PT3788044T - Compostos inibidores de rip1 e métodos para preparar e usar os mesmos - Google Patents
Compostos inibidores de rip1 e métodos para preparar e usar os mesmosInfo
- Publication number
- PT3788044T PT3788044T PT197240484T PT19724048T PT3788044T PT 3788044 T PT3788044 T PT 3788044T PT 197240484 T PT197240484 T PT 197240484T PT 19724048 T PT19724048 T PT 19724048T PT 3788044 T PT3788044 T PT 3788044T
- Authority
- PT
- Portugal
- Prior art keywords
- making
- methods
- same
- inhibitory compounds
- rip1
- Prior art date
Links
- 102100021559 KRR1 small subunit processome component homolog Human genes 0.000 title 1
- 101100301091 Mus musculus Ralbp1 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862666462P | 2018-05-03 | 2018-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3788044T true PT3788044T (pt) | 2023-08-31 |
Family
ID=66530556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT197240484T PT3788044T (pt) | 2018-05-03 | 2019-05-02 | Compostos inibidores de rip1 e métodos para preparar e usar os mesmos |
Country Status (36)
| Country | Link |
|---|---|
| US (7) | US10815206B2 (pt) |
| EP (2) | EP4248975A3 (pt) |
| JP (4) | JP2021523226A (pt) |
| KR (1) | KR20210005222A (pt) |
| CN (1) | CN112368278A (pt) |
| AU (2) | AU2019262144B2 (pt) |
| BR (1) | BR112020022420A2 (pt) |
| CA (1) | CA3099037A1 (pt) |
| CL (1) | CL2020002841A1 (pt) |
| CO (1) | CO2020015156A2 (pt) |
| CR (1) | CR20200581A (pt) |
| DK (1) | DK3788044T3 (pt) |
| DO (2) | DOP2020000198A (pt) |
| EA (1) | EA202092580A1 (pt) |
| EC (1) | ECSP20078326A (pt) |
| ES (1) | ES2956087T3 (pt) |
| FI (1) | FI3788044T3 (pt) |
| HR (1) | HRP20231381T1 (pt) |
| HU (1) | HUE063896T2 (pt) |
| IL (2) | IL278417B2 (pt) |
| JO (1) | JOP20200278A1 (pt) |
| LT (1) | LT3788044T (pt) |
| MA (1) | MA52488B1 (pt) |
| MD (1) | MD3788044T2 (pt) |
| MX (1) | MX2020011621A (pt) |
| PE (1) | PE20211383A1 (pt) |
| PH (1) | PH12020551847A1 (pt) |
| PL (1) | PL3788044T3 (pt) |
| PT (1) | PT3788044T (pt) |
| RS (1) | RS64736B1 (pt) |
| SA (1) | SA520420468B1 (pt) |
| SG (1) | SG11202010915XA (pt) |
| SI (1) | SI3788044T1 (pt) |
| UA (1) | UA128369C2 (pt) |
| WO (1) | WO2019213447A1 (pt) |
| ZA (2) | ZA202007486B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS64736B1 (sr) | 2018-05-03 | 2023-11-30 | Rigel Pharmaceuticals Inc | Jedinjenja inhibitori rip1 i postupci za njihovo dobijanje i upotrebu |
| HRP20230909T1 (hr) | 2018-05-03 | 2023-12-08 | Rigel Pharmaceuticals, Inc. | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu |
| CN111138448B (zh) * | 2018-11-02 | 2022-08-02 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2020088194A1 (zh) * | 2018-11-02 | 2020-05-07 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| US20210040115A1 (en) * | 2019-08-09 | 2021-02-11 | Bisichem Co., Ltd. | Fused ring heteroaryl compounds as ripk1 inhibitors |
| MX2022002717A (es) * | 2019-09-06 | 2022-08-10 | Rigel Pharmaceuticals Inc | Compuestos inhibidores de rip1 y metodos para prepararlos y usarlos. |
| WO2021046447A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 kinase inhibitors |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| MX2022003671A (es) | 2019-09-27 | 2022-04-25 | Univ Texas | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. |
| CN113015974B (zh) * | 2019-10-21 | 2024-05-28 | 谷歌有限责任公司 | 针对隐私保护的可验证同意 |
| JP7395730B2 (ja) | 2019-11-07 | 2023-12-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ヘテロ環式ｒｉｐ１阻害化合物 |
| BR112022010082A2 (pt) * | 2019-11-26 | 2022-08-30 | Univ Texas | Composto de fórmula estrutural i ou sal do mesmo, composição farmacêutica, uso do composto e uso da composição farmacêutica |
| CA3169099A1 (en) * | 2020-02-28 | 2021-09-02 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| TWI824259B (zh) | 2020-07-01 | 2023-12-01 | 美商雷傑製藥公司 | Rip1k抑制劑 |
| WO2022171111A1 (en) * | 2021-02-10 | 2022-08-18 | Zai Lab (Us) Llc | Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof |
