ATE541580T1 - Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor - Google Patents

Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Info

Publication number
ATE541580T1
ATE541580T1 AT04817014T AT04817014T ATE541580T1 AT E541580 T1 ATE541580 T1 AT E541580T1 AT 04817014 T AT04817014 T AT 04817014T AT 04817014 T AT04817014 T AT 04817014T AT E541580 T1 ATE541580 T1 AT E541580T1
Authority
AT
Austria
Prior art keywords
self
growth factor
assembling peptide
peptide amphiphiles
relevant methods
Prior art date
Application number
AT04817014T
Other languages
English (en)
Inventor
Samuel Stupp
Jack Donners
Gabriel Silva
Heather Behanna
Shawn Anthony
Original Assignee
Univ Northwestern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern filed Critical Univ Northwestern
Application granted granted Critical
Publication of ATE541580T1 publication Critical patent/ATE541580T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Surgery (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04817014T 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor ATE541580T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52750403P 2003-12-05 2003-12-05
PCT/US2004/040550 WO2005056039A1 (en) 2003-12-05 2004-12-06 Self-assembling peptide amphiphiles and related methods for growth factor delivery

Publications (1)

Publication Number Publication Date
ATE541580T1 true ATE541580T1 (de) 2012-02-15

Family

ID=34676751

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04817014T ATE541580T1 (de) 2003-12-05 2004-12-06 Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor

Country Status (12)

