compounds as b - raf inhibitors
|
EP2578585B1
(en)
|
2010-05-31 |
2016-07-20 |
ONO Pharmaceutical Co., Ltd. |
Purinone derivative as btk kinase inhibitor
|
CN107898791A
(zh)
|
2010-06-03 |
2018-04-13 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶(btk)抑制剂的应用
|
AU2011269041B2
(en)
|
2010-06-22 |
2015-05-07 |
Centre National De La Recherche Scientifique |
Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
|
BR112012033770A2
(pt)
|
2010-06-30 |
2016-11-22 |
Fujifilm Corp |
novo derivado de nicotinamida ou sal do mesmo
|
JPWO2012005299A1
(ja)
|
2010-07-07 |
2013-09-05 |
日本新薬株式会社 |
Rosチロシンキナーゼ阻害剤
|
EP2593462B1
(en)
|
2010-07-14 |
2016-09-07 |
Betta Pharmaceuticals Co., Ltd. |
Novel fused heterocyclic derivatives useful as c-met tyrosine kinase inhibitors
|
WO2012008564A1
(ja)
|
2010-07-16 |
2012-01-19 |
協和発酵キリン株式会社 |
含窒素芳香族複素環誘導体
|
KR20130091331A
(ko)
|
2010-07-16 |
2013-08-16 |
교와 핫꼬 기린 가부시키가이샤 |
함질소 방향족 복소환 유도체
|
AR085183A1
(es)
|
2010-07-30 |
2013-09-18 |
Lilly Co Eli |
Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
|
UY33539A
(es)
|
2010-08-02 |
2012-02-29 |
Astrazeneca Ab |
Compuestos químicos alk
|
CA2807051A1
(en)
|
2010-08-10 |
2012-02-16 |
Celgene Avilomics Research, Inc. |
Besylate salt of a btk inhibitor
|
EP2606886B1
(en)
|
2010-08-20 |
2020-01-08 |
Chugai Seiyaku Kabushiki Kaisha |
Composition comprising tetracyclic compound
|
EP2609100B1
(en)
|
2010-08-27 |
2015-06-24 |
Merck Patent GmbH |
Furopyridine derivatives
|
EP2609098B1
(en)
|
2010-08-27 |
2016-07-13 |
Merck Patent GmbH |
Triazolopyrazine derivatives
|
EP2423208A1
(en)
|
2010-08-28 |
2012-02-29 |
Lead Discovery Center GmbH |
Pharmaceutically active compounds as Axl inhibitors
|
US8637516B2
(en)
|
2010-09-09 |
2014-01-28 |
Irm Llc |
Compounds and compositions as TRK inhibitors
|
US8664244B2
(en)
|
2010-09-12 |
2014-03-04 |
Advenchen Pharmaceuticals, LLC |
Compounds as c-Met kinase inhibitors
|
WO2012037155A2
(en)
|
2010-09-13 |
2012-03-22 |
Gtx, Inc. |
Tyrosine kinase inhibitors
|
JO3062B1
(ar)
|
2010-10-05 |
2017-03-15 |
Lilly Co Eli |
R)-(e)-2-(4-(2-(5-(1-(3، 5-داي كلورو بيريدين-4-يل)إيثوكسي)-1h-إندازول-3-يل)?ينيل)-1h-بيرازول-1-يل)إيثانول بلوري
|
BR112013009260A2
(pt)
|
2010-10-08 |
2016-07-26 |
Xcovery Holding Co Llc |
compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase
|
US8846928B2
(en)
|
2010-11-01 |
2014-09-30 |
Portola Pharmaceuticals, Inc. |
Benzamides and nicotinamides as Syk modulators
|
CN102020651B
(zh)
|
2010-11-02 |
2012-07-18 |
北京赛林泰医药技术有限公司 |
6-芳基氨基吡啶酮甲酰胺mek抑制剂
|
CN102532141A
(zh)
|
2010-12-08 |
2012-07-04 |
中国科学院上海药物研究所 |
[1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途
|
US20130004481A1
(en)
|
2011-01-12 |
2013-01-03 |
Boehringer Ingelheim International Gmbh |
Anticancer therapy
|
PE20140378A1
(es)
|
2011-02-25 |
2014-03-28 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
JP2014507458A
(ja)
|
2011-03-11 |
2014-03-27 |
グラクソ グループ リミテッド |
Sykインヒビターとしてのピリド[3,4−B]ピラジン誘導体
|
GB201104153D0
(en)
|
2011-03-11 |
2011-04-27 |
Glaxo Group Ltd |
Novel compounds
|
ES2588680T3
(es)
|
2011-03-28 |
2016-11-04 |
F. Hoffmann-La Roche Ag |
Compuestos de tiazolopirimidina
|
EP2694486B1
(en)
|
2011-04-01 |
2018-01-10 |
University of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
EP2693881B1
(en)
|
2011-04-01 |
2019-09-04 |
University of Utah Research Foundation |
Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase
|
WO2012137089A1
(en)
|
2011-04-05 |
2012-10-11 |
Pfizer Limited |
Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases
|
KR20140025500A
(ko)
|
2011-05-04 |
2014-03-04 |
머크 샤프 앤드 돔 코포레이션 |
아미노-피리딘-함유 비장 티로신 키나제 (Syk) 억제제
|
AU2012253886A1
(en)
|
2011-05-10 |
2013-10-31 |
Merck Sharp & Dohme Corp. |
Pyridyl aminopyridines as Syk inhibitors
|
EP2706852B1
(en)
|
2011-05-10 |
2018-08-22 |
Merck Sharp & Dohme Corp. |
Bipyridylaminopyridines as syk inhibitors
|
KR20140028062A
(ko)
|
2011-05-10 |
2014-03-07 |
머크 샤프 앤드 돔 코포레이션 |
Syk 억제제로서의 아미노피리미딘
|
CN103649076B
(zh)
|
2011-05-13 |
2015-09-09 |
阵列生物制药公司 |
作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
|
EP2527440A1
(en)
*
|
2011-05-27 |
2012-11-28 |
Institut Curie |
Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
|
WO2012167423A1
(en)
|
2011-06-08 |
2012-12-13 |
Hutchison Medipharma Limited |
Substituted pyridopyrazines as novel syk inhibitors
|
CN102816162B
(zh)
|
2011-06-10 |
2016-04-27 |
中国科学院广州生物医药与健康研究院 |
嘧啶并嘧啶酮类化合物及其药用组合物和应用
|
CN103814016B
(zh)
|
2011-06-10 |
2017-03-08 |
默克专利有限公司 |
生产具有btk抑制活性的嘧啶和吡啶化合物的组合物和方法
|
CN102393896B
(zh)
|
2011-07-11 |
2014-08-27 |
成都西谷曙光数字技术有限公司 |
一种简单精确的射频定位系统和方法
|
WO2013009582A1
(en)
|
2011-07-12 |
2013-01-17 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
ES2950569T3
(es)
|
2011-07-19 |
2023-10-11 |
Merck Sharp & Dohme |
(S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
JP2014522860A
(ja)
|
2011-07-19 |
2014-09-08 |
