SG10201902598VA - Peptidomimetic macrocycles and formulations thereof - Google Patents

Peptidomimetic macrocycles and formulations thereof

Info

Publication number
SG10201902598VA
SG10201902598VA SG10201902598VA SG10201902598VA SG10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA SG 10201902598V A SG10201902598V A SG 10201902598VA
Authority
SG
Singapore
Prior art keywords
formulations
disclosed
peptidomimetic macrocycles
peptidomimetic
aqueous pharmaceutical
Prior art date
Application number
SG10201902598VA
Inventor
David Allen Annis
Krzysztof Darlak
Chris Rhodes
Sonoko Kanai
Joerg Hoernschemeyer
Michaela Grass
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of SG10201902598VA publication Critical patent/SG10201902598VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein. No suitable figure
SG10201902598VA 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof SG10201902598VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462054842P 2014-09-24 2014-09-24

Publications (1)

Publication Number Publication Date
SG10201902598VA true SG10201902598VA (en) 2019-04-29

Family

ID=55582019

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201702175YA SG11201702175YA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof
SG10201902598VA SG10201902598VA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201702175YA SG11201702175YA (en) 2014-09-24 2015-09-24 Peptidomimetic macrocycles and formulations thereof

Country Status (12)

Country Link
US (3) US10905739B2 (en)
EP (1) EP3197477A4 (en)
JP (3) JP2018503595A (en)
KR (1) KR102570210B1 (en)
CN (2) CN107106642B (en)
AU (1) AU2015320545C1 (en)
BR (1) BR112017005736A2 (en)
CA (1) CA2961029A1 (en)
IL (1) IL251122B (en)
MX (1) MX2017003819A (en)
SG (2) SG11201702175YA (en)
WO (1) WO2016049355A1 (en)

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CN106999541A (en) 2014-09-24 2017-08-01 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound and application thereof
SG11201707750YA (en) * 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017040990A1 (en) * 2015-09-03 2017-03-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
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WO2017205786A1 (en) * 2016-05-27 2017-11-30 Aileron Therapeutics, Inc. Cell permeable peptidomimetic macrocycles
WO2017218949A2 (en) * 2016-06-17 2017-12-21 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
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US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
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WO2020190742A1 (en) * 2019-03-15 2020-09-24 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN115484984A (en) * 2020-03-20 2022-12-16 于崇曦 Method for improving stability of pharmaceutical composition comprising high penetration drug and pharmaceutical composition obtained thereby
US20230330238A1 (en) * 2020-10-14 2023-10-19 Dana-Farber Cancer Institute, Inc. Chimeric conjugates for degradation of viral and host proteins and methods of use

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