DOP2022000051A - Compuestos inhibidores de rip1 y métodos para hacer y utilizar los mismos - Google Patents
Compuestos inhibidores de rip1 y métodos para hacer y utilizar los mismosInfo
- Publication number
- DOP2022000051A DOP2022000051A DO2022000051A DO2022000051A DOP2022000051A DO P2022000051 A DOP2022000051 A DO P2022000051A DO 2022000051 A DO2022000051 A DO 2022000051A DO 2022000051 A DO2022000051 A DO 2022000051A DO P2022000051 A DOP2022000051 A DO P2022000051A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- making
- methods
- same
- inhibitor compounds
- rip1
- Prior art date
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract
En la presente descripción se describen compuestos inhibidores de quinasa, tales como compuestos inhibidores de proteína quinasa 1 que interactúa con el receptor (RIPK1), así como también composiciones farmacéuticas y combinaciones que comprenden tales compuestos inhibidores. Los compuestos, composiciones farmacéuticas y/o combinaciones descritas pueden usarse para tratar o prevenir una enfermedad o afección asociada a quinasas, particularmente una enfermedad o afección asociada a RIP1.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962897223P | 2019-09-06 | 2019-09-06 | |
US201962932404P | 2019-11-07 | 2019-11-07 | |
US202063001016P | 2020-03-27 | 2020-03-27 | |
US202063004319P | 2020-04-02 | 2020-04-02 | |
US202063004290P | 2020-04-02 | 2020-04-02 | |
US202063004301P | 2020-04-02 | 2020-04-02 | |
PCT/US2020/049487 WO2021046407A1 (en) | 2019-09-06 | 2020-09-04 | Rip1 inhibitory compounds and methods for making and using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2022000051A true DOP2022000051A (es) | 2022-08-15 |
Family
ID=72561994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2022000051A DOP2022000051A (es) | 2019-09-06 | 2022-03-04 | Compuestos inhibidores de rip1 y métodos para hacer y utilizar los mismos |
Country Status (18)
Country | Link |
---|---|
US (6) | US20210070735A1 (es) |
EP (3) | EP4025568A1 (es) |
JP (4) | JP7443495B2 (es) |
KR (3) | KR20220042429A (es) |
CN (3) | CN114728918A (es) |
AU (3) | AU2020341681B2 (es) |
BR (3) | BR112022002580A2 (es) |
CA (3) | CA3149963A1 (es) |
CO (1) | CO2022002630A2 (es) |
DO (1) | DOP2022000051A (es) |
EC (1) | ECSP22016571A (es) |
IL (3) | IL290779A (es) |
JO (1) | JOP20220062A1 (es) |
MX (3) | MX2022002737A (es) |
PE (1) | PE20221628A1 (es) |
SA (1) | SA522431869B1 (es) |
TW (3) | TW202122388A (es) |
WO (3) | WO2021046407A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3094197C (en) * | 2015-07-02 | 2023-02-28 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
CA3099018A1 (en) | 2018-05-03 | 2019-11-07 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
AU2019262144B2 (en) | 2018-05-03 | 2023-11-16 | Rigel Pharmaceuticals, Inc. | RIP1 inhibitory compounds and methods for making and using the same |
WO2021046437A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
WO2021046407A1 (en) | 2019-09-06 | 2021-03-11 | Rigel Pharmaceuticals, Inc. | Rip1 inhibitory compounds and methods for making and using the same |
KR20220079919A (ko) | 2019-11-07 | 2022-06-14 | 리겔 파마슈티칼스, 인크. | 헤테로시클릭 rip1 억제 화합물 |
WO2021173917A1 (en) * | 2020-02-28 | 2021-09-02 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
AR121717A1 (es) | 2020-04-02 | 2022-06-29 | Rigel Pharmaceuticals Inc | Inhibidores de rip1k |
TWI824259B (zh) | 2020-07-01 | 2023-12-01 | 美商雷傑製藥公司 | Rip1k抑制劑 |
WO2022171111A1 (en) * | 2021-02-10 | 2022-08-18 | Zai Lab (Us) Llc | Heteroaryl-fused bicyclic compound as rip1-kinase inhibitors and uses thereof |
AR125587A1 (es) * | 2021-03-11 | 2023-08-02 | Rigel Pharmaceuticals Inc | Inhibidores heterocíclicos de la quinasa de rip1 |
CN113045560B (zh) * | 2021-03-30 | 2022-09-06 | 港科鹏禾生物(苏州)有限公司 | 一种酰胺类衍生物及其制备方法和应用 |
US20240228506A1 (en) * | 2021-04-27 | 2024-07-11 | Merck Sharp & Dohme Llc | Ripk1 inhibitors and methods of use |
US20240208986A1 (en) * | 2021-04-27 | 2024-06-27 | Merck Sharp & Dohme Llc | Phenyl azepines as ripk1 inhibitors and methods of use thereof |
CN114989156B (zh) * | 2021-05-19 | 2024-07-05 | 成都贝诺科成生物科技有限公司 | 一种受体相互作用蛋白抑制剂及其制备方法和用途 |
WO2023020486A1 (zh) * | 2021-08-17 | 2023-02-23 | 广州市恒诺康医药科技有限公司 | Rip1激酶抑制剂类化合物及其组合物和用途 |
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