DK0832096T3 - Syntese af proteiner ved nativ kemisk ligering - Google Patents

Syntese af proteiner ved nativ kemisk ligering

Info

Publication number
DK0832096T3
DK0832096T3 DK95919029T DK95919029T DK0832096T3 DK 0832096 T3 DK0832096 T3 DK 0832096T3 DK 95919029 T DK95919029 T DK 95919029T DK 95919029 T DK95919029 T DK 95919029T DK 0832096 T3 DK0832096 T3 DK 0832096T3
Authority
DK
Denmark
Prior art keywords
ligation
native
proteins
full length
native chemical
Prior art date
Application number
DK95919029T
Other languages
English (en)
Inventor
B H Kent Stephen
W Muir Tom
Philip E Dawson
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0832096T3 publication Critical patent/DK0832096T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
DK95919029T 1995-05-04 1995-05-04 Syntese af proteiner ved nativ kemisk ligering DK0832096T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/005668 WO1996034878A1 (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation
CA002218620A CA2218620C (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation

Publications (1)

Publication Number Publication Date
DK0832096T3 true DK0832096T3 (da) 2001-10-01

Family

ID=25679740

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95919029T DK0832096T3 (da) 1995-05-04 1995-05-04 Syntese af proteiner ved nativ kemisk ligering

Country Status (13)

