CL2020002841A1 - Compuestos inhibidores de rip1 y métodos para preparar y usar los mismos - Google Patents
Compuestos inhibidores de rip1 y métodos para preparar y usar los mismosInfo
- Publication number
- CL2020002841A1 CL2020002841A1 CL2020002841A CL2020002841A CL2020002841A1 CL 2020002841 A1 CL2020002841 A1 CL 2020002841A1 CL 2020002841 A CL2020002841 A CL 2020002841A CL 2020002841 A CL2020002841 A CL 2020002841A CL 2020002841 A1 CL2020002841 A1 CL 2020002841A1
- Authority
- CL
- Chile
- Prior art keywords
- inhibitor compounds
- making
- methods
- same
- rip1
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102100021559 KRR1 small subunit processome component homolog Human genes 0.000 title 1
- 101100301091 Mus musculus Ralbp1 gene Proteins 0.000 title 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 3
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
En la presente, se desvelan compuestos inhibidores de quinasa, tales como compuestos inhibidores de la proteína quinasa 1 que interactúa con el receptor (RIP1), así como composiciones farmacéuticas y combinaciones que comprenden tales compuestos inhibidores. Los compuestos, las composiciones farmacéuticas y/o las combinaciones desvelados se pueden usar para tratar o prevenir una enfermedad o afección asociada a la quinasa, en particular, una enfermedad o afección asociada a la RIP1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862666462P | 2018-05-03 | 2018-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020002841A1 true CL2020002841A1 (es) | 2021-05-24 |
Family
ID=66530556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002841A CL2020002841A1 (es) | 2018-05-03 | 2020-11-02 | Compuestos inhibidores de rip1 y métodos para preparar y usar los mismos |
Country Status (36)
| Country | Link |
|---|---|
| US (7) | US10815206B2 (es) |
| EP (2) | EP4248975A3 (es) |
| JP (4) | JP2021523226A (es) |
| KR (1) | KR20210005222A (es) |
| CN (1) | CN112368278A (es) |
| AU (2) | AU2019262144B2 (es) |
| BR (1) | BR112020022420A2 (es) |
| CA (1) | CA3099037A1 (es) |
| CL (1) | CL2020002841A1 (es) |
| CO (1) | CO2020015156A2 (es) |
| CR (1) | CR20200581A (es) |
| DK (1) | DK3788044T3 (es) |
| DO (2) | DOP2020000198A (es) |
| EA (1) | EA202092580A1 (es) |
| EC (1) | ECSP20078326A (es) |
| ES (1) | ES2956087T3 (es) |
| FI (1) | FI3788044T3 (es) |
| HR (1) | HRP20231381T1 (es) |
| HU (1) | HUE063896T2 (es) |
| IL (2) | IL278417B2 (es) |
| JO (1) | JOP20200278A1 (es) |
| LT (1) | LT3788044T (es) |
| MA (1) | MA52488B1 (es) |
| MD (1) | MD3788044T2 (es) |
| MX (1) | MX2020011621A (es) |
| PE (1) | PE20211383A1 (es) |
| PH (1) | PH12020551847A1 (es) |
| PL (1) | PL3788044T3 (es) |
| PT (1) | PT3788044T (es) |
| RS (1) | RS64736B1 (es) |
| SA (1) | SA520420468B1 (es) |
| SG (1) | SG11202010915XA (es) |
| SI (1) | SI3788044T1 (es) |
| UA (1) | UA128369C2 (es) |
| WO (1) | WO2019213447A1 (es) |
| ZA (2) | ZA202007486B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS64736B1 (sr) | 2018-05-03 | 2023-11-30 | Rigel Pharmaceuticals Inc | Jedinjenja inhibitori rip1 i postupci za njihovo dobijanje i upotrebu |