メルク・シャープ・アンド・ドーム・ベー・フェー |
Btk阻害剤としての4−イミダゾピリダジン−1−イル−ベンズアミドおよび4−イミダゾトリアジン−1−イル−ベンズアミド
|
AU2012288900B2
(en)
|
2011-07-27 |
2016-10-06 |
Ab Science |
Selective protein kinase inhibitors
|
CA2842841C
(en)
|
2011-07-27 |
2016-04-19 |
Nanjing Allgen Pharma Co. Ltd. |
Spirocyclic molecules as protein kinase inhibitors
|
KR20140071383A
(ko)
|
2011-09-01 |
2014-06-11 |
아이알엠 엘엘씨 |
C-kit 키나제 억제제로서의 화합물 및 조성물
|
US9199981B2
(en)
|
2011-09-01 |
2015-12-01 |
Novartis Ag |
Compounds and compositions as C-kit kinase inhibitors
|
CA2845169C
(en)
|
2011-09-01 |
2022-04-19 |
Irm Llc |
Compounds and compositions as c-kit kinase inhibitors
|
EP2751105A1
(en)
|
2011-09-01 |
2014-07-09 |
Irm Llc |
Compounds and compositions as c-kit kinase inhibitors
|
WO2013040515A1
(en)
|
2011-09-14 |
2013-03-21 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
WO2013047813A1
(ja)
|
2011-09-30 |
2013-04-04 |
大鵬薬品工業株式会社 |
1,2,4-トリアジン-6-カルボキサミド誘導体
|
US8987456B2
(en)
|
2011-10-05 |
2015-03-24 |
Merck Sharp & Dohme Corp. |
3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
|
WO2013052394A1
(en)
|
2011-10-05 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
WO2013052391A1
(en)
|
2011-10-05 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
UA111382C2
(uk)
|
2011-10-10 |
2016-04-25 |
Оріон Корпорейшн |
Інгібітори протеїнкінази
|
CN110801454A
(zh)
|
2011-10-19 |
2020-02-18 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶(btk)抑制剂的用途
|
RU2662443C2
(ru)
|
2011-11-01 |
2018-07-26 |
Ф. Хоффманн-Ля Рош Аг |
Имидазопиридазины
|
JP5976828B2
(ja)
|
2011-11-03 |
2016-08-24 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Btk活性阻害剤としてのアルキル化ピペラジン化合物
|
US8669251B2
(en)
|
2011-11-03 |
2014-03-11 |
Genentech, Inc. |
8-fluorophthalazin-1(2H)-one compounds
|
UA111756C2
(uk)
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
HUE033032T2
(hu)
|
2011-11-14 |
2017-11-28 |
Ignyta Inc |
Uracil-származékok mint AXL és c-MET kináz inhibitorok
|
DK2786996T3
(en)
|
2011-11-29 |
2016-12-19 |
Ono Pharmaceutical Co |
Hydrochloride PURINONDERIVAT
|
MX356401B
(es)
|
2011-12-12 |
2018-05-21 |
Dr Reddys Laboratories Ltd |
Pirazol[1,5-a]piridina sustituida como inhibidores de la cinasa del receptor de tropomiosina (trk).
|
SI2796460T1
(sl)
|
2011-12-21 |
2018-10-30 |
Jiangsu Hengrui Medicine Co. Ltd |
Pirolni šestčlenski derivat heteroarilnega obroča, postopek priprave zanj in medicinske uporabe le-tega
|
ES2661444T3
(es)
|
2011-12-28 |
2018-04-02 |
Fujifilm Corporation |
Nuevo derivado de nicotinamida o sal del mismo
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
CN104159904B
(zh)
|
2012-01-10 |
2016-12-14 |
霍夫曼-拉罗奇有限公司 |
噻吩并嘧啶化合物
|
KR20140108594A
(ko)
|
2012-01-10 |
2014-09-11 |
에프. 호프만-라 로슈 아게 |
피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도
|
CN103204844A
(zh)
|
2012-01-17 |
2013-07-17 |
上海艾力斯医药科技有限公司 |
氨基杂芳基化合物及其制备方法与应用
|
CN103204822B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途
|
RU2576384C1
(ru)
|
2012-01-19 |
2016-03-10 |
Тайхо Фармасьютикал Ко., Лтд. |
3,5-дизамещенное алкинилбензольное соединение и его соль
|
EP2804861B1
(en)
|
2012-01-20 |
2018-02-28 |
Genosco |
Substituted pyrimidine compounds and their use as syk inhibitors
|
LT2810937T
(lt)
|
2012-01-31 |
2017-02-10 |
Daiichi Sankyo Company, Limited |
Piridono darinys
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
CN104114558B
(zh)
|
2012-02-21 |
2016-10-26 |
默克专利股份公司 |
呋喃并吡啶衍生物
|
WO2013124869A2
(en)
|
2012-02-21 |
2013-08-29 |
Amrita Vishwa Vidyapeetham University |
The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations
|
CA2865040C
(en)
|
2012-02-21 |
2020-07-14 |
Merck Patent Gmbh |
Cyclic diaminopyrimidine derivatives
|
JP6479476B2
(ja)
|
2012-02-21 |
2019-03-06 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung |
SykチロシンキナーゼインヒビターおよびGCN2セリンキナーゼインヒビターとしての8−置換2−アミノー[1,2,4]トリアゾロ[1,5−A]ピラジン類
|
AR090161A1
(es)
|
2012-02-28 |
2014-10-22 |
Astellas Pharma Inc |
Derivados heterociclicos nitrogenados con accion sobre el cancer de vejiga
|
AP3834A
(en)
|
2012-03-14 |
2016-09-30 |
Lupin Ltd |
Heterocyclyl compounds
|
CN108658873B
(zh)
|
2012-03-15 |
2021-09-14 |
西建卡尔有限责任公司 |
表皮生长因子受体激酶抑制剂的固体形式
|
CN104428298B
(zh)
|
2012-03-22 |
2017-03-01 |
奥斯克技术有限公司 |
取代的吡啶并嘧啶化合物及其作为flt3抑制剂的用途
|
US9365566B2
(en)
|
2012-03-27 |
2016-06-14 |
Takeda Pharmaceutical Company Limited |
Cinnoline derivatives
|
US20150072019A1
(en)
|
2012-03-30 |
2015-03-12 |
Novartis Ag |
Fgfr inhibitor for use in the treatment of hypophosphatemic disorders
|
WO2013149581A1
(en)
|
2012-04-03 |
2013-10-10 |
Novartis Ag |
Combination products with tyrosine kinase inhibitors and their use
|
US9353062B2
(en)
|
2012-04-04 |
2016-05-31 |
Hangzhouderenyucheng Biotechnology Ltd |
Substituted quinolines as bruton's tyrosine kinases inhibitors
|
MX358311B
(es)
|
2012-04-17 |
2018-08-14 |
Fujifilm Corp |
Compuesto heterociclico que contiene nitrogeno o sal del mismo.
