ECSP22016567A - Compuestos inhibidores de rip1 y m?todos para prepararlos y usarlos - Google Patents

Compuestos inhibidores de rip1 y m?todos para prepararlos y usarlos

Info

Publication number
ECSP22016567A
ECSP22016567A ECSENADI202216567A ECDI202216567A ECSP22016567A EC SP22016567 A ECSP22016567 A EC SP22016567A EC SENADI202216567 A ECSENADI202216567 A EC SENADI202216567A EC DI202216567 A ECDI202216567 A EC DI202216567A EC SP22016567 A ECSP22016567 A EC SP22016567A
Authority
EC
Ecuador
Prior art keywords
inhibitor compounds
rip1
preparing
methods
compounds
Prior art date
Application number
ECSENADI202216567A
Other languages
English (en)
Inventor
Zhushou Luo
Vanessa Taylor
Simon Shaw
Ihab Darwish
Somasekhar Bhamidipati
Yan Chen
Jiaxin Yu
Rao Kolluri
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of ECSP22016567A publication Critical patent/ECSP22016567A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente descripci?n se describen compuestos inhibidores de quinasa, tales como compuestos inhibidores de quinasa de prote?na 1 que interact?a con el receptor (RIP1), as? como tambi?n composiciones farmac?uticas y combinaciones que comprenden tales compuestos inhibidores. Los compuestos, composiciones farmac?uticas y/o combinaciones descritos pueden usarse para tratar o prevenir una enfermedad o afecci?n asociada a la quinasa, particularmente una enfermedad o afecci?n asociada a RIP1.
ECSENADI202216567A 2019-09-06 2022-03-04 Compuestos inhibidores de rip1 y m?todos para prepararlos y usarlos ECSP22016567A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962897223P 2019-09-06 2019-09-06
US201962932404P 2019-11-07 2019-11-07
US202063001016P 2020-03-27 2020-03-27
US202063004319P 2020-04-02 2020-04-02
US202063004290P 2020-04-02 2020-04-02

Publications (1)

Publication Number Publication Date
ECSP22016567A true ECSP22016567A (es) 2022-08-31

Family

ID=72613994

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202216567A ECSP22016567A (es) 2019-09-06 2022-03-04 Compuestos inhibidores de rip1 y m?todos para prepararlos y usarlos

Country Status (18)

Country Link
US (1) US11564930B2 (es)
EP (1) EP4025575A1 (es)
JP (2) JP7493586B2 (es)
KR (1) KR20220042206A (es)
CN (1) CN114728958A (es)
AU (1) AU2020341708B2 (es)
BR (1) BR112022002378A2 (es)
CA (1) CA3149729A1 (es)
CO (1) CO2022002374A2 (es)
CR (1) CR20220075A (es)
DO (1) DOP2022000042A (es)
EC (1) ECSP22016567A (es)
IL (1) IL290781A (es)
JO (1) JOP20220056A1 (es)
MX (1) MX2022002717A (es)
PE (1) PE20221762A1 (es)
TW (1) TW202122397A (es)
WO (1) WO2021046437A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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DK3788045T3 (da) 2018-05-03 2023-06-26 Rigel Pharmaceuticals Inc RIP1-hæmmende forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
JOP20220056A1 (ar) 2019-09-06 2023-01-30 Rigel Pharmaceuticals Inc مركبات rip1 تثبيطية وطرق عملها واستخدامها
JP7443495B2 (ja) 2019-09-06 2024-03-05 ライジェル ファーマシューティカルズ， インコーポレイテッド ヘテロ環式ｒｉｐ１キナーゼ阻害剤
AR122703A1 (es) 2020-07-01 2022-09-28 Rigel Pharmaceuticals Inc Inhibidores de rip1k
CN115867557A (zh) * 2021-05-14 2023-03-28 中国医药研究开发中心有限公司 氮杂卓类稠环化合物及其医药用途
CN117460731A (zh) * 2021-06-11 2024-01-26 劲方医药科技(上海)有限公司 杂环内酰胺类化合物，其制法与医药上的用途
CN116478150A (zh) * 2022-01-21 2023-07-25 中国科学院上海药物研究所 具有ripk1抑制活性的化合物、其制备方法及其用途
CN115201250B (zh) * 2022-09-14 2022-11-25 中铁三局集团第三工程有限公司 一种冷再生沥青混合料热可逆老化程度的量化方法

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JOP20220056A1 (ar) 2019-09-06 2023-01-30 Rigel Pharmaceuticals Inc مركبات rip1 تثبيطية وطرق عملها واستخدامها
JP7443495B2 (ja) 2019-09-06 2024-03-05 ライジェル ファーマシューティカルズ， インコーポレイテッド ヘテロ環式ｒｉｐ１キナーゼ阻害剤
AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k

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Publication number Publication date
IL290781A (en) 2022-04-01
CA3149729A1 (en) 2021-03-11
PE20221762A1 (es) 2022-11-11
JP2022546605A (ja) 2022-11-04
JOP20220056A1 (ar) 2023-01-30
US11564930B2 (en) 2023-01-31
AU2020341708B2 (en) 2024-01-04
MX2022002717A (es) 2022-08-10
CR20220075A (es) 2022-07-14
CN114728958A (zh) 2022-07-08
JP7493586B2 (ja) 2024-05-31
CO2022002374A2 (es) 2022-08-09
US20210069208A1 (en) 2021-03-11
JP2024050568A (ja) 2024-04-10
DOP2022000042A (es) 2022-08-15
TW202122397A (zh) 2021-06-16
AU2020341708A1 (en) 2022-03-17
WO2021046437A1 (en) 2021-03-11
EP4025575A1 (en) 2022-07-13
BR112022002378A2 (pt) 2022-06-14
KR20220042206A (ko) 2022-04-04

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