| CN114989156B (zh) * | 2021-05-19 | 2024-07-05 | 成都贝诺科成生物科技有限公司 | 一种受体相互作用蛋白抑制剂及其制备方法和用途 |
| BR112023025850A2 (pt) | 2021-08-10 | 2024-03-05 | Abbvie Inc | Inibidores da nicotinamida ripk1 |
| CN118510774A (zh) | 2021-12-16 | 2024-08-16 | 里格尔药品股份有限公司 | Ripk1抑制剂的结晶形式 |
| WO2023138317A1 (zh) * | 2022-01-21 | 2023-07-27 | 中国科学院上海药物研究所 | 具有ripk1抑制活性的化合物、其制备方法及其用途 |
| CN114736197B (zh) * | 2022-06-13 | 2022-09-13 | 南京医工医药技术有限公司 | 咪唑啉酮衍生物及其用途 |
| CN115353513A (zh) * | 2022-07-29 | 2022-11-18 | 中国人民解放军海军军医大学 | 一种抑制程序性细胞坏死的硫代七元环衍生物及其应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| ATE107176T1 (de) | 1989-12-04 | 1994-07-15 | Searle & Co | System zur transdermalen albuterol applikation. |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| EP0495421B1 (en) | 1991-01-15 | 1996-08-21 | Alcon Laboratories, Inc. | Use of carrageenans in topical ophthalmic compositions |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| CA2123809A1 (en) | 1991-12-18 | 1993-06-24 | Debra L. Wilfong | Multilayered barrier structures |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| EP2192838A4 (en) | 2007-08-15 | 2011-07-27 | Harvard College | HETEROCYCLIC NEKROPTOSIS HEMMER |
| TWI648273B (zh) | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類（三） |
| EP2968276A4 (en) | 2013-03-15 | 2017-02-15 | President and Fellows of Harvard College | Hybrid necroptosis inhibitors |
| WO2016027253A1 (en) * | 2014-08-21 | 2016-02-25 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
| WO2016128936A1 (en) | 2015-02-13 | 2016-08-18 | Glaxosmithkline Intellectual Property Development Limited | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide |
| CN112979660A (zh) * | 2015-07-02 | 2021-06-18 | 豪夫迈·罗氏有限公司 | 二环内酰胺和其应用方法 |
| PL3362449T3 (pl) | 2015-10-13 | 2021-12-13 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Pochodne sybiriliny do zastosowania do zapobiegania i/lub leczenia zaburzeń związanych z nekroptozą komórkową |
| EP3366684B1 (en) | 2015-10-23 | 2020-09-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2017109724A1 (en) | 2015-12-21 | 2017-06-29 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| CN109071504B (zh) | 2016-02-05 | 2022-03-08 | 戴纳立制药公司 | 受体相互作用蛋白激酶1的抑制剂 |
| EP3526219B1 (en) * | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclic pyridone lactams and methods of use thereof |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| CN110573504A (zh) | 2017-02-27 | 2019-12-13 | 葛兰素史克知识产权开发有限公司 | 作为激酶抑制剂的杂环酰胺 |
| RS64736B1 (sr) * | 2018-05-03 | 2023-11-30 | Rigel Pharmaceuticals Inc | Jedinjenja inhibitori rip1 i postupci za njihovo dobijanje i upotrebu |
| HRP20230909T1 (hr) * | 2018-05-03 | 2023-12-08 | Rigel Pharmaceuticals, Inc. | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu |
| TW202019913A (zh) | 2018-06-26 | 2020-06-01 | 中國科學院上海有機化學研究所 | 細胞壞死抑制劑及其製備方法和用途 |
| CN111138448B (zh) | 2018-11-02 | 2022-08-02 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2020088194A1 (zh) | 2018-11-02 | 2020-05-07 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2021046447A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 kinase inhibitors |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
-
2019
- 2019-05-02 RS RS20230982A patent/RS64736B1/sr unknown
- 2019-05-02 CA CA3099037A patent/CA3099037A1/en active Pending
- 2019-05-02 IL IL278417A patent/IL278417B2/en unknown
- 2019-05-02 ES ES19724048T patent/ES2956087T3/es active Active
- 2019-05-02 MA MA52488A patent/MA52488B1/fr unknown
- 2019-05-02 KR KR1020207034549A patent/KR20210005222A/ko unknown
- 2019-05-02 UA UAA202007531A patent/UA128369C2/uk unknown
- 2019-05-02 JP JP2021510284A patent/JP2021523226A/ja not_active Withdrawn
- 2019-05-02 EP EP23181764.4A patent/EP4248975A3/en active Pending
- 2019-05-02 MX MX2020011621A patent/MX2020011621A/es unknown
- 2019-05-02 CN CN201980045101.1A patent/CN112368278A/zh active Pending
- 2019-05-02 PT PT197240484T patent/PT3788044T/pt unknown
- 2019-05-02 FI FIEP19724048.4T patent/FI3788044T3/fi active
- 2019-05-02 PL PL19724048.4T patent/PL3788044T3/pl unknown
