PL2076535T3 - Antagoniści somatostatyny selektywni względem receptora (SSTR2) - Google Patents
Antagoniści somatostatyny selektywni względem receptora (SSTR2)Info
- Publication number
- PL2076535T3 PL2076535T3 PL07854075T PL07854075T PL2076535T3 PL 2076535 T3 PL2076535 T3 PL 2076535T3 PL 07854075 T PL07854075 T PL 07854075T PL 07854075 T PL07854075 T PL 07854075T PL 2076535 T3 PL2076535 T3 PL 2076535T3
- Authority
- PL
- Poland
- Prior art keywords
- sstr2
- receptor
- somatostatin antagonists
- selective somatostatin
- selective
- Prior art date
Links
- 102000005157 Somatostatin Human genes 0.000 title 1
- 108010056088 Somatostatin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
- 229960000553 somatostatin Drugs 0.000 title 1
- 102000004052 somatostatin receptor 2 Human genes 0.000 title 1
- 108090000586 somatostatin receptor 2 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82963706P | 2006-10-16 | 2006-10-16 | |
| EP07854075A EP2076535B1 (en) | 2006-10-16 | 2007-10-15 | Receptor(sstr2)-selective somatostatin antagonists |
| PCT/US2007/081430 WO2008048942A2 (en) | 2006-10-16 | 2007-10-15 | Receptor(sstr2)-selective somatostatin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2076535T3 true PL2076535T3 (pl) | 2013-08-30 |
Family
ID=39144622
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07854075T PL2076535T3 (pl) | 2006-10-16 | 2007-10-15 | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
| PL11194516T PL2433963T3 (pl) | 2006-10-16 | 2007-10-15 | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
| PL11173287T PL2383289T3 (pl) | 2006-10-16 | 2007-10-15 | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11194516T PL2433963T3 (pl) | 2006-10-16 | 2007-10-15 | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
| PL11173287T PL2383289T3 (pl) | 2006-10-16 | 2007-10-15 | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7960342B2 (pl) |
| EP (3) | EP2076535B1 (pl) |
| JP (1) | JP5295967B2 (pl) |
| CN (2) | CN103288919B (pl) |
| AU (1) | AU2007311137B2 (pl) |
| BR (1) | BRPI0717135B8 (pl) |
| CA (1) | CA2666642C (pl) |
| DK (1) | DK2076535T3 (pl) |
| ES (2) | ES2410207T3 (pl) |
| PL (3) | PL2076535T3 (pl) |
| PT (1) | PT2076535E (pl) |
| SI (1) | SI2076535T1 (pl) |
| WO (1) | WO2008048942A2 (pl) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8691761B2 (en) * | 2006-10-16 | 2014-04-08 | Jean E. F. Rivier | Somatostatin receptor 2 antagonists |
| PL2076535T3 (pl) | 2006-10-16 | 2013-08-30 | Salk Inst Biological Studies | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
| CA2939778C (en) | 2007-01-31 | 2019-01-29 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| KR20130099938A (ko) | 2010-08-13 | 2013-09-06 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CN104039342A (zh) | 2011-10-18 | 2014-09-10 | 爱勒让治疗公司 | 拟肽大环化合物 |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| SG11201503052RA (en) | 2012-11-01 | 2015-05-28 | Aileron Therapeutics Inc | Disubstituted amino acids and methods of preparation and use thereof |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| CN105051069B (zh) | 2013-01-14 | 2019-12-10 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| KR102497443B1 (ko) | 2014-03-28 | 2023-02-08 | 젠코어 인코포레이티드 | Cd38 및 cd3에 결합하는 이중특이적 항체 |
| CN104045689B (zh) * | 2014-06-25 | 2016-08-24 | 新乡医学院 | 一种关于生长抑素受体激动剂多肽及其应用 |
| CN104086630B (zh) * | 2014-06-25 | 2016-06-29 | 天津欧德莱生物医药科技有限公司 | 一种生长抑素受体激动剂多肽及其应用 |
| CN104045690B (zh) * | 2014-06-25 | 2016-06-08 | 舟山医院 | 生长抑素受体激动剂多肽及其应用 |
| MX2017003797A (es) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
| CN104491890A (zh) * | 2014-11-21 | 2015-04-08 | 北京肿瘤医院 | 放射性核素标记的新型生长抑素类似物分子探针及其应用 |