|
PL2838998T3
(pl)
|
2012-04-18 |
2018-04-30 |
Cell Signaling Technology, Inc. |
EGFR i ROS1 w nowotworze
|
ES2605388T3
(es)
|
2012-04-26 |
2017-03-14 |
Ono Pharmaceutical Co., Ltd. |
Compuesto inhibidor de Trk
|
CN103930425B
(zh)
|
2012-05-14 |
2016-04-27 |
华东理工大学 |
蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用
|
WO2013176970A1
(en)
|
2012-05-22 |
2013-11-28 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
US9580413B2
(en)
|
2012-05-30 |
2017-02-28 |
Nippon Shinyaku Co., Ltd. |
Substituted pyrrolidines as ROS tyrosine kinase inhibitors
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
EP3822273B1
(en)
|
2012-06-13 |
2024-04-10 |
Incyte Holdings Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
CN104349775B
(zh)
|
2012-06-14 |
2017-06-06 |
伊莱利利公司 |
Jak1和jak2的抑制剂
|
EP2863913B1
(en)
|
2012-06-20 |
2018-09-12 |
Merck Sharp & Dohme Corp. |
Imidazolyl analogs as syk inhibitors
|
EP2863914B1
(en)
|
2012-06-20 |
2018-10-03 |
Merck Sharp & Dohme Corp. |
Pyrazolyl derivatives as syk inhibitors
|
US9416111B2
(en)
|
2012-06-22 |
2016-08-16 |
Merck Sharp & Dohme Corp. |
Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
|
EP2863916B1
(en)
|
2012-06-22 |
2018-07-18 |
Merck Sharp & Dohme Corp. |
Substituted pyridine spleen tyrosine kinase (syk) inhibitors
|
TWI520962B
(zh)
|
2012-06-29 |
2016-02-11 |
|
As the c-Met tyrosine kinase inhibitors novel fused pyridine derivatives
|
CA2782774A1
(en)
|
2012-07-06 |
2014-01-06 |
Pharmascience Inc. |
Protein kinase inhibitors
|
WO2014009319A1
(en)
|
2012-07-11 |
2014-01-16 |
Boehringer Ingelheim International Gmbh |
Indolinone derivatives anticancer compounds
|
ES2618004T3
(es)
|
2012-08-07 |
2017-06-20 |
Merck Patent Gmbh |
Derivados de piridopirimidina como inhibidores de proteínas quinasas
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
EP2882741B1
(en)
|
2012-08-10 |
2018-10-24 |
Boehringer Ingelheim International GmbH |
Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
|
CN104520297B
(zh)
|
2012-08-13 |
2016-08-24 |
瑞士诺华动物保健有限公司 |
作为肾酪氨酸激酶抑制剂的双环杂芳基环烷基二胺衍生物
|
WO2014031438A2
(en)
|
2012-08-20 |
2014-02-27 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
US9334278B2
(en)
|
2012-08-21 |
2016-05-10 |
Hoffmann-La Roche Inc. |
Pyrrolo[2,3-B]pyrazines as SYK inhibitors
|
CN103122000B
(zh)
|
2012-09-03 |
2013-12-25 |
中美冠科生物技术(太仓)有限公司 |
用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
|
US9266895B2
(en)
|
2012-09-10 |
2016-02-23 |
Principia Biopharma Inc. |
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
|
EP2897950A1
(en)
|
2012-09-18 |
2015-07-29 |
Ziarco Pharma Ltd |
2-(2-aminocyclohexyl)amino-pyrimidine-5-carboxamides as spleen tyrosine kinasei(syk) inhibitors
|
CN111388478A
(zh)
|
2012-09-25 |
2020-07-10 |
中外制药株式会社 |
Ret抑制剂
|
WO2014051654A2
(en)
|
2012-09-27 |
2014-04-03 |
Portola Pharmaceuticals, Inc. |
Bicyclic oxa-lactam kinase inhibitors
|
US9586931B2
(en)
|
2012-09-28 |
2017-03-07 |
Merck Sharp & Dohme Corp. |
Triazolyl derivatives as Syk inhibitors
|
EP2903972B1
(en)
|
2012-10-04 |
2019-12-04 |
University of Utah Research Foundation |
Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors
|
CN104822663B
(zh)
|
2012-10-04 |
2017-03-08 |
犹他大学研究基金会 |
作为酪氨酸受体激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物
|
BR112015007217A2
(pt)
|
2012-10-19 |
2017-08-08 |
Hoffmann La Roche |
compostos e usos do composto
|
CN104640850A
(zh)
|
2012-10-26 |
2015-05-20 |
霍夫曼-拉罗奇有限公司 |
3,4-二取代的1h-吡唑和4,5-二取代的噻唑的syk抑制剂
|
US20150291554A1
(en)
|
2012-11-02 |
2015-10-15 |
Pfizer Inc. |
Bruton's Tyrosine Kinase Inhibitors
|
CN102977014B
(zh)
|
2012-11-05 |
2015-01-07 |
沈阳药科大学 |
新的喹啉类化合物及其用途
|
US20150284381A1
(en)
|
2012-11-07 |
2015-10-08 |
Merck Sharp & Dohme Corp. |
Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors
|
US9828360B2
(en)
|
2012-11-13 |
2017-11-28 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
WO2014078417A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
US9546156B2
(en)
|
2012-11-13 |
2017-01-17 |
Array Biopharma Inc. |
N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors
|
US9790178B2
(en)
|
2012-11-13 |
2017-10-17 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
SG11201503728XA
(en)
|
2012-11-13 |
2015-06-29 |
Array Biopharma Inc |
N-pyrrolidinyl, n'-pyrazolyl- urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014078331A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(arylalkyl)-n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014078322A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014078325A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
WO2014078408A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
CN104854107A
(zh)
|
2012-11-15 |
2015-08-19 |
药品循环公司 |
作为激酶抑制剂的吡咯并嘧啶化合物
|
CN103848810A
(zh)
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
WO2014086032A1
(en)
|
2012-12-07 |
2014-06-12 |
Hutchison Medipharma Limited |
Substituted pyridopyrazines as syk inhibitors
|
EP2931281B1
(en)
|
2012-12-12 |
2018-01-17 |
Merck Sharp & Dohme Corp. |
Amino-pyrimidine-containing spleen tyrosine kinase inhibitors
|
WO2014100314A1
(en)
|
2012-12-21 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
|
WO2014105958A2
(en)
|
2012-12-26 |
2014-07-03 |
Medivation Technologies, Inc. |
Fused pyrimidine compounds and use thereof
|
EP2940014B1
(en)
|
2012-12-28 |
2018-09-26 |
Crystalgenomics, Inc. |
2,3-dihydro-isoindole-1-on derivative as btk kinase suppressant, and pharmaceutical composition including same
|
ES2827233T3
(es)
|
2013-01-18 |
2021-05-20 |
Guangzhou Maxinovel Pharmaceuticals Co Ltd |
Compuesto heterocíclico de cinco y seis miembros, y método de preparación, composición farmacéutica y uso del mismo