| HRP20230909T1 (hr) | 2018-05-03 | 2023-12-08 | Rigel Pharmaceuticals, Inc. | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu |
| CN111138448B (zh) * | 2018-11-02 | 2022-08-02 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2020088194A1 (zh) * | 2018-11-02 | 2020-05-07 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| US20210040115A1 (en) * | 2019-08-09 | 2021-02-11 | Bisichem Co., Ltd. | Fused ring heteroaryl compounds as ripk1 inhibitors |
| MX2022002717A (es) * | 2019-09-06 | 2022-08-10 | Rigel Pharmaceuticals Inc | Compuestos inhibidores de rip1 y metodos para prepararlos y usarlos. |
| WO2021046447A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 kinase inhibitors |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| MX2022003671A (es) | 2019-09-27 | 2022-04-25 | Univ Texas | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. |
| CN113015974B (zh) * | 2019-10-21 | 2024-05-28 | 谷歌有限责任公司 | 针对隐私保护的可验证同意 |
| JP7395730B2 (ja) | 2019-11-07 | 2023-12-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ヘテロ環式ｒｉｐ１阻害化合物 |
| BR112022010082A2 (pt) * | 2019-11-26 | 2022-08-30 | Univ Texas | Composto de fórmula estrutural i ou sal do mesmo, composição farmacêutica, uso do composto e uso da composição farmacêutica |
| CA3169099A1 (en) * | 2020-02-28 | 2021-09-02 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
| TWI824259B (zh) | 2020-07-01 | 2023-12-01 | 美商雷傑製藥公司 | Rip1k抑制劑 |
| WO2022171111A1 (en) * | 2021-02-10 | 2022-08-18 | Zai Lab (Us) Llc | Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof |
| CN114989156B (zh) * | 2021-05-19 | 2024-07-05 | 成都贝诺科成生物科技有限公司 | 一种受体相互作用蛋白抑制剂及其制备方法和用途 |
| BR112023025850A2 (pt) | 2021-08-10 | 2024-03-05 | Abbvie Inc | Inibidores da nicotinamida ripk1 |
| CN118510774A (zh) | 2021-12-16 | 2024-08-16 | 里格尔药品股份有限公司 | Ripk1抑制剂的结晶形式 |
| WO2023138317A1 (zh) * | 2022-01-21 | 2023-07-27 | 中国科学院上海药物研究所 | 具有ripk1抑制活性的化合物、其制备方法及其用途 |
| CN114736197B (zh) * | 2022-06-13 | 2022-09-13 | 南京医工医药技术有限公司 | 咪唑啉酮衍生物及其用途 |
| CN115353513A (zh) * | 2022-07-29 | 2022-11-18 | 中国人民解放军海军军医大学 | 一种抑制程序性细胞坏死的硫代七元环衍生物及其应用 |
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| RS64736B1 (sr) * | 2018-05-03 | 2023-11-30 | Rigel Pharmaceuticals Inc | Jedinjenja inhibitori rip1 i postupci za njihovo dobijanje i upotrebu |
| HRP20230909T1 (hr) * | 2018-05-03 | 2023-12-08 | Rigel Pharmaceuticals, Inc. | Spojevi inhibitori rip1 i postupci za njihovo dobivanje i upotrebu |
| TW202019913A (zh) | 2018-06-26 | 2020-06-01 | 中國科學院上海有機化學研究所 | 細胞壞死抑制劑及其製備方法和用途 |
| CN111138448B (zh) | 2018-11-02 | 2022-08-02 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2020088194A1 (zh) | 2018-11-02 | 2020-05-07 | 中国科学院上海药物研究所 | 抑制rip1激酶的杂环酰胺及其用途 |
| WO2021046447A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Heterocyclic rip1 kinase inhibitors |
| AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
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2019
- 2019-05-02 RS RS20230982A patent/RS64736B1/sr unknown
- 2019-05-02 CA CA3099037A patent/CA3099037A1/en active Pending
- 2019-05-02 IL IL278417A patent/IL278417B2/en unknown
- 2019-05-02 ES ES19724048T patent/ES2956087T3/es active Active
- 2019-05-02 MA MA52488A patent/MA52488B1/fr unknown