| CA2967426A1 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and tumor antigens |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108699136B (zh) | 2015-12-07 | 2022-03-18 | Xencor股份有限公司 | 结合cd3和psma的异二聚抗体 |
| WO2017136943A1 (en) * | 2016-02-09 | 2017-08-17 | Cdrd Ventures Inc. | Somatostatin receptor antagonist compounds and methods of using the same |
| CA3026151A1 (en) | 2016-06-14 | 2017-12-21 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| MX2018016265A (es) | 2016-06-28 | 2019-07-04 | Xencor Inc | Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina. |
| US10849955B2 (en) | 2016-09-28 | 2020-12-01 | City Of Hope | Methods of treating pancreatic cancer using GPCR antagonists |
| KR20200085828A (ko) | 2017-11-08 | 2020-07-15 | 젠코어 인코포레이티드 | 신규의 항-pd-1 서열을 사용한 이중특이적 및 단일특이적 항체 |
| EP3773911A2 (en) | 2018-04-04 | 2021-02-17 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| TW202547563A (zh) * | 2018-06-21 | 2025-12-16 | 德商愛利穆治療有限公司 | 用於放射性醫藥之含有體抑素類似物之組成物 |
| TW202015744A (zh) * | 2018-06-21 | 2020-05-01 | 法商艾普森藥品公司 | 用於放射性醫藥之含有體抑素類似物之組成物 |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| JP7773528B2 (ja) | 2020-08-19 | 2025-11-19 | ゼンコア インコーポレイテッド | 抗ｃｄ２８組成物 |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
| DE102021111452B3 (de) * | 2021-05-04 | 2022-07-28 | Positron Precision GmbH | Markierungsvorläufer und Radiotracer für neuroendokrine Theranostik |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
| CN120282804A (zh) | 2022-09-23 | 2025-07-08 | 核素迪姆股份公司 | 高纯度铜放射性药物组合物及其诊断和治疗用途 |
| CN115583989B (zh) * | 2022-12-09 | 2023-02-28 | 烟台蓝纳成生物技术有限公司 | 一种靶向sstr2的化合物及其制备方法和应用 |
| CN119708199A (zh) * | 2023-09-27 | 2025-03-28 | 钱杭江医药科技(嘉兴)有限公司 | 生长抑素肽类类似物、螯合物及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3904594A (en) * | 1973-07-02 | 1975-09-09 | Salk Inst For Biological Studi | Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof |
| US4372884A (en) * | 1975-08-06 | 1983-02-08 | The Salk Institute For Biological Studies | Pharmaceutically active peptides |
| US4428942A (en) | 1982-05-17 | 1984-01-31 | The Salk Institute For Biological Studies | Analogs of somatostatin |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US5776894A (en) * | 1988-12-05 | 1998-07-07 | Novartis Ag | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5590656A (en) | 1992-09-15 | 1997-01-07 | The Ohio State University Research Foundation | Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| CA2183421A1 (en) | 1994-02-18 | 1995-08-24 | John Mertens | Labelled peptide compounds |
| US5663292A (en) | 1994-12-12 | 1997-09-02 | The Salk Institute For Biological Studies | Cyclic CRF analogs |
| US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
| US5708135A (en) | 1995-09-29 | 1998-01-13 | Biomeasure Incorporated | Cyclic peptide analogs of somatostatin |
| US5750499A (en) | 1995-10-18 | 1998-05-12 | The Salk Institute For Biological Studies | Receptor-selective somatostatin analogs |
| US5846934A (en) | 1996-02-20 | 1998-12-08 | American Cyanamid Company | Pure somatostatin antagonist and methods of use thereof |
| PL334089A1 (en) * | 1996-12-04 | 2000-01-31 | Sod Conseils Rech Applic | Compounds antagonistic in respect to somatostatin |
| US6262229B1 (en) | 1996-12-04 | 2001-07-17 | Biomeasure Incorporated | Somatostatin antagonists |
| US5925618A (en) | 1997-03-06 | 1999-07-20 | American Cyanamid Company | Peptides useful as somatostatin antagonists |
| CA2246791A1 (en) | 1998-09-01 | 2000-03-01 | Alison Buchan | Treatment of endothelium with somatostatin analogues |
