DK3370828T3 - Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren - Google Patents
Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren Download PDFInfo
- Publication number
- DK3370828T3 DK3370828T3 DK16793975.0T DK16793975T DK3370828T3 DK 3370828 T3 DK3370828 T3 DK 3370828T3 DK 16793975 T DK16793975 T DK 16793975T DK 3370828 T3 DK3370828 T3 DK 3370828T3
- Authority
- DK
- Denmark
- Prior art keywords
- muscarin
- agonists
- receptor
- oxim
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1519352.7A GB201519352D0 (en) | 2015-11-02 | 2015-11-02 | Pharmaceutical compounds |
| PCT/GB2016/053396 WO2017077292A1 (en) | 2015-11-02 | 2016-11-02 | Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3370828T3 true DK3370828T3 (da) | 2020-07-13 |
Family
ID=55130557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16793975.0T DK3370828T3 (da) | 2015-11-02 | 2016-11-02 | Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11208396B2 (da) |
| EP (2) | EP3797778A1 (da) |
| JP (1) | JP6799596B2 (da) |
| CN (1) | CN108290055B (da) |
| AU (1) | AU2016348847B2 (da) |
| CA (1) | CA3003669C (da) |
| DK (1) | DK3370828T3 (da) |
| ES (1) | ES2804774T3 (da) |
| GB (1) | GB201519352D0 (da) |
| HK (1) | HK1253036A1 (da) |
| WO (1) | WO2017077292A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104039321B (zh) | 2011-11-18 | 2017-02-22 | 赫普泰雅治疗有限公司 | 药物化合物 |
| EP3394061B1 (en) | 2015-12-23 | 2020-03-11 | Merck Sharp & Dohme Corp. | 6,7-dihydro-5h-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2017107089A1 (en) | 2015-12-23 | 2017-06-29 | Merck Sharp & Dohme Corp. | 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| WO2018112843A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor |
| WO2018112842A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor |
| GB201709652D0 (en) | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| EP3661939B1 (en) * | 2017-08-01 | 2021-07-21 | Boehringer Ingelheim International GmbH | Intermediate compounds and methods |
| WO2019079410A1 (en) | 2017-10-17 | 2019-04-25 | Vanderbilt University | ANTAGONISTS OF THE MUSCARINIC RECEPTOR OF ACETYLCHOLINE M4 |
| CN111565718A (zh) * | 2017-10-31 | 2020-08-21 | 范德比尔特大学 | 毒蕈碱性乙酰胆碱受体m4的拮抗剂 |
| GB201810239D0 (en) * | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| CA3156320A1 (en) | 2019-10-09 | 2021-04-15 | Novartis Ag | 2-AZASPIRO[3,4] OCTANE DERIVATIVES USED AS M4 AGONISTS |
| EP4041737A1 (en) | 2019-10-09 | 2022-08-17 | Novartis AG | 5-oxa-2-azaspiro[3.4]octane derivatives as m4 agonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100439357B1 (ko) | 1999-05-04 | 2004-07-07 | 쉐링 코포레이션 | Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체 |
| HUP0202734A3 (en) | 1999-05-04 | 2003-11-28 | Schering Corp | Use of pegylated interfron alfa-ccr5 antagonist combination for hiv therapy |
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| EP1725235B1 (en) | 2004-02-05 | 2009-04-15 | Schering Corporation | Piperidine derivatives useful as ccr3 antagonists |
| CN104039321B (zh) | 2011-11-18 | 2017-02-22 | 赫普泰雅治疗有限公司 | 药物化合物 |
| DK2897948T3 (da) * | 2012-09-18 | 2016-12-05 | Heptares Therapeutics Ltd | Bicykliske aza-forbindelser som muskarin m1-receptoragonister |
| EP2953940B1 (en) | 2013-02-07 | 2018-08-22 | Heptares Therapeutics Limited | Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic m4 receptor agonists |
| EP3406609A1 (en) | 2014-02-06 | 2018-11-28 | Heptares Therapeutics Limited | Bicyclic aza compounds as muscarinic receptor agonists |
-
2015
- 2015-11-02 GB GBGB1519352.7A patent/GB201519352D0/en not_active Ceased
