DK3679946T3 - Flydende neurotoksinformulering stabiliseret med tryptophan eller tyrosin - Google Patents

Flydende neurotoksinformulering stabiliseret med tryptophan eller tyrosin Download PDF

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Publication number
DK3679946T3
DK3679946T3 DK20152386.7T DK20152386T DK3679946T3 DK 3679946 T3 DK3679946 T3 DK 3679946T3 DK 20152386 T DK20152386 T DK 20152386T DK 3679946 T3 DK3679946 T3 DK 3679946T3
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Denmark
Prior art keywords
tryptophan
tyrosine
formulation stabilized
neurotoxin formulation
liquid
Prior art date
Application number
DK20152386.7T
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English (en)
Inventor
Anders Jarstad
Anna Friis
Ulf Stahl
Ann Gurell
Barbro Agren
Emilia Edstrom
Andrew Pickett
Original Assignee
Ipsen Biopharm Ltd
Galderma Holding SA
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Application filed by Ipsen Biopharm Ltd, Galderma Holding SA filed Critical Ipsen Biopharm Ltd
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Publication of DK3679946T3 publication Critical patent/DK3679946T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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  • Organic Chemistry (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
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  • Endocrinology (AREA)
  • Diabetes (AREA)
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DK20152386.7T 2016-05-27 2017-05-26 Flydende neurotoksinformulering stabiliseret med tryptophan eller tyrosin DK3679946T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2016062085 2016-05-27
EP17728095.5A EP3463432B1 (en) 2016-05-27 2017-05-26 Liquid neurotoxin formulation stabilized with tryptophan or tyrosine

Publications (1)

Publication Number Publication Date
DK3679946T3 true DK3679946T3 (da) 2022-02-07

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Family Applications (3)

Application Number Title Priority Date Filing Date
DK21211390.6T DK4026532T3 (da) 2016-05-27 2017-05-26 Flydende neurotoxinformulering stabiliseret med tryptophan eller tyrosin
DK17728095.5T DK3463432T3 (da) 2016-05-27 2017-05-26 Flydende neurotoksin-formulering stabiliseret med tryptofan eller tyrosin
DK20152386.7T DK3679946T3 (da) 2016-05-27 2017-05-26 Flydende neurotoksinformulering stabiliseret med tryptophan eller tyrosin

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK21211390.6T DK4026532T3 (da) 2016-05-27 2017-05-26 Flydende neurotoxinformulering stabiliseret med tryptophan eller tyrosin
DK17728095.5T DK3463432T3 (da) 2016-05-27 2017-05-26 Flydende neurotoksin-formulering stabiliseret med tryptofan eller tyrosin

Country Status (32)

Country Link
US (5) US20190183988A1 (da)
EP (3) EP4026532B1 (da)
JP (1) JP7053498B2 (da)
KR (2) KR102423739B1 (da)
CN (2) CN111701010B (da)
AR (1) AR108631A1 (da)
AU (1) AU2017270359B2 (da)
CA (1) CA3025437A1 (da)
CY (2) CY1124237T1 (da)
DK (3) DK4026532T3 (da)
EA (1) EA038124B1 (da)
ES (2) ES2911124T3 (da)
FI (1) FI4026532T3 (da)
GE (2) GEP20207139B (da)
HR (3) HRP20202070T1 (da)
HU (2) HUE052023T2 (da)
IL (2) IL285190B (da)
LT (3) LT4026532T (da)
MX (1) MX392529B (da)
NZ (1) NZ788585A (da)
PL (3) PL3679946T3 (da)
PT (3) PT3463432T (da)
RS (3) RS61340B1 (da)
RU (1) RU2741497C9 (da)
SA (1) SA518400513B1 (da)
SG (1) SG11201810561YA (da)
SI (3) SI3679946T1 (da)
SM (3) SMT202100003T1 (da)
TW (1) TWI777955B (da)
UA (1) UA123679C2 (da)
WO (1) WO2017203038A1 (da)
ZA (1) ZA201807904B (da)

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IL308091B1 (en) 2016-09-13 2026-01-01 Allergan Inc Protein-free stabilized Clostridium toxin preparations
CN112351991A (zh) * 2017-12-20 2021-02-09 阿勒根公司 肉毒杆菌毒素细胞结合结构域多肽及其用于治疗纤维化相关障碍的方法
UY38744A (es) * 2019-06-07 2020-12-31 Nestle Skin Health S A Tratamiento de líneas glabelares y líneas cantales laterales de moderadas a muy graves
BR112022020327A2 (pt) * 2020-04-08 2022-12-13 Medytox Inc Formulação de seringa pré-carregada com toxina botulínica
CN116440281A (zh) * 2022-01-07 2023-07-18 重庆誉颜制药有限公司 一种肉毒毒素蛋白组合物
JP2025500698A (ja) * 2022-01-14 2025-01-09 ガルデルマ・ホールディング・エスアー 中等度から最重度の眉間皺及び外眼角皺の治療
TW202348248A (zh) * 2022-02-15 2023-12-16 德商梅茲製藥有限兩合公司 液體製劑及其製備方法與用途
TW202525330A (zh) 2023-08-10 2025-07-01 德商梅茲製藥有限兩合公司 液體肉毒桿菌毒素製劑及其製作方法

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