Country Link
US (3) US7544661B2 (de)
EP (2) EP2314305A3 (de)
JP (2) JP4851939B2 (de)
KR (1) KR20070004560A (de)
CN (2) CN102225964A (de)
AT (1) ATE541580T1 (de)
AU (2) AU2004296181A1 (de)
CA (1) CA2549164A1 (de)
ES (1) ES2380340T3 (de)
MX (1) MXPA06006388A (de)
NZ (1) NZ547671A (de)
WO (1) WO2005056039A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2003215280A1 (en) * 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) * 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) * 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) * 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
US7390526B2 (en) 2003-02-11 2008-06-24 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
EP2314305A3 (de) 2003-12-05 2011-08-10 Northwestern University Selbst anordnende Peptid-Amphiphile und relevante Verfahren für die Abgabe von Wachstumsfaktoren
MXPA06006387A (es) * 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos ramificados, compuestos epitopes relacionados y estructuras auto-ensambladas de los mismos.
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
EP1838846A4 (de) 2005-01-21 2008-12-10 Univ Northwestern Verfahren und zusammensetzungen zur verkapselung von zellen
MX2007010771A (es) * 2005-03-04 2008-03-10 Univ Northwestern Anfifilos peptidicos para union a heparina angiogenicos.
US9162005B2 (en) * 2005-04-25 2015-10-20 Arch Biosurgery, Inc. Compositions for prevention of adhesions and other barrier applications
US8299032B2 (en) * 2005-06-27 2012-10-30 Menicon Co., Ltd. Self-assembling peptide and gel produced from the same
CN100475836C (zh) * 2005-12-09 2009-04-08 中国人民解放军军事医学科学院野战输血研究所 间充质干细胞亲和肽的筛选与用途
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
WO2007098541A1 (en) * 2006-02-28 2007-09-07 Regenertech Pty Limited Tissue regeneration ii
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
FR2919188B1 (fr) * 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
US20090291113A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor, a soluble cation salt and organic support
US20090291114A1 (en) * 2008-04-14 2009-11-26 Adocia Osteogenic composition comprising a growth factor/amphiphilic polymer complex, a soluble cation salt and an organic support
JP5763535B2 (ja) * 2008-06-24 2015-08-12 バイオアクティブ サージカル インコーポレイテッド 幹細胞または他の生理活性材料が組み込まれた外科手術用縫合糸
CN102176882A (zh) 2008-08-07 2011-09-07 生物活性外科公司 医疗器械和植入物的干细胞捕获和固定涂层
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
US8883967B2 (en) * 2009-03-27 2014-11-11 Kansas State University Research Foundation Branched amphipathic oligo-peptides that self-assemble into vesicles
KR20120012811A (ko) * 2009-04-13 2012-02-10 노오쓰웨스턴 유니버시티 신규한 연골 재생용 펩티드-기반 스카폴드 및 이들의 사용 방법
US20100322979A1 (en) * 2009-06-22 2010-12-23 University Of South Carolina Peptidomimetic Resorbable Peptide-Polymer Hybrid Polyester Nanoparticles
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
SG10201502519WA (en) * 2010-03-31 2015-05-28 Agency Science Tech & Res Amphiphilic Linear Peptide/Peptoid And Hydrogel Comprising The Same
US8940858B2 (en) * 2010-05-17 2015-01-27 Northwestern University Fibrous microcapsules and methods of assembly and use thereof
GB201011602D0 (en) * 2010-07-09 2010-08-25 Univ London Pharmacy Delivery of hydrophilic peptides
KR20130137164A (ko) * 2010-09-01 2013-12-16 더 리전트 오브 더 유니버시티 오브 캘리포니아 지방생성 및 근섬유모세포 분화 제어 작용제에 대한 세포 배양 스크리닝
EP3412279B1 (de) 2010-09-24 2021-02-17 The Brigham and Women's Hospital, Inc. Nanostrukturierte gele geeignet zur kontrollierten freisetzung verkapselter mittel
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2012149515A2 (en) * 2011-04-29 2012-11-01 Northwestern University Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
US9241891B2 (en) 2012-10-30 2016-01-26 The Procter & Gamble Company Personal care compositions comprising self-assembling peptides
AU2013347797A1 (en) 2012-11-25 2015-07-02 The Regents Of The University Of California Peptides that stimulate subcutaneous adipogenesis
US9169294B2 (en) * 2013-03-11 2015-10-27 Northwestern University Anti-angiogenic molecules, nanostructures and uses thereof
MX2015012461A (es) 2013-03-15 2016-08-08 Bioven 3 Ltd Proteinas sintéticas autoensamblables.
ES2756531T3 (es) 2013-08-22 2020-04-27 Arch Biosurgery Inc Mallas implantables para controlar el movimiento de fluidos
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
BR112016012230A2 (pt) * 2013-11-30 2017-08-08 Agency Science Tech & Res Peptídeo hidrofóbico e/ou peptídeo-mimético, capaz de formar um hidrogel; composição ou mistura; hidrogel; uso do hidrogel; método para preparar um hidrogel; curativo de ferida ou agente cicatrizante de ferida; implante cirúrgico; composição cosmética e/ou farmacêutica e/ou um dispositivo biomédico e/ou dispositivo eletrônico; kit de peças; método in vitro ou in vivo de regeneração de tecido; método de tratamento de uma ferida e para cicatrização de ferida; dispositivo de bioimagem; e; substrato de cultura da célula 2d ou 3d
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
DE102015000363A1 (de) 2015-01-20 2016-07-21 Emc Microcollections Gmbh Neue modular funktionalisierbare Peptid-Hydrogele
WO2016168302A1 (en) * 2015-04-14 2016-10-20 Northwestern University Supramolecular glyconanostructures
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
WO2017066545A1 (en) * 2015-10-14 2017-04-20 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
US11021516B2 (en) * 2016-09-09 2021-06-01 Research Foundation Of The City University Of New York Self-assembling peptide polymer
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
CN106749522B (zh) * 2016-11-23 2023-11-14 华东理工大学 一种含有聚组氨酸的抗癌多肽及其制备与应用
EP3548518A1 (de) 2016-11-30 2019-10-09 Universiteit Twente Funktionalisierung von biopolymeren mit wachstumsfaktorbindenden peptiden
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
US10584146B2 (en) 2016-12-07 2020-03-10 Uchicago Argonne, Llc Heme peptide materials for anti-inflammatory regenerative nanobiomedicine
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US10881745B2 (en) 2017-05-08 2021-01-05 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
WO2019195741A1 (en) * 2018-04-06 2019-10-10 Northwestern University Bdnf mimetic peptide amphiphiles
US11839605B2 (en) 2018-10-11 2023-12-12 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release
AU2020277404A1 (en) * 2019-05-20 2021-11-25 Convalesce Inc. Hydrogels, methods of making, and methods of use
CN110283231B (zh) * 2019-06-03 2021-04-27 中南民族大学 一种基于两亲性寡肽自组装新型溶致液晶的制备和应用
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
WO2022099123A1 (en) * 2020-11-06 2022-05-12 The Medical College Of Wisconsin, Inc. Peptide inhibitors of human mitochondrial fission protein 1 and methods of use
CA3225407A1 (en) * 2021-07-29 2023-02-02 Shelby Chi YUAN Self-assembling peptide amphiphiles displaying a transforming growth factor beta 1 (tgf-.beta.1) mimetic epitope
EP4384532A1 (de) * 2021-08-09 2024-06-19 Gel4Med, Inc. Selbstanordnende amphiphile peptidhydrogele zur behandlung von nervenläsionen
WO2024064661A2 (en) * 2022-09-20 2024-03-28 The Curators Of The University Of Missouri Amino acid-modified lipids for rna delivery

