CR20220075A - Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos - Google Patents

Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos

Info

Publication number
CR20220075A
CR20220075A CR20220075A CR20220075A CR20220075A CR 20220075 A CR20220075 A CR 20220075A CR 20220075 A CR20220075 A CR 20220075A CR 20220075 A CR20220075 A CR 20220075A CR 20220075 A CR20220075 A CR 20220075A
Authority
CR
Costa Rica
Prior art keywords
inhibitory compounds
rip1
making
methods
same
Prior art date
Application number
CR20220075A
Other languages
English (en)
Inventor
Zhushou Luo
Simon Shaw
Yan Chen
Ihab Darwish
Vanessa Taylor
Somasekhar Bhamidipati
Jiaxin Yu
Rao Kolluri
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CR20220075A publication Critical patent/CR20220075A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

En la presente descripción se describen compuestos inhibidores de quinasa, tales como compuestos inhibidores de quinasa de proteína 1 que interactúa con el receptor (RIP1), así como también composiciones farmacéuticas y combinaciones que comprenden tales compuestos inhibidores. Los compuestos, composiciones farmacéuticas y/o combinaciones descritos pueden usarse para tratar o prevenir una enfermedad o afección asociada a la quinasa, particularmente una enfermedad o afección asociada a RIP1.
CR20220075A 2019-09-06 2020-09-04 Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos CR20220075A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962897223P 2019-09-06 2019-09-06
US201962932404P 2019-11-07 2019-11-07
US202063001016P 2020-03-27 2020-03-27
US202063004319P 2020-04-02 2020-04-02
US202063004290P 2020-04-02 2020-04-02
PCT/US2020/049527 WO2021046437A1 (en) 2019-09-06 2020-09-04 Rip1 inhibitory compounds and methods for making and using the same

Publications (1)

Publication Number Publication Date
CR20220075A true CR20220075A (es) 2022-07-14

Family

ID=72613994

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220075A CR20220075A (es) 2019-09-06 2020-09-04 Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos

Country Status (18)

