FR2881430B1 - Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations - Google Patents

Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations

Info

Publication number
FR2881430B1
FR2881430B1 FR0500978A FR0500978A FR2881430B1 FR 2881430 B1 FR2881430 B1 FR 2881430B1 FR 0500978 A FR0500978 A FR 0500978A FR 0500978 A FR0500978 A FR 0500978A FR 2881430 B1 FR2881430 B1 FR 2881430B1
Authority
FR
France
Prior art keywords
bcl
protein family
novel peptides
apoptotic members
peptides interacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0500978A
Other languages
English (en)
Other versions
FR2881430A1 (fr
Inventor
Olivier Geneste
John Hickman
Jean Christophe Rain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybrigenics SA
Laboratoires Servier SAS
Original Assignee
Hybrigenics SA
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0500978A priority Critical patent/FR2881430B1/fr
Application filed by Hybrigenics SA, Laboratoires Servier SAS filed Critical Hybrigenics SA
Priority to CA002596674A priority patent/CA2596674A1/fr
Priority to JP2007553644A priority patent/JP4713597B2/ja
Priority to US11/883,400 priority patent/US7927813B2/en
Priority to EP06709202A priority patent/EP1844067A2/fr
Priority to PCT/FR2006/000206 priority patent/WO2006082304A2/fr
Priority to CNA2006800038055A priority patent/CN101111517A/zh
Publication of FR2881430A1 publication Critical patent/FR2881430A1/fr
Application granted granted Critical
Publication of FR2881430B1 publication Critical patent/FR2881430B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
FR0500978A 2005-02-01 2005-02-01 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations Expired - Fee Related FR2881430B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0500978A FR2881430B1 (fr) 2005-02-01 2005-02-01 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
JP2007553644A JP4713597B2 (ja) 2005-02-01 2006-01-31 Ｂｃｌ−２タンパク質ファミリーの抗アポトーシスメンバーと相互作用する新規なペプチドおよびその使用
US11/883,400 US7927813B2 (en) 2005-02-01 2006-01-31 Peptides which interact with anti-apoptotic members of the Bcl-2 protein family, and uses
EP06709202A EP1844067A2 (fr) 2005-02-01 2006-01-31 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
CA002596674A CA2596674A1 (fr) 2005-02-01 2006-01-31 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
PCT/FR2006/000206 WO2006082304A2 (fr) 2005-02-01 2006-01-31 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
CNA2006800038055A CN101111517A (zh) 2005-02-01 2006-01-31 与bcl-2蛋白质家族抗细胞凋亡成员相互作用的新肽及其用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0500978A FR2881430B1 (fr) 2005-02-01 2005-02-01 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations

Publications (2)

Publication Number Publication Date
FR2881430A1 FR2881430A1 (fr) 2006-08-04
FR2881430B1 true FR2881430B1 (fr) 2010-10-22

Family

ID=35335679

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0500978A Expired - Fee Related FR2881430B1 (fr) 2005-02-01 2005-02-01 Nouveaux peptides interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations

Country Status (7)

Country Link
US (1) US7927813B2 (fr)
EP (1) EP1844067A2 (fr)
JP (1) JP4713597B2 (fr)
CN (1) CN101111517A (fr)
CA (1) CA2596674A1 (fr)
FR (1) FR2881430B1 (fr)
WO (1) WO2006082304A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
CA2807685C (fr) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. Macrocycle peptidomimetique derive de p53
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2013123266A1 (fr) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
EP3347372A4 (fr) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7064193B1 (en) * 1997-09-17 2006-06-20 The Walter And Eliza Hall Institute Of Medical Research Therapeutic molecules
AU2001271426A1 (en) * 2000-07-17 2002-01-30 Washington University Modulation of apoptosis
US7588914B2 (en) * 2001-11-13 2009-09-15 Burnham Institute For Medical Research Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods
DE60210919T2 (de) * 2002-03-07 2007-05-10 Institut Pasteur Verfahren zum Screening von Verbindungen, die die Apoptose modulieren, derart identifizierte Verbindungen, sowie Verwendung der Verbindungen als pharmazeutische Agentien
AU2003302167A1 (en) * 2002-12-12 2004-06-30 The Burnham Institute Conversion of apoptotic proteins
FR2858621B1 (fr) * 2003-08-06 2007-09-07 Servier Lab Nouveau peptide interagissant avec bcl-xl et bcl-2
PL2332968T3 (pl) * 2003-11-05 2017-08-31 Dana-Farber Cancer Institute, Inc. Stabilizowane alfa-helikalne peptydy i ich zastosowania

Also Published As

Publication number Publication date
WO2006082304A2 (fr) 2006-08-10
JP4713597B2 (ja) 2011-06-29
US20090325883A1 (en) 2009-12-31
US7927813B2 (en) 2011-04-19
FR2881430A1 (fr) 2006-08-04
JP2008528048A (ja) 2008-07-31
EP1844067A2 (fr) 2007-10-17
CA2596674A1 (fr) 2006-08-10
WO2006082304A3 (fr) 2007-02-15
CN101111517A (zh) 2008-01-23

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Legal Events

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ST Notification of lapse

Effective date: 20131031