BR112017005736A2 - macrociclos peptidomiméticos e formulações dos mesmos - Google Patents

macrociclos peptidomiméticos e formulações dos mesmos

Info

Publication number
BR112017005736A2
BR112017005736A2 BR112017005736A BR112017005736A BR112017005736A2 BR 112017005736 A2 BR112017005736 A2 BR 112017005736A2 BR 112017005736 A BR112017005736 A BR 112017005736A BR 112017005736 A BR112017005736 A BR 112017005736A BR 112017005736 A2 BR112017005736 A2 BR 112017005736A2
Authority
BR
Brazil
Prior art keywords
disclosed
formulations
peptidomimetic macrocycles
pharmaceutical formulations
aqueous pharmaceutical
Prior art date
Application number
BR112017005736A
Other languages
English (en)
Inventor
Rhodes Chris
Allen Annis David
Hoernschemeyer Joerg
Darlak Krzysztof
Grass Michaela
KANAI Sonoko
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of BR112017005736A2 publication Critical patent/BR112017005736A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

são divulgadas formulações farmacêuticas aquosas, para administração parenteral, compreendendo um macrociclo peptidomimético ou um sal farmaceuticamente aceitável do mesmo onde o macrociclo peptidomimético liga-se às proteínas mdm2 e/ou mdmx. também são divulgados métodos para tratar doenças e distúrbios usando as formulações farmacêuticas aquosas divulgadas nesta invenção.
BR112017005736A 2014-09-24 2015-09-24 macrociclos peptidomiméticos e formulações dos mesmos BR112017005736A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462054842P 2014-09-24 2014-09-24
PCT/US2015/052018 WO2016049355A1 (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof

Publications (1)

Publication Number Publication Date
BR112017005736A2 true BR112017005736A2 (pt) 2017-12-12

Family

ID=55582019

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005736A BR112017005736A2 (pt) 2014-09-24 2015-09-24 macrociclos peptidomiméticos e formulações dos mesmos

Country Status (12)

Country Link
US (3) US10905739B2 (pt)
EP (1) EP3197477A4 (pt)
JP (3) JP2018503595A (pt)
KR (1) KR102570210B1 (pt)
CN (2) CN112972378A (pt)
AU (1) AU2015320545C1 (pt)
BR (1) BR112017005736A2 (pt)
CA (1) CA2961029A1 (pt)
IL (1) IL251122B (pt)
MX (1) MX2017003819A (pt)
SG (2) SG11201702175YA (pt)
WO (1) WO2016049355A1 (pt)

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JP5656407B2 (ja) 2006-12-14 2015-01-21 エイルロン セラピューティクス，インコーポレイテッド ビス−スルフヒドリル大環状化系
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AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
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AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2017011834A (es) * 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20170114098A1 (en) * 2015-09-03 2017-04-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017173346A1 (en) * 2016-04-01 2017-10-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Par3 mimetic peptides and uses thereof
WO2017205786A1 (en) * 2016-05-27 2017-11-30 Aileron Therapeutics, Inc. Cell permeable peptidomimetic macrocycles
WO2017218949A2 (en) * 2016-06-17 2017-12-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2018098534A1 (en) * 2016-12-02 2018-06-07 Garvan Institute Of Medical Research Methods of treating cancer and reagents thereof
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SG11202103947XA (en) * 2018-10-24 2021-05-28 Allysta Pharmaceuticals Inc Adiponectin peptidomimetics formulations
US20200289609A1 (en) * 2019-03-15 2020-09-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CA3176107A1 (en) * 2020-03-20 2021-09-23 Techfields Inc. Method for improving the stability of a pharmaceutical composition comprising a high penetration drug, and the pharmaceutical composition obtained therefrom
EP4228699A1 (en) * 2020-10-14 2023-08-23 Dana-Farber Cancer Institute, Inc. Chimeric conjugates for degradation of viral and host proteins and methods of use

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