|
US20140206681A1
(en)
|
2013-01-23 |
2014-07-24 |
Ronald M. Kim |
Btk inhibitors
|
WO2014113942A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2014113932A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
JP6248948B2
(ja)
|
2013-02-08 |
2017-12-20 |
日産化学工業株式会社 |
3環性ピロロピリジン化合物及びjak阻害剤
|
SG10201700808UA
(en)
|
2013-02-19 |
2017-02-27 |
Ono Pharmaceutical Co |
Trk-INHIBITING COMPOUND
|
AR094812A1
(es)
|
2013-02-20 |
2015-08-26 |
Eisai R&D Man Co Ltd |
Derivado de piridina monocíclico como inhibidor del fgfr
|
WO2014130693A1
(en)
|
2013-02-25 |
2014-08-28 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
JO3377B1
(ar)
|
2013-03-11 |
2019-03-13 |
Takeda Pharmaceuticals Co |
مشتقات بيريدينيل وبيريدينيل مندمج
|
EA025561B1
(ru)
|
2013-03-11 |
2017-01-30 |
Игнита, Инк. |
Твёрдые формы производного хиназолина и их применение в качестве ингибитора braf
|
EP2970163B1
(en)
|
2013-03-14 |
2018-02-28 |
Boehringer Ingelheim International GmbH |
5-thiazolecarboxamide dervatives and their use as btk inhibitors
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
JP6495886B2
(ja)
|
2013-03-15 |
2019-04-03 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Btk阻害剤としての複素環式芳香族化合物
|
WO2014146492A1
(en)
|
2013-03-19 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
N-(2-cyano heterocyclyl)pyrazolo pyridones as janus kinase inhibitors
|
US9617260B2
(en)
|
2013-04-02 |
2017-04-11 |
Hoffmann-La Roche Inc. |
Inhibitors of bruton's tyrosine kinase
|
TWI628176B
(zh)
|
2013-04-04 |
2018-07-01 |
奧利安公司 |
蛋白質激酶抑制劑
|
US10072298B2
(en)
*
|
2013-04-17 |
2018-09-11 |
Life Technologies Corporation |
Gene fusions and gene variants associated with cancer
|
SG10201708520YA
(en)
|
2013-04-19 |
2017-12-28 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
US9745295B2
(en)
|
2013-04-26 |
2017-08-29 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
US9499534B2
(en)
|
2013-04-26 |
2016-11-22 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
|
AU2014262326B2
(en)
|
2013-05-10 |
2018-03-22 |
Jiangsu Hansoh Pharmaceutical Co., Ltd. |
[1,2,4] triazol [4,3-a] pyridine derivate, preparation method therefor or medical application thereof
|
EP3786162B1
(en)
|
2013-05-17 |
2023-08-09 |
Incyte Holdings Corporation |
Bipyrazole derivatives as jak inhibitors
|
CN105408334B
(zh)
|
2013-05-21 |
2017-10-10 |
江苏迈度药物研发有限公司 |
作为激酶抑制剂的取代的吡唑并嘧啶类化合物
|
WO2014193932A1
(en)
|
2013-05-29 |
2014-12-04 |
Cephalon, Inc. |
Pyrrolotriazines as alk inhibitors
|
WO2014204263A1
(en)
|
2013-06-20 |
2014-12-24 |
The Asan Foundation |
Substituted pyridinone compounds as mek inhibitors
|
TW201534597A
(zh)
|
2013-06-20 |
2015-09-16 |
Ab Science |
作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物
|
MX355943B
(es)
|
2013-06-26 |
2018-05-07 |
Abbvie Inc |
Carboxamidas primarias como inhibidores de btk.
|
BR112015032539B1
(pt)
|
2013-06-28 |
2022-07-12 |
Beigene, Ltd |
Compostos ureia tricíclicos fundidos como inibidores de raf cinase e/ou dímero de raf cinase e composição farmacêutica compreendendo os referidos compostos
|
JP6458018B2
(ja)
|
2013-07-02 |
2019-01-23 |
ファーマサイクリックス エルエルシー |
キナーゼ阻害剤としてのプリノン化合物
|
TWI649308B
(zh)
|
2013-07-24 |
2019-02-01 |
小野藥品工業股份有限公司 |
喹啉衍生物
|
US10407509B2
(en)
|
2013-07-30 |
2019-09-10 |
Blueprint Medicines Corporation |
NTRK2 fusions
|
CN105814057B
(zh)
|
2013-07-31 |
2019-05-03 |
默克专利有限公司 |
用作btk抑制剂的嘧啶、吡啶和吡嗪及其用途
|
WO2015017610A1
(en)
|
2013-07-31 |
2015-02-05 |
Gilead Sciences, Inc. |
Syk inhibitors
|
JP2016527274A
(ja)
|
2013-08-02 |
2016-09-08 |
イグナイタ インコーポレイテッド |
AXL/cMET阻害剤を単独または他の薬剤と組み合わせて用いて各種がんを治療する方法
|
EP2947086B1
(en)
|
2013-08-12 |
2018-01-03 |
Taiho Pharmaceutical Co., Ltd. |
Novel fused pyrimidine compound or salt thereof
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
US20160361314A1
(en)
|
2013-08-28 |
2016-12-15 |
Novartis Ag |
Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases
|
WO2015039612A1
(zh)
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
WO2015039333A1
(en)
|
2013-09-22 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
WO2015039334A1
(en)
|
2013-09-22 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
SG11201602070TA
(en)
|
2013-09-30 |
2016-04-28 |
Beijing Synercare Pharma Tech Co Ltd |
Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
|
CR20160203A
(es)
|
2013-09-30 |
2016-08-31 |
Pharmacyclics Llc |
Inhibidores de tirosina cinasa de bruton
|
RU2641106C2
(ru)
|
2013-10-16 |
2018-01-16 |
Фуджифилм Корпорэйшн |
Соль азотсодержащего гетероциклического соединения или ее кристаллическая форма, фармацевтическая композиция и ингибитор flt3
|
AU2014340249B2
(en)
|
2013-10-21 |
2017-05-25 |
Genosco |
Substituted pyrimidine compounds and their use as SYK inhibitors
|
DK3060550T3
(da)
|
2013-10-21 |
2019-07-22 |
Merck Patent Gmbh |
Heteroarylforbindelser som btk-inhibitorer og anvendelser deraf
|
CA2927635C
(en)
|
2013-10-25 |
2021-07-20 |
Shanghai Hengrui Pharmaceutical Co., Ltd. |
Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof
|
BR112016008276B1
(pt)
|
2013-10-25 |
2021-03-02 |
Novartis Ag |
derivados bicíclicos de piridila fundidos ao anel, seus usos e seu intermediário, e composição farmacêutica
|
US9586967B2
(en)
|
2013-11-08 |
2017-03-07 |
Ono Pharmaceutical Co., Ltd. |
Pyrrolo pyrimidine derivative
|
EP3078659B1
(en)
|
2013-12-02 |
2017-11-15 |
Jenkem Technology Co., Ltd. (Beijing) |
3-furyl-2-cyano-2-acrylamide derivative, preparation method therefor, pharmaceutical composition and use thereof
|
MX2016007111A
(es)
|
2013-12-05 |
2016-08-11 |
Pharmacyclics Llc |
Inhibidores de tirosina quinasa de bruton.
