GB9708092D0 - Materials and methods relating to inhibiting the interaction of p53 and mdm2 - Google Patents

Materials and methods relating to inhibiting the interaction of p53 and mdm2

Info

Publication number
GB9708092D0
GB9708092D0 GBGB9708092.3A GB9708092A GB9708092D0 GB 9708092 D0 GB9708092 D0 GB 9708092D0 GB 9708092 A GB9708092 A GB 9708092A GB 9708092 D0 GB9708092 D0 GB 9708092D0
Authority
GB
United Kingdom
Prior art keywords
mdm2
cells
inhibiting
interaction
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9708092.3A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Priority to GBGB9708092.3A priority Critical patent/GB9708092D0/en
Publication of GB9708092D0 publication Critical patent/GB9708092D0/en
Priority to CA002287344A priority patent/CA2287344A1/en
Priority to PCT/GB1998/001144 priority patent/WO1998047525A1/en
Priority to AU70644/98A priority patent/AU731431B2/en
Priority to DE69813204T priority patent/DE69813204T2/en
Priority to EP98917411A priority patent/EP0977580B1/en
Priority to AT98917411T priority patent/ATE236651T1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Mdm2 binds to p53 in cells in which mdm2 is not overexpressed, i.e. in cells in which mdm2 is expressed at normal or low levels, and that in these cells, this interaction targets the p53 for degradation. This finding means that inhibiting mdm2 production and/or inhibiting the binding of mdm2 to p53 allows levels of p53 to increase by reducing the clearance of p53 by mdm2, and can be used to activate p53 function in cells other than those in which mdm2 is overexpressed. This allows the use of an agent having the property of disrupting the binding of p53 and mdm2 or inhibiting the production of mdm2 in a population of cells, in the preparation of a medicament for activating p53, wherein the population of cells do not overexpress mdm2. Such medicaments are useful in the treatment of conditions such as cancer, viral infections or conditions in which p53 or mdm2 is not functional.
GBGB9708092.3A 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2 Pending GB9708092D0 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GBGB9708092.3A GB9708092D0 (en) 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2
CA002287344A CA2287344A1 (en) 1997-04-22 1998-04-20 Materials and methods relating to inhibiting the interaction of p53 and mdm2
PCT/GB1998/001144 WO1998047525A1 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATING TO INHIBITING THE INTERACTION OF p53 AND mdm2
AU70644/98A AU731431B2 (en) 1997-04-22 1998-04-20 Materials and methods relating to inhibiting the interaction of p53 and mdm2
DE69813204T DE69813204T2 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATED TO INHIBITING THE INTERACTION OF THE P53 AND MDM2
EP98917411A EP0977580B1 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATING TO INHIBITING THE INTERACTION OF p53 AND mdm2
AT98917411T ATE236651T1 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATED TO INHIBITING THE INTERACTION OF P53 AND MDM2

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708092.3A GB9708092D0 (en) 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2

Publications (1)

Publication Number Publication Date
GB9708092D0 true GB9708092D0 (en) 1997-06-11

Family

ID=10811137

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9708092.3A Pending GB9708092D0 (en) 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2

Country Status (7)

Country Link
EP (1) EP0977580B1 (en)
AT (1) ATE236651T1 (en)
AU (1) AU731431B2 (en)
CA (1) CA2287344A1 (en)
DE (1) DE69813204T2 (en)
GB (1) GB9708092D0 (en)
WO (1) WO1998047525A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108929375A (en) 2011-10-18 2018-12-04 爱勒让治疗公司 Peptidomimetic macrocyclic compound
TWI583792B (en) * 2011-11-09 2017-05-21 曼茲法瑪股份有限公司 Neurotoxins exhibiting shortened biological activity
ES2817877T3 (en) 2012-02-15 2021-04-08 Aileron Therapeutics Inc Peptidomimetic macrocycles
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
JP6526563B2 (en) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド Disubstituted amino acids and methods for their preparation and use
BR112017005736A2 (en) 2014-09-24 2017-12-12 Aileron Therapeutics Inc peptidomimetic macrocycles and formulations thereof
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108368161A (en) 2015-09-10 2018-08-03 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound as MCL-1 conditioning agents
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
US5770377A (en) * 1994-07-20 1998-06-23 University Of Dundee Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
DE69738754D1 (en) * 1996-07-05 2008-07-17 Cancer Rec Tech Ltd HEMMER OF INTERACTION BETWEEN P53 AND MDM2

Also Published As

Publication number Publication date
EP0977580A1 (en) 2000-02-09
EP0977580B1 (en) 2003-04-09
AU7064498A (en) 1998-11-13
ATE236651T1 (en) 2003-04-15
WO1998047525A1 (en) 1998-10-29
DE69813204D1 (en) 2003-05-15
AU731431B2 (en) 2001-03-29
DE69813204T2 (en) 2004-02-05
CA2287344A1 (en) 1998-10-29

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