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) * 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5110604A (en) 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
DK0585368T3 (da) 1991-04-25 1998-03-16 Univ Brown Res Found Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
JPH11510837A (ja) 1995-07-28 1999-09-21 フォーカル,インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
DE69731632D1 (de) * 1996-06-12 2004-12-23 Treofan Germany Gmbh & Co Kg Durchsichtige sperrüberzüge mit verringerter dünnfilm-interferenz
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
PT988056E (pt) 1997-01-22 2003-09-30 Univ Texas Metodos e composicoes de factor tecidual para o tratamento da coagulacao e de tumores
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
AU7245598A (en) 1997-04-03 1998-10-22 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
US6391297B1 (en) 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (sv) * 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
PT1107791E (pt) 1998-09-04 2007-07-06 Scios Inc Composições de hidrogel para a administração com libertação controlada de factores de crescimento
CA2277732A1 (en) * 1998-09-15 2000-03-15 Isotis B.V. Method for coating medical implants
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
EP1181323B1 (de) 1999-02-01 2011-06-29 Eidgenössische Technische Hochschule Zürich Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind
EP1156816A4 (de) 1999-02-02 2004-12-29 Univ Jefferson Peptide die die aktivitäten von heparin und anderen glykosaminoglykanen oder proteoglykanen modulieren
AU3391300A (en) 1999-03-02 2000-09-21 University Of Massachusetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
ES2255257T3 (es) 1999-04-22 2006-06-16 Eidgenossische Technische Hochschule (Eth) Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina.
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
IL147179A0 (en) 1999-06-30 2002-08-14 Advanced Cell Tech Inc Cytoplasmic transfer to de-differentiate recipient cells
US6444723B1 (en) 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
WO2001048148A1 (en) * 1999-12-28 2001-07-05 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
US20040018969A1 (en) * 2000-01-31 2004-01-29 Rosen Craig A. Nucleic acids, proteins, and antibodies
CA2395666A1 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
DE60100433T2 (de) 2000-02-04 2004-04-15 Chienna B.V. Proteinbeschichtung
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
EP1287039A1 (de) 2000-04-28 2003-03-05 University College Dublin Ampiphile makrozyklische derivate und ihre analoge
EP1352338A2 (de) 2000-05-11 2003-10-15 University Of Southern California Techniken der maschinellen übersetzung
EP1315830A4 (de) * 2000-09-08 2005-10-19 Univ Texas Zusammensetzungen und verfahren zur zielgerichteten, in vivo einbringung von peptiden in den menschen
AU2002245205B2 (en) 2000-10-19 2007-07-19 Ecole Polytechnique Federale De Lausanne Block copolymers for multifunctional self-assembled systems
CA2431552A1 (en) * 2000-11-06 2002-05-16 Thrasos, Inc. Screening methods for bone morphogenetic mimetics
JP2004524559A (ja) 2001-01-23 2004-08-12 エデュケーショナル テスティング サービス 論文の自動分析方法
US7449180B2 (en) 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
WO2002062969A2 (en) * 2001-02-06 2002-08-15 Massachusetts Institute Of Technology Cellular reprogramming in peptide hydrogel and uses thereof
WO2003006043A1 (en) 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2002361601A1 (en) 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
AU2002365162A1 (en) 2001-11-14 2003-07-09 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
AU2003215280A1 (en) * 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) * 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
US6890654B2 (en) 2002-04-18 2005-05-10 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
AU2003285853A1 (en) 2002-07-23 2004-04-30 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
US7534761B1 (en) * 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
AU2003304280A1 (en) 2002-11-12 2005-01-21 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7683025B2 (en) * 2002-11-14 2010-03-23 Northwestern University Synthesis and self-assembly of ABC triblock bola peptide amphiphiles
US7390526B2 (en) 2003-02-11 2008-06-24 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
CN100364672C (zh) 2003-02-11 2008-01-30 西北大学 纳米晶体表面涂层和肽亲水脂分子纳米纤维向其上附着的方法和材料
GB0303362D0 (en) 2003-02-13 2003-03-19 Enact Pharma Plc Tissue regeneration
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
MXPA06006387A (es) 2003-12-05 2006-09-04 Univ Northwestern Peptidos anfifilicos ramificados, compuestos epitopes relacionados y estructuras auto-ensambladas de los mismos.
EP2314305A3 (de) 2003-12-05 2011-08-10 Northwestern University Selbst anordnende Peptid-Amphiphile und relevante Verfahren für die Abgabe von Wachstumsfaktoren
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
WO2005094862A1 (en) * 2004-03-23 2005-10-13 Lifeline Nutraceuticals Corporation Compositions and method for alleviating inflammation and oxidative stress in a mammal
WO2006079019A2 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stabitity containing at least one counterion
EP1838846A4 (de) 2005-01-21 2008-12-10 Univ Northwestern Verfahren und zusammensetzungen zur verkapselung von zellen
MX2007010771A (es) * 2005-03-04 2008-03-10 Univ Northwestern Anfifilos peptidicos para union a heparina angiogenicos.
ES2363758T3 (es) 2005-08-15 2011-08-16 Vegenics Pty Ltd Vegf y pdgf modificados con propiedades angiogénicas mejoradas.
CN1915438A (zh) 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
WO2008101104A2 (en) * 2007-02-14 2008-08-21 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) * 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods
KR20120012811A (ko) * 2009-04-13 2012-02-10 노오쓰웨스턴 유니버시티 신규한 연골 재생용 펩티드-기반 스카폴드 및 이들의 사용 방법