Country Link
EP (1) EP0832096B1 (da)
JP (1) JP3599346B2 (da)
AT (1) ATE203248T1 (da)
AU (1) AU711451B2 (da)
CA (1) CA2218620C (da)
DE (1) DE69521815T2 (da)
DK (1) DK0832096T3 (da)
ES (1) ES2161885T3 (da)
GR (1) GR3036895T3 (da)
MX (1) MX9708500A (da)
PT (1) PT832096E (da)
SI (1) SI0832096T1 (da)
WO (1) WO1996034878A1 (da)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
AU6020998A (en) 1997-01-08 1998-08-03 Life Technologies, Inc. Methods for production of proteins
EP1518862B1 (en) * 1997-06-13 2007-02-21 Gryphon Therapeutics, Inc. Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
EP1001968B1 (en) * 1997-06-13 2004-12-22 Gryphon Therapeutics, Inc. Solid phase native chemical ligation of unprotected or n-terminal cysteine protected peptides in aqueous solution
US6168784B1 (en) 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
US6844161B2 (en) 1997-09-04 2005-01-18 Gryphon Therapeutics, Inc. Modular protein libraries and methods of preparation
US6875594B2 (en) * 1997-11-13 2005-04-05 The Rockefeller University Methods of ligating expressed proteins
KR20010085743A (ko) 1998-08-31 2001-09-07 추후제출 지질 매트릭스 보조 화학결합 및 막 폴리펩티드의 합성
AUPP589598A0 (en) 1998-09-14 1998-10-08 University Of Queensland, The Novel peptides
CA2364997A1 (en) 1999-03-05 2000-09-08 Maxygen, Inc. Encryption of traits using split gene sequences
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US6277957B1 (en) * 2000-03-23 2001-08-21 Derek Hudson Method for production of acylthio derivatives
AU2001269906A1 (en) * 2000-06-19 2002-01-02 Zyomyx, Inc. Methods for immobilizing polypeptides
US6977292B2 (en) 2000-09-01 2005-12-20 Gryphon Therapeutics Nucleophile-stable thioester generating compounds, methods of production and use
WO2002019963A2 (en) 2000-09-08 2002-03-14 Gryphon Therapeutics, Inc. Synthetic erythropoiesis stimulating proteins
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
GB0123262D0 (en) * 2001-09-27 2001-11-21 Adprotech Ltd Polymeric compounds
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
JP2005532267A (ja) * 2002-02-19 2005-10-27 エールエムエフ・ディクタジェーヌ・ソシエテ・アノニム インターフェロンの製造方法
EP1616003A4 (en) 2002-12-30 2007-06-20 Gryphon Therapeutics Inc WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
DE10335584B4 (de) * 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
US7635750B2 (en) 2003-09-05 2009-12-22 Sloan-Kettering Institute For Cancer Research Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation
PL2332968T3 (pl) 2003-11-05 2017-08-31 Dana-Farber Cancer Institute, Inc. Stabilizowane alfa-helikalne peptydy i ich zastosowania
US8754192B2 (en) 2006-04-11 2014-06-17 Sloan-Kettering Institute For Cancer Research Compositions comprising homogeneously glycosylated erythropoietin
US20100113342A1 (en) * 2006-06-20 2010-05-06 Yount Nannette I Antimicrobial kinocidin compositions and methods of use
CN105061577A (zh) 2006-12-14 2015-11-18 爱勒让治疗公司 双巯基大环化系统
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
SG183068A1 (en) 2007-07-31 2012-08-30 Otsuka Chemical Co Ltd Method for producing peptide
WO2010011313A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
US20110262945A1 (en) 2008-08-19 2011-10-27 Otsuka Chemical Co., Ltd. Glycoprotein production method and screening method
CA2737921C (en) 2008-09-22 2019-01-15 Aileron Therapeutics, Inc. Methods for preparing purified alpha-helical peptidomimetic macrocycle compositions with low metal ppm levels
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
CN102803286B (zh) * 2009-06-26 2015-01-14 株式会社糖锁工学研究所 肽硫酯的制造方法
CN102510755A (zh) 2009-07-13 2012-06-20 哈佛大学校长及研究员协会 双功能钉接多肽和其用途
JPWO2011007747A1 (ja) 2009-07-16 2012-12-27 株式会社糖鎖工学研究所 糖鎖付加ａｉｌｉｍ細胞外ドメイン及びその製造方法
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
FR2971509B1 (fr) 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
RU2586524C2 (ru) 2011-03-10 2016-06-10 Глитек, Инк. Способ получения гликопептида, имеющего сиалированную сахарную цепь, и способ получения производного сиалилгликоаспарагина
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
SG11201400936QA (en) 2011-09-26 2014-10-30 Glytech Inc Method for producing polypeptide fragment with high efficiency, which is suitable for ncl method
FR2981352B1 (fr) 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
FR2988392B1 (fr) 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN110105434A (zh) 2013-03-13 2019-08-09 哈佛大学的校长及成员们 钉合且缝合的多肽及其用途
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
CN111620940A (zh) 2014-05-21 2020-09-04 哈佛大学的校长及成员们 Ras抑制肽和其用途
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
AU2018228182B2 (en) 2017-03-02 2024-04-11 Glytech, Inc. Production method for amino-acid polymer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228537B (it) * 1987-07-30 1991-06-20 Magis Farmaceutici Derivati della cisteina ad azione espettorante
JP3124018B2 (ja) * 1989-05-02 2001-01-15 アボット・ラボラトリーズ 結合アッセイ用固相の調製方法

Also Published As

Publication number Publication date
WO1996034878A1 (en) 1996-11-07
SI0832096T1 (en) 2001-12-31
JP3599346B2 (ja) 2004-12-08
PT832096E (pt) 2002-01-30
DE69521815D1 (de) 2001-08-23
ES2161885T3 (es) 2001-12-16
AU2474095A (en) 1996-11-21
CA2218620C (en) 2007-02-27
EP0832096A4 (en) 1998-08-05
DE69521815T2 (de) 2002-04-04
CA2218620A1 (en) 1996-11-07
ATE203248T1 (de) 2001-08-15
AU711451B2 (en) 1999-10-14
EP0832096A1 (en) 1998-04-01
GR3036895T3 (en) 2002-01-31
MX9708500A (es) 1998-02-28
JPH11508874A (ja) 1999-08-03
EP0832096B1 (en) 2001-07-18

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