- 2019-05-02 EA EA202092580A patent/EA202092580A1/ru unknown
- 2019-05-02 DK DK19724048.4T patent/DK3788044T3/da active
- 2019-05-02 SG SG11202010915XA patent/SG11202010915XA/en unknown
- 2019-05-02 WO PCT/US2019/030476 patent/WO2019213447A1/en active Application Filing
- 2019-05-02 HR HRP20231381TT patent/HRP20231381T1/hr unknown
- 2019-05-02 IL IL299784A patent/IL299784B2/en unknown
- 2019-05-02 EP EP19724048.4A patent/EP3788044B1/en active Active
- 2019-05-02 AU AU2019262144A patent/AU2019262144B2/en active Active
- 2019-05-02 PE PE2020001784A patent/PE20211383A1/es unknown
- 2019-05-02 HU HUE19724048A patent/HUE063896T2/hu unknown
- 2019-05-02 CR CR20200581A patent/CR20200581A/es unknown
- 2019-05-02 LT LTEPPCT/US2019/030476T patent/LT3788044T/lt unknown
- 2019-05-02 MD MDE20210212T patent/MD3788044T2/ro unknown
- 2019-05-02 US US16/402,111 patent/US10815206B2/en active Active
- 2019-05-02 SI SI201930598T patent/SI3788044T1/sl unknown
- 2019-05-02 JO JOP/2020/0278A patent/JOP20200278A1/ar unknown
- 2019-05-02 BR BR112020022420-0A patent/BR112020022420A2/pt active Search and Examination
-
2020
- 2020-09-16 US US17/023,138 patent/US11377428B2/en active Active
- 2020-09-16 US US17/023,127 patent/US11332451B2/en active Active
- 2020-09-16 US US17/023,136 patent/US11370764B2/en active Active
- 2020-09-16 US US17/023,149 patent/US11370765B2/en active Active
- 2020-10-16 US US17/072,862 patent/US11472782B2/en active Active
- 2020-11-02 CL CL2020002841A patent/CL2020002841A1/es unknown
- 2020-11-02 DO DO2020000198A patent/DOP2020000198A/es unknown
- 2020-11-03 PH PH12020551847A patent/PH12020551847A1/en unknown
- 2020-11-03 SA SA520420468A patent/SA520420468B1/ar unknown
- 2020-12-01 CO CONC2020/0015156A patent/CO2020015156A2/es unknown
- 2020-12-01 ZA ZA2020/07486A patent/ZA202007486B/en unknown
- 2020-12-03 EC ECSENADI202078326A patent/ECSP20078326A/es unknown
-
2021
- 2021-11-04 ZA ZA2021/08603A patent/ZA202108603B/en unknown
-
2022
- 2022-08-10 JP JP2022128202A patent/JP7187729B2/ja active Active
- 2022-09-07 US US17/939,020 patent/US12116354B2/en active Active
- 2022-11-30 JP JP2022191875A patent/JP7367169B2/ja active Active
-
2023
- 2023-08-25 DO DO2023000169A patent/DOP2023000169A/es unknown
- 2023-10-11 JP JP2023175695A patent/JP2024009916A/ja active Pending
- 2023-10-26 AU AU2023254980A patent/AU2023254980A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202108603B (en) | Rip1 inhibitory compounds and methods for making and using the same | |
| IL291033A (en) | rip1 inhibitory compounds and methods for their preparation and use | |
| ZA202007487B (en) | Rip1 inhibitory compounds and methods for making and using the same | |
| IL290781A (en) | rip1 inhibitory compounds and methods for their preparation and use | |
| EP3746124A4 (en) | COMPOUNDS AND USES THEREOF | |
| HUE052049T2 (hu) | Kristályos 2-fluor-3-nitrotoluol és eljárás annak elõállítására | |
| SG11202009175RA (en) | Silicon-terminated organo-metal compounds and processes for preparing the same | |
| SG11202009138QA (en) | Silicon-terminated organo-metal compounds and processes for preparing the same | |
| IL277502A (en) | Compounds and uses for them | |
| EP3853216A4 (en) | PYRIDINYL SUBSTITUTE COMPOUNDS AND THEIR USES | |
| EP3899293A4 (en) | LOCK NUT | |
| IL283309A (en) | rip1 inhibitors | |
| IL279483A (en) | Cyanotriazole compounds and their uses | |
| EP3724933A4 (en) | SUPRAL CONDUCTING COMPOUNDS AND METHOD FOR PRODUCING THEREOF | |
| EP3743635A4 (en) | ANTI-KICKBACK LOCK | |
| GB201917427D0 (en) | The flylead | |
| GB201916822D0 (en) | The degravitator | |
| EP3883564A4 (en) | CONNECTIONS AND USES THEREOF | |
| ZA201906782B (en) | Mulcher | |
| GB201904750D0 (en) | The dehydrometer | |
| GB201902293D0 (en) | The hangit | |
| GB201808686D0 (en) | The dogtooth | |
| AU2018902788A0 (en) | 2018-05-25 6d | |
| AU2018903548A0 (en) | Substituted-pyridinyl compounds and uses thereof | |
| GB201800634D0 (en) | The Tasteaire |