-
2016
- 2016-11-02 CA CA3003669A patent/CA3003669C/en active Active
- 2016-11-02 CN CN201680065981.5A patent/CN108290055B/zh active Active
- 2016-11-02 EP EP20169369.4A patent/EP3797778A1/en not_active Withdrawn
- 2016-11-02 ES ES16793975T patent/ES2804774T3/es active Active
- 2016-11-02 AU AU2016348847A patent/AU2016348847B2/en active Active
- 2016-11-02 JP JP2018522540A patent/JP6799596B2/ja active Active
- 2016-11-02 DK DK16793975.0T patent/DK3370828T3/da active
- 2016-11-02 US US15/772,785 patent/US11208396B2/en active Active
- 2016-11-02 WO PCT/GB2016/053396 patent/WO2017077292A1/en active Application Filing
- 2016-11-02 EP EP16793975.0A patent/EP3370828B1/en active Active
-
2018
- 2018-09-27 HK HK18112415.2A patent/HK1253036A1/zh unknown
-
2021
- 2021-12-15 US US17/551,976 patent/US20220298133A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN108290055A (zh) | 2018-07-17 |
| US11208396B2 (en) | 2021-12-28 |
| CA3003669A1 (en) | 2017-05-11 |
| CN108290055B (zh) | 2021-05-14 |
| HK1253036A1 (zh) | 2019-06-06 |
| AU2016348847A1 (en) | 2018-06-07 |
| US20200165220A1 (en) | 2020-05-28 |
| JP2018536653A (ja) | 2018-12-13 |
| GB201519352D0 (en) | 2015-12-16 |
| EP3370828B1 (en) | 2020-04-15 |
| ES2804774T3 (es) | 2021-02-09 |
| AU2016348847B2 (en) | 2021-07-08 |
| WO2017077292A1 (en) | 2017-05-11 |
| EP3370828A1 (en) | 2018-09-12 |
| CA3003669C (en) | 2024-04-09 |
| JP6799596B2 (ja) | 2020-12-23 |
| EP3797778A1 (en) | 2021-03-31 |
| US20220298133A1 (en) | 2022-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3370828T3 (da) | Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren | |
| DK3271358T3 (da) | Spirocykliske forbindelser som agonister af muscarin m1-receptor og/eller m4-receptor | |
| DK3271316T3 (da) | Stabilisering af 1-chlor-3,3,3-trifluorpropen | |
| BR112016015706A2 (pt) | composto, uso do mesmo e composição farmacêutica | |
| BR112016030968A2 (pt) | análogos de pridopidina, preparação e uso destes | |
| DK3668851T3 (da) | Fremgangsmåde til fremstilling af thiocarbonater | |
| DK3174858T3 (da) | Fremgangsmåde til fremstilling af pyrazoler | |
| DK3325443T3 (da) | Fremgangsmåde til fremstilling af pridopidin | |
| DK3303305T3 (da) | 2-(phenyloxy eller phenylthio)pyrimidin-derivater som herbicider | |
| DK3393655T3 (da) | Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme | |
| DK3380080T3 (da) | Topikal filmdannende spray | |
| CL2014003612S1 (es) | Peine para aparato de aseo | |
| DK3348556T3 (da) | Heteroarylamider som hæmmere af proteinaggregering | |
| DK3280408T3 (da) | Fremgangsmåde til fremstilling af dicycloplatin | |
| DK3645398T3 (da) | Rotorflyfartøj | |
| DK3497085T3 (da) | Sulfonamider som gpr40- og gpr120-agonister | |
| DK3303323T3 (da) | Heterocykliske forbindelser af 3,3-difluorpiperidincarbamat som NR2B-NMDA-receptorantagonister | |
| BR112016024667A2 (pt) | composições de revestimento melhorado e processos para fabricação das mesmas | |
| DK3330267T3 (da) | Salt af quinazolinderivat eller crystal deraf samt fremgangsmåde til fremstilling af salt af quinazolinderivat eller crystal deraf | |
| DK3265430T3 (da) | Anvendelse af krystallinske tantaloxidpartikler som pinningcenter i superleder | |
| FI20145117A (fi) | Stabiloitu liima-aineformulaatio | |
| DK3204380T3 (da) | Hidtil ukendte aminopyridinforbindelser, der er anvendelige som hæmmere af proteinprenylering | |
| FI20145118A (fi) | Stabiloitu liima-aineformulaatio | |
| FR3037106B1 (fr) | Turbomachine d’aeronef | |
| DK3641728T3 (da) | En olie-i-vand-nanoemulsionssammensætning af clobetasol |