|
TWI731317B
(zh)
|
2013-12-10 |
2021-06-21 |
美商健臻公司 |
原肌球蛋白相關之激酶(trk)抑制劑
|
EP3083559B1
(en)
|
2013-12-20 |
2021-03-10 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
EP3082807B1
(en)
|
2013-12-20 |
2018-07-04 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
EP3082809B1
(en)
|
2013-12-20 |
2021-01-20 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
US9834554B2
(en)
|
2013-12-20 |
2017-12-05 |
Merck Sharp & Dohme Corp. |
BTK inhibitors
|
EP3083560B1
(en)
|
2013-12-20 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
TWI662037B
(zh)
|
2013-12-23 |
2019-06-11 |
美商基利科學股份有限公司 |
脾酪胺酸激酶抑制劑
|
ES2654931T3
(es)
|
2013-12-26 |
2018-02-15 |
Ignyta, Inc. |
Derivados de pirazolo[1,5-a]piridina y procedimientos de uso de los mismos
|
WO2015116485A1
(en)
|
2014-01-29 |
2015-08-06 |
Boehringer Ingelheim International Gmbh |
Pyrazole compounds as btk inhibitors
|
CA2934989C
(en)
|
2014-02-03 |
2017-08-08 |
Cadila Healthcare Limited |
Novel heterocyclic compounds
|
JP6390626B2
(ja)
|
2014-02-04 |
2018-09-19 |
アステラス製薬株式会社 |
ジアミノヘテロ環カルボキサミド化合物を有効成分とする医薬組成物
|
KR102205354B1
(ko)
|
2014-02-27 |
2021-01-20 |
장쑤 어센테지 바이오메드 디벨롭먼트 인크. |
역형성 림프종 키나제(alk) 억제제로서의 인돌로퀴놀론 화합물
|
US9775839B2
(en)
|
2014-03-13 |
2017-10-03 |
Merck Sharp & Dohme Corp. |
2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
|
US9914735B2
(en)
|
2014-03-19 |
2018-03-13 |
Boehringer Ingelheim International Gmbh |
Heteroaryl Syk inhibitors
|
CN106414433A
(zh)
|
2014-03-24 |
2017-02-15 |
Ab科学有限公司 |
作为脾酪氨酸激酶抑制剂的二氮杂螺烷酮取代的噁唑衍生物
|
WO2015143653A1
(en)
|
2014-03-26 |
2015-10-01 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
|
WO2015143654A1
(en)
|
2014-03-26 |
2015-10-01 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
|
WO2015143652A1
(en)
|
2014-03-26 |
2015-10-01 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
|
AU2015238298B2
(en)
|
2014-03-27 |
2019-04-18 |
Janssen Pharmaceutica Nv |
Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors
|
BR112016022105B1
(pt)
|
2014-03-27 |
2023-01-31 |
Janssen Pharmaceutica Nv |
Derivados de 4,5,6,7-tetra-hidro-pirazolo[1,5- a]pirazina substituídos e derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1,4]diazepina como inibidores do ros1 e composição farmacêutica que os compreende
|
CN106458914B
(zh)
|
2014-03-28 |
2020-01-14 |
常州捷凯医药科技有限公司 |
作为axl抑制剂的杂环化合物
|
CN105017256A
(zh)
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
CN105085474B
(zh)
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
US9890165B2
(en)
|
2014-05-14 |
2018-02-13 |
Nissan Chemical Industries, Ltd. |
Tricyclic compound and JAK inhibitor
|
NZ727418A
(en)
|
2014-05-15 |
2023-03-31 |
Array Biopharma Inc |
1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
|
KR101881886B1
(ko)
|
2014-05-30 |
2018-07-25 |
베이징 피어 바이오테크놀로지 리미티드 라이어빌리티 컴페니 |
Alk 키나제 억제제, 이의 제조방법 및 이의 용도
|
CA2952787A1
(en)
|
2014-06-17 |
2015-12-23 |
Korea Research Institute Of Chemical Technology |
Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
|
WO2015200341A1
(en)
|
2014-06-23 |
2015-12-30 |
Dr. Reddy's Laboratories Ltd. |
Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
|
TWI723572B
(zh)
|
2014-07-07 |
2021-04-01 |
日商第一三共股份有限公司 |
具有四氫吡喃基甲基之吡啶酮衍生物及其用途
|
TW201617074A
(zh)
|
2014-07-14 |
2016-05-16 |
吉李德科學股份有限公司 |
Syk(脾酪胺酸激酶)抑制劑
|
AU2015296215A1
(en)
|
2014-08-01 |
2017-03-23 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
US10160727B2
(en)
|
2014-08-06 |
2018-12-25 |
Shionogi & Co., Ltd. |
Heterocycle and carbocycle derivatives having TrkA inhibitory activity
|
NO2721710T3
(es)
|
2014-08-21 |
2018-03-31 |
|
|
KR101710127B1
(ko)
|
2014-08-29 |
2017-02-27 |
한화제약주식회사 |
야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민
|
WO2016036796A1
(en)
|
2014-09-03 |
2016-03-10 |
Genzyme Corporation |
Cyclic urea compounds as tropomyosin-related kinase (trk) inhibitors
|
CN105524068B
(zh)
|
2014-09-30 |
2017-11-24 |
上海海雁医药科技有限公司 |
氮杂双环衍生物、其制法与医药上的用途
|
US20180185341A1
(en)
|
2014-10-03 |
2018-07-05 |
Novartis Ag |
Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
|
CN107001362A
(zh)
|
2014-10-06 |
2017-08-01 |
默克专利有限公司 |
用作btk抑制剂的杂芳基化合物及其用途
|
CN111171000B
(zh)
|
2014-10-11 |
2023-09-01 |
上海翰森生物医药科技有限公司 |
Egfr抑制剂及其制备和应用
|
BR112017007563A2
(pt)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
compostos atropisômeros tricíclicos
|
EP3212653A2
(en)
|
2014-10-30 |
2017-09-06 |
Sandoz AG |
Active acrylamides
|
CN105085489B
(zh)
|
2014-11-05 |
2019-03-01 |
益方生物科技(上海)有限公司 |
嘧啶或吡啶类化合物、其制备方法和医药用途
|
WO2016079763A1
(en)
|
2014-11-20 |
2016-05-26 |
Council Of Scientific & Industrial Research |
Novel benzimidazole based egfr inhibitors
|
CN105601573B
(zh)
|
2014-11-24 |
2021-07-02 |
中国科学院上海药物研究所 |
2-氨基嘧啶类化合物及其药物组合物和应用
|
SG11201704090WA
(en)
|
2014-12-11 |
2017-06-29 |
Bayer Pharma AG |
Use of pan fgfr inhibitors and method of identifying patients with cancer eligible for treatment with a pan fgfr inhibitor
|
EP3233829B1
(en)
|
2014-12-18 |
2019-08-14 |
Pfizer Inc |
Pyrimidine and triazine derivatives and their use as axl inhibitors
|
JP6708130B2
(ja)
|
2014-12-25 |
2020-06-10 |
小野薬品工業株式会社 |
キノリン誘導体
|