| US6579967B1 (en) * | 1999-12-14 | 2003-06-17 | The Salk Institute For Biological Studies | Receptor-selective somatostatin analogs |
| DK1355940T3 (da) * | 2000-10-20 | 2008-01-07 | Univ Tulane | Urotensin II-agonister og -antagonister |
| DK1372688T3 (da) * | 2001-03-08 | 2008-08-25 | Univ Tulane | Somatostatin-antagonister |
| US7019109B2 (en) | 2001-03-16 | 2006-03-28 | The Salk Institute For Bilogical Studies | SSTR1-selective analogs |
| EP1283216A1 (en) | 2001-08-10 | 2003-02-12 | Mallinckrodt Inc. | Somatostatin analogues binding to all somatostatin receptor subtypes and their use |
| CN1589151A (zh) | 2001-09-21 | 2005-03-02 | 图兰恩教育基金管理人 | 诊断或治疗性促生长素抑制素或铃蟾肽类似物的连接物及其用途 |
| WO2004009614A2 (en) | 2002-07-24 | 2004-01-29 | The Salk Institute For Biological Studies | Receptor (sstr4)- selective somatostatin analogs |
| DK1603598T3 (da) | 2003-03-19 | 2009-01-26 | Univ Bern | Radiomærkede konjugater baseret på substans P og anvendelser heraf |
| PL2076535T3 (pl) | 2006-10-16 | 2013-08-30 | Salk Inst Biological Studies | Antagoniści somatostatyny selektywni względem receptora (SSTR2) |
-
2007
- 2007-10-15 PL PL07854075T patent/PL2076535T3/pl unknown
- 2007-10-15 PL PL11194516T patent/PL2433963T3/pl unknown
- 2007-10-15 AU AU2007311137A patent/AU2007311137B2/en active Active
- 2007-10-15 EP EP07854075A patent/EP2076535B1/en active Active
- 2007-10-15 ES ES07854075T patent/ES2410207T3/es active Active
- 2007-10-15 EP EP11194516.8A patent/EP2433963B1/en active Active
- 2007-10-15 SI SI200731231T patent/SI2076535T1/sl unknown
- 2007-10-15 WO PCT/US2007/081430 patent/WO2008048942A2/en not_active Ceased
- 2007-10-15 JP JP2009533471A patent/JP5295967B2/ja active Active
- 2007-10-15 EP EP11173287.1A patent/EP2383289B1/en active Active
- 2007-10-15 ES ES11173287.1T patent/ES2526292T3/es active Active
- 2007-10-15 PL PL11173287T patent/PL2383289T3/pl unknown
- 2007-10-15 CA CA2666642A patent/CA2666642C/en active Active
- 2007-10-15 US US11/872,367 patent/US7960342B2/en active Active
- 2007-10-15 DK DK07854075.4T patent/DK2076535T3/da active
- 2007-10-15 CN CN201310138908.4A patent/CN103288919B/zh active Active
- 2007-10-15 PT PT78540754T patent/PT2076535E/pt unknown
- 2007-10-15 BR BRPI0717135A patent/BRPI0717135B8/pt active IP Right Grant
- 2007-10-15 CN CN2007800386522A patent/CN101631801B/zh active Active
-
2011
- 2011-06-13 US US13/159,020 patent/US8501687B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0717135B1 (pt) | 2020-09-15 |
| EP2076535A2 (en) | 2009-07-08 |
| AU2007311137A1 (en) | 2008-04-24 |
| ES2410207T3 (es) | 2013-07-01 |
| PL2383289T3 (pl) | 2015-03-31 |
| EP2383289A1 (en) | 2011-11-02 |
| CN101631801B (zh) | 2013-06-05 |
| AU2007311137B2 (en) | 2013-06-20 |
| DK2076535T3 (da) | 2013-06-10 |
| JP5295967B2 (ja) | 2013-09-18 |
| CA2666642A1 (en) | 2008-04-24 |
| CN101631801A (zh) | 2010-01-20 |
| US20080260638A1 (en) | 2008-10-23 |
| EP2383289B1 (en) | 2014-10-08 |
| EP2076535B1 (en) | 2013-03-06 |
| US7960342B2 (en) | 2011-06-14 |
| BRPI0717135B8 (pt) | 2021-05-25 |
| CN103288919A (zh) | 2013-09-11 |
| WO2008048942A3 (en) | 2008-09-18 |
| EP2433963B1 (en) | 2014-06-04 |
| JP2010506943A (ja) | 2010-03-04 |
| HK1132515A1 (en) | 2010-02-26 |
| ES2526292T3 (es) | 2015-01-09 |
| US8501687B2 (en) | 2013-08-06 |
| BRPI0717135A2 (pt) | 2013-10-15 |
| WO2008048942A2 (en) | 2008-04-24 |
| EP2433963A1 (en) | 2012-03-28 |
| US20110269683A1 (en) | 2011-11-03 |
| PL2433963T3 (pl) | 2014-11-28 |
| CN103288919B (zh) | 2014-11-12 |
| CA2666642C (en) | 2015-11-17 |
| PT2076535E (pt) | 2013-06-12 |
| SI2076535T1 (sl) | 2013-07-31 |
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