- 2019-05-02 KR KR1020207034549A patent/KR20210005222A/ko unknown
- 2019-05-02 UA UAA202007531A patent/UA128369C2/uk unknown
- 2019-05-02 JP JP2021510284A patent/JP2021523226A/ja not_active Withdrawn
- 2019-05-02 EP EP23181764.4A patent/EP4248975A3/en active Pending
- 2019-05-02 MX MX2020011621A patent/MX2020011621A/es unknown
- 2019-05-02 CN CN201980045101.1A patent/CN112368278A/zh active Pending
- 2019-05-02 PT PT197240484T patent/PT3788044T/pt unknown
- 2019-05-02 FI FIEP19724048.4T patent/FI3788044T3/fi active
- 2019-05-02 PL PL19724048.4T patent/PL3788044T3/pl unknown
- 2019-05-02 EA EA202092580A patent/EA202092580A1/ru unknown
- 2019-05-02 DK DK19724048.4T patent/DK3788044T3/da active
- 2019-05-02 SG SG11202010915XA patent/SG11202010915XA/en unknown
- 2019-05-02 WO PCT/US2019/030476 patent/WO2019213447A1/en active Application Filing
- 2019-05-02 HR HRP20231381TT patent/HRP20231381T1/hr unknown
- 2019-05-02 IL IL299784A patent/IL299784B2/en unknown
- 2019-05-02 EP EP19724048.4A patent/EP3788044B1/en active Active
- 2019-05-02 AU AU2019262144A patent/AU2019262144B2/en active Active
- 2019-05-02 PE PE2020001784A patent/PE20211383A1/es unknown
- 2019-05-02 HU HUE19724048A patent/HUE063896T2/hu unknown
- 2019-05-02 CR CR20200581A patent/CR20200581A/es unknown
- 2019-05-02 LT LTEPPCT/US2019/030476T patent/LT3788044T/lt unknown
- 2019-05-02 MD MDE20210212T patent/MD3788044T2/ro unknown
- 2019-05-02 US US16/402,111 patent/US10815206B2/en active Active
- 2019-05-02 SI SI201930598T patent/SI3788044T1/sl unknown
- 2019-05-02 JO JOP/2020/0278A patent/JOP20200278A1/ar unknown
- 2019-05-02 BR BR112020022420-0A patent/BR112020022420A2/pt active Search and Examination
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2020
- 2020-09-16 US US17/023,138 patent/US11377428B2/en active Active
- 2020-09-16 US US17/023,127 patent/US11332451B2/en active Active
- 2020-09-16 US US17/023,136 patent/US11370764B2/en active Active
- 2020-09-16 US US17/023,149 patent/US11370765B2/en active Active
- 2020-10-16 US US17/072,862 patent/US11472782B2/en active Active
- 2020-11-02 CL CL2020002841A patent/CL2020002841A1/es unknown
- 2020-11-02 DO DO2020000198A patent/DOP2020000198A/es unknown
- 2020-11-03 PH PH12020551847A patent/PH12020551847A1/en unknown
- 2020-11-03 SA SA520420468A patent/SA520420468B1/ar unknown
- 2020-12-01 CO CONC2020/0015156A patent/CO2020015156A2/es unknown
- 2020-12-01 ZA ZA2020/07486A patent/ZA202007486B/en unknown
- 2020-12-03 EC ECSENADI202078326A patent/ECSP20078326A/es unknown
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2021
- 2021-11-04 ZA ZA2021/08603A patent/ZA202108603B/en unknown
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2022
- 2022-08-10 JP JP2022128202A patent/JP7187729B2/ja active Active
- 2022-09-07 US US17/939,020 patent/US12116354B2/en active Active
- 2022-11-30 JP JP2022191875A patent/JP7367169B2/ja active Active
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2023
- 2023-08-25 DO DO2023000169A patent/DOP2023000169A/es unknown
- 2023-10-11 JP JP2023175695A patent/JP2024009916A/ja active Pending
- 2023-10-26 AU AU2023254980A patent/AU2023254980A1/en active Pending
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