WO2016106628A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106626A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors
|
WO2016106624A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
WO2016106629A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106627A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106652A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Biarylether imidazopyrazine btk inhibitors
|
WO2016106623A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Benzamide imidazopyrazine btk inhibitors
|
CN104530063B
(zh)
|
2015-01-13 |
2017-01-18 |
北京赛特明强医药科技有限公司 |
喹唑啉并杂环类化合物及其制备方法和作为用于治疗癌症的表皮生长因子受体抑制剂的应用
|
CN105837576B
(zh)
|
2015-01-14 |
2019-03-26 |
湖北生物医药产业技术研究院有限公司 |
Btk抑制剂
|
UA118149C2
(uk)
|
2015-01-20 |
2018-11-26 |
Вуксі Фортуне Фармасьютікал Ко., Лтд |
Інгібітор jak
|
RU2017129757A
(ru)
|
2015-01-23 |
2019-02-25 |
ДжиВиКей БИОСАЕНСЕЗ ПРАЙВИТ ЛИМИТЕД |
ИНГИБИТОРЫ TrkA КИНАЗЫ
|
AU2016214923A1
(en)
|
2015-02-03 |
2017-08-24 |
Trillium Therapeutics Inc. |
Novel fluorinated derivatives as EGFR inhibitors useful for treating cancers
|
US10221165B2
(en)
|
2015-02-03 |
2019-03-05 |
Council Of Scientific And Industrial Research |
Flavone based EGFR inhibitors and process for preparation thereof
|
MX2017010673A
(es)
|
2015-02-20 |
2018-03-21 |
Incyte Corp |
Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr).
|
WO2016161572A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
WO2016161571A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Indazole and azaindazole btk inhibitors
|
WO2016161570A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Azacarbazole btk inhibitors
|
SG11201707638UA
(en)
|
2015-04-14 |
2017-10-30 |
Qurient Co Ltd |
Quinoline derivatives as tam rtk inhibitors
|
MX370933B
(es)
|
2015-04-29 |
2020-01-09 |
Wuxi Fortune Pharmaceuticals Co Ltd |
Inhibidores jak.
|
ES2753159T3
(es)
|
2015-05-28 |
2020-04-07 |
Theravance Biopharma R&D Ip Llc |
Compuestos de naftiridina como inhibidores de quinasa JAK
|
ES2822748T3
(es)
|
2015-05-29 |
2021-05-04 |
Wuxi Fortune Pharmaceutical Co Ltd |
Inhibidor de cinasa Janus
|
CN107709315A
(zh)
|
2015-06-02 |
2018-02-16 |
药品循环有限责任公司 |
布鲁顿酪氨酸激酶的抑制剂
|
ES2878030T3
(es)
|
2015-06-03 |
2021-11-18 |
Principia Biopharma Inc |
Inhibidores de tirosina cinasa
|
WO2016192074A1
(en)
|
2015-06-04 |
2016-12-08 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
EP3313839A1
(en)
|
2015-06-24 |
2018-05-02 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
JP6812059B2
(ja)
|
2015-07-07 |
2021-01-13 |
塩野義製薬株式会社 |
TrkA阻害活性を有する複素環誘導体
|
CN107709337B
(zh)
|
2015-07-07 |
2021-11-16 |
日本烟草产业株式会社 |
7H-吡咯并[2,3-d]嘧啶衍生物的制备方法和其中间体
|
EP3319960B1
(en)
|
2015-07-09 |
2020-11-18 |
Merck Patent GmbH |
Pyrimidine derivatives as btk inhibitors and uses thereof
|
MX2018000577A
(es)
|
2015-07-16 |
2018-09-05 |
Array Biopharma Inc |
Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la ret quinasa.
|
CN107835811B
(zh)
|
2015-07-16 |
2019-11-08 |
正大天晴药业集团股份有限公司 |
苯胺嘧啶衍生物及其用途
|
AU2016296877B2
(en)
|
2015-07-20 |
2020-09-17 |
Dana-Farber Cancer Institute, Inc. |
Novel pyrimidines as EGFR inhibitors and methods of treating disorders
|
DK3594343T3
(da)
*
|
2015-07-23 |
2021-06-28 |
Inst Curie |
Anvendelse af en kombination af dbait-molekyle og parp-inhibitorer til behandling af kræft
|
EP3327014A4
(en)
|
2015-07-24 |
2019-01-02 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. |
Egfr inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof
|
KR101766194B1
(ko)
|
2015-08-07 |
2017-08-10 |
한국과학기술연구원 |
RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물
|
CN106467541B
(zh)
|
2015-08-18 |
2019-04-05 |
暨南大学 |
取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用
|
US10214515B2
(en)
|
2015-08-20 |
2019-02-26 |
Zhejiang Hisun Pharmaceutical Co., Ltd. |
Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
|
MA41559A
(fr)
|
2015-09-08 |
2017-12-26 |
Taiho Pharmaceutical Co Ltd |
Composé de pyrimidine condensé ou un sel de celui-ci
|
CN114685516A
(zh)
|
2015-09-16 |
2022-07-01 |
洛克索肿瘤学股份有限公司 |
用于治疗癌症的作为btk抑制剂的吡唑并嘧啶衍生物
|
EP3144307A1
(en)
|
2015-09-18 |
2017-03-22 |
AB Science |
Novel oxazole derivatives that inhibit syk
|
CN106554347B
(zh)
|
2015-09-25 |
2020-10-30 |
浙江博生医药有限公司 |
Egfr激酶抑制剂及其制备方法和应用
|
WO2017059280A1
(en)
|
2015-10-02 |
2017-04-06 |
The University Of North Carolina At Chapel Hill |
Novel pan-tam inhibitors and mer/axl dual inhibitors
|
WO2017066014A1
(en)
|
2015-10-14 |
2017-04-20 |
Sunnylife Pharma Inc. |
Bruton's tyrosine kinase inhibitors
|
WO2017070708A1
(en)
|
2015-10-23 |
2017-04-27 |
Array Biopharma, Inc. |
2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases
|
MY195427A
(en)
|
2015-11-03 |
2023-01-20 |
Theravance Biopharma R&D Ip Llc |
Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease
|
CN106699743B
(zh)
|
2015-11-05 |
2020-06-12 |
湖北生物医药产业技术研究院有限公司 |
嘧啶类衍生物及其用途
|
EP3371189A1
(en)
|
2015-11-06 |
2018-09-12 |
Acerta Pharma B.V. |
Imidazopyrazine inhibitors of bruton's tyrosine kinase
|
MX2018006195A
(es)
|
2015-11-19 |
2018-09-05 |
Blueprint Medicines Corp |
Compuestos y composiciones utiles para el tratamiento de trastornos relacionados con ntrk.