Country Link
US (1) US11564930B2 (es)
EP (1) EP4025575A1 (es)
JP (2) JP2022546605A (es)
KR (1) KR20220042206A (es)
CN (1) CN114728958A (es)
AU (1) AU2020341708B2 (es)
BR (1) BR112022002378A2 (es)
CA (1) CA3149729A1 (es)
CO (1) CO2022002374A2 (es)
CR (1) CR20220075A (es)
DO (1) DOP2022000042A (es)
EC (1) ECSP22016567A (es)
IL (1) IL290781A (es)
JO (1) JOP20220056A1 (es)
MX (1) MX2022002717A (es)
PE (1) PE20221762A1 (es)
TW (1) TW202122397A (es)
WO (1) WO2021046437A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2947446T3 (es) 2018-05-03 2023-08-09 Rigel Pharmaceuticals Inc Compuestos inhibidores de RIP1 y métodos para fabricar y usar los mismos
CR20220075A (es) 2019-09-06 2022-07-14 Rigel Pharmaceuticals Inc Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos
AU2020341681B2 (en) 2019-09-06 2024-02-15 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
AR122703A1 (es) 2020-07-01 2022-09-28 Rigel Pharmaceuticals Inc Inhibidores de rip1k
WO2022237890A1 (zh) * 2021-05-14 2022-11-17 中国医药研究开发中心有限公司 氮杂卓类稠环化合物及其医药用途
WO2022258052A1 (zh) * 2021-06-11 2022-12-15 劲方医药科技(上海)有限公司 杂环内酰胺类化合物，其制法与医药上的用途
CN116478150A (zh) * 2022-01-21 2023-07-25 中国科学院上海药物研究所 具有ripk1抑制活性的化合物、其制备方法及其用途
CN115201250B (zh) * 2022-09-14 2022-11-25 中铁三局集团第三工程有限公司 一种冷再生沥青混合料热可逆老化程度的量化方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
ES2055280T3 (es) 1989-12-04 1994-08-16 Searle & Co Sistema monocapa para la administracion transdermica de farmacos.
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
CA2123809A1 (en) 1991-12-18 1993-06-24 Debra L. Wilfong Multilayered barrier structures
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
EP2192838A4 (en) 2007-08-15 2011-07-27 Harvard College HETEROCYCLIC NEKROPTOSIS HEMMER
TWI638815B (zh) 2013-02-15 2018-10-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（一）
JP2016514693A (ja) 2013-03-15 2016-05-23 プレジデント アンド フェローズ オブ ハーバード カレッジ ハイブリッド型ネクロトーシス阻害剤
EP3182974A1 (en) 2014-08-21 2017-06-28 GlaxoSmithKline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
JP2018505199A (ja) 2015-02-13 2018-02-22 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ （Ｓ）−５−ベンジル−Ｎ−（５−メチル−４−オキソ−２，３，４，５テトラヒドロベンゾ［ｂ］［１，４］オキサゼピン−３−イル）−４Ｈ−１，２，４−トリアゾール−３−カルボキサミドの結晶形
KR102603915B1 (ko) 2015-07-02 2023-11-21 에프. 호프만-라 로슈 아게 이환형 락탐 및 이의 사용 방법
DK3362449T3 (da) 2015-10-13 2021-07-19 Inst Nat Sante Rech Med Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose
JP6754772B2 (ja) * 2015-10-23 2020-09-16 武田薬品工業株式会社 複素環化合物
WO2017109724A1 (en) 2015-12-21 2017-06-29 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
KR20180114910A (ko) 2016-02-05 2018-10-19 데날리 테라퓨틱스 인크. 수용체-상호작용 단백질 키나제 1의 억제제
CN109843886B (zh) 2016-10-17 2022-04-19 豪夫迈·罗氏有限公司 二环吡啶酮内酰胺及其使用方法
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
WO2018154520A1 (en) 2017-02-27 2018-08-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
WO2019134680A1 (zh) 2018-01-05 2019-07-11 广州市恒诺康医药科技有限公司 细胞凋亡信号调节激酶-1抑制剂及其应用
ES2947446T3 (es) 2018-05-03 2023-08-09 Rigel Pharmaceuticals Inc Compuestos inhibidores de RIP1 y métodos para fabricar y usar los mismos
JP2021523226A (ja) 2018-05-03 2021-09-02 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｒｉｐ１阻害剤化合物並びにそれを製造及び使用するための方法
JP2022511213A (ja) 2018-06-26 2022-01-31 シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ 細胞壊死阻害剤、その調製方法およびその使用
JP7045526B2 (ja) 2018-11-02 2022-03-31 中国科学院上海薬物研究所 Ｒｉｐ１キナーゼを阻害する複素環状アミド及びその使用
CN111138448B (zh) 2018-11-02 2022-08-02 中国科学院上海药物研究所 抑制rip1激酶的杂环酰胺及其用途
CR20220075A (es) 2019-09-06 2022-07-14 Rigel Pharmaceuticals Inc Compuestos inhibidores de rip1 y métodos para prepararlos y usarlos
AU2020341681B2 (en) 2019-09-06 2024-02-15 Rigel Pharmaceuticals, Inc. RIP1 inhibitory compounds and methods for making and using the same
AR121717A1 (es) 2020-04-02 2022-06-29 Rigel Pharmaceuticals Inc Inhibidores de rip1k

Also Published As

Publication number Publication date
KR20220042206A (ko) 2022-04-04
PE20221762A1 (es) 2022-11-11
JP2024050568A (ja) 2024-04-10
CA3149729A1 (en) 2021-03-11
CO2022002374A2 (es) 2022-08-09
WO2021046437A1 (en) 2021-03-11
US11564930B2 (en) 2023-01-31
ECSP22016567A (es) 2022-08-31
JOP20220056A1 (ar) 2023-01-30
TW202122397A (zh) 2021-06-16
CN114728958A (zh) 2022-07-08
BR112022002378A2 (pt) 2022-06-14
JP2022546605A (ja) 2022-11-04
EP4025575A1 (en) 2022-07-13
IL290781A (en) 2022-04-01
MX2022002717A (es) 2022-08-10
US20210069208A1 (en) 2021-03-11
AU2020341708A1 (en) 2022-03-17
AU2020341708B2 (en) 2024-01-04
DOP2022000042A (es) 2022-08-15

Similar Documents

Publication Publication Date Title
JOP20220062A1 (ar) مركبات rip1 تثبيطية وطرق عملها واستخدامها
PH12020551847A1 (en) Rip1 inhibitory compounds and methods for making and using the same
PH12020551848A1 (en) Rip1 inhibitory compounds and methods for making and using the same
MX2022002717A (es) Compuestos inhibidores de rip1 y metodos para prepararlos y usarlos.
JOP20220246A1 (ar) مثبطات rip1k
MX2022005509A (es) Compuestos inhibidores de rip1 heterociclicos.
ECSP22097749A (es) Inhibidores de ripk1
TWI840311B (zh) Rip1k抑制劑
AR120412A1 (es) Compuestos heterocíclicos inhibidores de rip1