CO2022004513A2 - Compuestos inhibidores de prmt5 mta–cooperativos - Google Patents

Compuestos inhibidores de prmt5 mta–cooperativos

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Publication number
CO2022004513A2
CO2022004513A2 CONC2022/0004513A CO2022004513A CO2022004513A2 CO 2022004513 A2 CO2022004513 A2 CO 2022004513A2 CO 2022004513 A CO2022004513 A CO 2022004513A CO 2022004513 A2 CO2022004513 A2 CO 2022004513A2
Authority
CO
Colombia
Prior art keywords
prmt5
mta
cooperatives
inhibitory compounds
compounds
Prior art date
Application number
CONC2022/0004513A
Other languages
English (en)
Inventor
Thomas P Bobinski
Christopher Ronald Smith
Matthew Arnold Marx
John Michael Ketcham
Aaron Craig Burns
John David Lawson
Svitlana Kulyk
Jon Kuehler
Anthony Ivetac
Original Assignee
Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of CO2022004513A2 publication Critical patent/CO2022004513A2/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)

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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a compuestos que inhiben la actividad de la proteína arginina N–metil transferasa 5 (PRMT5). En particular, la presente invención se refiere a compuestos, composiciones farmacéuticas y métodos de uso, tales como métodos para tratar el cáncer, utilizando los compuestos y las composiciones farmacéuticas de la presente invención.
CONC2022/0004513A 2019-09-12 2022-04-08 Compuestos inhibidores de prmt5 mta–cooperativos CO2022004513A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962899575P 2019-09-12 2019-09-12
US201962942833P 2019-12-03 2019-12-03
US202062961371P 2020-01-15 2020-01-15
US202062994927P 2020-03-26 2020-03-26
US202063060261P 2020-08-03 2020-08-03
PCT/US2020/050457 WO2021050915A1 (en) 2019-09-12 2020-09-11 Mta-cooperative prmt5 inhibitors

Publications (1)

Publication Number Publication Date
CO2022004513A2 true CO2022004513A2 (es) 2022-06-21

Family

ID=72659905

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0004513A CO2022004513A2 (es) 2019-09-12 2022-04-08 Compuestos inhibidores de prmt5 mta–cooperativos

Country Status (15)

Country Link
US (3) US11479551B2 (es)
EP (1) EP4028388A1 (es)
JP (1) JP2022548255A (es)
KR (1) KR20220083691A (es)
CN (1) CN114728912A (es)
AU (1) AU2020345899A1 (es)
BR (1) BR112022004248A2 (es)
CA (1) CA3150515A1 (es)
CL (1) CL2022000603A1 (es)
CO (1) CO2022004513A2 (es)
IL (1) IL290341A (es)
MX (1) MX2022002938A (es)
NO (1) NO20220309A1 (es)
TW (1) TW202122387A (es)
WO (1) WO2021050915A1 (es)

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WO2022192745A1 (en) * 2021-03-11 2022-09-15 Mirati Therapeutics, Inc. Mta-cooperative prmt5 inhibitors
KR20230167053A (ko) 2021-04-08 2023-12-07 미라티 테라퓨틱스, 인크. 암 치료를 위해 prmt5 저해제를 사용하는 병용 요법
KR20230167050A (ko) 2021-04-08 2023-12-07 미라티 테라퓨틱스, 인크. 암 치료를 위해 prmt5 저해제를 사용하는 병용 요법
KR20240019172A (ko) * 2021-06-02 2024-02-14 아이디어야 바이오사이언시스 인코포레이티드 Mat2a 억제제 및 유형 ii prmt 억제제를 포함하는 병용 요법
WO2023059798A1 (en) 2021-10-06 2023-04-13 Mirati Therapeutics, Inc. Methods for separation of enantiomers
CA3233157A1 (en) 2021-10-06 2023-04-13 Peter Olson Combination therapies using prmt5 inhibitors for the treatment of cancer
WO2023081367A2 (en) 2021-11-05 2023-05-11 Mirati Therapeutics, Inc. 2-amino imidazole derivatives
AU2022401750A1 (en) * 2021-11-30 2024-02-15 Abbisko Therapeutics Co., Ltd. Pyrazole derivative, and preparation method therefor and use thereof in medicine
WO2023125540A1 (zh) * 2021-12-27 2023-07-06 南京明德新药研发有限公司 吡唑-1(2h)-酞嗪酮类化合物及其应用
CN114315735B (zh) * 2021-12-29 2023-08-01 广州中医药大学(广州中医药研究院) 一种鲁米诺酯化衍生物及其制备方法与应用
CN116903611A (zh) * 2022-01-26 2023-10-20 上海优理惠生医药有限公司 一种酞嗪酮类化合物、其制备方法、包含其药物组合物及其应用
WO2023174250A1 (en) * 2022-03-15 2023-09-21 Beigene , Ltd. 4- (aminomethyl) -6- (1-methyl-1h-pyrazol-4-yl) isoquinolin-1 (2h) -one derivatives as mta-cooperative inhibitors of prmt5
WO2023202626A1 (zh) * 2022-04-22 2023-10-26 北京望实智慧科技有限公司 稠和哒嗪酮化合物作为prmt5抑制剂
CN117843634A (zh) * 2022-05-24 2024-04-09 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
WO2024008176A1 (zh) * 2022-07-07 2024-01-11 西藏海思科制药有限公司 一种可抑制prmt5·mta的杂环化合物及其用途
CN117430596A (zh) * 2022-07-13 2024-01-23 上海海和药物研究开发股份有限公司 二并环类mat2a抑制剂及其用途
WO2024022186A1 (zh) * 2022-07-29 2024-02-01 四川科伦博泰生物医药股份有限公司 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途
WO2024027703A1 (zh) * 2022-08-02 2024-02-08 上海艾力斯医药科技股份有限公司 一种prmt5抑制剂、其制备方法及应用
WO2024038004A1 (en) 2022-08-15 2024-02-22 Astrazeneca Ab Mta-cooperative prmt5 inhibitors for use in the treatment of cancer
WO2024049948A1 (en) 2022-09-01 2024-03-07 Mirati Therapeutics, Inc. Combination therapies using prmt5 inhibitors and bcl-2 family inhibitors for the treatment of cancer

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ES2287170T3 (es) * 2000-10-12 2007-12-16 MERCK & CO., INC. Aza- y poliaza-naftalenil-carboxamidas utilies como inhibidores de la vih integrasa.
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GB201604027D0 (en) 2016-03-09 2016-04-20 Ctxt Pty Ltd Compounds

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NO20220309A1 (en) 2022-03-11
CL2022000603A1 (es) 2023-01-27
US11479551B2 (en) 2022-10-25
EP4028388A1 (en) 2022-07-20
KR20220083691A (ko) 2022-06-20
WO2021050915A1 (en) 2021-03-18
JP2022548255A (ja) 2022-11-17
US20230054883A1 (en) 2023-02-23
US20210078994A1 (en) 2021-03-18
BR112022004248A2 (pt) 2022-05-31
CA3150515A1 (en) 2021-03-18
CN114728912A (zh) 2022-07-08
IL290341A (en) 2022-04-01
US20210079003A1 (en) 2021-03-18

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