|
ES2784523T3
(es)
|
2015-11-24 |
2020-09-28 |
Theravance Biopharma R&D Ip Llc |
Profármacos de un compuesto inhibidor de JAK para el tratamiento de enfermedades inflamatorias gastrointestinales
|
DK3360878T3
(da)
|
2015-12-11 |
2020-11-09 |
Sichuan Kelun Biotech Biopharmaceutica Co Ltd |
Azetidinderivat, fremstillingsfremgangsmåde derfor og anvendelse deraf
|
PL3390390T3
(pl)
|
2015-12-16 |
2022-01-24 |
Boehringer Ingelheim International Gmbh |
Pochodne bipirazolilu przydatne w leczeniu chorób autoimmunologicznych
|
CN106928231B
(zh)
|
2015-12-31 |
2021-06-01 |
合肥中科普瑞昇生物医药科技有限公司 |
一类新型的egfr野生型和突变型的激酶抑制剂
|
AU2017204973A1
(en)
|
2016-01-06 |
2018-07-12 |
Trillium Therapeutics Inc. |
Novel fluorinated quinazoline derivatives as EGFR inhibitors
|
ES2898882T3
(es)
|
2016-01-11 |
2022-03-09 |
Merck Patent Gmbh |
Derivados de quinolin-2-ona
|
JP6916185B2
(ja)
|
2016-01-13 |
2021-08-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Btk阻害剤としてのイソキノロン類
|
WO2017127371A1
(en)
|
2016-01-21 |
2017-07-27 |
Sunnylife Pharma Inc. |
Bruton's tyrosine kinase inhibitors
|
JP6770580B2
(ja)
|
2016-01-26 |
2020-10-14 |
杭州華東医薬集団生物医薬有限公司Hangzhou Huadong Medicine Group Biopharmaceutical Co., Ltd. |
ピロロピリミジン5員環アザ環状誘導体およびその利用
|
CN107021963A
(zh)
|
2016-01-29 |
2017-08-08 |
北京诺诚健华医药科技有限公司 |
吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用
|
WO2017135399A1
(ja)
|
2016-02-04 |
2017-08-10 |
塩野義製薬株式会社 |
TrkA阻害活性を有する含窒素複素環および炭素環誘導体
|
CN107530348B
(zh)
|
2016-02-19 |
2020-10-20 |
江苏恒瑞医药股份有限公司 |
一种含有jak激酶抑制剂或其可药用盐的药物组合物
|
MD3269370T2
(ro)
|
2016-02-23 |
2020-05-31 |
Taiho Pharmaceutical Co Ltd |
Compus pirimidinic condensat nou sau sare a acestuia
|
US10821128B2
(en)
*
|
2016-03-01 |
2020-11-03 |
Onxeo |
Treatment of cancer by systemic administration of Dbait molecules
|
CN107151249B
(zh)
|
2016-03-04 |
2020-08-14 |
华东理工大学 |
作为flt3抑制剂的蝶啶酮衍生物及应用
|
US10183928B2
(en)
|
2016-03-17 |
2019-01-22 |
Blueprint Medicines Corporation |
Inhibitors of RET
|
CN107286077B
(zh)
|
2016-04-01 |
2021-04-02 |
合肥中科普瑞昇生物医药科技有限公司 |
一种选择性的c-kit激酶抑制剂
|
CA3021558A1
(en)
|
2016-04-29 |
2017-11-02 |
X-Chem, Inc. |
Covalent btk inhibitors and uses thereof
|
EP3464275B1
(en)
|
2016-05-26 |
2024-05-08 |
Recurium IP Holdings, LLC |
Egfr inhibitor compounds
|
CN107759600A
(zh)
|
2016-06-16 |
2018-03-06 |
正大天晴药业集团股份有限公司 |
作为jak抑制剂的吡咯并嘧啶化合物的结晶
|
EP3476848A4
(en)
|
2016-06-27 |
2020-01-15 |
Hangzhou Rex Pharmaceutical Co., Ltd |
BENZOFURANE-PYRAZOLE-AMINE PROTEIN KINASE INHIBITOR
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
JP6715357B2
(ja)
|
2016-06-30 |
2020-07-01 |
杭州三因泰医薬科技有限公司Hangzhou Sanyintai Pharmaceutical Technology Co., Ltd. |
イミダゾピリジンアミンフェニル誘導体およびその使用
|
ES2965081T3
(es)
|
2016-07-07 |
2024-04-11 |
Daewoong Pharmaceutical Co Ltd |
Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados
|
CN107619388A
(zh)
|
2016-07-13 |
2018-01-23 |
南京天印健华医药科技有限公司 |
作为fgfr抑制剂的杂环化合物
|
US10227329B2
(en)
|
2016-07-22 |
2019-03-12 |
Blueprint Medicines Corporation |
Compounds useful for treating disorders related to RET
|
US10035789B2
(en)
|
2016-07-27 |
2018-07-31 |
Blueprint Medicines Corporation |
Compounds useful for treating disorders related to RET
|
CN107698593A
(zh)
|
2016-08-09 |
2018-02-16 |
南京天印健华医药科技有限公司 |
作为fgfr抑制剂的杂环化合物
|
CA3034239A1
(en)
|
2016-08-16 |
2018-02-22 |
Merck Patent Gmbh |
2-oxo-imidazopyridines as reversible btk inhibitors and uses thereof
|
EP4001273A3
(en)
|
2016-08-29 |
2022-08-24 |
The Regents Of The University Of Michigan |
Aminopyrimidines as alk inhibitors
|
EP3512519A1
(en)
|
2016-09-14 |
2019-07-24 |
Gilead Sciences, Inc. |
Syk inhibitors
|
TW201822764A
(zh)
|
2016-09-14 |
2018-07-01 |
美商基利科學股份有限公司 |
Syk抑制劑
|
CN107840846B
(zh)
|
2016-09-19 |
2020-11-24 |
郑州泰基鸿诺医药股份有限公司 |
一种含嘧啶环的化合物、egfr抑制剂及其应用
|
CN107840842A
(zh)
|
2016-09-19 |
2018-03-27 |
北京天诚医药科技有限公司 |
炔代杂环化合物、其制备方法及其在医药学上的应用
|
JP2018052878A
(ja)
|
2016-09-29 |
2018-04-05 |
第一三共株式会社 |
ピリジン化合物
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
TWI704148B
(zh)
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
WO2018079759A1
(ja)
|
2016-10-31 |
2018-05-03 |
塩野義製薬株式会社 |
TrkA阻害活性を有する縮合複素環および縮合炭素環誘導体
|
KR20180051220A
(ko)
|
2016-11-08 |
2018-05-16 |
주식회사 대웅제약 |
신규한 피롤로피리미딘 유도체 및 이를 포함하는 약학적 조성물
|
EP3543239A1
(en)
|
2016-11-15 |
2019-09-25 |
Hangzhou Hertz Pharmaceutical Co., Ltd. |
Selective bruton's tyrosine kinase inhibitor and use thereof
|
JP2020500194A
(ja)
|
2016-11-18 |
2020-01-09 |
ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン |
Alk阻害物質としての5,6−ジヒドロ−11h−インドロ[2,3−b]キノリン−11−オン
|
CN108101905A
(zh)
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
EP3553065A4
(en)
|
2016-12-12 |
2020-07-01 |
Hangzhou Innogate Pharma Co., Ltd. |
HETEROCYCLIC CONNECTION AS A SYK INHIBITOR AND / OR SYK-HDAC DOUBLE INHIBITOR
|
WO2018108064A1
(zh)
|
2016-12-13 |
2018-06-21 |
南京明德新药研发股份有限公司 |
作为第四代egfr激酶抑制剂的螺环芳基磷氧化合物
|
EA201991198A1
(ru)
|
2016-12-15 |
2020-01-13 |
Ариад Фармасьютикалз, Инк. |
АМИНОТИАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ c-Kit
|
MX2019007080A
(es)
|
2016-12-15 |
2019-10-15 |
Ariad Pharma Inc |
Compuestos de benzimidazol como inhibidores de c-kit.