Also Published As

Publication number Publication date
EP2314305A2 (de) 2011-04-27
WO2005056039A1 (en) 2005-06-23
US20050209145A1 (en) 2005-09-22
NZ547671A (en) 2009-10-30
KR20070004560A (ko) 2007-01-09
US8580923B2 (en) 2013-11-12
JP2012006951A (ja) 2012-01-12
JP2007513174A (ja) 2007-05-24
EP2314305A3 (de) 2011-08-10
MXPA06006388A (es) 2006-09-04
US7544661B2 (en) 2009-06-09
US8138140B2 (en) 2012-03-20
CN1905892A (zh) 2007-01-31
US20090269847A1 (en) 2009-10-29
EP1696945A1 (de) 2006-09-06
JP4851939B2 (ja) 2012-01-11
EP1696945A4 (de) 2007-03-21
AU2004296181A1 (en) 2005-06-23
AU2011201593A1 (en) 2011-04-28
CA2549164A1 (en) 2005-06-23
ES2380340T3 (es) 2012-05-10
US20120264912A1 (en) 2012-10-18
EP1696945B1 (de) 2012-01-18
CN102225964A (zh) 2011-10-26

Similar Documents

Publication Publication Date Title
ATE541580T1 (de) Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
SG153865A1 (en) Metastin derivatives and use thereof
HK1080517A1 (en) Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
EA200601313A1 (ru) Варианты участка f
CY1111225T1 (el) Νεα πεπτιδια ως αναστολεις πρωτεασης νs3-σερινης ιου ηπατiτιδας c
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
EP1990059A3 (de) Verfahren zur Behandlung von Krebs
YU9404A (sh) Multimerna, usmerena kontrastna sredstva na bazi peptida
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
IL173929A0 (en) Analogues of kahalalide f and pharmaceutical compositions containing the same
NO20073914L (no) Biologisk aktive peptider
DE602004028239D1 (de) Protease, für die protease codierende dna und verfahren zur herstellung der protease
ATE370964T1 (de) Isoliertes fluoreszierendes protein aus clytia gregaria cgfp, sowie dessen verwendung
DE602004001047D1 (de) Phospholipidester von Clofarabin
WO2003093300A3 (en) Anti-microbial peptides and compositions
ATE505538T1 (de) Dna-vektoren
DE60120187D1 (de) Verkürztes bard1 protein und dessen diagnostische und therapeutische anwendungen
ATE426033T1 (de) Promoter sequenzen aus moos und dessen verwendung
ATE529437T1 (de) Verfahren zur sauerstoff-regulierten produktion von recombinanter staphylokinase