|
CN108250200A
(zh)
|
2016-12-28 |
2018-07-06 |
中国科学院上海药物研究所 |
一种具有Axl抑制活性的化合物及其制备和应用
|
WO2018121650A1
(zh)
|
2016-12-29 |
2018-07-05 |
南京明德新药研发股份有限公司 |
Fgfr抑制剂
|
JP7053665B2
(ja)
|
2016-12-30 |
2022-04-12 |
南京明徳新薬研発有限公司 |
Egfr阻害としてのキナゾリン系化合物
|
CN108276410B
(zh)
|
2017-01-06 |
2021-12-10 |
首药控股(北京)股份有限公司 |
一种间变性淋巴瘤激酶抑制剂及其制备方法和用途
|
WO2018129645A1
(en)
|
2017-01-10 |
2018-07-19 |
Wang, Wei |
Lasofoxifene modulation of membrane-initiated estrogen signals and methods for tumor treatment
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
EP3571203B1
(en)
|
2017-01-18 |
2023-06-07 |
Array BioPharma Inc. |
Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors
|
CN106831787B
(zh)
|
2017-01-20 |
2018-10-23 |
成都倍特药业有限公司 |
用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用
|
CN110072865B
(zh)
|
2017-02-08 |
2022-02-11 |
中国医药研究开发中心有限公司 |
吡咯并芳杂环类化合物及其制备方法和医药用途
|
US10464923B2
(en)
|
2017-02-27 |
2019-11-05 |
Merck Patent Gmbh |
Crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-piperidin-1-yl)-propenone
|
WO2018153293A1
(zh)
|
2017-02-27 |
2018-08-30 |
北京赛特明强医药科技有限公司 |
二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用
|
CN110382499B
(zh)
|
2017-02-27 |
2023-01-03 |
贝达药业股份有限公司 |
Fgfr抑制剂及其应用
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
AU2018237123B2
(en)
|
2017-03-22 |
2022-08-04 |
Xibin Liao |
Bruton's tyrosine kinase inhibitors
|
WO2018187355A1
(en)
|
2017-04-03 |
2018-10-11 |
Health Research Inc. |
Met kinase inhibitors and uses therefor
|
CN108721298A
(zh)
|
2017-04-19 |
2018-11-02 |
华东理工大学 |
作为布鲁顿酪氨酸激酶抑制剂的嘧啶并杂环化合物及其应用
|
CN108727382B
(zh)
|
2017-04-19 |
2022-07-19 |
华东理工大学 |
作为btk抑制剂的杂环化合物及其应用
|
CN107043366B
(zh)
|
2017-04-25 |
2020-05-26 |
中国药科大学 |
4-氨基嘧啶类化合物、其制备方法及医药用途
|
CA3061302A1
(en)
|
2017-04-27 |
2019-10-23 |
Mochida Pharmaceutical Co., Ltd. |
Novel tetrahydronaphthyl urea derivative
|
AR111495A1
(es)
|
2017-05-01 |
2019-07-17 |
Theravance Biopharma R&D Ip Llc |
Compuestos de imidazo-piperidina fusionada como inhibidores de jak
|
WO2018208132A1
(en)
|
2017-05-12 |
2018-11-15 |
Korea Research Institute Of Chemical Technology |
Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
|
RU2769696C2
(ru)
|
2017-05-22 |
2022-04-05 |
Ф. Хоффманн-Ля Рош Аг |
Терапевтические соединения и композиции и способы их применения
|
TW201900648A
(zh)
|
2017-05-22 |
2019-01-01 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及組成物以及其使用方法
|
CN107176954B
(zh)
|
2017-06-02 |
2019-01-11 |
无锡双良生物科技有限公司 |
一种egfr抑制剂的药用盐及其晶型、制备方法和应用
|
WO2018228475A1
(zh)
|
2017-06-14 |
2018-12-20 |
正大天晴药业集团股份有限公司 |
Syk抑制剂及其使用方法
|
CN109111446B
(zh)
|
2017-06-22 |
2021-11-30 |
上海度德医药科技有限公司 |
一种具有药物活性的杂芳基化合物
|
EP3645526A4
(en)
|
2017-06-27 |
2020-10-28 |
Janssen Pharmaceutica NV |
NEW QUINOLEINONE COMPOUNDS
|
KR20200028966A
(ko)
|
2017-07-05 |
2020-03-17 |
씨에스 파마테크 리미티드 |
Efgr 티로신 키나제의 임상적으로 중요한 돌연변이체의 선택적 억제제
|
US11377449B2
(en)
|
2017-08-12 |
2022-07-05 |
Beigene, Ltd. |
BTK inhibitors with improved dual selectivity
|
JP7341122B2
(ja)
|
2017-08-15 |
2023-09-08 |
石薬集団中奇制薬技術(石家庄)有限公司 |
Fgfr阻害剤及びその医薬品の用途
|
WO2019034075A1
(zh)
|
2017-08-15 |
2019-02-21 |
南京明德新药研发股份有限公司 |
Fgfr和egfr抑制剂
|
CN109400610A
(zh)
|
2017-08-18 |
2019-03-01 |
浙江海正药业股份有限公司 |
吡咯并三嗪类衍生物、其制备方法及其在医药上的用途
|
KR20200041954A
(ko)
|
2017-08-18 |
2020-04-22 |
북경한미약품 유한공사 |
화합물, 이의 약제학적 조성물, 및 이의 용도 및 응용
|
EP3668867B1
(en)
|
2017-08-18 |
2023-10-04 |
Universität Regensburg |
Synthesis, pharmacology and use of new and selective fms-like tyrosine kinase 3 (flt3) flt3 inhibitors
|